DNA base adducts in urine andwhite blood cells of cancer patients receiving combination chemotherapies which include N-methyl-N-nitrosourea

References

• Bianchini F., Wild C. P. Comparison of 7-MedG formation in white blood cells, liver and target organs in rats treated with methylating carcinogens. Carcinogenesis 1994a; 15: 1137–1141
   PubMed Web of Science ®Google Scholar
• Bianchini F., Wild C. P. Effect of route of administration of environmental methylating agents on 7-methylguanine formation in white blood cells and internal organs: implications for molecular epidemiology. Cancer Letters 1994b; 87: 131–137
   PubMed Web of Science ®Google Scholar
• Bianchini F., Mintesano R., Shuker D. E. G., Cuzick J., Wild C. P. Quantification of 7-methyldeoxyguanosine using immunoaffinity purification and HPLC with electrochemical detection. Carcinogenesis 1993; 14: 1677–1682
   PubMed Web of Science ®Google Scholar
• Cocconi G., Bella M., Calabresi F., Tonato M., Canaletti R., Boni C., Buzzi F., Ceci G., Corgna E., Costa P., Lottici R., Papadia F. M., Sofra M. C., Bacchi M. Treatment of metastatic malignant-melanoma with dacarbazine plus tamoxifen. New England Journal of Medicine 1992; 327: 516–523
   PubMed Web of Science ®Google Scholar
• Degan P., Montesano R., Wild C. P. Antibodies against 7-methyldeoxyguanosine: its detection in rat peripheral blood lymphocyte DNA and potential applications to molecular epidemiology. Cancer Research 1988; 48: 5065–5070
   PubMed Web of Science ®Google Scholar
• Den Engelse L., Menkveld G. J., De Bru R. J., Tates A. D. Formation and stability of alkylated pyrimidines and purines (including imidazole ringapened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea and dimethylnitrosamine. Carcinogenesis 1986; 7: 393–403
   PubMed Web of Science ®Google Scholar
• Emanuel N. M., Vermel E. M., Ostrovskaya L. A., Korman N. P. Experimental and clinical studies of the anti tumor activity of 1-methyl-1-nitrosourea (NSC-23909). Cancer Chemotherapy Reports 1974; 5: 135–148
   Google Scholar
• Fong L. Y. Y., Jensen D. E., Magee P. N. DNA methyl-adduct dosimetry and O6-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosourea. Carcinogenesis 1990; 11: 411–417
   PubMed Web of Science ®Google Scholar
• Foffi L. Y. Y., Bevill R. F., Thurman J. C., Magee P. N. DNA Adduct dosimetry and DNA repair in rats and pigs given repeated doses of procarbazine under conditions of carcinogenicity and human cancer chemotherapy respectively. Carcinogenesis 1992; 13: 2153–2159
   PubMed Web of Science ®Google Scholar
• Gershanovich M. L., Arkhipov A. I., Vilensky B. S. Application of nitrosourea derivatives for the treatment of Hodgkin's disease involving central nervous system (in Russian). Voprosy Onkologii 1988; 34: 542–549
   PubMed Web of Science ®Google Scholar
• Kaldor J. M., Day, Band N. E.P., Choi N. W., Clarke E. A., Coleman M. P., Hakama M., Koch M., Langmark F., Neal F. E., Pettersson F., Pompe-Kirin V., Prior P., Storm H. H. Second malignancies following testicular cancer, ovarian cancer and Hodgkin's disease: an international collaborative study among cancer registries. International Journal of Cancer 1978; 39: 571–585
   Google Scholar
• Kaldor J. M., Day N. E., Clarke E. A. Leukemia following Hodgkin's disease. New England Journal of Medicine 1990; 322: 7–13
   PubMed Web of Science ®Google Scholar
• Kolaric K. Combination chemotherapy with 1-methyi-1-nitrosourea (MNU) and cyclophosphamide in solid tumours. Zeitschrift für Krebsforchung 1977; 89: 311–319
   Google Scholar
• Lee S. M., Margison G. P., Thatcher N., O'Connor P. J., Cooper D. P. Formation and loss of O6-methyldeoxyguanosine in human leucocyte DNA following sequential DTlC and fotemustine chemotherapy. British Journal of Cancer 1994; 69: 853–857
   PubMed Web of Science ®Google Scholar
• Maxwell S. E., Delaney H. D. Designing Experiments and Analyzing Data. Wadsworth Publishing Company, Belmont CAI 1990; 455–488
   Google Scholar
