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Biomarkers Volume 1, 1996 - Issue 1
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Research Article

1H NMR spectroscopic studies on the characterization of renal cell lines and identification of novel potential markers of in vitro nephrotoxicity

Maria L. Anthony Department of Chemistry, Birkbeck College, University of London, Gordon House, 29 Gordon Square, London, WC1H 0PP, UK
,
Peter C. R. McDowell Department of Chemistry, Birkbeck College, University of London, Gordon House, 29 Gordon Square, London, WC1H 0PP, UK
,
Tim J. B. Gray Department of Toxicology, sanofi Research Division, Willow burn Avenue. Alnwick, Northumberland, NE662/H, UK
,
Melanie Blackmore Department of Toxicology, sanofi Research Division, Willow burn Avenue. Alnwick, Northumberland, NE662/H, UK
&
Jeremy K. Nicholson Department of Chemistry, Birkbeck College, University of London, Gordon House, 29 Gordon Square, London, WC1H 0PP, UK
Pages 35-43 | Received 18 Oct 1995, Accepted 02 Nov 1995, Published online: 27 Sep 2008

References

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  • Anthony M. L., Beddell C. R., Lindon J. C., Nicholson J. K. Studies on the effects of L(αS,59)-aminr.3chloro-4,5dihydro-5-isoxazoleacetic acid (AT-125on 4-aminophenoknduced nephrotoxicity in the Fischer 344 rat. Archives of Toxicology 1993; 67: 696–705
  • Anthony M. L., Gartland K. P. R., Bedell C. R., Lindon J. C., Nicholson J. K., et al. Studies on the biochemical toxicology of uranyl nitrate in the rat. Archives of Toxicology 1994; 68: 43–53
  • Anthony M. L., Beddell C. R., Lindon J. C., Nicholson J. K. Studies into the comparative toxicity of S-(1,2dichlorovinyl)-L-cysteine, S (1,2dichlorovinyl)-L-hhomocysteine and 1,1,2-trichlorr.3,3,3trifluoro-l propone in the Fischer 344 rat. Archives of Toxicology 1994; 69: 99–110
  • Bagnasco S., Balaban R., Fales H. M., Yang Y. M., Burg M. B. Predominant osmotically active organic solutes in rat and rabbit renal medulla. Journal of Biological Chemistry 1986; 261: 5872–5877
  • Beck F. S., Schmolke M., Guder W. G. Osmolytes. Current Opinion in Nephrology and Hypertension 1992; 1: 43–52
  • Bohets H. H., Van Thielen M. N., Van der Best I., Van Landeghem G. F., D'Haese P. C., Nouwen E. J., De Broe M. E., Diericxx P. J. Cytotoxicity of mercury compounds in LLC-PK., MDCK and human proximal tubular cells. Kidney International 1995; 47: 395–403
  • Borenfreund E., Puerner J. A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicology Letters 1985; 24: 199–124
  • Commadeur J. M. N., Vermeulen N. P. E. Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review. Chemical Research in Toxicology 1990; 3: 171–194
  • Elfarra A. A., Jakobson I., Andrs M. W. Mechanisms of S-(1,2-dichlorovinyl)glutathioneinduced nephrotoxicity. Biochemical Pharmacology 1986; 35: 283–288
  • Foxall P. J. D., Parkinson J. A., Sadler I. H., Lindon J. C., Nicholson J. K. Analysis of biological fluids using 600 MHz proton NMR spectroscopy: application of homonuclear twodimensional kesolved spectroscopy to urine and blood plasma for spectral simplification and assignment. Journal of Pharmaceutical and Biomedical Analysis 1993; 11: 21–31
  • Gartland K. P. R., Bonner F. W., Nicholson J. K. Investigations into the biochemical effects of regionspecific nephrotoxins. Molecular Pharmacology 1989; 35: 242–250
  • Gartland K. P. R., Eason C. I., Bonner F. W., Nicholson J. K. The effect of biliary cannulation and glutathione depletion on the nephrotoxicity of para-aminophenol in the Fischer 344 rat. Archives of Toxicology 1990; 64: 14–25
  • Holmes E., Caddick S., Lindon J. C., Wilson I. D., Kryvawych S., Nicholso J. K. 1H and 2H NMR spectroscopic studies on the biochemical effects and metabolism of 2-bromoethanamine in the rat: induction of transient glutarlc aciduria. Biochemical Pharmacology 1995; 49: 1349–1359
  • Murgatroyd L. B., Pickford R., Smith I. K., Wilson I. D. 1H-MMR spectroscopy as a means of monitoring nephrotoxicity as exemplified by studies with cephaloridine. Human and Experimental Toxicology 1992; 11: 35–41
  • Nicholson J. K., Wilson I. D. High resolution proton magnetic resonance spectroscopy of biological fluids. Progress in NMR Spectroscopy 1989; 21: 449–501
  • Nicholson J. K., Timbrell J. A., Sadler P. J. Proton NMR spectra of urine as indicators of renal damage: mercury-induced nephrotoxicity in rats. Molecular Pharmacology 1985; 27: 644–651
  • Powell C. J., Grasso P., Ioannides C., Wilson J., Bridges J. W. Haloalkylamine-induced renal papillary necrosis: a histopathological study of structure-activity relationships. International Journal of Experimental Pathology 1991; 72: 631–646

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