Successful Management of Excited Delirium Syndrome with Prehospital Ketamine: Two Case Examples

References

• Wetli CV, Fishbain DA. Cocaine-induced psychosis and sudden death in recreational cocaine users. J Forensic Sci. 1985;30:873-80.
   PubMed Web of Science ®Google Scholar
• Ross DL. Factors associated with excited delirium deaths in police custody. Mod Pathol. 1998;11:1127-37.
   PubMed Web of Science ®Google Scholar
• Grant JR, Southall PE, Mealey J, Scott SR, Fowler DR. Excited delirium deaths in custody. Am J Forensic Med Pathol. 2009;30:1-5.
   PubMed Web of Science ®Google Scholar
• Vilke GM, DeBard ML, Chan TC, Excited delirium syndrome (ExDS): defining based on a review of the literature. J Emerg Med. 2011; Mar 24 (Epub ahead of print). doi:10.1016/j.jemermed.2011.02.017.
   Web of Science ®Google Scholar
• Hennepin County Emergency Medical Services System. Advanced Life Support Protocols, 2012 edition. Adult Behavioral Emergencies Protocol, p 68. Available at: http://www.hennepin.us/files/HennepinUS/HSPHD/Public %20Health%20Protection/Emergency%20Medical%20Services/ EMS-System%20Policies/System_Policies-Protocols/ALS%20Protocols-Large-Redacted.pdf. Accessed June 30, 2012.
   Google Scholar
• Hall CA, Kader AS, McHale AMD, Stewart L, Fick GH, Vilke GM. Frequency of signs of excited delirium syndrome in subjects undergoing police use of force: descriptive evaluation of a prospective, consecutive cohort. J Forensic Leg Med. 2012;19:83-9.
   PubMed Web of Science ®Google Scholar
• Bell L. On a form of disease resembling some advanced stages of mania and fever, but so contradistinguished from any ordinary observed or described combination of symptoms as to render it probable that it may be overlooked and hitherto unrecorded malady. Am J Insanity. 1849;6:97-127.
   Google Scholar
• Stratton SJ, Rogers C, Brickett K, Gruzinski G. Factors associated with sudden death of individuals requiring restraint for excited delirium. Am J Emerg Med. 2001;19:187-91.
   PubMed Web of Science ®Google Scholar
• Ho JD, Heegaard WG, Dawes DM, Natarajan S, Reardon RF, Miner JR. Unexpected arrest-related deaths in America: 12 months of open source surveillance. West J Emerg Med. 2009;10:68-73.
   PubMedGoogle Scholar
• Vilke GM, Payne-James J, Karch SB. Excited delirium syndrome (ExDS): redefining an old diagnosis. J Forensic Leg Med. 2012;19:7-11.
   PubMed Web of Science ®Google Scholar
• Davis KL, Fiori M, Davis BM, Mohs RC, Horvath TB, Davidson M. Dopaminergic dysregulation in schizophrenia: a target for new drugs. Drug Dev Res. 1986;9:71-83.
   Web of Science ®Google Scholar
• Mash DC, Duque L, Pablo J, Brain biomarkers for identifying excited delirium as a cause of sudden death. Forensic Sci Int. 2009;190:E13-E19.
   Web of Science ®Google Scholar
• Di Maio TG, Di Maio VJM. Excited Delirium Syndrome Cause of Death and Prevention, ed 1. Boca Raton, FL: Taylor & Francis, 2006.
   Google Scholar
• Otahbachi M, Cevik C, Bagdure S, Nugent K. Excited delirium, restraints, and unexpected death—a review of pathogenesis. Am J Forensic Med Pathol. 2010;31:107-12.
   PubMed Web of Science ®Google Scholar
• Ho JD, Dawes DM, Nelson RS, Acidosis and catecholamine evaluation following simulated law enforcement “use of force” encounters. Acad Emerg Med. 2010;17:E60-E68.
