395
Views
13
CrossRef citations to date
0
Altmetric
Review Article

A review of formulation techniques that impact the disintegration and mechanical properties of oradispersible drug delivery technologies

, , , , , & show all
Pages 354-366 | Received 02 Apr 2014, Accepted 25 Nov 2014, Published online: 05 Jan 2015

References

  • Saigal N, Baboota S, Ahuja A, Ali J. Fast-dissolving intra-oral drug delivery systems. Expert Opinion Therap Patents 2008;18:769–781
  • Jaysuk JH, Dhaval AR, Kantilal RV. Orally disintegrating tablets: a review. Tropical J Pham Res 2009;8:161–172
  • Bharawaj S, Jain V, Sharma S, et al. Orally disintegrating tablets: a review. Drug Invention Today 2010;2:81–88
  • Shaikh R, Raj Singh TR, Garland MJ, et al. Mucoadhesive drug delivery systems. J Pharm Bioall Sci 2011;3:89–100
  • Sastry SV, Nyashadham, JR, Fix, JA. Recent technological advances in oral drug delivery- a review. Pharma Sci Tech 2000;3:138–145
  • Alagusundaram M, Chetty CM, Dhachinammorthi D. Advances in buccoadhesive drug delivery systems: a review. Int J Rev Life Sci 2011;1:35–44
  • Vema RK, Garg S. Current status of drug delivery technologies and future directions. Pharm Tech 2001;25:9–10
  • Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. J Control Release 2011;153:106–116
  • Bhatt AD, Vaidya AB. Bio-availability and drug delivery systems: clinical perspective. J Postgrad Med 1992;38:130–134
  • Parthasarathy G, Bhaskar K, Jayaveer KN, Prasanth VV. Buccal mucosa: a gifted choice for systemic drug delivery. Int J Drug Del 2011;3:586–596
  • Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system. A review. Int J Res Pharm Sci 2010;1:170–186
  • Nibha KP, Pancholi SS. An overview on: sublingual route for systemic drug delivery. Int J Res Pharm Bio Sci 2012;3:913–923
  • Shojaei AH, Chang RK, Guo X. Systemic drug delivery via the buccal mucosal route. Pharm Tech 2001;June issue:70–81
  • Harmon TM. Orally disintegrating tablets: a valuable life cycle management strategy. Pham Comm [online] 2007:1–4. Available from: www.pharmaceuticalcommerce.com [last accessed 10 July 2010]
  • Patel R, Pillay V, Choonara YE. A novel cellulose-based hydrophilic wafer matrix for rapid bioactive delivery. J Bioactive Compatible Poly 2007;22:119–142
  • US Industry forecasts for 2012 and 2017. Drug delivery systems Freedonia Group Product FED00151 [online] 2008;1–8. Available from: www.freedonia.com [last accessed 12 June 2010]
  • Kumar V, Aggarwal G, Zakir F, Choudhary A. Buccal bioadhesive drug delivery – a novel technique. Int J Pharm Bio Sci 2011;1:89–102
  • Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery – a promising option for orally less efficient drugs. J Control Release 2006;114:15–40
  • Siddiqui MDN, Garg G, Sharma P. A short review on a novel approach in oral fast dissolving drug delivery system and their patents. Adv Biol Res 2011;5:291–303
  • Chowdary KPR, Aislwaya KVNR. Recent research on fast dissolving tablets: a review. J Global Trends Pharm Sci 2013;4:940–954
  • Nair M, Chien YW. Buccal delivery of progestational steroids: characterisation of barrier properties and effect of penetrant hydrophilicity. Int J Pharm 1993;89:41–49
  • Bari H. Prolonged release parenteral drug delivery system. Int J Pharm Sci Rev Res 2010;3:1–11
  • Brown BAS, Hamed E. In oral transmucosal delivery: OraVescent® technology offers greater oral transmucosal delivery. Drug Deliv Tech 2007;7:42–45
  • Shinkar DM, Dhake AS, Setty CM. Drug delivery from the oral cavity: a focus on mucoadhesive buccal drug delivery system. PDA J Pharm Sci Tech 2012;66:466–500
