266
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Formulation and process considerations for the design of sildenafil-loaded polymeric microparticles by vibrational spray-drying

, , , &
Pages 691-698 | Received 01 Jul 2015, Accepted 07 Sep 2015, Published online: 07 Jan 2016

References

  • Ameri M, Maa YF. Spray drying of biopharmaceuticals: stability and process considerations. Drying Technol 2006;24:763–768
  • Re MI. Formulating drug delivery systems by spray drying. Drying Technol 2006;24:433–446
  • Cal K, Sollohub K. Spray drying technique. I: hardware and process parameters. J Pharm Sci 2010;99:575–586
  • Sollohub K, Cal K. Spray drying technique: II. Current applications in pharmaceutical technology. J Pharm Sci 2010;99:587–597
  • Vehring R. Pharmaceutical particle engineering via spray drying. Pharm Res 2008;25:999–1022
  • Chow AH, Tong HH, Chattopadhyay P, Shekunov BY. Particle engineering for pulmonary drug delivery. Pharm Res 2007;24:411–437
  • Hickey AJ. Controlled delivery of inhaled therapeutic agents. J Control Release 2014;190:182–188
  • Loira-Pastoriza C, Todoroff J, Vanbever R. Delivery strategies for sustained drug release in the lungs. Adv Drug Deliv Rev 2014;75:81–91
  • Liang Z, Ni R, Zhou J, Mao S. Recent advances in controlled pulmonary drug delivery. Drug Discov Today 2015;20:380–389
  • Gessler T, Seeger W, Schmehl T. The potential for inhaled treprostinil in the treatment of pulmonary arterial hypertension. Ther Adv Respir Dis 2011;5:195–206
  • Kurmi BD, Kayat J, Gajbhiye V, et al. Micro- and nanocarrier-mediated lung targeting. Expert Opin Drug Deliv 2010;7:781–794
  • Pilcer G, Amighi K. Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm 2010;392:1–19
  • Galiè N, Ghofrani HA, Torbicki A, et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005;353:2148–2157
  • Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 2006;5:689–702
  • Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997;28:5–24
  • Dailey LA, Wittmar M, Kissel T. The role of branched polyesters and their modifications in the development of modern drug delivery vehicles. J Control Release 2005;101:137–149
  • Wang X, Xie X, Cai C, et al. Biodegradable branched polyesters poly(vinyl sulfonate-co-vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid) as a negatively charged electrolyte platform for drug delivery: synthesis and characterization. Macromolecules 2008;41:2791–2799
  • Beck-Broichsitter M, Schweiger C, Schmehl T, et al. Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery. J Control Release 2012;158:329–335
  • Bege N, Renette T, Endres T, et al. In situ forming nimodipine depot system based on microparticles for the treatment of posthemorrhagic cerebral vasospasm. Eur J Pharm Biopharm 2013;84:99–105
  • Beck-Broichsitter M, Paulus IE, Greiner A, Kissel T. Modified vibrating-mesh nozzles for advanced spray-drying applications. Eur J Pharm Biopharm 2015;92:96–101
  • Beck-Broichsitter M, Strehlow B, Kissel T. Direct fractionation of spray-dried polymeric microparticles by inertial impaction. Powder Technol 2015;286:311–317
  • Lebhardt T, Roesler S, Uusitalo HP, Kissel T. Surfactant-free redispersible nanoparticles in fast-dissolving composite microcarriers for dry-powder inhalation. Eur J Pharm Biopharm 2011;78:90–96
  • Hellmann C, Greiner A, Wendorff JH. Design of pheromone releasing nanofibers for plant protection. Polym Adv Technol 2011;22:407–413
  • Beck-Broichsitter M, Kleimann P, Gessler T, et al. Nebulization performance of biodegradable sildenafil-loaded nanoparticles using the Aeroneb Pro: formulation aspects and nanoparticle stability to nebulization. Int J Pharm 2012;422:398–408
  • Beck-Broichsitter M, Schmehl T, Gessler T, et al. Development of a biodegradable nanoparticle platform for sildenafil: formulation optimization by factorial design analysis combined with application of charge-modified branched polyesters. J Control Release 2012;157:469–477
  • Panyam J, Williams D, Dash A, et al. Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles. J Pharm Sci 2004;93:1804–1814
  • Bohr A, Kristensen J, Dyas M, et al. Release profile and characteristics of electrosprayed particles for oral delivery of a practically insoluble drug. J R Soc Interface 2012;9:2437–2449
  • Melnikov P, Corbi PP, Cuin A, et al. Physicochemical properties of sildenafil citrate (Viagra) and sildenafil base. J Pharm Sci 2003;92:2140–2143
  • Groneberg DA, Witt C, Wagner U, et al. Fundamentals of pulmonary drug delivery. Respir Med 2003;97:382–387
  • Rau JL. The inhalation of drugs: advantages and problems. Respir Care 2005;50:367–382
  • Vehring R, Foss WR, Lechuga-Ballesteros D. Particle formation in spray drying. J Aerosol Sci 2007;38:728–746
  • Vicente J, Pinto J, Menezes J, Gaspar F. Fundamental analysis of particle formation in spray drying. Powder Technol 2013;247:1–7
  • Heng D, Lee SH, Ng WK, Tan RBH. The nano spray dryer B-90. Expert Opin Drug Deliv 2011;8:965–972
  • Draheim C, de Crécy F, Hansen S, et al. A design of experiment study of nanoprecipitation and Nano Spray Drying as processes to prepare PLGA nano- and microparticles with defined sizes and size distributions. Pharm Res 2015;32:2609–2624
  • Schafroth N, Arpagaus C, Jadhav UY, et al. Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids Surf B Biointerfaces 2012;90:8–15
  • Quinteros DA, Ramirez Rigo V, Jimenez Kairuz AF, et al. Interaction between a cationic polymethacrylate (Eudragit E100) and anionic drugs. Eur J Pharm Sci 2008;33:72–79
  • Mahieu A, Willart JF, Dudognon E, et al. A new protocol to determine the solubility of drugs into polymer matrixes. Mol Pharm 2013;10:560–566
  • Carvalho TC, Peters JI, Williams III RO. Influence of particle size on regional lung deposition – what evidence is there? Int J Pharm 2011;406:1–10
  • Hofmann W. Modelling inhaled particle deposition in the human lung – a review. J Aerosol Sci 2011;42:693–724
  • Ishihara T, Mizushima T. Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles. Expert Opin Drug Deliv 2010;7:565–575
  • Fredenberg S, Wahlgren M, Reslow M, Axelsson A. The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems – a review. Int J Pharm 2011;415:34–52
  • Bohr A, Wan F, Kristensen J, et al. Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics. J Mater Sci Mater Med 2015;26:article 61
  • Siepmann J, Siepmann F. Modeling of diffusion controlled drug delivery. J Control Release 2012;161:351–362
  • Panyam J, Dali MM, Sahoo SK, et al. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. J Control Release 2003;92:173–187
  • Siepmann J, Faisant N, Akiki J, et al. Effect of the size of biodegradable microparticles on drug release: experiment and theory. J Control Release 2004;96:123–134
  • Mosen C, Bäckström K, Thalberg K, et al. Particle formation and capture during spray drying of inhalable particles. Pharm Dev Technol 2004;9:409–417
  • Thybo P, Hovgaard L, Lindelov JS, et al. Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion. Pharm Res 2008;25:1610–1620

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.