   Web of Science ®Google Scholar
• Hick JL, Smith SW, Lynch MT. Metabolic acidosis in restraint-associated cardiac arrest: a case series. Acad Emerg Med. 1999;6:239-43.
   PubMed Web of Science ®Google Scholar
• Stevens DC, Campbell JP, Carter JE, Watson WA. Acid–base abnormalities associated with cocaine toxicity in emergency department patients. Clin Toxicol. 1994;32:31-9.
   Web of Science ®Google Scholar
• Allam S, Noble JS. Cocaine-excited delirium and severe acidosis. Anesthesia. 2001;56:385-6.
   PubMed Web of Science ®Google Scholar
• Vilke GM, Bozeman WP, Dawes DM, DeMers G, Wilson MP. Excited delirium syndrome (ExDS): treatment options and considerations. J Forensic Leg Med. 2012;19:117-21.
   PubMed Web of Science ®Google Scholar
• Green SM, Rothrock SG, Harris T, Hopkins GA, Garrett W, Sherwin T. Intravenous ketamine for pediatric sedation in the emergency department: safety profile with 156 cases. Acad Emerg Med. 1998;5:971-6.
   PubMed Web of Science ®Google Scholar
• Miner JR, Gray RO, Bahr J, Patel R, McGill JW. Randomized clinical trial of propofol versus ketamine for procedural sedation in the emergency department. Acad Emerg Med. 2010;17:604-11.
   PubMed Web of Science ®Google Scholar
• Melamed E, Oron Y, Ben-Avraham R, Blumenfeld A, Lin G. The combative multitrauma patient: a protocol for prehospital management. Eur J Emerg Med. 2007;14:265-8.
   PubMed Web of Science ®Google Scholar
• Ho JD, Conterato M, Mahoney BD, Miner JR, Benson JL. Successful patient outcome after field extremity amputation and cardiac arrest. Prehosp Emerg Care. 2003;7:149-53.
   PubMedGoogle Scholar
• Hick JL, Ho JD. Ketamine chemical restraint to facilitate rescue of a combative “jumper.” Prehosp Emerg Care. 2005;9:85-9.
   PubMedGoogle Scholar
• Burnett AM, Watters BJ, Barringer KW, Griffith KR, Frascone RJ. Laryngospasm and hypoxia after intramuscular administration of ketamine to a patient in excited delirium. Prehosp Emerg Care. 2012;16:412-4.
   PubMed Web of Science ®Google Scholar
• Martel M, Miner J, Fringer R, Discontinuation of droperidol for the control of acutely agitated out-of-hospital patients. Prehosp Emerg Care. 2005;9:44-8.
   PubMedGoogle Scholar
• Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes. Heart. 2003;89:1363-72.
   PubMed Web of Science ®Google Scholar
• Bozeman WP, Ali K, Winslow JE. Long QT syndrome unmasked in an adult subject presenting with excited delirium. J Emerg Med. 2012; May 31 (Epub ahead of print). doi:10.1016/j.jemermed.2012.02.054.
   Web of Science ®Google Scholar
• Martel M, Sterzinger A, Miner J, Clinton J, Biros M. Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam. Acad Emerg Med. 2005;12:1167-72.
   PubMed Web of Science ®Google Scholar
• Green SM, Rothrock SG, Lynch EL, Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. Ann Emerg Med. 1998;31:688-97.
   PubMed Web of Science ®Google Scholar
• Green SM, Clark R, Hostetler MA, Cohen M, Carlson D, Rothrock SG. Inadvertent ketamine overdose in children: clinical manifestations and outcome. Ann Emerg Med. 1999;34:492-7.
   PubMed Web of Science ®Google Scholar
• Chan TC, Vilke GM, Neuman T, Clausen JL. Restraint position and positional asphyxia. Ann Emerg Med. 1997;30:578-86.
   PubMed Web of Science ®Google Scholar