Can intracellular signalling pathways predict developmental abnormalities?

References

• Bergman B., Bokström H., Born O., Enk L., Hedner T., Wängberg B. Transfer of terbutaline across the human placenta in late pregnancy. European Journal of Respiratory Disease 1984; 65: 81–86
   Google Scholar
• Bey M., Blanchard A. C., Darnell J., Stephens K. Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline for suppression of premature labor. American Journal of Obstetrics and Gynecology 1992; 167: 292
   PubMedGoogle Scholar
• Bhat N. R., Shanker G., Pieringer R. A. Cell prolieration in growing cultures of dissociated embryonic mouse brain: macromolecule and ornithine decarboxylase synthesis and regulation by hormones and drugs. Journal of Neuroscience Research 1983; 10: 221–230
   PubMedGoogle Scholar
• Boutillier A. L, Barthel F., Roberts J. L., Loeffler J. P. β-Adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein (CREB)-dependent and tissue-specific CREB-independent mechanisms in corticotrope cells. Journal of Biological Chemistry 1992; 267: 23520–23526
   PubMedGoogle Scholar
• Chaudhry A., Granneman J. G. Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat. American Journal of Physiology 1991; 261: R403–R411
   Google Scholar
• Chien K. R., Zhu H., Knowton K. U., Miller-Hance W., Van-Bilsen M., O'Brien T. X., Evans S. M. Transcriptional regulation during cardiac growth and development. Annual Review of Physiology 1993; 55: 77–95
   PubMed Web of Science ®Google Scholar
• Chirgwin S. M., Przybyla A. E., MacDonald R. J., Rutter W. J. Isolation of RNA from living tissues using a modified guanidine thiocyanate/cesium chloride method. Biochemistry 1979; 18: 5294–5299
   PubMed Web of Science ®Google Scholar
• Chiu R., Boyle W. J., Meek J., Smeal T, Hunter T, Karin M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 1988; 54: 541–552
   PubMed Web of Science ®Google Scholar
• Claycomb W. C. Biochemical aspects of cardiac muscle differentiation. Journal of Biological Chemistry 1976; 251: 6082–6089
   PubMed Web of Science ®Google Scholar
• Cochard P., Goldstein M., Black I. B. Ontogenetic appearance and disappearance of tyrosine hydroxylase and catecholamines in the rat embryo. Proceedings of the National Academy of Sciences, USA 1978; 75: 2986–2990
   PubMedGoogle Scholar
• Collaco-Moraes Y, De Belleroche J. S. Differential effects of dexamethasone on the induction of c-fos, Zif-268 and ornithine decarboxylase by excitotoxin. Biochemical Society Transactions 1994; 22: S151
   PubMedGoogle Scholar
• Coupland R. E. The development and fate of catecholamine secreting endocrine cells. Biogenic Amines in Development, H. Parvez, S. Parvez. Elsevier, Amsterdam 1980; 3–28
   Google Scholar
• Coyle J. T., Axelrod J. Development of the uptake and storage of l-[3H]norepinephrine in the rat brain. Journal of Neurochemistry 1971; 18: 2061–2075
   PubMedGoogle Scholar
• Curran T. Isolation and characterization of the c-fos (rat) cDNA and analysis of post-translational modification in vitro. Oncogene 1987; 2: 74–87
   Google Scholar
• Fletcher S. E., Fyfe D. A., Case C. L., Wiles H. B., Upshur J. K., Newan R. B. Myocardial necrosis in a newborn after long-term maternal subcutaneous terbutaline infusion for suppression of preterm labor. American Journal of Obstetrics and Gynecology 1991; 165: 1401–1404
   PubMed Web of Science ®Google Scholar
• Galliani G., Colombo G., Luzzani F. Contragestational effects of DL-difluoromethylornithine, and irreversible inhibitor of ornithine decarboxylase, in the hamster. Contraception 1983; 28: 159–170
   PubMedGoogle Scholar
• Gatherer D. Gene knockouts and murine development. Development Growth & Differentiation 1993; 35: 365–370
   Web of Science ®Google Scholar
• Ginty D. D., Bonni A., Greenberg M. E. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription phosphorylation of CREB. Cell 1994; 77: 713–725
