Distribution of neprilysin and deposit patterns of Aβ subtypes in the brains of aged squirrel monkeys (Saimiri sciureus)

References

• Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353–356.
   PubMed Web of Science ®Google Scholar
• Revesz T, Ghiso J, Lashley T, Plant G, Rostagno A, Frangione B, Holton JL. Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view. J Neuropathol Exp Neurol 2003;62:885–898.
   PubMed Web of Science ®Google Scholar
• LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest 1997;100:310–320.
   PubMed Web of Science ®Google Scholar
• Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet 1999;354:919–920.
   PubMed Web of Science ®Google Scholar
• Goedert M, Spillantini MG. A century of Alzheimer's disease. Science 2006;314:777–781.
   PubMed Web of Science ®Google Scholar
• Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004;44:181–193.
   PubMed Web of Science ®Google Scholar
• Farris W, Schutz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, et al Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol 2007;171:241–251.
   PubMedGoogle Scholar
• Iwata N, Tsubuk S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Metabolic regulation of brain Abeta by neprilysin. Science 2001;292:1550–1552.
   PubMed Web of Science ®Google Scholar
• Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, et al Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med 2000;6:143–150.
   PubMed Web of Science ®Google Scholar
• Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, et al Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 2001;276:21895–21901.
   PubMed Web of Science ®Google Scholar
• Miners JS, Van Helmond Z, Chalmers K, Wilcock G, Love S, Kehoe PG. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2006;65:1012–1021.
   PubMed Web of Science ®Google Scholar
• Yasojima K, Akiyama H, McGeer EG, McGeer PL. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide. Neurosci Lett 2001;297:97–100.
   PubMed Web of Science ®Google Scholar
• Saido TC, Iwata N. Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci Res 2006;54:235–253.
   Google Scholar
• Attems J, Lauda F, Jellinger KA. Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study. J Neurol 2008;255:70–76.
   PubMedGoogle Scholar
• Weller RO, Subash M, Preston SD, Mazanti I, Carare RO. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008;18:253–266.
   PubMed Web of Science ®Google Scholar
• Wilhelmus MM, Otte-Holler I, van Triel JJ, Veerhuis R, Maat-Schieman ML, Bu G, de Waal RM, Verbeek MM. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. Am J Pathol 2007;171:1989–1999.
   PubMed Web of Science ®Google Scholar
• Czasch S, Paul S, Baumgartner W. A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain. Neurobiol Aging 2006;27:293–305.
   PubMed Web of Science ®Google Scholar
• Shimada A, Kuwamura M, Umemura T, Takada K, Ohama E, Itakura C. Modified Bielschowsky and immunohistochemical studies on senile plaques in aged dogs. Neurosci Lett 1991;129:25–28.
   PubMed Web of Science ®Google Scholar
• Uchida K, Nakayama H, Goto N. Pathological studies on cerebral amyloid angiopathy, senile plaques and amyloid deposition in visceral organs in aged dogs. J Vet Med Sci 1991;53:1037–1042.
   PubMed Web of Science ®Google Scholar
• Uchida K, Yoshino T, Yamaguchi R, Tateyama S, Kimoto Y, Nakayama H, Goto N. Senile plaques and other senile changes in the brain of an aged American black bear. Vet Pathol 1995;32:412–414.
   PubMed Web of Science ®Google Scholar
• Nakamura S, Nakayama H, Kiatipattanasakul W, Uetsuka K, Uchida K, Goto N. Senile plaques in very aged cats. Acta Neuropathol 1996;91:437–439.
   PubMed Web of Science ®Google Scholar
• Nakamura S, Nakayama H, Goto N, Ono-Ochikubo F, Sakakibara I, Yoshikawa Y. Histopathological studies on senile plaques and cerebral amyloid angiopathy in aged cynomolgus monkeys. Exp Anim 1995;43:711–718.
