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Original Article

Reduced platelet monoamine oxidase type B activity and lymphocyte muscarinic receptor binding in unmedicated children with attention deficit hyperactivity disorder

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Pages 513-522 | Received 18 May 2009, Accepted 25 Jun 2009, Published online: 28 Oct 2009

References

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IVTR, 4th edn, text revision. Washington, DC: American Psychiatric Association.
  • Anderson JC, Williams S, McGee R, Silva PA. (1987). DSM-III disorders in preadolescent children. Prevalence in a large sample from the general population. Arch Gen Psychiatry 44:69–76.
  • Anthenelli RM, Smith TL, Craig CE, Tabakoff B, Schuckit MA. (1995). Platelet monoamine oxidase activity levels in subgroups of alcoholics: diagnostic, temporal, and clinical correlates. Biol Psychiatry 38:361–8.
  • Arrojo M, Baca-Garcia E, Perez-Rodriguez MM, Dolengevich-Segal H, Navio-Acosta M, Rodriguez-Salgado B, Saiz-Ruiz J. (2007). Platelet monoamine oxidase activity in obsessive- compulsive disorder. Eur Psychiatry 22:525–9.
  • Baumgartel A, Wolraich ML, Dietrich M. (1995). Comparison of diagnostic criteria for attention deficit disorders in a German elementary school sample. J Am Acad of Child Adolesc Psychiatry 34:629–38.
  • Biederman J, Faraone SV. (2005). Attention-deficit hyperactivity disorder. Lancet 366:237–48.
  • Biederman J, Kwon A, Aleardi M, Chouinard VA, Marino T, Cole H, Mick E, Faraone SV. (2005). Absence of gender effects on attention deficit hyperactivity disorder:findings in nonreferred subjects. Am J Psychiatry 162:1083–9.
  • Biederman J, Mick E, Faraone SV, Braaten E, Doyle A, Spencer T, Wilens TE, Frazier E, Johnson MA. (2002). Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. Am J Psychiatry 159:36–42.
  • Birmaher B, Khetarpal S, Brent D, Cully M, Balach L, Kaufman J, Neer SM. (1997). The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics. J Am Acad Child Adolesc Psychiatry 36:545–53.
  • Blanco C, Orensanz-Munoz L, Blanco-Jerez C, Saiz-Ruiz J. (1996). Pathological gambling and platelet MAO activity:a psychobiological study. Am J Psychiatry 153:119–21.
  • Carrasco JL, Diaz-Marsa M, Hollander E, Cesar J, Saiz-Ruiz J. (2000). Decreased platelet monoamine oxidase activity in female bulimia nervosa. Eur Neuropsychopharmacol 10:113–17.
  • Coccini T, Castoldi AF, Gandini C, Randine G, Vittadini G, Baiardi P, Manzo L. (2002). Platelet monoamine oxidase B activity as a state marker for alcoholism: trend over time during withdrawal and influence of smoking and gender. Alcohol Alcohol 37:566–72.
  • Coccini T, Randine G, Castoldi AF, Balloni L, Baiardi P, Manzo L. (2005). Lymphocyte muscarinic receptors and platelet monoamine oxidase-B as biomarkers of CNS function. Effects of age and gender in healthy humans. Environ Toxicol Pharmacol 19:715–20.
  • Conners CK. (1997). Conners’ Rating Scales – Revised: Technical manual. Toronto, Ontario, Canada: Multi-Health Systems Inc.
  • Cubo E, Fern Ndez Jaén A,Moreno C, Anaya B, Gonz Lez M, Kompoliti K. (2008). Donepezil use in children and adolescents with tics and attention-deficit/hyperactivity disorder: an 18-week, single-center, dose-escalating, prospective, open- label study. Clin Ther 30:182–189.
  • Danielczyk W, Streifler M, Konrad C, Riedere P, Moil G. (1988). Platelet MAO-B activity and the psychopathology of Parkinson’s disease, senile dementia and multi-infarct dementia. Acta Psychiatr Scand 78:730–6.
  • Dick DM, Aliev F, Kramer J, Wang JC, Anthony Hinrichs A, Bertelsen S, Kuperman S, Schuckit M, Nurnberger Jr J. Edenberg HJ, Porjesz B, Begleiter H, Hesselbrock V, Goate A, Bierut L. (2007). Association of CHRM2 with IQ:Converging evidence for a gene influencing intelligence. Behav Genet 37:265–72.
  • Doyle RL, Frazier J, Spencer TJ, Geller D, Biederman J, Wilens T. (2006). Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series. J Atten Disord 9:543–9.
  • Faraone SV, Biederman J. (2002). Pathophysiology of Attention-Deficit/Hyperactivity Disorder. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology: The Fifth Generation of Progress. Philadelphia, PA: Lippincott WIlliams & Wilkins. p. 577–96.
  • Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P. (2005). Molecular genetics of attention deficit/hyperactivity disorder. Biol Psychiatry 57:1313–23.
