Introductory Lecture: Genetic Approaches to CNS Disorders with Particular

References

• Risch N. J. Mapping genes for psychiatric disorders. Genetic approaches to mental disorders, E. S. Gershon, C. R. Cloniger. American Psychiatric Press Inc. 1994; 47–61
   Google Scholar
• George-Hyslap P.H. St., Tanzi R. H., Polinsky R. J., Haines J. L., Nee L., Watkins P. C., Myers R. H., Feldman R. G., Pollen D., Drachman D., Growdon J., Bruni A., Foncin J.-F., Salmon D., Frommelt P., Amaducci L., Sorbi S., Piacentini S., Stewart G. D., Hobbs W. J., Conneally P. M., Gusella J. F. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987; 235: 885–890
   PubMedGoogle Scholar
• Hall J. M., Lee M. K., Newman B., Morow J. E., Anderson L. A., Huey B., King M.-C. Linkage of early onset familial breast cancer to chromosome 17q21. Science 1990; 250: 1684–1689
   PubMed Web of Science ®Google Scholar
• Bell G. I., Xiang K., Newman M. V., Wu S.-H., Wright L. G., Fajans S. S., Spielman R. S., Cox N. J. Gene for non-insulin dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 2q. Proc. Natl. Acad. Sci. USA 1991; 88: 1484–1488
   PubMed Web of Science ®Google Scholar
• Froguel P. H., Vaxillaire M., Sun F., Velho G., Zouali H., Butel M. O., Lesage S., Vionnet N., Clement K., Fougerousse F., Tanizawa Y., Weissenbach J., Beckmann J. S., Lathrop G. M., Passa P., Permutt M. A., Cohen D. Close linkage of glucokinase locus on chromosome 7p to early onset non-insulin-dependent diabetes mellitus. Nature 1992; 356: 162–164
   PubMed Web of Science ®Google Scholar
• McGuffin P., Owen J. M., Farmer A. E. Genetic basis of schizophrenia. Lancet 1995; 346: 678–682
   PubMed Web of Science ®Google Scholar
• Propping P., Nöthen M. Schizophrenia: genetic tools for unraveling the nature of a complex disorder. Proc. Natl. Acad. Sci. USA 1995; 92: 7607–7608
   PubMedGoogle Scholar
• Williams J., Spurlock G., McGuffin P., Mallet J., Nöthen M. M., Gill M., Aschauer H., Nylander P. O., Macciardi F., Owen M. J. Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. Lancet 1996; 347: 1294–1296
   PubMed Web of Science ®Google Scholar
• Harrison P. J., Geddes J. R. Schizophrenia and the 5HT2a receptor gene. Lancet 1996; 347: 1274
   PubMedGoogle Scholar
• Arranz M., Collier D., Shodi M., Ball D., Roberts G., Price J., Sham P., Kerwin R. Association between clozapine response and allelic variation in 5HT2a receptor gene. Lancet 1995; 346: 281–282
   PubMed Web of Science ®Google Scholar
• Lyon M. F., King T. R., Gondo Y., Gardner J. M., Nakatsu Y., Eicher E. M., Brilliant M. H. Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. Proc. Natl. Acad. Sci. USA 1992; 89: 6968–6972
   PubMedGoogle Scholar
• Culiat C. T., Stubbs L., Nicholls R. D., Montgomery C. S., Russell L. B., Johnson D. K., Rinchik E. M. Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the β3 subunit of the type A γ-aminobutyric acid receptor. Proc. Natl. Acad. Sci. USA 1993; 90: 5105–5109
   PubMedGoogle Scholar
• Nakatsu Y., Tyndale R. F., DeLorey T. M., Durham-Pierre D., Gardner J. M., McDanel H. J., Nguyen Q., Wagstaff J., Lalande N., Sikela J. M., Olsen R. W., Tobin A. J., Brilliant M. H. A cluster of three GABAA-receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature 1993; 364: 448–450
   PubMed Web of Science ®Google Scholar
• Benke, et al, unpublished
   Google Scholar
• Culiat C. T., Stubbs L. J., Montgomery C. S., Russel L. B., Rinchik E. M. Phenotypic consequences of cleletion of the γ3, α5, or β3 subunit of the type A γ-aminobutyric acid receptor in mice. Proc. Natl. Acad. Sci. USA 1994; 91: 2815–2818
   PubMed Web of Science ®Google Scholar
• Culiat C. T., Stubbs L., Woychik R. P., Russel L. B., Johnson D. K., Rinchik E. M. Deficiency of the β3-subunit of the type A γ-aminobutyric acid receptor causes cleft palate in mice. Nature Genetics 1995; 11: 344–346
   PubMed Web of Science ®Google Scholar
• Wee E. L., Zimmerman E. F. Involvement of GABA in palate morphogenesis and its relation to diazepam teratogenesis in two mouse strains. Teratol. 1983; 28: 15–22
   PubMedGoogle Scholar
• Angelmann H. “Puppet” children. A report on three cases. Dev. Med. Child. Neurol. 1965; 7: 681–683
