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Research Article

Drug-conjugated PLA–PEG–PLA copolymers: a novel approach for controlled delivery of hydrophilic drugs by micelle formation

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Pages 947-957 | Received 30 Nov 2014, Accepted 22 Nov 2015, Published online: 06 Jan 2016

References

  • Chen W, Zhang JZ, Hu J, et al. Preparation of amphiphilic copolymers for covalent loading of paclitaxel for drug delivery system. J Polym Sci A Polym Chem 2014;52:366–374
  • Asadi H, Rostamizadeh K, Salari D, Hamidi M. Preparation and characterization of tri-block poly(lactide)-poly(ethylene glycol)-poly(lactide) nanogels for controlled release of naltrexone. Int J Pharm 2011;416:356–364
  • Asadi H, Rostamizadeh K, Salari Hamidi M. Preparation of biodegradable nanoparticles of tri-block PLA-PEG-PLA copolymer and determination of factors controlling the particle size using artificial neural network. J Microencapsul 2011;28:406–416
  • Ke X, Ng VWL, Ono RJ, et al. Role of non-covalent and covalent interactions in cargo loading capacity and stability of polymeric micelles. J Control Release 2014;193:9–26
  • Cabral H, Kataoka K. Progress of drug-loaded polymeric micelles into clinical studies. J Control Rel 2014;190:465–476
  • Zhang X, Dong Y, Zeng X, et al. The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment. Biomaterials 2014;35:1932–1943
  • Danafar H, Rostamizadeh K, Davaran S, et al. Biodegradable m-PEG/PCL core-shell micelles: preparation and characterization as a sustained release formulation for curcumin. Adv Pharm Bull 2014;4:501–510
  • Danafar H, Rostamizadeh K, Davaran S, Hamidi M. PLA-PEG-PLA copolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs: preparation and evaluation with atorvastatin and lisinopril. Drug Dev Ind Pharm 2014;40:1411–1420
  • Abebe DG, Kandil R, Kraus T, et al. Three-layered biodegradable micelles prepared by two-step self-assembly of PLA-PEI-PLA and PLA-PEG-PLA triblock copolymers as efficient gene delivery system. Macromol Biosci 2015;15:698–711
  • Cao P, Bae Y. Polymer nanoparticulate drug delivery and combination cancer therapy. Future Oncol 2012;8:1471–1480
  • Ren Zhong X, Zhao WZ, Guang LZ, et al. Recent advances in PEG-PLA block copolymer nanoparticles. Inte J Nanomedicine 2010;5:1057–1065
  • Ishihara T, Takahashi M, Higaki M, et al. Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents. Int J Pharm 2010;385:170–175
  • Sun Q, Radosz M, Shen Y. Challenges in design of translational nanocarriers. J Control Rel 2012;164:156–169
  • Schoenmakersa RG, Weteringa P, Elbertb DL, Hubbella JA. The effect of the linker on the hydrolysis rate of drug-linked ester bonds. J Control Rel 2004;95:291–300
  • Deng C, Jiang Y, Cheng R, et al. Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: promises, progress and prospects. Nano Today 2012;7:467–480
  • Pechar M, Ulbrich K, Jelínková M, Říhova B. Conjugates of antibody targeted PEG multiblock polymers with doxorubicin in cancer therapy. Macromol Biosci 2003;3:364–372
  • Pang X, Du HL, Zhang HQ, et al. Polymer-drug conjugates: present state of play and future perspectives. Drug Discov Today 2013;18:1316–1322
  • Canal F, Sanchis J, Vicent MJ. Polymer-drug conjugates as nano-sized medicines. Curr Opin Biotechnol 2011;22:894–900
  • Hoste K, De Winne K, Schacht E. Polymeric prodrugs. Int J Pharm 2004;277:119–131
  • Zak KKJK. Conjugated polymers as robust carriers for controlled delivery of anti-inflammatory drugs. J Mater Sci 2014;49:5738–5745
  • Kopeček J. Polymer-drug conjugates: origins, progress to date and future directions. Adv Drug Deliv Rev 2013;65:49–59
  • Choi HK, Chun MK, Lee SH, et al. In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action. Int J Pharm 2007;341:50–57
  • Yao YLZ, Zhang SYN. Preparation of pH sensitive pluronic-docetaxel conjugate micelles to balance the stability and controlled release issues. Materials 2015;8:379–391
  • Zhang J, Fan XD, Liu Y, et al. Synthesis of poly (ethylene glycol) - metaxalone conjugates and study of its controlled release in vitro. Int J Pharm 2007;197:125–131
  • Yan L, Haiqing D, Xuequan L, et al. Single polymer-drug conjugate carrying two drugs for fixed-dose co-delivery. Med Chem 2014;4:676–683
  • Lu ZR, Shiah JG, Sakuma S, et al. Design of novel bioconjugates for targeted drug delivery. J Control Rel 2002;78:165–173
  • Xiaoye X, Guangxi PYZ. Polymer-drug conjugates: recent progress on administration routes. Expert Opin Drug Deliv 2014;11:1075–1086
  • Hans M, Shimoni K, Danino D, et al. Synthesis and characterization of mPEG-PLA prodrug micelles. Biomacromolecules 2005;6:2708–2817
  • Yoo HS, Park TG. Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages. J Control Rel 2002;82:17–27
  • Dai Z, Piao L, Zhang X, et al. Probing the micellization of diblock and triblock copolymers of poly(l-lactide) and poly(ethylene glycol) in aqueous and NaCl salt solutions. Colloid Polym Sci 2004;282:343–350
  • Ritger PL, Peppas NA. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J Control Rel 1987;5:37–42
  • Yoo HS, Park TG. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Rel 2001;70:63–70
  • Zhigang X, Huili G, Xuesi C, et al. A novel polymer-paclitaxel conjugate based on amphiphilic triblock copolymer. J Control Rel 2007;117:210–216
  • Li Y, Qi XR, Maitani Y, Nagai T. PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations. Nanotechnology 2009;20:055106

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