Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

References

• Antoine DJ, Dear JW, Lewis PS, et al. (2013). Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology 58:777–87
   PubMed Web of Science ®Google Scholar
• Antoine DJ, Jenkins RE, Dear JW, et al. (2012). Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers of mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol 56:1070–9
   PubMed Web of Science ®Google Scholar
• Budnitz DS, Lovegrove MC, Crosby AE. (2011). Emergency department visits for overdose of acetaminophen-containing products. Am J Prev Med 40:585–92
   PubMed Web of Science ®Google Scholar
• Craig DG, Lee P, Pryde EA, et al. (2013). Elevated levels of the long pentraxin 3 in paracetamol-induced human acute liver injury. Eur J Gastroenterol Hepatol 25:359–67
   PubMed Web of Science ®Google Scholar
• Davern TJ 2nd, James LP, Hinson JA, et al. Acute Liver Failure Study Group. (2006). Measurement of serum acetaminophen–protein adducts in patients with acute liver failure. Gastroenterology 130:687–94
   PubMed Web of Science ®Google Scholar
• Dufour DR, Lott JA, Nolte FS, et al. (2000). Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring. Clin Chem 46:2050–68
   PubMed Web of Science ®Google Scholar
• Gunawan BK, Liu ZX, Han D, et al. (2006). c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131:165–78
   PubMed Web of Science ®Google Scholar
• Haines RJ, Pendleton LC, Eichler DC. (2011). Argininosuccinate synthetase: at the center of arginine metabolism. Int J Biochem Mol Biol 2:8–23
   PubMedGoogle Scholar
• Heard K. (2011). Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen. Clin Toxicol (PA) 49:90–3
   PubMed Web of Science ®Google Scholar
• Jaeschke H, McGill MR, Ramachandran A. (2012). Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev 44:88–106
   PubMed Web of Science ®Google Scholar
• Jollow DJ, Mitchell JR, Potter WZ, et al. (1973). Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 187:195–202
   PubMed Web of Science ®Google Scholar
• Katyare SS, Satav JG. (1989). Impaired mitochondrial oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat. Br J Pharmacol 96:51–8
   PubMed Web of Science ®Google Scholar
• Kon K, Kim JS, Jaeschke H, Lemasters JJ. (2004). Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40:1170–9
   PubMed Web of Science ®Google Scholar
• McGill MR, Jaeschke H. (2013). Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res 30:2174–87
   PubMed Web of Science ®Google Scholar
• McGill MR, Lebofsky M, Norris HR, et al. (2013). Plasma and liver acetaminophen–protein adduct levels in mice after acetaminophen treatment: dose–response, mechanisms, and clinical implications. Toxicol Appl Pharmacol 269:240–9
   PubMed Web of Science ®Google Scholar
• McGill MR, Li F, Sharpe MR, et al. (2014). Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol 88:391–401
   PubMed Web of Science ®Google Scholar
• McGill MR, Sharpe MR, Williams CD, et al. (2012a). The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest 122:1574–83
   PubMed Web of Science ®Google Scholar
• McGill MR, Williams CD, Xie Y, et al. (2012b). Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol 264:387–94
   PubMed Web of Science ®Google Scholar
• Meyers LL, Beierschmitt WP, Khairallah EA, Cohen SD. (1988). Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice. Toxicol Appl Pharmacol 93:378–87
   PubMed Web of Science ®Google Scholar
• Ostapowicz G, Fontana RJ, Schiødt FV, et al. Acute Liver Failure Study Group. (2002). Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 137:947–54
   PubMed Web of Science ®Google Scholar
• Prima V, Cao M, Svetlov SI. (2013). ASS and SULT2A1 are novel and sensitive biomarkers of acute hepatic injury – a comparative study in animal models. J Liver 2:1000115
   PubMedGoogle Scholar
• Prima V, Wang A, Molina G, et al. (2011). Inhibition of LPS toxicity by hepatic argininosuccinate sythase (ASS): novel roles for ASS in innate immune responses to bacterial infection. Int Immunopharmacol 11:1180–8
   PubMedGoogle Scholar
• Ramachandran A, McGill MR, Xie Y, et al. (2013). The receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology 58:2099–108
   PubMed Web of Science ®Google Scholar
• Saito C, Lemasters JJ, Jaeschke H. (2010). c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 246:8–17
   PubMed Web of Science ®Google Scholar
• Schomaker S, Warner R, Bock J, et al. (2013). Assessment of emerging biomarkers of liver injury in human subjects. Toxicol Sci 132:276–83
   PubMed Web of Science ®Google Scholar
• Simpson KJ, Bates CM, Henderson NC, et al. (2009). The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. Liver Transpl 15:600–9
   PubMed Web of Science ®Google Scholar
• Singer AJ, Carracio TR, Mofenson HC. (1995). The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med 26:49–53
   PubMed Web of Science ®Google Scholar
• Svetlov SI, Xiang Y, Oli MW, et al. (2006). Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Biomarkers 11:355–69
   PubMed Web of Science ®Google Scholar
• Tirmenstein MA, Nelson SD. (1989). Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver. J Biol Chem 264:9814–19
   PubMed Web of Science ®Google Scholar
• Wong SG, Card JW, Racz WJ. (2000). The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity. Toxicol Lett 116:171–81
   PubMed Web of Science ®Google Scholar
• Woolbright BL, Ramachandran A, McGill MR, et al. (2012). Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol 111:417–25
   PubMedGoogle Scholar
• Yoshikawa Y, Morita M, Hosomi H, et al. (2009). Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat. Toxicology 264:89–95
   PubMed Web of Science ®Google Scholar