  • Bind AK, Gnanarajan G, Kothiyal P. A review: sublingual route for systemic drug delivery. Int J Drug Tech 2013;3:31–36
  • Bredenberg S, Duberg M, Lennernus B. In vitro and in vivo evaluation of a new sublingual tablet system for rapid oradispersible absorption using fentanyl citrate as the active substance. Eur J Pharm Biopharm 2003;20:327–334
  • Goel H, Rai P, Rana V, Tiwary AK. Orally disintegrating systems: innovations in formulation and technology. Recent Patents Drug Deliv Formul 2008;2:258–274
  • Ashish P, Harsoliya MS, Pathan JK, Shruti S. A review-formulation of mouth dissolving tablet. Int J Pharm Clin Sci 2011;1:1–8
  • Ghosh TK, Chatterjee DJ, Pfister WR. Quick dissolving oral dosage forms: scientific and regulatory considerations from a clinical pharmacology and biopharmaceuticals perspective. In: Ghosh TK, Pfister WR, eds. Drug delivery to the oral cavity. Molecules to market. New York: CRC Press; 2005:337–356
  • Deepak K. Orally disintegrating tablets. Tablets Capsules 2004;7:30–35
  • Brown D. Orally disintegrating tablets: taste over speed. Drug Deliv Technol 2001;3:58–61
  • Thakur RR, Narwal S. Orally disintegrating preparations: recent advancement in formulation and technology. J Drug Del Ther 2012;2:87–96
  • Bhati R, Nagrajan Rk. A detailed review on oradispersible drug delivery system. Int J Pharm Sci Res 2012;3:659–681
  • Chang RK, Gou X, Burnside B. Fast dissolving tablets. Pharm Tech 2000;24:52–58
  • Jeong SH, Younong F, Park K. Frosta technology for making fast disintegrating tablets. Expert Opin Drug Deliv 2007;2:1–10
  • Myers GL, Battist GE, Fuisz RC. Process and apparatus for making rapidly dissolving dosage units and product. PCT Patent No. WO 95/34293-A1; 1995
  • Laboratoire L. Lafon, Maisons-Alfort, France. Galenic form for oral administration and its method of preparation by lyophilisation of an oil-in-water emulsion. European Patent No. 0 159 237; 1985
  • Squire CA, Johnson NW, Hopps RM. Human oramucosa development, structure and function. Oxford: Blackwell; 1976
  • Hooda R, Tripathi M, Kapoor K. A review on oradispersible drug delivery system. The Pharma Innovation 2011;1:13–20
  • Wertz PW, Cox PS, Squier CA, Downing DT. Lipids of epidermis and keratinized and non-keratinized oral epithelia. Bio Physiol 1986;13:529–531
  • Wertz PW, Squier CA. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev The Drug Cair Syst 1991;8:237–269
  • Bobade NN, Atram SC, Wankhade VP, et al. A review on buccal drug delivery system. Int J Pharm Sci Res 2013;3:35–40
  • Collins LMC, Dawes C. The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oramucosa. J Dent Res 1987;66:1300–1302
  • Lokhande SS, Lahoti SS. Buccoadhesive drug delivery system: need. Asia J Bio Pharm Sci 2012;14:29–36
  • Meyer J, Gerson SJ. A comparison of human palatal and buccal mucosa. Periodontics 1964;2:284–291
  • Senel S, Hinc AA. Drug penetration enhancement via buccal route: possibilities and limitations. J Control Release 2001;72:133–144
  • Squier CA, Nanny D. Measurement of blood flow in the oramucosa and skin of the rhesus monkey using radiolabelled microspheres. Arch Oral Biol 1985;30:313–318
  • Edgar WM. Saliva: its secretion, composition and functions. Br Dent J 1992;172:305–312
  • Mahajan P, Kaur A, Aggarwal G, Harkumar SL. Mucoadhesive drug delivery system: a review. Int J Drug Dev Res 2013;5:11–20
  • Patel TS, Mukul S. Fast dissolving tablet technology – a review. W J Pharm Pharm Sci [online] 2013;2:485–508
