Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X

References

• Ahima RS, Flier JS. (2000). Leptin. Annu Rev Physiol 62:413–437.
   PubMed Web of Science ®Google Scholar
• Al Suwaidi J, Higano ST, Holmes DR Jr, Lerman A. (2001). Pathophysiology, diagnosis, and current management strategies for chest pain in patients with normal findings on angiography. Mayo Clin Proc 76:813–822.
   PubMed Web of Science ®Google Scholar
• Beltowski J. (2006). Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens 24:789–801.
   PubMed Web of Science ®Google Scholar
• Beltrame JF. (2005). Advances in understanding the mechanisms of angina pectoris in cardiac syndrome X. Eur Heart J 26:946–948.
   PubMed Web of Science ®Google Scholar
• Cannon RO 3rd. (2009). Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms. J Am Coll Cardiol 54:877–885.
   PubMed Web of Science ®Google Scholar
• Cannon RO 3rd, Bonow RO, Bacharach SL, Green MV, Rosing DR, Leon MB, Watson RM, Epstein SE. (1985). Left ventricular dysfunction in patients with angina pectoris, normal epicardial coronary arteries, and abnormal vasodilator reserve. Circulation 71:218–226.
   PubMedGoogle Scholar
• Cannon RO 3rd, Watson RM, Rosing DR, Epstein SE. (1983). Angina caused by reduced vasodilator reserve of the small coronary arteries. J Am Coll Cardiol 1:1359–1373.
   PubMed Web of Science ®Google Scholar
• Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. (2003). Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278:45021–45026.
   PubMed Web of Science ®Google Scholar
• Eroglu S, Sade LE, Bozbas H, Haberal A, Ozbicer S, Demir O, Muderrisoglu H. (2009). Association of serum adiponectin levels and coronary flow reserve in women with normal coronary angiography. Eur J Cardiovasc Prev Rehabil 16:290–296.
   PubMedGoogle Scholar
• Finucane FM, Luan J, Wareham NJ, Sharp SJ, O’Rahilly S, Balkau B, Flyvbjerg A, Walker M, Højlund K, Nolan JJ, Savage DB; European Group for the Study of Insulin Resistance: Relationship between Insulin Sensitivity and Cardiovascular Disease Risk Study Group). (2009). Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 52:2345–2349.
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502.
   PubMed Web of Science ®Google Scholar
• Friedman JM. (1998). Leptin, leptin receptors, and the control of body weight. Nutr Rev 56:s38–s46; discussion s54.
   PubMed Web of Science ®Google Scholar
• Galluccio E, Piatti P, Citterio L, Lucotti PC, Setola E, Cassina L, Oldani M, Zavaroni I, Bosi E, Colombo A, Alfieri O, Casari G, Reaven GM, Monti LD. (2008). Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis. Am J Physiol Endocrinol Metab 294:E978–E986.
   PubMed Web of Science ®Google Scholar
• Gensini GG. (1983). A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 51:606.
   PubMed Web of Science ®Google Scholar
• Gualillo O, González-Juanatey JR, Lago F. (2007). The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives. Trends Cardiovasc Med 17:275–283.
   PubMed Web of Science ®Google Scholar
• Hajer GR, van Haeften TW, Visseren FL. (2008). Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29:2959–2971.
   PubMed Web of Science ®Google Scholar
• Han SH, Quon MJ, Kim JA, Koh KK. (2007). Adiponectin and cardiovascular disease: response to therapeutic interventions. J Am Coll Cardiol 49:531–538.
   PubMed Web of Science ®Google Scholar
• Hong SJ, Seo HS, Rha SW, Oh DJ, Kwon JA, Lee KN, Jang YS, Ro YM, Park CG. (2006). Decrease in plasma adiponectin concentrations in patients with variant angina pectoris. Circ J 70:414–418.
   PubMedGoogle Scholar
• Huang SS, Huang PH, Leu HB, Wu TC, Lin SJ, Chen JW. (2010). Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X. Heart 96:1227–1232.
   PubMed Web of Science ®Google Scholar
• Inoue M, Yano M, Yamakado M, Maehata E, Suzuki S. (2006). Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia. Metab Clin Exp 55:1248–1254.
   PubMed Web of Science ®Google Scholar
• Karakas M, Zierer A, Herder C, Baumert J, Meisinger C, Koenig W, Thorand B. (2010). Leptin, adiponectin, their ratio and risk of coronary heart disease: results from the MONICA/KORA Augsburg Study 1984–2002. Atherosclerosis 209:220–225.
   PubMed Web of Science ®Google Scholar
• Kaski JC, Russo G. (2000). Cardiac syndrome X: an overview. Hosp Pract (Minneap) 35:75–76, 79.
   PubMed Web of Science ®Google Scholar
• Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. (2010). Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med 152:93–100.
   PubMed Web of Science ®Google Scholar
• Kotani K, Sakane N, Saiga K, Kurozawa Y. (2005). Leptin: adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes: relationship of the index to carotid intima-media thickness. Diabetologia 48:2684–2686.
   PubMed Web of Science ®Google Scholar
• Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y; Osaka CAD Study Group. Coronary artery disease. (2003). Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85–89.
