Splice Variants of the OB Receptor Gene are Differentially Expressed in Brain and Peripheral Tissues of Mice

References

• Campfield L. A., Smith F. J., Burn P. Genetics of Obesity. Encyclopedia of Neuroscience2nd ed., G. Adelman, B. Smith. Elsevier Science, Amsterdam 1998
   Google Scholar
• Campfield L. A., Smith F. J., Burn P. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Hormone and Metabolic Research 1996; 28: 619–632
   PubMed Web of Science ®Google Scholar
• Campfield L. A., Smith F. J., Burn P. OB protein: a hormonal controller of central neural networks mediating behavioral, metabolic and neuroendocrine responses. Endocrinology and Metabolism March, 1997
   Web of Science ®Google Scholar
• Coleman D. I. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978; 14: 141–148
   PubMed Web of Science ®Google Scholar
• Coleman D. L., Hummel K. P. The influence of genetic background on the expression of the obese (ob) gene in the mouse. Diabetologia 1973; 9: 287–293
   PubMed Web of Science ®Google Scholar
• Bray G. A., York D. A. Genetically transmitted obesity in rodents. Physiol. Rev. 1971; 51: 598–646
   PubMed Web of Science ®Google Scholar
• Bray G. A., Campfield L. A. Metabolic factors in the control of energy stores. Metabolism 1975; 24: 99–117
   PubMed Web of Science ®Google Scholar
• Bray G. A., York D. A. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 1979; 59: 719–809
   PubMed Web of Science ®Google Scholar
• Campfield L. A., Smith F. J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546–549
   PubMed Web of Science ®Google Scholar
• Campfield L. A., Smith F. J., Guisez Y., Devos R., Burn P. OB protein: A peripheral signal linking adiposity and central neural networks. Appetite 1996; 26: 302
   PubMed Web of Science ®Google Scholar
• Halaas J. L., Gajiwala K. S., Maffei M., Cohen S. L., Chait B. T., Rabinowitz D., Lallone R. L., Burley S. K., Friedman J. M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543–546
   PubMed Web of Science ®Google Scholar
• Pelleymounter M., Cullen M., Baker M., Hecht R., Winters D., Bone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540–543
   PubMed Web of Science ®Google Scholar
• Levin N., Nelson C., Gurney A., Vandlen R., DeSauvage F. Decreased food intake does not completely account for adiposity reduction after OB protein infusion. Proc. Nat. Acad. Sci. USA 1996; 93: 1726–1730
   PubMed Web of Science ®Google Scholar
• Rentsch J., Levens N., Chiesi M. Recombinant ob-gene product reduces food intake in fasted mice. Biochem. Biophy. Res. Com. 1995; 214: 131–136
   PubMed Web of Science ®Google Scholar
• Schwartz M. W., Baskin D. G., Bukowski T. R., Kuijper J. L., Foster D., Lasser G., Prunkard D. E., Porte D., Jr., Woods S. C., Seeley R. J., Weigle D. S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996; 45: 531–535
   PubMed Web of Science ®Google Scholar
• Stephens T. W., Basinski M., Bristow P. K., Bue-Valleskey J. M., Burgett S. G., Craft L., Hale J., Hoffmann J., Hsiung H. M., Kriauciunas A., MacKeller W., Rosteck P. R., Jr., Schoner B., Smith D., Tinsley F. C., Zhang X.-Y., Heiman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530–532
   PubMed Web of Science ®Google Scholar
• Weigle D. S., Bukowski T. R., Foster D. C., Holderman S., Kramer J. M., Lasser G., Lofton-Day C. E., Prunkard D. E., Raymond C., Kuiper J. L. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J. Clin. Invest 1995; 96: 2065–2070
   PubMed Web of Science ®Google Scholar
• Devos R., Richards J. G., Campfield L. A., Tartaglia L. A., Guisez Y., Van der Heyden J., Travernier J., Plaetinck G., Burn P. OB protein binds specifically to the choroid plexus of mice and rats. Proc. Nat. Acad. Sci. USA 1996; 93: 5668–5673
   PubMed Web of Science ®Google Scholar
• Malik K. F., Young W. S., 3rd. Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinology 1996; 137: 1497–1500
   PubMed Web of Science ®Google Scholar
• Lynn R. B., Cao G. Y., Considine R. V., Hyde T. M., Caro J. F. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem. Biophy. Res. Com. 1996; 219: 884–889
