Subcutaneous Fentanyl Administration: A Novel Approach for Pain Management in a Rural and Suburban Prehospital Setting

References

• Kanowitz A , Dunn TM , Kanowitz EM , Dunn WW , Vanbuskirk K . Safety and effectiveness of fentanyl administration for prehospital pain management. Prehosp Emerg Care. 2006;10(1):1–7.
   PubMed Web of Science ®Google Scholar
• McManus JG Jr , Sallee DR Jr . Pain management in the prehospital environment. Emerg Med Clin North Am. 2005;23(2):415–31.
   PubMed Web of Science ®Google Scholar
• American College of Emergency Physicians, Clinical policy for procedural sedation and analgesia in the emergency department. Ann Emerg Med. 1998;31(5):663–77.
   PubMed Web of Science ®Google Scholar
• Alonso-Serra HM , Wesley K . Prehospital pain management. Prehosp Emerg Care. 2003;7(4):482–8.
   PubMedGoogle Scholar
• Borland ML , Jacobs I , Rogers IR . Options in prehospital analgesia. Emerg Med (Fremantle). 2002;14(1):77–84.
   Google Scholar
• Bendall JC , Simpson PM , Middleton PM . Prehospital analgesia in New South Wales, Australia. Prehosp Disaster Med. 2011;26(6):422–6.
   PubMed Web of Science ®Google Scholar
• Braude D , Richards M . Appeal for fentanyl prehospital use. Prehosp Emerg Care. 2004;8(4):441–2.
   PubMedGoogle Scholar
• Dailey MV , Burton J , Day L , DeMartino W . Prehospital analgesic protocol in the United States: a national survey. Acad Emerg Med. 2009;16(4 suppl):S197.
   Google Scholar
• Bendall JC , Simpson PM , Middleton PM . Effectiveness of prehospital morphine, fentanyl, and methoxyflurane in pediatric patients. Prehosp Emerg Care. 2011;15(2):158–65.
   PubMed Web of Science ®Google Scholar
• Park CL , Roberts DE , Aldington DJ , Moore RA . Prehospital analgesia: systematic review of evidence. J R Army Med Corps. 2010;156(4 Suppl 1):295–300.
   PubMedGoogle Scholar
• Fosnocht DE , Swanson ER , Donaldson GW , Blackburn CC , Chapman CR . Pain medication use before ED arrival. Am J Emerg Med. 2003;21(5):435–7.
   PubMed Web of Science ®Google Scholar
• White LJ , Cooper JD , Chambers RM , Gradisek, RE . Prehospital use of analgesia for suspected extremity fractures. Prehosp Emerg Care. 2000;4(3):205–8.
   PubMedGoogle Scholar
• Rickard C , O'Meara P , McGrail M , Garner D , McLean A , Le Lievre Pl . A randomized controlled trial of intranasal fentanyl vs intravenous morphine for analgesia in the prehospital setting. Am J Emerg Med. 2007;25(8):911–7.
   PubMed Web of Science ®Google Scholar
• Christrup LL , Foster D , Popper LD , Troen T , Upton R . Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study. Clin Ther. 2008;30(3):469–81.
   PubMed Web of Science ®Google Scholar
• Foster D , Upton R , Christrup L , Popper L . Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery. Ann Pharmacother. 2008;42(10):1380–7.
   PubMed Web of Science ®Google Scholar
• Donovan PJ , Cline DM , Whitley TW , Foster C , Outlaw M . Prehospital care by EMTs and EMT-Is in a rural setting: prolongation of scene times by ALS procedures. Ann Emerg Med. 1989;18(5):495–500.
   PubMed Web of Science ®Google Scholar
• Prottengeier J , Albermann M , Heinrich S , Birkholz T , Gall C , Schmidt J . The prehospital intravenous access assessment: a prospective study on intravenous access failure and access delay in prehospital emergency medicine. Eur J Emerg Med. 2015. [ePub ahead of print]
   PubMed Web of Science ®Google Scholar
• Hansen MS , Dahl JB . Limited evidence for intranasal fentanyl in the emergency department and the prehospital setting—a systematic review. Dan Med J. 2013;60(1):A4563.
   PubMed Web of Science ®Google Scholar
• Hennes H , Kim MK , Pirrallo RG . Prehospital pain management: a comparison of providers’ perceptions and practices. Prehosp Emerg Care. 2005;9(1):32–9.
   PubMedGoogle Scholar
• McEachin CC , McDermott JT , Swor R .,Few emergency medical services patients with lower-extremity fractures receive prehospital analgesia. Prehosp Emerg Care. 2002;6(4):406–10.
   PubMedGoogle Scholar
• Bradford P , Bulatovic R , McKenzie S , et al. Analysis of prehospital treatment of pain in the multisystem trauma patient at a community level 2 trauma centre. CJEM. 2013;15(S1):S36.