   PubMed Web of Science ®Google Scholar
• Liang KW, Lee WJ, Lee WL, Chen YT, Ting CT, Sheu WH. (2008a). Diabetes exacerbates angiographic coronary lesion progression in subjects with metabolic syndrome independent of CRP levels. Clin Chim Acta 388:41–45.
   PubMedGoogle Scholar
• Liang KW, Sheu WH, Lee WL, Liu TJ, Ting CT, Hsieh YC, Wang KY, Chen YT, Lee WJ. (2008b). Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris. Int J Cardiol 129:76–80.
   PubMedGoogle Scholar
• Liang KW, Lee WJ, Lee WL, Ting CT, Sheu WH. (2009). Decreased ratio of high-molecular-weight to total adiponectin is associated with angiographic coronary atherosclerosis severity but not restenosis. Clin Chim Acta 405:114–118.
   PubMedGoogle Scholar
• Liang KW, Lee WJ, Lee IT, Lee WL, Lin SY, Hsu SL, Wan CJ, Yu CY, Tsai IC, Fu CP, Ting CT, Sheu WH. (2011). Persistent elevation of paraoxonase-1 specific enzyme activity after weight reduction in obese non-diabetic men with metabolic syndrome. Clin Chim Acta 412:1835–1841.
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Shimada K, Fukuda D, Shimada Y, Ehara S, Hirose M, Kataoka T, Kamimori K, Shimodozono S, Kobayashi Y, Yoshiyama M, Takeuchi K, Yoshikawa J. (2004). Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart 90:528–533.
   PubMed Web of Science ®Google Scholar
• Norata GD, Raselli S, Grigore L, Garlaschelli K, Dozio E, Magni P, Catapano AL. (2007). Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery. Stroke 38:2844–2846.
   PubMed Web of Science ®Google Scholar
• Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, Kakizawa H, Hayakawa N, Suzuki A, Takeda J, Horikawa Y, Itoh M. (2008). The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metab Clin Exp 57:268–273.
   PubMed Web of Science ®Google Scholar
• Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H. (2006). Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. J Am Coll Cardiol 48:1155–1162.
   PubMed Web of Science ®Google Scholar
• Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y. (1999). Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100:2473–2476.
   PubMed Web of Science ®Google Scholar
• Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, Kumada M, Ohashi K, Okamoto Y, Nishizawa H, Kishida K, Maeda N, Nagasawa A, Kobayashi H, Hiraoka H, Komai N, Kaibe M, Rakugi H, Ogihara T, Matsuzawa Y. (2003). Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42:231–234.
   PubMed Web of Science ®Google Scholar
• Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. (2004). Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291:1730–1737.
   PubMed Web of Science ®Google Scholar
• Satoh N, Naruse M, Usui T, Tagami T, Suganami T, Yamada K, Kuzuya H, Shimatsu A, Ogawa Y. (2004). Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 27:2488–2490.
   PubMedGoogle Scholar
• Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, Ståhle E, Feldman TE, van den Brand M, Bass EJ, Van Dyck N, Leadley K, Dawkins KD, Mohr FW; SYNTAX Investigators. (2009). Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 360:961–972.
   PubMed Web of Science ®Google Scholar
• Shimano M, Shibata R, Tsuji Y, Kamiya H, Uchikawa T, Harata S, Muto M, Ouchi N, Inden Y, Murohara T. (2008). Circulating adiponectin levels in patients with atrial fibrillation. Circ J 72:1120–1124.
   PubMed Web of Science ®Google Scholar
• Singh M, Singh S, Arora R, Khosla S. (2010). Cardiac syndrome X: current concepts. Int J Cardiol 142:113–119.
   PubMed Web of Science ®Google Scholar
• Singhal A, Farooqi IS, Cole TJ, O’Rahilly S, Fewtrell M, Kattenhorn M, Lucas A, Deanfield J. (2002). Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 106:1919–1924.
   PubMed Web of Science ®Google Scholar
• Susam I, Yaylali YT, Dursunoglu D, Göksoy H, Oztürk M, Yaylali O, Semiz E. (2010). Decreased plasma adiponectin concentrations in patients with syndrome X. Acta Cardiol 65:217–220.
   PubMed Web of Science ®Google Scholar
• van den Heuvel M, Sorop O, Koopmans SJ, Dekker R, de Vries R, van Beusekom HM, Eringa EC, Duncker DJ, Danser AH, van der Giessen WJ. (2012). Coronary microvascular dysfunction in a porcine model of early atherosclerosis and diabetes. Am J Physiol Heart Circ Physiol 302:H85–H94.
   Google Scholar
• Vermeltfoort IA, Raijmakers PG, Riphagen II, Odekerken DA, Kuijper AF, Zwijnenburg A, Teule GJ. (2010). Definitions and incidence of cardiac syndrome X: review and analysis of clinical data. Clin Res Cardiol 99:475–481.
   PubMed Web of Science ®Google Scholar
• Yoon JH, Park JK, Oh SS, Lee KH, Kim SK, Cho IJ, Kim JK, Kang HT, Ahn SG, Lee JW, Lee SH, Eom A, Kim JY, Ahn SV, Koh SB. (2011). The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: the Korean Genomic Rural Cohort Study. Clin Chim Acta 412:2199–2205.
   PubMed Web of Science ®Google Scholar
• Zaletel J, Barlovic DP, Prezelj J. (2010). Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes. J Endocrinol Invest 33:514–518.
   PubMed Web of Science ®Google Scholar