   PubMed Web of Science ®Google Scholar
• Struble RG, Price DL Jr, Cork LC, Price DL. Senile plaques in cortex of aged normal monkeys. Brain Res 1985;361:267–275.
   PubMed Web of Science ®Google Scholar
• Walker LC, Masters C, Beyreuther K, Price DL. Amyloid in the brains of aged squirrel monkeys. Acta Neuropathol 1990;80:381–387.
   PubMed Web of Science ®Google Scholar
• Wisniewski HM, Ghetti B, Terry RD. Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 1973;32:566–584.
   PubMed Web of Science ®Google Scholar
• Cork LC, Powers RE, Selkoe DJ, Davies P, Geyer JJ, Price DL. Neurofibrillary tangles and senile plaques in aged bears. J Neuropathol Exp Neurol 1988;47:629–641.
   PubMed Web of Science ®Google Scholar
• Roertgen KE, Parisi JE, Clark HB, Barnes DL, O'Brien TD, Johnson KH. A beta-associated cerebral angiopathy and senile plaques with neurofibrillary tangles and cerebral hemorrhage in an aged wolverine (Gulo gulo). Neurobiol Aging 1996;17:243–247.
   PubMed Web of Science ®Google Scholar
• Nakamura S, Nakayama H, Uetsuka K, Sasaki N, Uchida K, Goto N. Senile plaques in an aged two-humped (Bactrian) camel (Camelus bactrianus). Acta Neuropathol 1995;90:415–418.
   PubMed Web of Science ®Google Scholar
• Nakayama H, Katayama K, Ikawa A, Miyawaki K, Shinozuka J, Uetsuka K, Nakamura S, Kimura N, Yoshikawa Y, Doi K. Cerebral amyloid angiopathy in an aged great spotted woodpecker (Picoides major). Neurobiol Aging 1999;20:53–56.
   PubMed Web of Science ®Google Scholar
• Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. The canine as an animal model of human aging and dementia. Neurobiol Aging 1996;17:259–268.
   PubMed Web of Science ®Google Scholar
• Gotz J, Ittner LM. Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 2008;9:532–544.
   PubMed Web of Science ®Google Scholar
• Herzig MC, Van Nostrand WE, Jucker M. Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models. Brain Pathol 2006;16:40–54.
   PubMedGoogle Scholar
• Cork LC, Walker LC. Age-Related Lesions, Nervous System. In: Hunt RD, Jones TC, Mohr U, editors. Nonhuman Primates Berlin: Springer-Verlag; 1993. pp 173–183.
   Google Scholar
• Walker LC, Kitt CA, Schwam E, Buckwald B, Garcia F, Sepinwall J, Price DL. Senile plaques in aged squirrel monkeys. Neurobiol Aging 1987;8:291–296.
   PubMedGoogle Scholar
• Collin RW, van Strien D, Leunissen JA, Martens GJ. Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis. Eur J Biochem 2004;271:1906–1912.
   PubMedGoogle Scholar
• Coulson EJ, Paliga K, Beyreuther K, Masters CL. What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 2000;36:175–184.
   PubMed Web of Science ®Google Scholar
• Levy E, Amorim A, Frangione B, Walker LC. beta-Amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy. Neurobiol Aging 1995;16:805–808.
   PubMed Web of Science ®Google Scholar
• Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D, Ward PJ. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 1990;248:1122–1124.
   PubMed Web of Science ®Google Scholar
• Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990;248:492–495.
   PubMed Web of Science ®Google Scholar
• Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc Natl Acad Sci USA 1996;93:13170–13175.
   PubMed Web of Science ®Google Scholar
• Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, et al Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999;286:735–741.
   PubMed Web of Science ®Google Scholar
• Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochem Soc Trans 2007;35:416–420.
   PubMed Web of Science ®Google Scholar
• Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 1994;13:45–53.
   PubMed Web of Science ®Google Scholar
• Jarrett JT, Berger EP, Lansbury PT Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 1993;32:4693–4697.
   PubMed Web of Science ®Google Scholar
• Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 1992;359:325–327.
