Genomic Organization and Expression of the CXCR4 Gene in Mouse and Man: Absence of a Splice Variant Corresponding to Mouse CXCR4-B in Human Tissues

References

• Murphy P. M. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Fact. Rev. 1997; 7: 47–64
   Google Scholar
• Ye R. D., Boulay F. Structure and function of leukocyte chemoattractant receptors. Adv. Pharmacol. 1997; 39: 221–289
   PubMedGoogle Scholar
• Baggiolini M., Dewald B., Moser B. Human chemokines: an update. Annu. Rev. Immunol. 1997; 15: 675–705
   PubMed Web of Science ®Google Scholar
• Baggiolini M. Chemokines and leukocyte traffic. Nature 1997; 392: 565–568
   Google Scholar
• Rollins B. J. Chemokines. Blood 1997; 90: 909–928
   PubMed Web of Science ®Google Scholar
• Cao Y., Chen C., Weatherbee J. A., Tsang M., Folkman J. Gro-β, a C-X-C chemokine, is an angiogenesis inhibitor that suppresses the growth of lewis lung carcinoma in mice. J. Exp. Med 1995; 182: 2069–2077
   PubMed Web of Science ®Google Scholar
• Arenberg D. A., Kunkel S. L., Polverini P. J., Morris S. B., Burdick M. D., Glass M. C., Taub D. T., Iannettoni M. D., Whyte R. I., Strieter R. M. Interferon-γ-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. J. Exp. Med 1996; 184: 981–992
   PubMed Web of Science ®Google Scholar
• Schall T. The Cytokine Handbook, A. Thompson. Academic Press, San Diego, Second Edition 1994; 419–460
   Google Scholar
• Verfaillie C. M. Chemokines as inhibitors of hematopoietic progenitors. J. Lab. Clin. Med, 127: 148–150
   Google Scholar
• Bleul C. C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski. J., Springer T. A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996; 382: 829–833
   PubMed Web of Science ®Google Scholar
• Oberlin E., Amara A., Bachelerie F., Bessia C., Virelizier J.-L., Arenzana-Seisdedos F., Schwartz O., Heard J.-M., Clark-Lewis I, Legler D. F., Loetscher M., Baggiolini M., Moser B. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line adapted HIV-1. Nature 1996; 382: 833–835
   PubMed Web of Science ®Google Scholar
• Nagasawa T., Kikutani H., Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc. Natl. Acad. Sci. USA 1994; 91: 2305–2309
   PubMed Web of Science ®Google Scholar
• Jiang W., Zhou P., Kahn S. M., Tomita N., Johnson M. D., Weinstein I. B. Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). Exp. Cell. Res. 1994; 215: 284–293
   Google Scholar
• Shirozu M., Nakano T., Inazawa J., Tashiro K., Tada H., Shinohara T., Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 1995; 28: 495–500
   PubMed Web of Science ®Google Scholar
• Bleul C. C., Fuhlbrigge R. C., Casasnovas J. M., Aiuti A., Springer T. A. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med 1996; 184: 1101–1109
   PubMed Web of Science ®Google Scholar
• Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S-I., Kitamura Y., Yoshida N., Kikutani H., Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996; 382: 635–638
   PubMed Web of Science ®Google Scholar
• Aiuti A., Webb I. J., Bleul C., Springer T., Gutierrez-Ramos J. C. The chemokine SDF-1 is a chemoattractant for human CD34+hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+progenitors to peripheral blood. J. Exp. Med. 1997; 185: 111–120
   PubMed Web of Science ®Google Scholar
• Kim C. H., Broxmeyer H. E. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment. Blood 1998; 91: 100–110
   PubMed Web of Science ®Google Scholar
• D'Apuzzo M., Rolink A., Loetscher M., Hoxie J. A., Clark-Lewis I., Melchers F., Baggiolini M., Moser B. The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. Eur. J. Immunol. 1997; 27: 1788–1793
   PubMed Web of Science ®Google Scholar
• Bleul C. C., Schultze J. L., Springer T. A. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement. J. Exp. Med 1998; 187: 753–762
   PubMed Web of Science ®Google Scholar
• Campbell J. J., Hedrick J., Zlotnik A., Siani M. A., Thompson D. A., Butcher E. C. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 1998; 279: 381–384
   PubMed Web of Science ®Google Scholar