   PubMedGoogle Scholar
• Guidotti A. Adenosine 3′, 5′-monophosphate concentrations and isoproterenol-induced synthesis of deoxyribonucleic acid mouse parotid gland. Molecular Pharmacology 1972; 8: 521–530
   PubMed Web of Science ®Google Scholar
• Heby O., Emanuelsson H. Role of the polyamines in germ cell differentiation and in early embryonic development. Medical Biology 1981; 59: 417–422
   PubMedGoogle Scholar
• Heck S., Kullmann M., Gast A., Ponta H., Rahmsdorf H. J., Herrlich P., Cato A. C. B. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO Journal 1994; 13: 4087–4095
   PubMed Web of Science ®Google Scholar
• Hesketh J. E., Whitelaw P. F. The role of cellular oncogenes in myogenesis and muscle cell hypertrophy. International Journal of Biochemistry 1992; 24: 193–203
   PubMedGoogle Scholar
• Hou Q.-C., Slotkin T. A. Effects of prenatal dexamethasone or terbutaline exposure on development of neural and intrinsic control of heart rate. Pediatric Research 1989; 26: 554–557
   PubMedGoogle Scholar
• Hultgårdh-Nhsson A., Querol-Ferrer V., Jonzon B., Krondahl U., Nilsson J. Cyclic AMP, early response gene expression, and DNA synthesis in rat smooth muscle cells. Experimental Cell Research 1994; 214: 297–302
   PubMedGoogle Scholar
• Jonakait G. M., Wolf J., Cochard P., Goldstein M., Black I. B. Selective loss of noradrenergic phenotypic characters in neuroblasts of the rat embryo. Proceedings of the National Academy of Sciences, USA 1979; 76: 4683–4686
   PubMedGoogle Scholar
• Kawai Y., Arinze I. J. Glucocorticoid regulation of G-protein subunits in neonatal liver. Molecular and Cellular Endocrinology 1993; 90: 203–209
   PubMedGoogle Scholar
• Kerppola T. K., Luk D., Currant T. Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro. Molecular and Cellular Biology 1993; 13: 3782–3791
   PubMed Web of Science ®Google Scholar
• Kudlacz E. M., Navarro H. A., Eylers J. P., Lappi S. E., Dobbins S. S., Slotkin T. A. Effects of prenatal terbutaline exposure on cellular development in lung and liver of neonatal rat: ornithine decarboxylase activity and macromolecules. Pediatric Research 1989; 25: 617–622
   PubMedGoogle Scholar
• Kudlacz E. M., Navarro H. A., Eylers J. P., Slotkin T. A. Adrenergic modulation of cardiac development in the rat: effects of prenatal exposure to propranolol via continuous maternal infusion. Journal of Developmental Physiology 1990a; 13: 243–249
   PubMedGoogle Scholar
• Kudlacz E. M., Navarro H. A., Eylers J. P., Slotkin T. A. Prenatal exposure to propranolol via continuous maternal infusion: effects on physiological and biochemical processes mediated by beta adrenergic receptors in fetal and neonatal rat lung. Journal of Pharmacology and Experimental Therapeutics 1990b; 252: 42–50
   PubMedGoogle Scholar
• Kudlacz E. M., Navarro H. A., Slotkin T. A. Regulation of β-adrenergic receptor-mediated processes in fetal rat lung: selective desensitization caused by chronic terbutaline exposure. Journal of Developmental Physiology 1990c; 14: 103–108
   PubMedGoogle Scholar
• Lau C., Kavlock R. J. Functional toxicity in the developing heart, lung, and kidney. Developmental Toxicology, 2nd edition, C. A. Kimmel, J. Buelke-Sam. Raven Press, New York 1994; 119–188
   Google Scholar
• Lau C., Slotkin T. A. Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. Molecular Pharmacology 1979; 16: 504–512
   PubMed Web of Science ®Google Scholar
• Lauder J. M., Krebs H. Serotonin as a differentiation signal in early neurogenesis. Developmental Neuroscience 1978; 1: 15–30
   PubMed Web of Science ®Google Scholar
• Lenselink D. R., Kuhlmann R. S., Lawrence J. M., Kolesari G. L. Cardiovascular teratogenicity of terbutaline and ritodrine in the chick embryo. American Journal of Obstetrics and Gynecology 1994; 171: 501–506