   Google Scholar
• Magenis R. E., Toth-Fejel S., Allen L. J., Balck M., Brown M. G., Budden S., Cohen R., Friedman J. M., Kalousek D., Zonana J., et al. Comparison of the 15q deletions in Prader-Willi and Angelman syndromes: specific regions, extent of deletions, parental origin, and clinical consequences. Amer. J. Med. Gen. 1990; 35: 333–349
   PubMed Web of Science ®Google Scholar
• Knoll J. H., Sinnet D., Wagstaff J., Glatt K., Wilcox A. S., Whiting P. M., Wingrove P., Sikela J. M., Lalande M. FISH ordering of reference markers and of the gene for the α5 subunit of the γ-aminobutyric acid receptor (GABAR5) within the Angelman and Prader-Willi syndrome chromosomal regions. Hum. Mol. Gen. 1993; 2: 183–189
   PubMed Web of Science ®Google Scholar
• Sinnett C., Wagstaff J., Glatt K., Woolf E., Kirkness E. J., Lalande M. High-resolution mapping of the γ-aminobutyric acid receptor subunit β3 and α5 gene cluster on chromosome 15q11–q13, and localization of breakpoint in two Angelman syndrome patients. Amer. J. Hum. Genet. 1993; 52: 1216–1229
   PubMed Web of Science ®Google Scholar
• Reis A., Kunze J., Ladanyi L., Enders H., Klein-Vogler U., Niemann G. Exclusion of the GABAA-receptor β3 subunit gene as the Angelman's syndrome gene. Lancet 1993; 341: 122–123
   PubMedGoogle Scholar
• Nicholls R. D., Gottlieb W., Russell L. B., Davda M., Hosthernke B., Rinchik E. M. Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11-q13 syndromes by fine-structure homology mapping in the mouse. Proc. Natl. Acad. Sci. USA 1993; 90: 2050–2054
   PubMed Web of Science ®Google Scholar
• Korpi E. R., Kleingoor C., Kettenmann H., Seeburg P. H. Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA-receptor. Nature 1993; 361: 356–359
   PubMed Web of Science ®Google Scholar
• Hellevuo H., Kiianmaa K., Korpi E. R. Effect of GABAergic drugs on motor impairment from ethanol, barbital and lorazepam in rat lines selected for differential sensitivity to ethanol. Pharmacol. Biochem. Behav. 1989; 34: 399–404
   PubMedGoogle Scholar
• Kleingoor C., Wieland H. A., Korpi E. R., Seeburg P. H., Kettenmann H. Current potentiation by cliazepam but not GABA sensitivity is determined by a single histidine residue. Neuroreport 1993; 4: 187–190
   PubMedGoogle Scholar
• Harris R. A., McQuilkin S. J., Paylor R., Abeliovich A., Tonegawa S., Wehner J. M. Mutant mice lacking the γ isoform of protein kinase C show decreased behavioural actions of ethanol and altered function of γ-aminobutyrate type A receptors. Proc. Natl. Acad. Sci. USA 1995; 92: 3658–3662
   PubMed Web of Science ®Google Scholar
• Ffrench-Constant R. H., Rocheleau T. A., Steichen J. C., Chalmers A. E. A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature 1993; 363: 449–451
   PubMed Web of Science ®Google Scholar
• Ffrench-Constant R. H., Steichen J. C., Rocheleau T. A., Aronenstein K., Roush R. T. A single-amino acid substitution in a γ-aminobutyric acid subtype. A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations. Proc. Natl. Acad. Sci. USA 1993; 90: 1957–1961
   PubMed Web of Science ®Google Scholar
• Gurley D., Amin J., Ross P. C., Weiss D. S., White G. Point mutations in the M2 region of the α, β or γ subunit of the GABAA channel that abolish block by picrotoxin. Recept. Channel 1995; 3: 13–20
   PubMedGoogle Scholar
• Günther U., Benson J., Benke D., Fritschy J.-M., Reyes G. H., Knoflach F., Crestani F., Aguzzi A., Arigoni M., Lang Y., Blüthmann H., Mohler H., Lüscher B. Benzodiazepine-insensitive mice generated by targeted disruption of the γ-aminobutyric acid type A receptors. Proc. Natl. Acad. Sci. USA 1995; 92: 7749–7753
   PubMed Web of Science ®Google Scholar
• Nöthen M. M., Rietschel M., Erdmann J., Oberländer H., Moller H.-J., Naber D., Propping P. Genetic variation of the 5HT2a receptor and response to clozapine. Lancet 1995; 346: 908–909
   PubMed Web of Science ®Google Scholar
• Masellis M., Paterson A. D., Badri F., Liebermann J. A., Meltzer H. Y., Cavazzoni P., Kennedy J. L. Genetic variation of 5HT2a receptor and response to clozapine. Lancet 1995; 346: 1108
   PubMed Web of Science ®Google Scholar