  • Thosar MM. Intra oral sprays-an overview. Int J Pharm Life Sci 2011;11:1235–1246
  • Bircan Y, Comoglu T. Formulation technologies of orally fast disintegrating tablets. Marmara Pharm J 2012;16:77–81
  • Kumar S, Gupta SK, Sarma PK. A review on recent trends in oral drug delivery fast dissolving formulation technology. Advan Biol Res 2012;6:6–13
  • Parkash V, Maan S, Deepika, et al. Fasting disintegrating tablets: opportunity in drug delivery system. J Adv Pharm Tech Res 2011;2:223–235
  • Virley P, Yarwood R. Zydis® – a novel, fast dissolving dosage form. J Manufacturing Chem 1990;61:36–37
  • Dobetti L. Fast melting tablets: developments and technologies. Pharm Technol Eur 2001;12:32–42
  • Ahmed YS, Nafadi MM, Fatahalla FA. Formulation of fast-dissolving ketoprofen tablet using freeze-drying in blisters technique. Drug Dev Ind Pharm 2006;32:437–442
  • Ahmed IS, Shamma RN, Shoukri RA. Development and optimization of lyophilized orally disintegrating tablets using factorial design. Pharm Dev Tech 2013;18:935–943
  • Stange U, Führling C, Gieseler H. Formulation, preparation, and evaluation of novel orally disintegrating tablets containing taste-masked naproxen sodium granules and naratriptan hydrochloride. J Pharm Sci 2014;103:1233–1245
  • Gregory GKE, Ho D. Pharmaceutical dosage form packages. US Patent No. 4,305,502; 1981
  • Raja S, Vedavathi T. Recent trends of oral fast disintegrating tablets – an overview of formulation and taste masking technology. Res J Pharm Bio Chem Sci 2012;3:771–792
  • Fix JA. Advances in quick-dissolving tablets technology employing Wowtab. Int IIR Conference on Drug Delivery Systems, October, 1998. Washington DC, USA
  • Segar H. Drug delivery product and the Zydis® fast-dissolving dosage form. J Pharm Pharmacol 1998;50:375–382
  • Garg A, Gupta MM. Mouth dissolving tablets: a review. J Drug Del Therap 2013;3:207–214
  • Wang WJH, van den Beucken JJJP, Yang F, Walboomes XF 2012. Local delivery of small and large biomolecules in craniomaxillofacial bone. [Online] 2012. Available from: http://www.sciencedirect.com/science/article/pii/S0169409X12000993?v=s5 [last accessed 15 June 2012]
  • Allen LV, Wang B, Devies JD. Rapidly dissolving tablets. US Patent No. 6,066,337; 2000
  • Kim JI, Cho SM, Cui JH, et al. In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin–drug complex. Int J Pharm 2013;455:31–39
  • Badgajar BP, Mundada AS. The technologies used for developing orally disintegrating tablets: a review. Acta Pharm 2011;61:117–139
  • Gupta A, Mishra AK, Gupta V, et al. Recent trends of fast dissolving tablet – an overview formulation technology. Int J Pharm Bio Arch 2010;2:1
  • Nayak AK, Manna K. Current development in orally disintegrating tablet technology. J Pharm Educ Res 2011;2:21–34
  • Kuno Y, Kojima M, Andos S, Nakagami H. Effect of preparation method on properties of orally disintegrating tablets made by phase transition. Int J Pharm 2008;355:87–92
  • Shahi SR, Kanzarkar MV, Rhadabadi SS, Zadbuke N. Formulation and evaluation of atenolol orodispersible tablets by phase transition technology. Int J Pharm Sci 2013;5:604–609
  • Abdelbary G, Prinderre P, Eouani C, et al. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm 2004;278:423–433
  • Perissutti B, Rubessa F, Moneghiri M, Voinovich D. Formulation design of carbamazepine fast release tablets prepared by melt granulation technique. Int J Pharm 2003;256:53–63
  • Sree GPB, Siva SN, Gupta SM, et al. Formulation and evaluation of orodispersible tablets of levocetrizine by melt granulation technology. Der Pharm Lettre 2013;5:107–115