  • Faraone SV, Sergeant J, Gillberg C, Biederman J. (2003). The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2:104–13.
  • Fahlke C, Garpenstrand H, Oreland L, Suomi SJ, Higley JD. (2002). Platelet monoamine oxidase activity in a nonhuman primate model of type 2 excessive alcohol consumption. Am J Psychiatry 159:2107–9.
  • Fujii T, Takada-Takatori Y, Kawashima K. (2008). Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy. J Pharmacol Sci 106:186–92.
  • Fujimoto K, Matsui M, Fujii T, Kawashima K. (2001). Decreased acetylcholine content and choline acetyltransferase mRNA expression in circulating mononuclear leukocytes and lymphoid organs of the spontaneously hypertensive rat. Life Sci 69:1629–38.
  • Halperin JM, Newcorn JH, Schwartz ST, Sharma V, Siever LJ, Koda VH, Gabriel S. (1997). Age-related changes in the association between serotonergic function and aggression in boys with ADHD. Biol Psychiatry 41:682–9.
  • Hand DJ, Fox AT, Reilly MP. (2006). Response acquisition with delayed reinforcement in a rodent model of attention-deficit/ hyperactivity disorder (ADHD). Behav Brain Res 175:337–42.
  • Hercigonja Novkovic V, Rudan V, Pivac N, Nedic G, Muck-Seler D. (2009). Platelet serotonin concentration in children with attention-deficit/hyperactivity disorder. Neuropsychobiology 59:17–22.
  • Kaneda Y, Fujii A, Nagamine I. (2001). Platelet serotonin concentrations in medicated schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 25:983–92.
  • Kaufman J, Birmaher B, Brent D, Rao U, Ryan N. (1996). Kiddie-SADS-Present and Lifetime Version (KSADS-PL), version 1.0 of October, 1996 edn. Pittsburgh, PA: Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Press.
  • Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–88.
  • Kawashima K, Fujii T. (2000). Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther 86:29–48.
  • Kiive E, Fischer K, Harro M, Harro J. (2007). Platelet monoamine oxidase activity in association with adolescent inattentive and hyperactive behaviour: a prospective longitudinal study. Pers Individ Dif 43:155–66.
  • Leblond L, Beaufort C, Delerue F, Durkin TP. (2002). Differential roles for nicotinic and muscarinic cholinergic receptors in sustained visuo-spatial attention? A study using a 5-arm maze protocol in mice. Behav Brain Res 128:91–102.
  • Levine RR, Birdsall NJM, Nathanson NM, editors. (2001). Proceedings of the Ninth International Symposium on Subtypes of Muscarinic Receptors. Life Sci 68:2449–642.
  • Li J, Kang C, Zhang H, Wang Y, Zhou R, Wang B, Guan L, Yang L, Faraone SV. (2007). Monoamine oxidase a gene polymorphism predicts adolescent outcome of attention-deficit/ hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genetic 144B:430–3.
  • Malmberg K, Wargelius HL, Lichtenstein P, Oreland L, Larsson JO. (2008). ADHD and disruptive behavior scores – associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents. BMC Psychiatry 8:28.
  • Manzo L, Artigas F, Martinez E, Mutti A, Bergamaschi E, Nicotera P, Tonini M, Candura SM, Ray DE, Costa LG. (1996). Biochemical markers of neurotoxicity. A review of mechanistic studies and applications. Hum Exp Toxicol 15:S20–S35.
  • Manzo L, Castoldi AF, Coccini T, Prockop LD. (2001). Assessing effects of neurotoxic pollutants by biochemical markers. Environ Res 85:31–6.
  • Masuyama K, Uno K, Minoda R, Eura M, Samejima Y, Ishikawa T. (1996). Muscarinic acetylcholine receptors in patients with Meniere’s disease. Acta Oto-Laryngol (Stockholm) 116:369–73.
  • Mitsis EM, Halperin JM, Newcorn JH. (2000). Serotonin and aggression in children. Curr Psychiatry Rep 2:95–101.
  • Nass RD. (2005). Evaluation and assessment issues in the diagnosis of attention deficit hyperactivity disorder. Seminars in Pediatric Neurology 12:200–16.
  • Oades RD. (2008). Dopamine-serotonin interactions in attention- deficit hyperactivity disorders (ADHD). Prog Brain Res 172:543–65.
  • Oreland L. (2004). Platelet monoamine oxidase, personality and alcoholism: the rise, fall and resurrection. NeuroToxicology 25:79–89.
  • Oreland L, Hallman J, Damberg M. (2004). Platelet MAO and personality – function and dysfunction. Curr Med Chem 11:2007–16.
  • Oreland L, Nilsson K, Damberg M, Hallman J. (2007). Monoamine oxidases – activities, genotypes and the shaping of behaviour. J Neural Transm 114:817–22.
  • Pardey MC, Homewood J, Taylor A, Cornish JL. (2009). Re-evaluation of an animal model for ADHD using a free-operant choice task. J Neurosci Methods 176:166–71.
