¹²⁵I-labeled ApoE binds competitively to β(1-40) fibrils with pathological chaperone proteins

References

• Hamazaki H. Ca(2+)-dependent binding of human serum amyloid P component to Alzheimer's beta-amyloid peptide. J Biol Chem 1995; 270: 10392–4
   PubMedGoogle Scholar
• Hawkins P N, Aprile C, Capri G, Vigano L, Munzone E, Gianni L, Pepys M B, Merlini G. Scintigraphic imaging and turnover studies with iodine-131 labelled serum amyloid P component in systemic amyloidosis. Eur J Nucl Med 1998; 25: 701–8
   PubMedGoogle Scholar
• Swartz R H, Black S E, George-Hyslop P S. Apolipoprotein E and Alzheimer's Disease: a genetic, molecular, and neuroimaging review. Can J Neurol Sci 1999; 26: 77–88
   PubMed Web of Science ®Google Scholar
• Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993; 342: 697–9
   PubMed Web of Science ®Google Scholar
• Saunders A M, Strittmatter W J, Schmechel D, George Hyslop P H, Pericak Vance M A, Joo S H, Rosi B L, Gusella J F, Crapper-MacLachlan D R, Alberts M J, Hulette C, Crain B, Goldgaber D, Roses A D. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993; 43: 1467–72
   PubMed Web of Science ®Google Scholar
• Meyer M R, Tschanz J T, Norton M C, Welsh Bohmer K A, Steffens D C, Wyse B W, Breitner J C. APOE genotype predicts when—not whether—one is predisposed to develop Alzheimer disease [letter]. Nat Genet 1998; 19: 321–2
   PubMed Web of Science ®Google Scholar
• Veinbergs I, Masliah E. Synaptic alterations in apolipoprotein E knockout mice. Neuroscience 1999; 91: 401–403
   PubMedGoogle Scholar
• Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994; 17: 525–30
   PubMed Web of Science ®Google Scholar
• Buttini M, Orth M, Bellosta S, Akeefe H, Pitas R E, Wyss-Coray T, Mucke L, Mahley R W. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration. J. Neuroscience 1999; 19: 4867–4880
   PubMed Web of Science ®Google Scholar
• Holtzman D M, Bales K R, Wu S, Bhat P, Parsadanian M, Fagan A M, Chang L K, Sun Y, Paul S M. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 1999; 103: R15–R21
   PubMed Web of Science ®Google Scholar
• Igeta Y, Kawarabayashi T, Sato M, Yamada N, Matsubara E, Ishiguro X, Kanai M, Tomidokoro Y, Osuga J, Okamoto K, Hirai S, Shoji M. Apolipoprotein E accumulates with the progression of A beta deposition in transgenic mice. J Neuropathol Exp Neurol 1997; 56: 1228–35
   PubMed Web of Science ®Google Scholar
• Laemmli U K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–5
   PubMed Web of Science ®Google Scholar
• Beffert U, Aumont N, Dea D, Lussier Cacan S, Davignon J, Poirier J. Beta-amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons. J Neurochem 1998; 70: 1458–66
   PubMed Web of Science ®Google Scholar
• Weisgraber K H, Innerarity T L, Harder K J, Mahley R W, Milne R W, Marcel Y L, Sparrow J T. The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. J Biol Chem 1983; 258: 12348–54
   PubMedGoogle Scholar
• Innerarity T L, Pitas R E, Mahley R W. Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem 1979; 254: 4186–90
   PubMedGoogle Scholar
• Shuvaev W, Siest G. Interaction between human amphipathic apolipoproteins and amyloid beta-peptide: surface plasmon resonance studies. FEBS Lett 1996; 383: 9–12
   PubMed Web of Science ®Google Scholar
• Matsubara E, Frangione B, Ghiso J. Characterization of apolipoprotein J-Alzheimer's A beta interaction. J Biol Chem 1995; 270: 7563–7
   PubMed Web of Science ®Google Scholar
• Matsubara E, Soto C, Governale S, Frangione B, Ghiso J. Apolipoprotein J and Alzheimer's amyloid beta solubility. Biochem J 1996; 316: 671–9
   PubMed Web of Science ®Google Scholar
• Harr S D, Uint L, Hollister R, Hyman B T, Mendez A J. Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease. J. Neurochem. 1996; 66: 2429–2435
   PubMed Web of Science ®Google Scholar
• Janciauskiene S, Garcia de Frutos P, Carlemalm E, Dahlback B, Eriksson S. Inhibition of Alzheimer beta-peptide fibril formation by serum amyloid P component. J Biol Chem 1995; 270: 26041–4
   PubMed Web of Science ®Google Scholar
