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Special Contribution

Guidance Document for the Prehospital Use of Tranexamic Acid in Injured Patients

, MD, MS, FACS, , MD, FACS, , MD, FACEP, , MD, MPH, , MD, FACS, , MD, FACS, , MD, FACS, , MD, MSc, FACS, , MD, FACEP, , MD, MPH, FACS, , MD, FACS, , MD, NRP, , MD, , DPM, DO, FACS & , PhD, NREMT show all

References

  • Crash- Trial Collaborators, Shakur H , Roberts I , et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23–32.
  • Napolitano LM , Cohen MJ , Cotton BA , Schreiber MA , Moore EE . Tranexamic acid in trauma: how should we use it? J Trauma Acute Care Surg. 2013;74(6):1575–86.
  • Morrison JJ , Dubose JJ , Rasmussen TE , Midwinter MJ . Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg. 2012;147(2): 113–19.
  • Crash- Trial Collaborators, Roberts I , Shakur H , et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096–101, 1101 e1091–92.
  • Stockinger Z , Gross KR , Butler FK , Bailey JA . Does TXA Matter? Refining Indications For its Use in Combat Casualties. Paper presented at: Eastern Association for the Surgery of Trauma Annual Scientific Assembly; January 13–17, 2015; Lake Buena Vista, Florida.
  • Goobie SM , Meier PM , Pereira LM , et al. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. Anesthesiology. 2011;114(4): 862–71.
  • Dadure C , Sauter M , Bringuier S , et al. Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study. Anesthesiology. 2011;114(4):856–61.
  • Faraoni D , Goobie SM . The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature. Anesth Analg. 2014;118(3):628–36.

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