• Hesselgesser J., Halks-Miller M., Delvecchio V., Peiper S. C., Hoxie J., Kolson D. L., Taub D., Horuk R. CD-4 independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr. Biol. 1997; 7: 112–121
   PubMed Web of Science ®Google Scholar
• Jazin E. E., SÖDerstrÖM S., Ebendal T., Larhammar D. Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR4 HIV-1 co-receptor. J. Neuroimmunol. 1997; 79: 148–154
   PubMed Web of Science ®Google Scholar
• Rimland J., Xin W., Sweetnam P., Saijoh K., Nestler E., Duman R. S. Sequence and expression of a neuropeptide Y receptor cDNA. Mol. Pharmacol. 1991; 40: 869–875
   PubMed Web of Science ®Google Scholar
• Herzog H., Hort Y. J., Shine J., Selbie L. A. Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA and Cell Biol. 1993; 12: 465–471
   PubMed Web of Science ®Google Scholar
• Nomura H., Nielsen B. W., Matsushima K. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int. Immunol. 1993; 5: 1239–1249
   PubMed Web of Science ®Google Scholar
• Federsppiel B., Melhado I. G., Duncan A. M.V., Delaney A., Schappert K., Clark-Lewis I., Jirik F. R. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomics 1993; 16: 707–712
   PubMed Web of Science ®Google Scholar
• Jazin E. E., Yoo H., Blomqvist A. G., Yee F., Weng G., Walker M. W., Salon J., Larhammer D., Wahlestedt C. A proposed bovine neuropetide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul. Pept. 1993; 47: 247–258
   PubMed Web of Science ®Google Scholar
• Loetscher M., Geiser T., O'Reilly T., Zwahlen R., Baggiolini M., Moser B. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leucocytes. J. Biol. Chem 1994; 269: 232–237
   PubMed Web of Science ®Google Scholar
• Doms R. W., Peiper S. P. Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry. Virology 1997; 235: 179–190
   PubMed Web of Science ®Google Scholar
• Moore J. P., Trkola A., Dragic T. Co-receptors for HIV-1 entry, Curr. Opin. Immunol. 1997; 9: 551–562
   Google Scholar
• Dimitrov D. S. How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. Cell 1997; 91: 721–730
   PubMed Web of Science ®Google Scholar
• Endres M. J., Clapham P. R., Marsh M., Ahuja M., Turner J. D., McKnight A., Thomas J. F., Stoebenau-Haggarty B., Choe S., Vance P. J., Wells T. N.C., Power C. A., Sutterwala S. S., Doms R. W., Landau N. R., Hoxie J. A. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 1996; 87: 745–756
   PubMed Web of Science ®Google Scholar
• Pleskoff O., Sol N., Labrosse B., Alizon M. Human immunodeficiency virus strains differ in their ability to infect CD4+cells expressing the rat homolog of CXCR-4 (fusin). J. Virol. 1997; 71: 3259–3262
   Google Scholar
• Nagasawa T., Nakajima T., Tachibana K., Iizasa H., Bleul C. C., Yoshie O., Matsushima K., Yoshida N., Springer T. A., Kishimoto T. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc. Natl. Acad. Sci. USA 1996; 93: 14726–14729
   PubMed Web of Science ®Google Scholar
• Heesen M., Berman M. A., Benson J. D., Gerard C., Dorf M. E. Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor. J. Immunol 1996; 157: 5455–5460
   PubMed Web of Science ®Google Scholar
• Moepps B., Frodl R., Rodewald H.-R., Baggiolini M., Gierschik P. Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell-derived factor 1αactivation of Gi2are differentially expressed,in vivo. Eur. J. Immunol. 1997; 27: 2102–2112
   PubMed Web of Science ®Google Scholar
• Heesen M., Berman M. A., HÖPken U. E., Gerard N. P., Dorf M. E. Alternate splicing of mouse fusin/CXC chemokine receptor-4. J. Immunol 1997; 158: 3561–3564
   PubMedGoogle Scholar
• Miller S. A., Dykes D. D., Polesky; H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16: 1215
   PubMed Web of Science ®Google Scholar
• Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, Second Edition 1989
   Google Scholar
• Singer-Sam J., Lebon J. M., Dai A., Riggs A. D. A sensitive, quantitative assay for measurement of allele-specific transcripts differing by a single nucleotide. PCR Methods Appl. 1992; 1: 160–163
   PubMedGoogle Scholar
• Breathnach R., Benoist C., O'Hare K., Gannon F., Chambon P. Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc. Natl. Acad. Sci. USA 1978; 75: 4853–4857