• Beffert U, Poirier J. ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation. Neuroreport 1998; 9: 3321–3
   PubMedGoogle Scholar
• Castano E M, Prelli F, Wisniewski T, Golabek A, Kumar R A, Soto C, Frangione B. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. Biochem J 1995; 306: 599–604
   PubMed Web of Science ®Google Scholar
• Evans K C, Berger E P, Cho C G, Weisgraber K H, Lansbury P T, Jr. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proc Natl Acad Sci US A 1995; 92: 763–7
   PubMed Web of Science ®Google Scholar
• Gallo G, Wisniewski T, Choi Miura N H, Ghiso J, Frangione B. Potential role of apolipoprotein-E in fibrillogenesis. Am J Pathol 1994; 145: 526–30
   PubMed Web of Science ®Google Scholar
• Naiki H, Gejyo F, Nakakuki K. Concentration-dependent inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro. Biochemistry 1997; 36: 6243–50
   PubMed Web of Science ®Google Scholar
• Soto C, Castano E M, Prelli F, Kumar R A, Baumann M. Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, gelsolin and AA amyloids. FEBS Lett 1995; 371: 110–4
   PubMed Web of Science ®Google Scholar
• Wood S J, Chan W, Wetzel R. An ApoE-Abeta inhibition complex in Abeta fibril extension. Chem Biol 1996; 3: 949–56
   PubMedGoogle Scholar
• Wood S J, Chan W, Wetzel R. Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E. Biochemistry 1996; 35: 12623–8
   PubMed Web of Science ®Google Scholar
• Winkler K, Scharnagl H, Tisljar U, Hoschutzky H, Friedrich I, Hoffmann M M, Huttinger M, Wieland H, Marz W. Competition of Abeta amyloid peptide and apolipoprotein E for receptor-mediated endocytosis. J Lipid Res 1999; 40: 447–55
   PubMed Web of Science ®Google Scholar
• Yang D S, Small D H, Seydel U, Smith J D, Hallmayer J, Gandy S E, Martins R N. Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience 1999; 90: 1217–1226
   PubMedGoogle Scholar
• LaFerla F M, Troncoso J C, Strickland D K, Kawas C H, Jay G. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest 1997; 100: 310–20
   PubMed Web of Science ®Google Scholar
• Zlokovic B V. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci 1996; 59: 1483–97
   PubMed Web of Science ®Google Scholar
• Cribbs D H, Velazquez P, Soreghan B, Glabe C G, Tenner A J. Complement activation by cross-linked truncated and chimeric full-length beta-amyloid. Neuroreport 1997; 8: 3457–62
   PubMedGoogle Scholar
• Jiang H, Burdick D, Glabe C G, Cotman C W, Tenner A J. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the Clq a chain. J Immunol 1994; 152: 5050–9
   PubMed Web of Science ®Google Scholar
• Snyder S W, Wang G T, Barrett L, Ladror U S, Casuto D, Lee C M, Krafft G A, Holzman R B, Holzman T F. Complement Clq does not bind monomeric beta-amyloid. Exp Neurol 1994; 128: 136–42
   PubMedGoogle Scholar
• Webster S, Glabe C, Rogers J. Multivalent binding of complement protein ClQ to the amyloid beta-peptide (A beta) promotes the nucleation phase of A beta aggregation. Biochem Biophys Res Commun 1995; 217: 869–75
   PubMed Web of Science ®Google Scholar
• Chan W, Fornwald J, Brawner M, Wetzel R. Native complex formation between apolipoprotein E isoforms and the Alzheimer's disease peptide A beta. Biochemistry 1996; 35: 7123–30
   PubMed Web of Science ®Google Scholar
• Golabek A A, Soto C, Vogel T, Wisniewski T. The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation. J Biol Chem 1996; 271: 10602–6
   PubMed Web of Science ®Google Scholar
• Soto C, Golabek A, Wisniewski T, Castano E M. Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro. Neuroreport 1996; 7: 721–5
   PubMed Web of Science ®Google Scholar
• Charge S B, Esiri M M, Bethune C A, Hansen B C, Clark A. Apolipoprotein E is associated with islet amyloid and other amyloidoses: implications for Alzheimer's disease. J Pathol 1996; 179: 443–7
   PubMed Web of Science ®Google Scholar
• Furumoto H, Shimizu T, Asagami C, Muto M, Takahashi M, Hoshii Y, Ishihara T, Nakamura K. Apolipoprotein E is present in primary localized cutaneous amyloidosis. J. Invest Dermatol 1998; 111: 417–21
   PubMedGoogle Scholar