   PubMedGoogle Scholar
• Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. Protein measurement with the Fohn phenol reagent. Journal of Biological Chemistry 1951; 193: 265–270
   PubMed Web of Science ®Google Scholar
• Matiuck N. V., Swain J. L. Proto-oncogenes and cardiac development. Trends in Cardiovascular Medicine 1992; 2: 61–65
   PubMedGoogle Scholar
• McLellan A. R., Tawil S., Lyall F., Milligan G., Connell J. M. C., Kenyon C. J. Effects of dexamethasone on G protein levels and adenylyl cyclase activity in rat vascular smooth muscle cells. Journal of Molecular Endocrinology 1992; 9: 237–244
   PubMedGoogle Scholar
• Miao G. G., Curran T. Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle. Molecular and Cellular Biology 1994; 14: 4295–4310
   PubMedGoogle Scholar
• Morris G., Slotkin T. A. Beta-2 adrenergic control of ornithine decarboxylase activity in brain regions of the developing rat. Journal of Pharmacology and Experimental Therapeutics 1985; 233: 141–147
   PubMedGoogle Scholar
• Navarro H. A., Seidler F. J., Eylers J. P., Baker F. E., Dobbins S. S., Lappi S. E., Slotkin T. A. Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain. Journal of Pharmacology and Experimental Therapeutics 1989; 251: 894–900
   PubMed Web of Science ®Google Scholar
• Nfarro H. A., Kudlacz E. M., Slotkin T. A. Control of adenylate cyclase activity. in developing rat heart and liver: effects of prenatal exposure to terbutaline or dexamethasone. Biology of the Neonate 1991; 60: 127–136
   PubMedGoogle Scholar
• Pracyk J. B., Slotkin T. A. Thyroid hormone differentially regulates development of β-adrenergic receptors, adenylate cyclase and ornithine heart in rat heart and kidney. Journal of Developmental Physiology 1991; 16: 251–261
   PubMedGoogle Scholar
• Pracyk J. B., Lappi S. E., Slotkin T. A. Role of thyroid hormone in the development of beta adrenergic control of ornithine decarboxylase in rat heart. and kidney. Journal of Pharmacology and Experimental Therapeutics 1991; 256: 757–766
   PubMedGoogle Scholar
• Reinis S., Goldman J. M. The Development of the Brain: Biological and Functional Perspectives. Charles C. Thomas, Springfield, IL 1980
   Google Scholar
• Saito N., Guitart X., Hayward M., Tallman J. F., Duman R. S., Nestler E. J. Corticosterone differentially regulates the expression of Gsα and Oiα messenger RNA and protein in rat cerebral cortex. Proceedings of the National Academy of Sciences, USA 1989; 86: 3906–3910
   PubMedGoogle Scholar
• Seamon K., Daly J. W. Actrvation of adenylate cyclase by the diterpene forskolin. does not require the guanine nucleotide regulatory protein. Journal of Biological Chemistry 1981; 256: 9799–9801
   PubMed Web of Science ®Google Scholar
• Slotkin T. A. Ornithine decarboxylase as a tool in developmental neurobiology. Life Sciences 1979; 24: 1623–1630
   PubMedGoogle Scholar
• Slotkin T. A. Endocrine control of synaptic development in the sympathetoc nervous system: the cardiac-sympathetic axis. Developmental Neurobiology of the Autonomic Nervous System, P. M. Gootman. Humana Press, Clifton, NJ 1986; 97–133
   Google Scholar
• Slotkin T. A., Bartolome J. Role of ornithine decarboxylase and the polyamines in nervous system development: a review. Brain Research Bulletin 1986; 17: 307–320
   PubMed Web of Science ®Google Scholar
• Slotkin T. A., Whitmore W. L, Orband-Miller L, Queen K. L., Haim K. Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: relationship to sympathetic neuronal development. Journal of Pharmacology and Experimental Therapeutics 1987; 243: 101–109
   PubMedGoogle Scholar
• Slotkin T. A., Windh R., Whitmore W. L., Seidler F. J. Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol. Brain Research Bulletin 1988; 21: 737–740
   PubMed Web of Science ®Google Scholar