   Google Scholar
• Middleton PM , Simpson PM , Sinclair G , Dobbins TA , Math B , Bendall JC . Effectiveness of morphine, fentanyl, and methoxyflurane in the prehospital setting. Prehosp Emerg Care. 2010;14(4):439–47.
   PubMed Web of Science ®Google Scholar
• Marinangeli F , Narducci C , Ursini ML , et al. Acute pain and availability of analgesia in the prehospital emergency setting in Italy: a problem to be solved. Pain Pract. 2009;9(4):282–8.
   PubMed Web of Science ®Google Scholar
• French SC , Chan SB , Ramaker J . Education on prehospital pain management: a follow-up study. West J Emerg Med. 2013;14(2):96–102.
   PubMedGoogle Scholar
• Letizia M , Shenk J , Jones TD . Intermittent subcutaneous injections of pain medication: effectiveness, manageability, and satisfaction. Am J Hosp Palliat Care. 1999;16(4):585–92.
   PubMedGoogle Scholar
• Bruera E , Gibney N , Stollery D , Marcushamer S . Use of the subcutaneous route of administration of morphine in the intensive care unit. J Pain Symptom Manage. 1991;6(4):263–5.
   PubMed Web of Science ®Google Scholar
• Tanguay A , Dallaire R , Hebert D , Begin F , Fleet R . Rural patient access to primary percutaneous coronary intervention centers is improved by a novel integrated telemedicine prehospital system. J Emerg Med, 2015; 49(5):657–64
   PubMed Web of Science ®Google Scholar
• Fleischman RJ , Frazer DG , Daya M , Jui J , Newgard CD . Effectiveness and safety of fentanyl compared with morphine for out-of-hospital analgesia. Prehosp Emerg Care. 2010;14(2):167–75.
   PubMed Web of Science ®Google Scholar
• Garrick JF , Kidane S , Pointer JE , Sugiyama W , Van Luen C , Clark R . Analysis of the paramedic administration of fentanyl. J Opioid Manag. 2011;7(3):229–34.
   PubMedGoogle Scholar
• Capper SJ , Loo S , Geue JP , et al. Pharmacokinetics of fentanyl after subcutaneous administration in volunteers. Eur J Anaesthesiol. 2010;27(3):241–6.
   PubMed Web of Science ®Google Scholar
• Jennings PA , Cameron P , Bernard S . Measuring acute pain in the prehospital setting. Emerg Med J. 2009;26(8):552–5.
   PubMed Web of Science ®Google Scholar
• McLean SA , Domeier RM , DeVore HK , Hill EM , Maio RF , Frederiksen SM . The feasibility of pain assessment in the prehospital setting. Prehosp Emerg Care. 2004;8(2):155–61.
   PubMedGoogle Scholar
• Kelly CA , Upex A , Bateman DN . Comparison of consciousness level assessment in the poisoned patient using the alert/verbal/painful/unresponsive scale and the Glasgow Coma Scale. Ann Emerg Med. 2004;44(2):108–13.
   PubMed Web of Science ®Google Scholar
• Bijur PE , Latimer CT , Gallagher EJ . Identifying the minimum clinically significant difference in acute pain in the elderly. Ann Emerg Med. 2010;56(5):517–21.
   Web of Science ®Google Scholar
• Kendrick DB , Strout TD . The minimum clinically significant difference in patient-assigned numeric scores for pain. Am J Emerg Med. 2005;23(7):828–32.
   PubMed Web of Science ®Google Scholar
• Cepeda MS , Africano JM , Polo R , Alcala R , Carr DB . What decline in pain intensity is meaningful to patients with acute pain? Pain. 2003;105(1-2):151–7.
   PubMed Web of Science ®Google Scholar
• Bijur PE , Latimer CT , Gallagher EJ . Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department. Acad Emerg Med. 2003;10(4):390–2.
   PubMed Web of Science ®Google Scholar
• Brown TB , Lovato LM , Parker D . Procedural sedation in the acute care setting. Am Fam Physician. 2005;71(1):85–90.
   PubMed Web of Science ®Google Scholar
• Reschreiter H , Maiden M , Kapila A . Sedation practice in the intensive care unit: a UK national survey. Crit Care. 2008;12(6):R152.
   PubMed Web of Science ®Google Scholar
• Hunt R , Fazekas B , Thorne D ., Brooksbank M. A comparison of subcutaneous morphine and fentanyl in hospice cancer patients. J Pain Symptom Manage. 1999;18(2):111–9.
   PubMed Web of Science ®Google Scholar
• Koshy RC , Kuriakose R , Sebastian P , Koshy C . Continuous morphine infusions for cancer pain in resource-scarce environments: comparison of the subcutaneous and intravenous routes of administration. J Pain Palliat Care Pharmacother. 2005;19(1):27–33.