  • Mehta K, Garala K, Basu B, et al. An emerging trend in oral drug delivery technology: rapid disintegrating tablets. J Pharm Sci Tech 2010;2:3180–3329
  • Koland M, Charyulu RN, Prabhu P. Mucoahdesive films of losartan potassium for buccal delivery: design and characterization. Indian J Pharm Educ Res 2010;44:315–323
  • Makino T, Yamado M, Kikuta JI. Fast dissolving tablet. US Patent No. 5,720,974; 1998
  • Koizumi IK. New method of preparing highly porous rapidly saliva soluble tablets by sublimation technique. Int J Pharm 1997;152:127–131
  • Mothilal M, Kumar AH, Krishna MC, et al. Formulation and evaluation of modafinil fast dissolving tablets by sublimation technique. J Chem Pharm Sci 2013;6:147–154
  • Shyamala B, Narmada CV. Rapid dissolving tablets: a novel dosage form. Indian Pharmacist 2002;1:9–12
  • Reddy D, Pillay V, Choonara YE, Du Toit LC. Rapidly disintegrating oradispersible drug delivery technologies. Pharm Dev Technol 2009;14:588–601
  • Chiver TE, Minn O. Process for making candy floss. US Patent No. 730057; 2003
  • Bangale GS, Shide GV, Rathinaraj BS. New generation of orodispersible tablets: recent advances and future prospects. Int J Adv Pharm Sci 2011;2:17–28
  • Bi Y, Sunada H, Yonezowa Y, et al. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Ball 1996;44:2121–2127
  • Cousin G, Bruna E, Gendrot E. Rapidly disintegratable multiparticular tablet. US Patent No. 5,464,632; 1995
  • Gillis PMV, Deconde VFV. Fast-dissolving galanthamine hydrobromide tablet. US Patent No. 6,099,863; 2000
  • Gattani SG, Shiyani BG, Kakade KN, et al. Formulation and development of mouth dissolving table of ondensetron hydrochloride by using superdisintegrants. Indian Drugs 2009;46:44–50
  • Tabakhian M, Shahtalebi M, Salehi E, Keshvari M. Formulation and evaluation of orally disintegrating tablet of Rizatriptan using natural superdisintegrant. J Herb Med Pharmacol 2014;3:21–29
  • Morales JO, Horng M, Gregg AM, McConville JT. Orally disintegrating tablets using starch and fructose. Pharm Tech 2010;34:92–99
  • Basalious EB, El-Sebaie W, El-Gazayerly O. Rapidly absorbed orodispersible tablet containing molecularly dispersed felodipine for management of hypertensive crisis: development, optimization and in vitro/in vivo studies. Pharm Dev Technol 2013;18:407–416
  • Aboelwafa AA, Fahmy RH. A pilot human pharmacokinetic study and influence of formulation factors on orodispersible tablet incorporating meloxicam solid dispersion using factorial design. Pharm Dev Technol 2012;17:1–14
  • Rahman Z, Siddiqui A, Khan MA. Orally disintegrating tablet of novel salt of antiepileptic drug: formulation strategy and evaluation. Eur J Pharm Biopharm 2013;85:1300–1309
  • Elan Corporation, plc. Orally disintegrating tablets (ODT)-Nanomelt™. Available from: http://www.elan.com/EDT/nanocrystal%5ftechnology/orally-disintegrating_tablet-asp [last accessed 15 June 2010]
  • Shukla D, Chakraborty S, Mishra B. Mouth dissolving tablets. In: An overview of formulation Technology. Scientia Pharmaceutica; 2009:310–320
  • Bhasin RK, Bhasin N, Ghosh PK. Advances in formulation of orally disintegrating dosage forms: a review article. Indo Global J Pharm Sci 2011;1:328–358
  • Jadhav YG, Galgatte UC, Chaudhari PD. Challenges in formulation development of fast dissolving oral films. Indo American J Pharm Res 2013;3:6391–6401
  • Karthikeyan D, Sri S, Kumar S. Development of fast dissolving oral film containing of Rizatriptan benzoate as an antimigraine medication. Indo American J Pharm Res 2013;3:2642–2654