   PubMed Web of Science ®Google Scholar
• Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M. H., Skoda R. C. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Nat. Acad. Sci. USA 1996; 93: 6231–6235
   PubMed Web of Science ®Google Scholar
• Baumann H., Morella K. K., White D. W., Dembski M., Bailon P. S., Kim H., Lai C.-F., Tartaglia L. A. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Nat. Acad. Sci. USA 1996; 93: 8374–8378
   PubMed Web of Science ®Google Scholar
• Tartaglia L. A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards J. G., Campfield L. A., Clark F. T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K. J., Smutko J. S., Mays G. G., Woolf E. A., Monroe C. A., Tepper R. I. Identification and expression cloning of a leptin receptor (OB-R). Cell 1995; 83: 1263–1271
   PubMed Web of Science ®Google Scholar
• Chen H., Charlat O., Tartaglia L. A., Woolf E. A., Weng X., Ellis S. J., Lakey N. D., Culpepper J., Moore K. J., Breitbart R. F., Duyk G. M., Tepper R. I., Morgenstern J. P. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491–495
   PubMed Web of Science ®Google Scholar
• Lee G., Proenca R., Montez J. M., Carrol K. M., Darvishzadeh J. G., Lee J. I., Friedman J. M. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632–635
   PubMed Web of Science ®Google Scholar
• Cioffi J. A., Shafer A. W., Zupancic T. J., Smith-Gbur J., Mikhail A., Platika D., Snodgrass H. R. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nature Med. 1996; 2: 585–589
   PubMed Web of Science ®Google Scholar
• Chua S. C., Chung W. K., Wu-Peng X. S., Zhang Y., Liu S.-M., Tartaglia L., Leibel R. L. Phenotypes of mouse diabetes and rat fatty due to mutations in th OB (leptin) receptor. Science 1996; 271: 994–996
   PubMed Web of Science ®Google Scholar
• Clement K., Vaisse C., Lahlou N., Cabrol S., Pelloux V., Cassuto D., Gourmelen M., Dina C., Chambaz J., Lacorte J. M., Basdevant A., Bougneres P., Lebouc Y., Froguel P., Guy-Grand B. A mutation in the human receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398–401
   PubMed Web of Science ®Google Scholar
• Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters 1996; 387: 113–116
   PubMed Web of Science ®Google Scholar
• Schwartz M. W., Seeley R. J., Campfield L. A., Burn P., Baskin D. G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest 1996; 98: 1101–1106
   PubMed Web of Science ®Google Scholar
• Hakansson M. L., Brown H., Ghilardi N., Skoda R. C., Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 1998; 18: 559–572
   PubMed Web of Science ®Google Scholar
• Mercer J. G., Moar K. M., Hoggard N. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 1998; 139: 29–34
   PubMed Web of Science ®Google Scholar
• Lugo D. I., Roberts J. L., Pintar J. E. Analysis of proopiomelanocortin gene expression during prenatal development of the rat pituitary gland. Molec. Endocrin. 1989; 3: 1313–1324
   PubMedGoogle Scholar
• Campfield L. A., Smith F. J. Physiol. Rev. 1998, in press
   Google Scholar
• Le Magnen J. Neurobiology of Feeding and Nutrition. Academic Press, San Diego, CA 1992
   Google Scholar
• Smith F. J., Campfield L. A., Moschera J. A., Bailon P., Burn P. Feeding inhibition by neuropeptide Y. Nature 1996; 386: 307
   Google Scholar
• Banks W. A., Kastin A. J., Huang W., Jaspan J. B., Maness L. M. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305–311
   PubMed Web of Science ®Google Scholar
• Kieffer T. J., Heller R. S., Habener J. F. Leptin receptors expressed on pancreatic beta-cells. Biochem. Biophys. Res. Commun. 1996; 224: 522–527
   PubMed Web of Science ®Google Scholar
• Pardridge W. M. The Blood-Brain Barrier: Cellular and Molecular Biology. Raven Press, New York 1993
   Google Scholar
• Kandel E. R., Schwartz J. H., Jessel T. M. Principles of Neural ScienceThird ed. Appleton & Lange, Norwalk, CO 1991
   Google Scholar
• Chehab F. F., Mounzih K., Lu R., Lim M. E. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275: 88–90
   PubMed Web of Science ®Google Scholar