• Slotkin T. A., Baker F. E., Dobbins S. S., Eylers J. P., Lappi S. E., Seidler F. J. Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum. Brain Research Bulletin 1989; 23: 263–265
   PubMedGoogle Scholar
• Slotkin T. A., Kudlacz E. M., Lappi S. E., Tayyeb M. I., Seidler F. J. Fetal terbutaline exposure causes selective postnatal increases in cerebellar α-adrenergic receptor binding. Life Sciences 1990a; 47: 2051–2057
   PubMedGoogle Scholar
• Slotkin T. A., Navarro H. A., McCook E. C., Seidler F. J. Fetal hechick exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. Life Sciences 1990b; 47: 1561–1567
   PubMed Web of Science ®Google Scholar
• Slotkin T. A., Lau C., McCook E. C., Lappi S. E., Seidler F. J. Glucocorticoids enhance intracellular signalling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization. Toxicology and Applied Pharmacology 1994a; 127: 64–75
   PubMedGoogle Scholar
• Slotkin T. A., Lau C., Seidler F. J. β-Adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes and coupling to adenylate cyclase via Gproteins. Toxicology and Applied Pharmacology 1994b; 129: 223–234
   PubMed Web of Science ®Google Scholar
• Slotkin T. A., Lappi S. E., Seidler F. J. PAdrenergic control of c-fos expression in fetal and neonatal rat tissues: relationship to cell differentiation and teratogenesis. Toxicology and Applied Pharmacology 1995; 133: 188–195
   PubMedGoogle Scholar
• Unlap T., Jope R. S. Dexamethasone attenuates kainate-induced AP-1 activation in rat brain. Molecular Brain Research 1994; 24: 275–282
   PubMedGoogle Scholar
• Van Wilk R., Wicks W. D., Bevers M. M., Van Run J. Rapid arrest of DNA synthesis by N6,02′dibutyryl cyclic adenosine 3′,5′-monophosphate in cultured hepatoma cells. Cancer Research 1973; 33: 1331–1338
   PubMedGoogle Scholar
• Vendrell M., Zawia N. H., Serratosa J., Bondy S. C. c-fos and ornithine decarboxylase gene expression in brain as early markers of neurotoxicity. Brain Research 1991; 544: 291–296
   PubMedGoogle Scholar
• Vernadakis A., Gibson D. A. Role of neurotransmitter substances in neural growth. Perinatal Pharmacology: Problems and Priorities, J. Dancis, J. C. Hwang. Raven Press, New York 1974; 65–76
   Google Scholar
• Wagner J. P., Seidler F. J., Slotkin T. A. Presynaptic input regulates development of β-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol. Brain Research Bulletin 1991; 26: 885–890
   PubMedGoogle Scholar
• Wagner J. P., Seidler F. J., Lappi S. E., McCook E. C., Slotkin T. A. Role of thyroid status in the ontogeny of adrenergic cell signalling in rat brain: beta receptors, adenylate cyclase, ornithine decarboxylase and c-fos protooncogene expression. Journal of Pharmacology and Experimental Therapeutics 1994a; 271: 472–483
   PubMedGoogle Scholar
• Wagner J. P., Seidler F. J., Schachat F. H., Slotkin T. A. Beta adrenergic control of c-fos protooncogene expression in developing rat brain regions. Journal of Pharmacology and Experimental Therapeutics 1994b; 269: 1292–1299
   PubMedGoogle Scholar
• Wagner J. P., Seidlerl F. J., Lappi S. E., McCook E. C., Slotkin T. A. Role of presynaptic input in the ontogeny of adrenergic cell signalling in rat brain: beta receptors, adenylate cyclase, and c-fos protooncogene expression. Journal of Pharmacology and Experimental Therapeutrcs 1995; 273: 415–426
   PubMedGoogle Scholar
• Wrighton C., Busslinger M. Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts. Molecular and Cellular Biology 1993; 13: 4657–4669
   PubMed Web of Science ®Google Scholar
• Yamada G., Sugimura K., Stuart E. T. Genetargeting approaches in the study of cellular processes involved in growth or differentiation: advances in the analysis of oncogenes, tumour-suppressor genes, cytokine/receptor systems and developmental control genes. European Journal of Biochemistry 1994; 226: 739–749
   PubMedGoogle Scholar