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Research Article

Improvement of enalapril maleate chemical stability by high shear melting granulation

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Pages 1002-1008 | Received 09 Mar 2014, Accepted 18 Aug 2014, Published online: 18 Sep 2014

References

  • Al-Omari MM, Abdelah MK, Badwan AA, Jaber AMY. Effect of the drug-matrix on the stability of enalapril maleate in tablet formulations. J Pharm Bio Anal 2001;25:893–902
  • Merslavic SM, Razen NMJ, Rotar LA. Stable formulation of enalapril salt, a process for the preparation thereof and the use thereof. WO Patent 1994
  • Resende RLO, Santoro MIRM, Matos JR. Stability and compatibility study on enalapril maleate using thermoanalytical techniques. J Therm Anal Cal 2008;93:881–886
  • Lima DM, Santos LD, Lima EM. Stability and in vitro release profile of enalapril maleate from different commercially available tablets: possible therapeutic implications. J Pharm Biom Anal 2008;47:934–937
  • Kowalski J, Kalb O, Joshi YM, Serajuddin ATM. Application of melt granulation technology to enhance stability of a moisture sensitive immediate-release drug product. Int J Pharm 2009;381:56–61
  • Wong TW, Cheong WS, Heng PWS. Melt granulation and pelletization. In: Parikh DM, ed. Handbook of granulation technology. 2nd ed. Boca Raton: Taylor & Francis Group; 2005:624
  • Thies R, Kleinebudde P. Melt pelletization of a hygroscopic drug in a high shear mixer. Part I: influence of process variables. Int J Pharm 1999;188:131–143
  • United States Pharmacopeia 31, National Formulary 26, United States Pharmacopeia Convention, Rockville, 2007
  • Zoppi A, Garnero C, Linck YG, et al. Enalapril: β-CD complex: stability enhancement in solid state. Carbohydrate Pol 2011;86:716–721
  • Cunha TA, Serpa RC, Oliveira APM, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS Pharm Sci Tech 2013;14:1150–1157
  • Evrard B, Amighi K, Beten D, et al. Influence of melting and rheological properties of fatty binders on the melt granulation process in a high-shear mixer. Drug Dev Ind Pharm 1999;25:1177–1184
  • Eliasen H, Kristensen G, Schæfer T. Electrostatic charging during a melt agglomeration process. Int J Pharm 1999;184:85–96
  • Cotton ML, Wu DW, Vadas EB. Drug-excipient interaction study of enalapril maleate using thermal analysis and scanning electron microscopy. Int J Pharm 1987;40:129–142
  • Gu L, Strickley RG. A profound solvent effect on the diketopiperazine formation of the new dipeptide angiotensin-converting enzyme inhibitor, moexipril. Int J Pharm 1990;60:99–107

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