  • Poznanski EO, Grossman JA, Buchsbaum Y, Banegas M, Freeman L, Gibbons R. (1984). Preliminary studies of the reliability and validity of the children’s depression rating scale. J Am Acad Child Psychiatry 23:191–7.
  • Rabey JM, Grynberg E, Graff E. (1991). Changes of muscarinic cholinergic binding by lymphocyte in Parkinson’s disease with and without dementia. Ann Neurol 30:847–50.
  • Rabey JM, Lewis A, Graff E, Korczyn AD. (1992). Decreased (3H) quinuclidinyl benzilate binding to lymphocytes in Gilles de la Tourette syndrome. Biol Psychiatry 31:889–95.
  • Ramoz N, Boni C, Downing AM, Close SL, Peters SL, Prokop AM, Allen AJ, Hamon M, Purper-Ouakil D, Gorwood P. (2009). A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD). Neuropsychopharmacology. Apr 22. Epub ahead of print.
  • Ruchkin VV, Koposov RA, Klinteberg B, Oreland L, Grigorenko EL. (2005). Platelet MAO-B, Personality, and Psychopathology. J Abnormal Psychology 114:477–82.
  • Sagvolden T, Johansen EB, Aase H, Russell VA. (2005a). A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. Behav Brain Sci 28:397–419.
  • Sagvolden T, Russell VA, Aase H, Johansen EB, Farshbaf M. (2005b). Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1239–47.
  • Shekim WO, Bylund DB, Alexson J, Glaser RD, Jones SB, Hodges K, Perdue S. (1986). Platelet MAO and measures of attention and impulsivity in boys with attention deficit disorder and hyperactivity. Psychiatry Res 18:179–88.
  • Snell LD, Glanz J, Tabakoff B. (2002). Relationships between effects of smoking, gender, and alcohol dependence on platelet monoamine oxidase-B: activity, affinity labelling, and protein measurements. Alcohol Clin Exp Res 26:1105–13.
  • Swanson JM, Sandman CA, Deutsch C, Baren M. (1983). Methylphenidate hydrochloride given with or before breakfast: behavioral, cognitive, and electrophysiological effects. Pediatrics 72:49–55.
  • Swanson JM, Sergeant JA, Taylor E, Sonuga-Barke EJ, Jensen PS, Cantwell DP. (1998). Attention deficit hyperactivity disorder and hyperkinetic disorder. Lancet 351:429–33.
  • Tayebati SK, Codini M, Gallai V, Mannino F, Parnetti L, Ricci A, Sarchielli P, Amenta F. (1999). Radioligand binding assay of M1-M5 muscarinic cholinergic receptor subtypes in human peripheral blood lymphocytes. J Neuroimmunol 99:224–9.
  • Tayebati SK, Amenta F, Amici S, El-Assouad D, Gallai V, Ricci A, Parnetti L. (2001). Peripheral blood lymphocytes muscarinic cholinergic receptor subtypes in Alzheimer’s disease: a marker of cholinergic dysfunction? J Neuroimmunol 121:126–31.
  • Tzavara ET, Bymaster FP, Overshiner CD, Davis RJ, Perry KW, Wolff M, McKinzie DL, Witkin JM, Nomikos GG. (2006). Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine. Mol Psychiatry 11:187–95.
  • Vakalopoulos C. (2006). Neuropharmacology of cognition and memory: a unifying theory of neuromodulator imbalance in psychiatry and amnesia. Med Hyp 66:394–431.
  • Vakalopoulos C. (2007). Neurocognitive deficits in major depression and a new theory of ADHD: a model of impaired antagonism of cholinergic-mediated prepotent behaviours in monoamine depleted individuals. Med Hyp 68:210–21.
  • Verkes RJ, Van der Mast RC, Kerkhof AJ, Fekkes D, Hengeveld MW, Tuyl JP, Van Kempen GM. (1998). Platelet serotonin, monoamine oxidase activity, and 3H paroxetine binding related to impulsive suicide attempts and borderline personality disorder. Biol Psychiatry 15:740–6.
  • Weiss M, Weiss G. (2002). Attention deficit hyperactivity disorder. In: Lewis M, editor. Child and Adolescent Psychiatry, a Comprehensive Textbook, 3rd edn. Baltimore: Williams & Wilkins. p. 645–69.
  • Weizman R, Weizman A, Deutsch SI. 1990. Biological studies of attention-deficit disorder. In: Deutsch SI, Weizman A, Weizman R. (Eds.), Application of Basic Neuroscience to Child Psychiatry. Plenum co., New York, pp. 231–239.
  • Wess J. (2003). Novel insights into muscarinic acetylcholine receptor function using gene targeting technology. TRENDS Pharmacol Sci 24:414–20.
  • Wess J, Eglen RM, Gautam D. (2007). Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721–33.
  • Wilens TE, Biederman J, Wong J, Spencer TJ, Prince JB. (2000). Adjunctive donepezil in attention deficit hyperactivity disorder youth: case series. J Child Adolesc Psychopharmacol 10:217–22.
  • Wilens TE, Verlinden MH, Adler LA, Wozniak PJ, West SA. (2006). ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot study. Biol Psychiatry 59:1065–70.

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