β₂-Adrenoceptor Agonist-Induced Down-Regulation After Short-Term Exposure

References

• Barnes P.J. Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 1995; 152: 838–860
   PubMed Web of Science ®Google Scholar
• Harden T.K. Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase. Pharmacol Rev 1983; 35: 5–32
   PubMed Web of Science ®Google Scholar
• Sibley D.R, Lefkowitz R.J. Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. Nature 1985; 317: 124–129
   PubMed Web of Science ®Google Scholar
• Hausdorff W.P., Caron M.G., Lefkowitz R.J. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J 1990; 4: 2881–2889, [published erratum appears in FASEB J 1990 Sep;4(12):3049]
   PubMed Web of Science ®Google Scholar
• Perkins JP, Hausdorff WP, Lefkowitz R.J. Mechanisms of ligand-induced desensitization of beta-adrenergic receptors. The Beta-Adrenergic Receptors, J.P. Perkins. Humana Press, Clifton 1991; 73–124
   Google Scholar
• Lohse M.J. Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta 1993; 1179: 171–188
   PubMed Web of Science ®Google Scholar
• Su Y.F., Harden T.K., Perkins J.P. Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. J Biol Chem 1979; 254: 38–41
   PubMed Web of Science ®Google Scholar
• Su Y.F., Harden T.K., Perkins J.P. Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. J Biol Chem 1980; 255: 7410–7419
   PubMed Web of Science ®Google Scholar
• Harden TK, Cotton CU, Waldo GL, Lutton JK, Perkins J.P. Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors. Science 1980; 210: 441–443
   PubMedGoogle Scholar
• Doss RC, Perkins JP, Harden T.K. Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. J Biol Chem 1981; 256: 12281–12286
   PubMedGoogle Scholar
• Mahan LC, Koachman AM, Insel P.A. Genetic analysis of beta-adrenergic receptor internalization and down-regulation. Proc Natl Acad Sci U S A 1985; 82: 129–133
   Google Scholar
• Pittman RN, Molinoff P.B. Interactions of full and partial agonists with beta-adrenergic receptors on intact L6 muscle cells. Mol Pharmacol 1983; 24: 398–408
   Google Scholar
• Tate KM, Briend-Sutren M.M., Emorine L.J., Delavier-Klutchko C., Marullo S., Strosberg A.D. Expression of three human beta-adrenergic-receptor subtypes in transfected Chinese hamster ovary cells. Eur J Biochem 1991; 196: 357–361
   PubMedGoogle Scholar
• Lima J.J. Relationship between beta adrenoceptor occupancy and receptor down-regulation induced by beta antagonists with intrinsic sympathomimetic activity. J Recept Signal Transduct Res 1996; 16: 357–372
   Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randal R.J. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265–275
   PubMed Web of Science ®Google Scholar
• Hausdorff WP, Bouvier M, O'Dowd B.F., Irons G.P., Caron M.G., Lefkowitz R.J. Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem 1989; 264: 12657–12665
   PubMed Web of Science ®Google Scholar
• Chuang DM, Kinnier WJ, Farber L, Costa E. A biochemical study of receptor internalization during beta-adrenergic receptor desensitization in frog erythrocytes. Mol Pharmacol 1980; 18: 348–355
   Google Scholar
• Homburger V, Lucas M, Cantau B, Barabe J, Penit J, Bockaert J. Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors. J Biol Chem 1980; 255: 10436–10444
   PubMed Web of Science ®Google Scholar
• Strader CD, Sibley DR, Lefkowitz R.J. Association of sequestered beta-adrenergic receptors with the plasma membrane: a novel mechanism for receptor down regulation. Life Sci 1984; 35: 1601–1610
   Google Scholar
• Hertel C, Coulter SJ, Perkins J.P. A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. J Biol Chem 1985; 260: 12547–12553
   Google Scholar
• Bouvier M, Collins S, O'Dowd B.F., et al. Two distinct pathways for cAMP-mediated down-regulation of the beta 2- adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. J Biol Chem 1989; 264: 16786–16792
   PubMed Web of Science ®Google Scholar
• Chijiwa T, Mishima A, Hagiwara M, et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 1990; 265: 5267–5272
   PubMed Web of Science ®Google Scholar
• Hadcock JR, Malbon C.C. Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels. Proc Natl Acad Sci U S A 1988; 85: 5021–5025
   PubMed Web of Science ®Google Scholar
• von Zastrow M, Kobilka B K. Ligand-regulated intermalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J Biol Chem 1992; 267: 3530–3538
   Google Scholar
• Hausdorff WP, Campbell PT, Ostrowski J, Yu SS, Caron MG, Lefkowitz R J. A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. Proc Natl Acad Sci U S A 1991; 88: 2979–2983
   PubMed Web of Science ®Google Scholar
• Hertel C, Nunnally MH, Wong SK, Murphy EA, Ross EM, Perkins J P. A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced intermalization and GTP-sensitive agonist binding characteristic of mammalian receptors. J Biol Chem 1990; 265: 17988–17994
   PubMed Web of Science ®Google Scholar
• Campbell PT, Hnatowich M, O'Dowd BF, Caron MG, Lefkowitz RJ, Hausdorff W P. Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. Mol Pharmacol 1991; 39: 192–198
   PubMedGoogle Scholar
• Strader CD, Sigal IS, Blake AD, et al. The carboxyl terminus of the hamster beta-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration. Cell 1987; 49: 855–863
   PubMedGoogle Scholar
• Valiquette M, Bonin H, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M. Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. Proc Natl Acad Sci U S A 1990; 87: 5089–5093
   PubMedGoogle Scholar