   PubMed Web of Science ®Google Scholar
• Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai XD, McKay DM, Tintner R, Frangione B. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 1992;258:126–129.
   PubMed Web of Science ®Google Scholar
• Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K, et al Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci 2004;7:954–960.
   PubMed Web of Science ®Google Scholar
• Ogomori K, Kitamoto T, Tateishi J, Sato Y, Suetsugu M, Abe M. Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. Am J Pathol 1989;134:243–251.
   PubMedGoogle Scholar
• Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, Duff K, Dickson D, Van Broeckhoven C. Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol 2005;167:527–543.
   PubMed Web of Science ®Google Scholar
• Rofina J, van Andel I, van Ederen AM, Papaioannou N, Yamaguchi H, Gruys E. Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 2003;10:86–96.
   PubMed Web of Science ®Google Scholar
• Shimada A, Kuwamura M, Awakura T, Umemura T, Takada K, Ohama E, Itakura C. Topographic relationship between senile plaques and cerebrovascular amyloidosis in the brain of aged dogs. J Vet Med Sci 1992;54:137–144.
   PubMed Web of Science ®Google Scholar
• Turner AJ. Proteolytic enzymes. In: Barrett AJ, editor. Proteolytic enzymes: aspartic and metallo peptidases., San Diego: Academic Press; 1995. pp 1080–1085.
   Google Scholar
• Roques BP, Noble F, Dauge V, Fournie-Zaluski MC, Beaumont A. Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. Pharmacol Rev 1993;45:87–146.
   PubMed Web of Science ®Google Scholar
• Akiyama H, Kondo H, Ikeda K, Kato M, McGeer PL. Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Res 2001;902:277–281.
   PubMed Web of Science ®Google Scholar
• Matsas R, Kenny AJ, Turner AJ. An immunohistochemical study of endopeptidase-24.11 (“enkephalinase”) in the pig nervous system. Neuroscience 1986;18:991–1012.
   PubMedGoogle Scholar
• Takeuchi Y, Uetsuka K, Murayama M, Kikuta F, Takashima A, Doi K, Nakayama H. Complementary distributions of amyloid-beta and neprilysin in the brains of dogs and cats. Vet Pathol 2008;45:455–466.
   PubMedGoogle Scholar
• Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, et al Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 2002;43:39–56.
   PubMed Web of Science ®Google Scholar
• Wang DS, Lipton RB, Katz MJ, Davies P, Buschke H, Kuslansky G, Verghese J, Younkin SG, Eckman C, Dickson DW. Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. J Neuropathol Exp Neurol 2005;64:378–385.
   PubMed Web of Science ®Google Scholar
• Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JA, Perry VH, Weller RO. Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol 2008;34:131–144.
   PubMed Web of Science ®Google Scholar
• Calhoun ME, Burgermeister P, Phinney AL, Stalder M, Tolnay M, Wiederhold KH, Abramowski D, Sturchler-Pierrat C, Sommer B, Staufenbiel M, et al Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc Natl Acad Sci USA 1999;96:14088–14093.
   PubMed Web of Science ®Google Scholar
• Preston SD, Steart PV, Wilkinson A, Nicoll JA, Weller RO. Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol Appl Neurobiol 2003;29:106–117.
   PubMed Web of Science ®Google Scholar
• Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol 1998;153:725–733.
   PubMed Web of Science ®Google Scholar
• Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ. beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc Natl Acad Sci USA 1993;90:10836–10840.
   PubMed Web of Science ®Google Scholar
• Elfenbein HA, Rosen RF, Stephens SL, Switzer RC, Smith Y, Pare J, Mehta PD, Warzok R, Walker LC. Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Histol Histopathol 2007;22:155–167.
   PubMed Web of Science ®Google Scholar
• Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JAR. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 2008;131:3299–3310.
   PubMed Web of Science ®Google Scholar
• Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target 2002;10:359–368.
   PubMed Web of Science ®Google Scholar