  • Dor P, JM, Chau A, Prevysh-Rogers V, et al. A New in vitro method versus the standard USP method to measure the disintegration time of fast-disintegration time tablets. Proceedings at the International Symposium of Controlled Release of Bioactive Materials. Controlled Release Society; Paris; 2000:27:6232
  • El-Arini SK, Clas SD. Evaluation of disintegration testing of different fast dissolving tablets using the texture analyzer. Pharm Dev Technol 2002;7:361–371
  • Abdelbary G, Eouani C, Prinderre P. Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration. Int J Pharm 2005;292:29–41
  • Sunada H, Bi Y. Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technol 2002;22:188–198
  • Mishra DN, Bindal M, Singh SK, Kumar SGV. Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006;54:99–102
  • Azarmi S, Roa W, Lobenberg R. Current perspectives in dissolution testing of conventional and novel dosage forms. Int J Pharm 2007;328:12–21
  • Hughes L, Gehris A. A new method of characterizing buccal dissolution of drugs. Rohm and Haas Research Laboratories – Spring House. Available from: http://www.rohmhaas.com/ionexchange/pharmaceuticals/formulations_doc/buccaldisssolution [last accessed 23 June 2010]
  • Global Spec (Pty) Ltd. Available from: http://www.global-spec.com/reference/5779/Evaluation-of-Orally-Disintegrating-Tablets-ODTS-Using-Precision-Compressive-Loading [last accessed 10 May 2010]
  • Global Spec (Pty) Ltd. Available from: http://www.bose-electroforce.com/pdf/Appbrief_ODTs. pdf [last accessed 10 March 2010]
  • Patil SL, Shivnikar MA. Formulation and technology of fast disintegrating tablets: a review. J Pharm Bio Sci 2011;9:1–7
  • European Pharmacopoeia, 4th edition. Chewing gum medicated, drug release from. Directorate for Quality of Medicines of the Council of Europe, Strasbourg, France; 2002:227–228
  • Habib W, Khankari R, Hontz J. Fast-dissolving drug delivery systems, clinical review in therapeutics. J Drug Carr Sys 2000;17:61–72
  • Elkhodairy KA, Hassan MA, Afifi SA. Formulation and optimization of orodispersible tablets of flutamide. Saudi Pharm J 2013;22:53–61
  • Okuda Y, Irisawa Y, Okimoto K, et al. A new formulation for orally disintegrating tablets using a suspension spray- coating method. Int J Pharm 2009;382:80–87
  • Okuda Y, Irisawa Y, Okimoto K, et al. Further improvement of orally disintegrating tablets using micronized ethylcellulose. Int J Pharm 2012;423:351–359
  • AlHusban F, Perrier Y, Mohammed AR. Formulation and characterisation of lyophilized rapid disintegrating tablets using amino acids as matrix forming agents. Eur J Pharm Biopharm 2010;75:254–262
  • AlHusban F, Perrier Y, Mohammed AR. Investigation of formulation and process of lyophilized orally disintegrating tablets (ODT) using novel amino acid combination. J Pharm 2010;2:1–17
  • Fukami J, Yonemochi E, Yoshihashi Y, Terada K. Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int J Pharm 2006;310:101–109
  • Chandrasekhar R, Hassan Z, AlHusban F, et al. The role of formulation excipients in the development of lyophilised fast-disintegrating tablets. Eur J Pharm Biopharm 2009;72:119–129
  • Elnaggar YSR, El-Massik MA, Abdullah OY, Ebian AER. Maltodextrin: a novel excipient used in sugar-based orally disintegrating tablets and phase transition process. Am Ass Pharm Sci Tech 2010;11:645–651
  • Raj BS, Punitha ISR, Dube S. Formulation and characterization of fast disintegrating tablets of amlodipine using superdisintegrants. J App Pharm Sci 2012;2:118–123

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.