   PubMedGoogle Scholar
• Tanguy-Goarin C , Cogulet V . [Drugs administration by subcutaneous injection within palliative care]. Therapie. 2010;65(6):525–31.
   PubMed Web of Science ®Google Scholar
• Dooney NM , Sundararajan K , Ramkumar T , et al. Pharmacokinetics of tramadol after subcutaneous administration in a critically ill population and in a healthy cohort. BMC Anesthesiol. 2014;14:33.
   PubMed Web of Science ®Google Scholar
• Fleet J , Jones M , Belan I . Subcutaneous administration of fentanyl in childbirth: an observational study on the clinical effectiveness of fentanyl for mother and neonate. Midwifery. 2014;30(1):36–42.
   PubMed Web of Science ®Google Scholar
• Hickey R , Wells L . Subcutaneous fentanyl and midazolam: an alternative method of weaning after intravenous sedation in pediatric patients. Crit Care Med. 1999;27(10):2320–1.
   PubMed Web of Science ®Google Scholar
• Paix A , Coleman A , Lees J , et al. Subcutaneous fentanyl and sufentanil infusion substitution for morphine intolerance in cancer pain management. Pain. 1995;63(2):263–9.
   PubMed Web of Science ®Google Scholar
• Daoust R , Paquet J , Lavigne G , Piette E , Chauny JM . Impact of age, sex and route of administration on adverse events after opioid treatment in the emergency department: a retrospective study. Pain Res Manag. 2015;20(1):23–8.
   PubMed Web of Science ®Google Scholar
• Cooper IM. Morphine for postoperative analgesia . A comparison of intramuscular and subcutaneous routes of administration. Anaesth Intensive Care. 1996;24(5):574–8.
   PubMed Web of Science ®Google Scholar
• Challiner YC , Jarrett D , Hayward MJ , al-Jubouri MA , Julious SA . A comparison of intravenous and subcutaneous hydration in elderly acute stroke patients. Postgrad Med J. 1994;70(821):195–7.
   PubMed Web of Science ®Google Scholar
• Gonzalez RP , Cummings GR , Phelan HA , Mulekar MS , Rodning CB . On-scene intravenous line insertion adversely impacts prehospital time in rural vehicular trauma. Am Surg. 2008;74(11):1083–7.
   PubMed Web of Science ®Google Scholar
• Fields JM , Piela NE , Au AK , Ku BS . Risk factors associated with difficult venous access in adult ED patients. Am J Emerg Med. 2014;32(10):1179–82.
   PubMed Web of Science ®Google Scholar
• Sebbane M , Claret PG , Lefebvre S , et al. Predicting peripheral venous access difficulty in the emergency department using body mass index and a clinical evaluation of venous accessibility. J Emerg Med. 2013;44(2):299–305.
   PubMed Web of Science ®Google Scholar
• Deaton T , Auten JD , Darracq MA . Nebulized fentanyl vs intravenous morphine for ED patients with acute abdominal pain: a randomized double-blinded, placebo-controlled clinical trial. Am J Emerg Med. 2015;33(6):791–5.
   PubMed Web of Science ®Google Scholar
• Stephen R , Lingenfelter E , Broadwater-Hollifield C , Madsen T . Intranasal sufentanil provides adequate analgesia for emergency department patients with extremity injuries. J Opioid Manag. 2012;8(4):237–41.
   PubMedGoogle Scholar
• Steenblik J , Goodman M , Davis V , et al. Intranasal sufentanil for the treatment of acute pain in a winter resort clinic. Am J Emerg Med. 2012;30(9):1817–21.
   PubMed Web of Science ®Google Scholar
• Johnston S , Wilkes GJ , Thompson JA , Ziman M , Brightwell R . Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. Emerg Med J. 2011;28(1):57–63.
   PubMed Web of Science ®Google Scholar
• Wolfe TR , Braude DA . Intranasal medication delivery for children: a brief review and update. Pediatrics. 2010;126(3): 532–7.
   PubMed Web of Science ®Google Scholar
• Soriya GC , McVaney KE , Liao MM , et al. Safety of prehospital intravenous fentanyl for adult trauma patients. J Trauma Acute Care Surg. 2012;72(3):755–9.
   PubMed Web of Science ®Google Scholar
• Smith MD , Wang Y , Cudnik M , Smith DA , Pakiela J , Emerman CL . The effectiveness and adverse events of morphine versus fentanyl on a physician-staffed helicopter. J Emerg Med. 2012;43(1):69–75.
   PubMed Web of Science ®Google Scholar
• DeVellis P , Thomas SH , Wedel SK , Stein JP , Vinci RJ . Prehospital fentanyl analgesia in air-transported pediatric trauma patients. Pediatr Emerg Care. 1998;14(5):321–3.
   PubMed Web of Science ®Google Scholar