   PubMed Web of Science ®Google Scholar
• Brelot A., Heveker N., Pleskoff O., Sol N., Alizon M. Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity. J. Virol 1997; 71: 4744–4751
   PubMed Web of Science ®Google Scholar
• Willett B. J., Picard L., Hosie M. J., Turner J. D., Adema K., Clapham P. R. Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. J. Virol 1997; 71: 6407–6415
   PubMed Web of Science ®Google Scholar
• Pretet J. L., Zerbib A. C., Girard M., Guillet J. G., Butor C. Chimpanzee CXCR4 and CCR5 act as coreceptors for HIV-1. AIDS Res. Hum. Retroviruses 1997; 13: 1583–1587
   Google Scholar
• Chen Z., Zhou P., Ho D. D., Landau N. R., Marx P. A. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. J. Virol. 1997; 71: 2705–2714
   Google Scholar
• Edinger A. L., Amedee A., Miller K., Doranz B. J., Endres M., Sharron M., Samson M., Lu Z.-H., Clements J. E., Murphey-Corb M., Peiper S. C., Parmentier M., Broder C. C., Doms R. W. Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proc. Natl. Acad. Sci. USA. 1997; 94: 4005–4010
   PubMed Web of Science ®Google Scholar
• Larosa G. J., Thomas K. M., Kaufmann M. E., Mark R., White M., Taylor L., Gray G., Witt D., Navarro J. Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity. J. Biol. Chem. 1992; 267: 25–402
   Google Scholar
• Gayle R. B., Sleath P. R., Srinivason S., Birks C. W., Weerawarna K. S., Cerretti D. P., Kozlosky C. J., Nelson N., Vanden Bos T., Beckmann M. P. Importance of the amino terminus of the interleukin-8 receptor in ligand interactions. J. Biol. Chem 1993; 268: 7283–7289
   PubMed Web of Science ®Google Scholar
• Ahuja S. K., Lee J. C., Murphy P. M. CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. J. Biol. Chem 1996; 271: 225–232
   PubMed Web of Science ®Google Scholar
• Monteclaro F. S., Charo I. F. The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1. Receptor activation by pseudo-tethered ligand. J. Biol. Chem 1997; 272: 23186–23190
   PubMedGoogle Scholar
• Feng Y., Broder C. C., Kennedy P. E., Berger E. A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272: 872–877
   PubMed Web of Science ®Google Scholar
• Lapham C. K., Ouyang J., Chandrasekhar B., Nguyen N. Y., Dimitrov D. S., Golding H. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science 1996; 274: 602–605
   PubMed Web of Science ®Google Scholar
• Lu Z.-H., Berson J. F., Chen Y.-H., Turner J. D., Zhang T.-Y., Sharron M., Jenks M. H., Wang Z.-X., Kim J., Rucker J., Hoxie J. A., Peiper S. C., Doms R. W. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc. Natl. Acad. Sci. USA 1997; 94: 6426–6431
   PubMed Web of Science ®Google Scholar
• Picard L., Wilkinson D. A., McKnight A., Gray P. W., Hoxie J. A., Clapham P. R., Weiss R. A. Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry. Virology 1997; 231: 105–111
   PubMed Web of Science ®Google Scholar
• Liao F., Lee H.-H., Farber J. M. Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics 1997; 40: 175–180
   PubMedGoogle Scholar
• Schweickart V. L., Raport C. J., Godiska R., Byers M. G., Eddy R. L., Jr., Shows T. B., Gray P. W. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12–q21.2. Genomics 1994; 23: 643–650
   PubMed Web of Science ®Google Scholar
• Marchese A., Heiber M., Nguyen T., Heng H. H.Q., Saldivia V. R., Cheng R., Murphy P. M., Tsui L.-C., Shi X., Gregor P., George S. R., O'Dowd B. F., Docherty J. M. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 1995; 29: 335–344
   PubMed Web of Science ®Google Scholar
• Loetscher M., Gerber B., Loetscher P., Jones S. A., Piali L., Clark-Lewis I., Baggiolini M., Moser B. Chemokine receptor specific for IP10 and Mig: structure, function, and expression in activated T-lymphocytes. J. Exp. Med 1996; 184: 963–969
   PubMed Web of Science ®Google Scholar
• Wegner S. A., Ehrenberg P. K., Chang G., Dayhoff D. E., Sleeker A. L., Michael N. L. Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J. Biol. Chem. 1998; 273: 4754–4760
   PubMed Web of Science ®Google Scholar