136
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with atopic asthma

&
Pages 158-166 | Received 24 Aug 2009, Accepted 04 Oct 2009, Published online: 09 Nov 2009

References

  • Abrams JR, Lebwohl MG, Guzzo CA, Jegasothy BV, Goldfarb MT, Goffe BS, Menter A, Lowe NJ, Krueger G, Brown MJ, Weiner RS, Birkhofer MJ, Warner GL, Berry KK, Linsley PS, Krueger JG, Ochs HD, Kelley SL, Kang S. (1999). CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest 103:1243–52.
  • ATS. (1987). Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis 136:225–44.
  • ATS/ERS. (2005). ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, (2005). Am J Respir Crit Care Med 171:912–30.
  • Beach JR, Young CL, Avery AJ, Stenton SC, Dennis JH, Walters EH, Hendrick DJ. (1993). Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and the method of assessing response. Thorax 48:239–43.
  • Berce V, Repnik K, Potocnik U. (2008). Association of CCR5-delta32 mutation with reduced risk of nonatopic asthma in Slovenian children. J Asthma 45:780–4.
  • Buonavista N, Balzano C, Pontarotti P, Le PD, Golstein P. (1992). Molecular linkage of the human CTLA4 and CD28 Ig-superfamily genes in yeast artificial chromosomes. Genomics 13:856–61.
  • Burr JS, Kimzey SL, Randolph DR, Green JM. (2001). CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergen. Am J Respir Cell Mol Biol 24:563–8.
  • Busse WW, Lemanske RF Jr. (2001). Asthma. N Engl J Med 344:350–62.
  • Choi JM, Ahn MH, Chae WJ, Jung YG, Park JC, Song HM, Kim YE, Shin JA, Park CS, Park JW, Park TK, Lee JH, Seo BF, Kim KD, Kim ES, Lee DH, Lee SK, Lee SK. (2006). Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. Nat Med 12:574–9.
  • Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, Cockcroft DW, Fish JE, Sterk PJ. (2000). Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July (1999). Am J Respir Crit Care Med 161:309–29.
  • Djukanovic R. (2000). The role of co-stimulation in airway inflammation. Clin Exp Allergy 30 (Suppl. 1):46–50.
  • Drazen JM, Silverman EK, Lee TH. (2000). Heterogeneity of therapeutic responses in asthma. Br Med Bull 56:1054–70.
  • EPR-3. (2007). Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma – Summary Report (2007). J Allergy Clin Immunol 120:S94–138.
  • Green JM. (2000). The B7/CD28/CTLA4 T-cell activation pathway. Implications for inflammatory lung disease. Am J Respir Cell Mol Biol 22:261–4.
  • Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, Candeloro P, Belladonna ML, Bianchi R, Fioretti MC, Puccetti P. (2002). CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3:1097–101.
  • Hawkins GA, Peters SP. (2008). Pharmacogenetics of asthma. Methods Mol Biol 448:359–78.
  • Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, Wallaert B, Lafitte JJ, Chrousos GP, Szefler SJ, Leung DY. 1999. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 159:1600–1604.
  • Hellings PW, Vandenberghe P, Kasran A, Coorevits L, Overbergh L, Mathieu C, Ceuppens JL. (2002). Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice. Eur J Immunol 32:585–94.
  • Holloway JW, Koppelman GH. (2008). 17q21 variants and asthma– questions and answers. N Engl J Med 359:1985–94.
  • Holt PG, Thomas JA. (1997). Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells. Immunology 91:145–50.
  • Holt PG, Upham JW. (2004). The role of dendritic cells in asthma. Curr Opin Allergy Clin Immunol 4:39–44.
  • Ip WK, Wong CK, Leung TF, Lam CW. (2006). Plasma concentrations of soluble CTLA-4, CD28, CD80 and CD86 costimulatory molecules reflect disease severity of acute asthma in children. Pediatr Pulmonol 41:674–82.
  • Jasek M, Luszczek W, Obojski A, Winiarska B, Halubek K, Nowak I, Manczak M, Wisniewski A, Pawlik A, Jonkisz A, Lebioda A, Majorczyk E, Dobosz T, Kusnierczyk P. (2006). Distribution of CTLA-4 polymorphisms in allergic asthma. Int Arch Allergy Immunol 141:223–9.
  • Jayaratnam A, Corrigan CJ, Lee TH. (2005). The continuing enigma of non-atopic asthma. Clin Exp Allergy 35:835–7.
  • Johnston SL. (2007). Innate immunity in the pathogenesis of virus-induced asthma exacerbations. Proc Am Thorac Soc 4:267–70.
