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Amyloid
The Journal of Protein Folding Disorders
Volume 18, 2011 - Issue 4
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Original Article

Ferret islet amyloid polypeptide (IAPP): characterization of in vitro and in vivo amyloidogenicity

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Pages 222-228 | Received 22 Aug 2011, Accepted 26 Sep 2011, Published online: 02 Nov 2011

References

  • DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992;15:318–368.
  • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 1999;281:2005–2012.
  • Kahn SE. The relative contributions of insulin resistance and β-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003;46:3–19.
  • Matveyenko AV, Butler PC. Relationship between β-cell mass and diabetes onset. Diabetes Obes Metab 2008;10 Suppl 4:23–31.
  • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102–110.
  • Westermark P. Quantitative studies on amyloid in the islets of Langerhans. Ups J Med Sci 1972;77:91–94.
  • Westermark P, Wernstedt C, Wilander E, Sletten K. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 1986;140:827–831.
  • Lukinius A, Wilander E, Westermark GT, Engström U, Westermark P. Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 1989;32:240–244.
  • Sanke T, Bell GI, Sample C, Rubenstein AH, Steiner DF. An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing. J Biol Chem 1988;263:17243–17246.
  • Marzban L, Trigo-Gonzalez G, Verchere CB. Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of β cells. Mol Endocrinol 2005;19:2154–2163.
  • Lutz TA. Pancreatic amylin as a centrally acting satiating hormone. Curr Drug Targets 2005;6:181–189.
  • Guardado-Mendoza R, Davalli AM, Chavez AO, Hubbard GB, Dick EJ, Majluf-Cruz A, Tene-Perez CE, et al. Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci USA 2009;106:13992–13997.
  • Hayden MR, Karuparthi PR, Manrique CM, Lastra G, Habibi J, Sowers JR. Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus. Exp Biol Med (Maywood) 2007;232:772–779.
  • Paulsson JF, Andersson A, Westermark P, Westermark GT. Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in β cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets. Diabetologia 2006;49:1237–1246.
  • Jurgens CA, Toukatly MN, Fligner CL, Udayasankar J, Subramanian SL, Zraika S, Aston-Mourney K, et al. ß-cell loss and ß-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol 2011;178:2632–2640.
  • Paulsson JF, Schultz SW, Köhler M, Leibiger I, Berggren PO, Westermark GT. Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation. Exp Diabetes Res 2008;2008:865850.
  • Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 1994;368:756–760.
  • Chen S. Pancreatic endocrinopathies in ferrets. Vet Clin North Am Exot Anim Pract 2008;11:107–23, vii.
  • Benoit-Biancamano MO, Morin M, Langlois I. Histopathologic lesions of diabetes mellitus in a domestic ferret. Can Vet J 2005;46:895–897.
  • Carpenter JW, Novilla MN. Diabetes mellitus in a black-footed ferret. J Am Vet Med Assoc 1977;171:890–893.
  • Garner MM, Raymond JT, O’Brien TD, Nordhausen RW, Russell WC. Amyloidosis in the black-footed ferret (Mustela nigripes). J Zoo Wildl Med 2007;38:32–41.
  • Quesenberry KE, Rosenthal KL. Endocrine Diseases. In: Quesenberry KE, Carpenter JW, editors. Ferrets, Rabbits and Rodents - Clin Med Sur 2nd ed. Philadelphia, Pennsylvania, USA: WB Saunders; 2004. pp 79–90.
  • Hoenig M, Hall G, Ferguson D, Jordan K, Henson M, Johnson K, O’Brien T. A feline model of experimentally induced islet amyloidosis. Am J Pathol 2000;157:2143–2150.
  • Wagner JD, Carlson CS, O’Brien TD, Anthony MS, Bullock BC, Cefalu WT. Diabetes mellitus and islet amyloidosis in cynomolgus monkeys. Lab Anim Sci 1996;46:36–41.
  • Hellman U, Wernstedt C, Westermark P, O’Brien TD, Rathbun WB, Johnson KH. Amino acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics. Biochem Biophys Res Commun 1990;169:571–577.
  • Betsholtz C, Christmansson L, Engström U, Rorsman F, Svensson V, Johnson KH, Westermark P. Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species. FEBS Lett 1989;251:261–264.
  • Westermark P, Engström U, Johnson KH, Westermark GT, Betsholtz C. Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 1990;87:5036–5040.
  • Nishi M, Steiner DF. Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus. Mol Endocrinol 1990;4:1192–1198.
  • Westermark GT, Gebre-Medhin S, Steiner DF, Westermark P. Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP. Mol Med 2000;6:998–1007.
  • Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC. Diabetes due to a progressive defect in β-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): A new model for type 2 diabetes. Diabetes 2004;53:1509–1516.
  • Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci USA 1996;93:7283–7288.
  • Verchere CB, D’Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE. Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic β cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci USA 1996;93:3492–3496.
  • Schultz SW, Nilsson KP, Westermark GT. Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation. PLoS ONE 2011;6:e20221.
  • Ma Z, Westermark GT, Johnson KH, O’Brien TD, Westermark P. Quantitative immunohistochemical analysis of islet amyloid polypeptide (IAPP) in normal, impaired glucose tolerant, and diabetic cats. Amyloid 1998;5:255–261.

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