Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer

References

• An X, Li YH, Lin XB, Wang FH, Feng F, Xu RH, Jiang WQ, He YJ. (2009). [Prognostic value of serum CA19-9 in patients with advanced pancreatic cancer receiving gemcitabine based chemotherapy.] Ai Zheng 28:286–91.
   PubMedGoogle Scholar
• Baize N, Abu Shalaa A, Berthier F, Demarquay JF, Bernard JL, Rahili A, Piche T, Huet PM, Tran A, Caroli-Bosc FX. (2005). Gemcitabine combined with oxaliplatin is safe and effective in patients with previously untreated advanced pancreatic adenocarcinoma. Gastroenterol Clin Biol 29:1006–9.
   PubMedGoogle Scholar
• Balkwill F, Mantovani A. (2001). Inflammation and cancer: back to Virchow? Lancet 357:539–45.
   PubMed Web of Science ®Google Scholar
• Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT, Lee K. (2009). Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 58:15–23.
   PubMed Web of Science ®Google Scholar
• Clark EJ, Connor S, Taylor MA, Madhavan KK, Garden OJ, Parks RW. (2007). Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinoma. HPB (Oxford) 9:456–60.
   PubMedGoogle Scholar
• De Braud F, Cascinu S, Gatta G. (2004). Cancer of pancreas. Crit Rev Oncol Hematol 50:147–55.
   PubMed Web of Science ®Google Scholar
• Engelken FJ, Bettschart V, Rahman MQ, Parks RW, Garden OJ. (2003). Prognostic factors in the palliation of pancreatic cancer. Eur J Surg Oncol 29:368–73.
   PubMed Web of Science ®Google Scholar
• Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C, Navaglia F, Zambon CF, Pasquali C, Venza E, Pedrazzoli S, Plebani M. (2006). Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas 32:22–8.
   PubMed Web of Science ®Google Scholar
• Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JP, Prasad KR. (2008a). Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 32:1757–62.
   PubMed Web of Science ®Google Scholar
• Gomez D, Morris-Stiff G, Toogood GJ, Lodge JP, Prasad KR. (2008b). Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol 97:513–18.
   PubMed Web of Science ®Google Scholar
• Halazun KJ, Aldoori A, Malik HZ, Al-Mukhtar A, Prasad KR, Toogood GJ, Lodge JP. (2008). Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 34:55–60.
   PubMed Web of Science ®Google Scholar
• Heinemann V, Quietzsch D, Gieseler F, Gonnermann M, Schonekas H, Rost A, Neuhaus H, Haag C, Clemens M, Heinrich B, Vehling-Kaiser U, Fuchs M, Fleckenstein D, Gesierich W, Uthgenannt D, Einsele H, Holstege A, Hinke A, Schalhorn A, Wilkowski R. (2006). Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 24:3946–52.
   PubMed Web of Science ®Google Scholar
• Herrmann R, Bodoky G, Ruhstaller T, Glimelius B, Bajetta E, Schuller J, Saletti P, Bauer J, Figer A, Pestalozzi B, Kohne CH, Mingrone W, Stemmer SM, Tamas K, Kornek GV, Koeberle D, Cina S, Bernhard J, Dietrich D, Scheithauer W. (2007). Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized multicenter phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 25:2212–17.
   PubMed Web of Science ®Google Scholar
• Hess V, Glimelius B, Grawe P, Dietrich D, Bodoky G, Ruhstaller T, Bajetta E, Saletti P, Figer A, Scheithauer W, Herrmann R. (2008). CA 19-9 tumour-marker response to chemotherapy in patients with advanced pancreatic cancer enrolled in a randomised controlled trial. Lancet Oncol 9:132–8.
   PubMed Web of Science ®Google Scholar
• Kishi Y, Kopetz S, Chun YS, Palavecino M, Abdalla EK, Vauthey JN. (2009). Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 16:614–22.
   PubMed Web of Science ®Google Scholar
• Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH. (2003). Platelets and granulocytes in particular the neutrophils form important compartments for circulating vascular endothelial growth factor. Angiogenesis 6:283–7.
   PubMedGoogle Scholar
• Maisey NR, Norman AR, Hill A, Massey A, Oates J, Cunningham D. (2005). CA19-9 as a prognostic factor in inoperable pancreatic cancer: the implication for clinical trials. Br J Cancer 93:740–3.
   PubMedGoogle Scholar
• Nieto J, Grossbard ML, Kozuch P. (2008). Metastatic pancreatic cancer 2008: is the glass less empty? Oncologist 13:562–76.
   PubMed Web of Science ®Google Scholar
• Ong SL, Garcea G, Thomasset SC, Mann CD, Neal CP, Abu Amara M, Dennison A, R Berry, DP. (2008). Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinoma. J Gastrointest Surg 12:1068–73.
   PubMedGoogle Scholar
• Rothenberg ML, Moore MJ, Cripps MC, Andersen JS, Portenoy RK, Burris HA 3rd, Green MR, Tarassoff PG, Brown TD, Casper ES, Storniolo AM, Von Hoff DD. (1996). A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol 7:347–53.
   PubMed Web of Science ®Google Scholar
• Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E. (2009). Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 137:425–8.
   PubMed Web of Science ®Google Scholar
• Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, Van Oosterom AT, Christian MC, Gwyther SG. (2000). New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer National Cancer Institute of the United States National Cancer Institute of Canada. J Natl Cancer Inst 92:205–16.
   Google Scholar