• Mitchell E. P., Schein P. S. Contributions of nitrosoureas to cancer treatment. Cancer Treatment Reports 1986; 1: 31–41
   Google Scholar
• Montgomery J. A. The development of the nitrosoureas: a study in congener synthesis. Nitrosoureas Current Status and New Developments, A. W. Prestayko, L. H. Baker, S. T. Cooke, S. K. Carter, P. S. Schein. Academic Press, London 1981; 3–67
   Google Scholar
• Mustonen R., Forsti A., Hietanen P., Hemminki K. Measurement by 32P-postlabelling of 7-methylguanine levels in white blood cell DNA of healthy individuals and cancer patients treated with dacarbazine and procarbazine. Human data and method development for 7-alkylguanines. Carcinogenesis 1991; 12: 1423–1431
   PubMed Web of Science ®Google Scholar
• Perevodchidova N. I., Gorbunova V. A., Orel N. F., Smironova N. B., Platinsky L. V., Moroz L. V., Borookina A. G., Kupchan D. Z., Sokolov Y. N., Gershanovich M. L., Kogonia M. L., Breivis P. V., Vajtkavichus J. A., Bramberga V. M., Grants E. A., Sarkisian O. N., Sidorenko Y. S., Zerhozeva A. I. Aranoza—a new nitrosourea derivative with antitumour action. Phase HI trials. International Journal of Experimental and Clinical Therapy 1992; 5: 231–236
   Google Scholar
• Philip P. A., Souliotis V. L., Harris A. L., Salisbury A., Tates A. D., Mitchell K., van Delft J. H. M., Ganesan T. S., Kyrtopoulos S. A. Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea. Clinical Cancer Research 1996; 2: 303–310
   PubMed Web of Science ®Google Scholar
• Porn L. F., Shuker D. E. G. DNA damage and mutagenesis induced by nitrogen mustards. Mutation Research 1994; 318: 205–226
   PubMed Web of Science ®Google Scholar
• Prevost V., Shuker D. E. G. Cigarette smoking and urinary 3-alkyladenine excretion in man. Chemical Research in Toxicology 1996; 9: 439–444
   PubMed Web of Science ®Google Scholar
• Prevost V., Shuker D. E. G., Bartsch H., Pastorelli R., Stillwell W. G., Truidel L. J., Tannenbaum S. R. The determination of urinary 3 methyladenine by immunoaffinity chromatography-monoclonal antibody based ELISA use in human biomonitoring studies. Carcinogenesis 1990; 11: 1747–1751
   PubMed Web of Science ®Google Scholar
• Prevost V., Shuker D. E. G., Friesen M. D., Eberle G., Rajewsky M. F., Bartsch H. Immunoaffinity purification and gas chromatography-mass spectrometric quantiation of 3-alkyladenines in urine: metabolism studies and basal excretion levels in man. Carcinogenesis 1993; 14: 199–204
   PubMed Web of Science ®Google Scholar
• Shuker D. E. G., Farmer P. B. Relevance of urinary DNA adducts as markers of carcinogen exposure. Chemical Research in Toxicology 1992; 5: 450–460
   PubMed Web of Science ®Google Scholar
• Souliotis V. L., Kajla S., Boussiotis V. A., Pangaliss G. A., Kyrtopoulos S. A. Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair. Cancer Research 1990; 50: 2759–2764
   PubMed Web of Science ®Google Scholar
• Soluliotis V. L., Boussiotis V. A., Pangalis G. A., Kyrtopoulos S. A. In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine. Carcinogenesis 1991; 12: 285–288
   PubMed Web of Science ®Google Scholar
• Tanayev V. G., Gershanovich M. L. Chemotherapy of disseminated malignant melanoma of the skin with combination of nitrosomethylurea vincristine and peplomycin or bleomycin (in Russian). Voprosy Orikologii 1991; 37: 163–167
   Web of Science ®Google Scholar
• Umbenhauer D., Wild C. P., Monitesano R., Saffhill R., Boyle J. M., Huh N., Kirstein U., Thomale J., Rajewsky M. F., Lu S. H. O6-Methyldeoxyguanosine in oesophageal DNA in populations at high risk of oesophageal cancer. International Journal of Cancer 1985; 36: 661–665
   PubMed Web of Science ®Google Scholar
• van Delft J. H. M., Van Den Ende A. M.C., Keizer H. J., Ouwerkerk J., Bann R. A. Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine. Carcinogenesis 1992; 13: 1257–1259
   PubMed Web of Science ®Google Scholar
• World Health Organization. WHO Hand book for Reporting Results of Cancer Treatment. WHO, Geneva 1979, WHO Offset Publication No. 48
   Google Scholar