Advanced search
Publication Cover
Biomarkers Volume 17, 2012 - Issue 3
Submit an article Journal homepage
125
Views
8
CrossRef citations to date
0
Altmetric
Letter to the Editor

Matrix metalloproteinase (MMP)-2 and MMP-9 polymorphisms and haplotypes as disease biomarkers

Marcelo Rizzatti LuizonDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, BrazilCorrespondence[email protected]
&
Vanessa de Almeida BeloDepartment of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Pages 286-288 | Received 18 Dec 2011, Accepted 11 Jan 2012, Published online: 07 Feb 2012

References

  • Belo VA, Souza-Costa DC, Luizon MR, Lanna CM, Carneiro PC, Izidoro-Toledo TC, Ferraz KC, Tanus-Santos JE. (2012). Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children. Int J Obes (Lond) 36:69–75.
  • Blankenberg S, Rupprecht HJ, Poirier O, Bickel C, Smieja M, Hafner G, Meyer J, Cambien F, Tiret L; AtheroGene Investigators. (2003). Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation 107:1579–1585.
  • Chaudhary AK, Pandya S, Mehrotra R, Singh M, Singh M. (2011). Role of functional polymorphism of matrix metalloproteinase-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter in oral submucous fibrosis and head and neck squamous cell carcinoma in an Indian population. Biomarkers 16:577–586.
  • Crawford DC, Nickerson DA. (2005). Definition and clinical importance of haplotypes. Annu Rev Med 56:303–320.
  • Demacq C, de Souza AP, Machado AA, Gerlach RF, Tanus-Santos JE. (2006). Genetic polymorphism of matrix metalloproteinase (MMP)-9 does not affect plasma MMP-9 activity in healthy subjects. Clin Chim Acta 365:183–187.
  • Demacq C, Vasconcellos VB, Marcaccini AM, Gerlach RF, Machado AA, Tanus-Santos JE. (2009). A genetic polymorphism of matrix metalloproteinase 9 (MMP-9) affects the changes in circulating MMP-9 levels induced by highly active antiretroviral therapy in HIV patients. Pharmacogenomics J 9:265–273.
  • Demacq C, Vasconcellos VB, Marcaccini AM, Gerlach RF, Silva WA Jr, Tanus-Santos JE. (2008). Functional polymorphisms in the promoter of the matrix metalloproteinase-9 (MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects. Clin Chem Lab Med 46:57–63.
  • Fernandes KS, Brum DG, Sandrim VC, Guerreiro CT, Barreira AA, Tanus-Santos JE. (2009). Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. J Neuroimmunol 214:128–131.
  • Lacchini R, Jacob-Ferreira AL, Luizon MR, Coeli FB, Izidoro-Toledo TC, Gasparini S, Ferreira-Sae MC, Schreiber R, Nadruz W, Jr., Tanus-Santos JE. (2010a). Matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients. Clin Chim Acta 411:1940–1944.
  • Lacchini R, Jacob-Ferreira AL, Luizon MR, Gasparini S, Ferreira-Sae MC, Schreiber R, Nadruz W, Jr., Tanus-Santos JE. (2011). Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients. J Hum Hypertens. DOI:10.1038/jhh.2011.8.
  • Lacchini R, Metzger IF, Luizon M, Ishizawa M, Tanus-Santos JE. (2010b). Interethnic differences in the distribution of matrix metalloproteinases genetic polymorphisms are consistent with interethnic differences in disease prevalence. DNA Cell Biol 29:649–655.
  • Luizon MR, Sandrim VC. (2011). Importance of haplotype analysis in association studies considering VEGF promoter polymorphisms. Clin Biochem 44:747; author reply 748.
  • Metzger IF, Luizon MR, Lacchini R, Tanus-Santos JE. (2011). Genetic Variants in Matrix Metalloproteinase-9 Gene Modify Metalloproteinase-9 Levels in Black Subjects. DNA Cell Biol. DOI:10.1089/dna.2011.1388.
  • Palei AC, Sandrim VC, Duarte G, Cavalli RC, Gerlach RF, Tanus-Santos JE. (2010). Matrix metalloproteinase (MMP)-9 genotypes and haplotypes in preeclampsia and gestational hypertension. Clin Chim Acta 411:874–877.
  • Sandrim VC, Tanus-Santos JE. (2007). Haplotype analysis can provide improved clinical information than single genotype analysis. Thromb Res 120:779.
  • Yu C, Zhou Y, Miao X, Xiong P, Tan W, Lin D. (2004). Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer. Cancer Res 64:7622–7628.
  • Zhou G, Zhai Y, Cui Y, Qiu W, Yang H, Zhang X, Dong X, He Y, Yao K, Zhang H, Peng Y, Yuan X, Zhi L, Zhang X, He F. (2007). Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma. Hum Mutat 28:1091–1097.
  • Zhou Y, Yu C, Miao X, Wang Y, Tan W, Sun T, Zhang X, Xiong P, Lin D. (2005). Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis 26:1117–1121.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.