Comparison of Droperidol and Haloperidol for Use by Paramedics: Assessment of Safety and Effectiveness

References

• Inapsine (droperidol) Dear Healthcare Professional Letter Dec 2001. Food and Drug Administration. 2001. Available at: www. fda.gov /Safety/MedWatch/SafetyInformation/SafetyAlertsfor HumanMedicalProducts/ucm173778.htm. Accessed October 19, 2012.
   Google Scholar
• Colwell C. Managing the acutely agitated patient. EMS World. 2010. Available at: www.emsworld.com /article/10319462/ managing-the-acutely-agitated-patient. Accessed October 22, 2012.
   PubMedGoogle Scholar
• Martel M, Miner J, Fringer R, Discontinuation of droperidol for the control of acutely agitated out-of-hospital patients. Prehosp Emerg Care. 2005;9(1):44–8.
   PubMedGoogle Scholar
• Horowitz BZ, Bizovi K, Moreno R. Droperidol—behind the black box warning. Acad Emerg Med. 2002;9(6):615–8.
   PubMed Web of Science ®Google Scholar
• Kao LW, Kirk MA, Evers SJ, Rosenfeld SH. Droperidol, QT prolongation, and sudden death: what is the evidence? Ann Emerg Med. 2003;41(4):546–58.
   PubMed Web of Science ®Google Scholar
• Shale JH, Shale CM, Mastin WD. A review of the safety and efficacy of droperidol for the rapid sedation of severely agitated and violent patients. J Clin Psychiatry. 2003;64(5):500–5.
   PubMedGoogle Scholar
• Hick JL, Mahoney BD, Lappe M. Prehospital sedation with intramuscular droperidol: a one-year pilot. Prehosp Emerg Care. 2001;5(4):391–4.
   PubMedGoogle Scholar
• Rosen CL, Ratliff AF, Wolfe RE, Branney SW, Roe EJ, Pons PT. The efficacy of intravenous droperidol in the prehospital setting. J Emerg Med. 1997;15(1):13–7.
   PubMedGoogle Scholar
• Thomas H, Schwartz E, Petrilli R. Droperidol versus haloperidol for chemical restraint of agitated and combative patients. Ann Emerg Med. 1992;21(4):407–13.
   PubMed Web of Science ®Google Scholar
• 2010 Census Gazetteer Files. US Census Bureau. Available at: www.census.gov /geo/www/gazetteer/gazetteer2010.html. Accessed October 19, 2012.
   Google Scholar
• Martel M, Sterzinger A, Miner J, Clinton J, Biros M. Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam. Acad Emerg Med. 2005;12(12):1167–72.
   PubMed Web of Science ®Google Scholar
• Isbister GK, Calver LA, Page CB, Stokes B, Bryant JL, Downes MA. Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study. Ann Emerg Med. 2010;56(4):392–401.e1.
   PubMed Web of Science ®Google Scholar
• Knott JC, Taylor DM, Castle DJ. Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department. Ann Emerg Med. 2006;47(1):61–7.
   PubMedGoogle Scholar
• Resnick M, Burton BT. Droperidol vs. haloperidol in the initial management of acutely agitated patients. J Clin Psychiatry. 1984;45(7):298–9.
   PubMedGoogle Scholar
• Moss AJ. Measurement of the QT interval and the risk associated with QTc interval prolongation: a review. Am J Cardiol. 1993;72(6):23B–5B.
   PubMed Web of Science ®Google Scholar
• Lawrence KR, Nasraway SA. Conduction disturbances associated with administration of butyrophenone antipsychotics in the critically ill: a review of the literature. Pharmacotherapy. 1997;17(3):531–7.
   PubMed Web of Science ®Google Scholar
• ACEP Excited Delirium White Paper. 2009:1–22.
   Google Scholar
• Southall P, Grant J, Fowler D, Scott S. Police custody deaths in Maryland, USA: an examination of 45 cases. J Forensic Legal Med. 2008;15(4):227–30.
   PubMedGoogle Scholar
• Wilson MP, Macdonald K, Vilke GM, Feifel D. A comparison of the safety of olanzapine and haloperidol in combination with benzodiazepines in emergency department patients with acute agitation. J Emerg Med. 2011.
   PubMedGoogle Scholar
• Gillies D, Beck A, McCloud A, Rathbone J, Gillies D. Benzodiazepines alone or in combination with antipsychotic drugs for acute psychosis. Cochrane Database Syst Rev. 2005;(4):CD003079.
   PubMedGoogle Scholar
• Lonergan E, Britton AM, Luxenberg J, Wyller T. Antipsychotics for delirium. Cochrane Database Syst Rev. 2007;(2):CD005594.
   PubMedGoogle Scholar
• Cheng KL, Dwyer PN, Amsden GW. Paradoxic excitation with diphenhydramine in an adult. Pharmacotherapy. 1997;17(6):1311–4.
   PubMed Web of Science ®Google Scholar
• de Leon J, Nikoloff DM. Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. CNS Spectr. 2008;13(2):133–5.
   PubMed Web of Science ®Google Scholar
• Burnett AM, Salzman JG, Griffith KR, Kroeger B, Frascone RJ. The emergency department experience with prehospital ketamine: a case series of 13 patients. Prehosp Emerg Care. 2012;16(4):553–559.
   PubMed Web of Science ®Google Scholar
• Burnett AM, Watters BJ, Barringer KW, Griffith KR, Frascone RJ. Laryngospasm and hypoxia after intramuscular administration of ketamine to a patient in excited delirium. Prehosp Emerg Care. 2012;16(3):412–414.
   PubMed Web of Science ®Google Scholar
• Thakurta RG, Das R, Bhattacharya AK, Rapid response with ketamine on suicidal cognition in resistant depression. Indian J Psychol Med. 2012;34(2):170–5.
   PubMedGoogle Scholar
• Le Cong M, Gynther B, Hunter E, Schuller P. Ketamine sedation for patients with acute agitation and psychiatric illness requiring aeromedical retrieval. Emerg Med J. 2012;29(4):335–7.
   PubMedGoogle Scholar
• Ho JD, Smith SW, Nystrom PC, Successful management of excited delirium syndrome with prehospital ketamine: two case examples. Prehosp Emerg Care. 2012;17(2):274–9.
   PubMedGoogle Scholar
• Melamed E, Oron Y, Ben-Avraham R, Blumenfeld A, Lin G. The combative multitrauma patient: a protocol for prehospital management. Eur J Emerg Med. 2007;14(5):265–8.
   PubMed Web of Science ®Google Scholar
• Hick JL, Ho JD. Ketamine chemical restraint to facilitate rescue of a combative “jumper”. Prehosp Emerg Care. 2005;9(1):85–9.
   PubMedGoogle Scholar