  • Kavvoura FK, Akamizu T, Awata T, Ban Y, Chistiakov DA, Frydecka I, Ghaderi A, Gough SC, Hiromatsu Y, Ploski R, Wang PW, Ban Y, Bednarczuk T, Chistiakova EI, Chojm M, Heward JM, Hiratani H, Juo SH, Karabon L, Katayama S, Kurihara S, Liu RT, Miyake I, Omrani GH, Pawlak E, Taniyama M, Tozaki T, Ioannidis JP. (2007). Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. J Clin Endocrinol Metab 92:3162–70.
  • Kawayama T, Kinoshita T, Imaoka H, Gauvreau GM, O’Byrne PM, Aizawa H. (2008). Effects of inhaled fluticasone propionate on CTLA-4-positive CD4+CD25+ cells in induced sputum in mild asthmatics. Respirology 13:1000–7.
  • Kristiansen OP, Larsen ZM, Pociot F. (2000). CTLA-4 in autoimmune diseases – a general susceptibility gene to autoimmunity? Genes Immun 1:170–84.
  • Lee SY, Lee YH, Shin C, Shim JJ, Kang KH, Yoo SH, In KH. (2002). Association of asthma severity and bronchial hyperresponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene. Chest 122:171–6.
  • Linsley PS, Nadler SG, Bajorath J, Peach R, Leung HT, Rogers J, Bradshaw J, Stebbins M, Leytze G, Brady W. (1995). Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules. J Biol Chem 270:15417–24.
  • Magistrelli G, Jeannin P, Herbault N, Benoit De CA, Gauchat JF, Bonnefoy JY, Delneste Y. (1999). A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells. Eur J Immunol 29:3596–602.
  • Malquori L, Carsetti L, Ruberti G. (2008). The 3’ UTR of the human CTLA4 mRNA can regulate mRNA stability and translational efficiency. Biochim Biophys Acta 1779:60–5.
  • Martinez FD. (2002). Development of wheezing disorders and asthma in preschool children. Pediatrics 109:362–7.
  • Nakao F, Ihara K, Ahmed S, Sasaki Y, Kusuhara K, Takabayashi A, Nishima S, Hara T. (2000). Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population. Exp Clin Immunogenet 17:179–84.
  • Pan J, Ju D, Wang Q, Zhang M, Xia D, Zhang L, Yu H, Cao X. (2001). Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol Lett 76:153–61.
  • Qin XJ, Shi HZ, Qin SM, Kang LF, Huang CP, Zhong XN. (2005). Effects of allergen inhalation and oral glucocorticoid on serum soluble CTLA-4 in allergic asthmatics. Allergy 60:774–9.
  • Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B, Hogg N, Garside P, Rudd CE. (2006). Reversal of the TCR stop signal by CTLA-4. Science 313:1972–5.
  • Shi HZ, Mo XY, Zhong XN. (2005). Soluble CTLA-4 in sera of patients with bronchial asthma. J Asthma 42:133–9.
  • Sohn MH, Kim SH, Song TW, Kim KW, Kim ES, Park HS, Kim KE. (2007). Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. Pediatr Pulmonol 42:542–7.
  • Sterk PJ, Fabbri LM, Quanjer PH, Cockcroft DW, O’Byrne PM, Anderson SD, Juniper EF, Malo JL. (1993). Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 16:53–83.
  • Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, Drazen J, Weiss ST. (2004). Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet 13:1353–9.
  • Torres B, Aguilar F, Franco E, Sanchez E, Sanchez-Roman J, Jimenez AJ, Nunez-Roldan A, Martin J, Gonzalez-Escribano MF. (2004). Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus. Arthritis Rheum 50:2211–15.
  • Turato G, Barbato A, Baraldo S, Zanin ME, Bazzan E, Lokar-Oliani K, Calabrese F, Panizzolo C, Snijders D, Maestrelli P, Zuin R, Fabbri LM, Saetta M. (2008). Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma. Am J Respir Crit Care Med 178:476–82.
  • Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di GG, and others (2003). Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506–11.
  • van Belzen MJ, Mulder CJ, Zhernakova A, Pearson PL, Houwen RH, Wijmenga C. (2004). CTLA4 + 49 A/G and CT60 polymorphisms in Dutch coeliac disease patients. Eur J Hum Genet 12:782–5.
  • van Wijk WF, Nierkens S, de Jong JW, Wehrens EJ, Boon L, van Kootens KP, Knippels LM, Pieters R. (2007). The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins. J Immunol 178:6894–900.
  • Wechsler ME, Israel E. (2005). How pharmacogenomics will play a role in the management of asthma. Am J Respir Crit Care Med 172:12–18.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.