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Original Article

Cellular localization of human herpesvirus-6 in the brains of children with AIDS encephalopathy

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Pages 30-39 | Received 28 Sep 1994, Accepted 19 Oct 1994, Published online: 10 Jul 2009

References

  • Ablashi D V, Balachandran N, Josephs S F., Hung G I, Krueger G RF, Kramarsky B, Salahuddin S Z, Gallo R C. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 1991; 184: 545–552
  • Ablashi D V, Salahuddin S Z, Josephs S F, Imam F, Lusso P, Gallo R C, Hung C, Lemp J, Markham P D. HBLV (or HHV-6) in human cell lines. Nature 1987; 329: 207
  • Achim C L, Wang R, Miners D K, Wiley C A. Brain viral burden in HIV infection. J Neuropathol Exp Neurol 1994; 53: 284–294
  • Agulnick A D, Thompson J R, Ricciardi R P. An ATF/CREB site is the major regulatory element in the human herpesvirus 6 DNA polymerase promoter. J Virol 1994; 68: 2970–2977
  • Asano Y, Yoshikawa T, Kajita Y, Ogura R, Suga S, Yazaki T, Nakashima T, Yamada A, Kurata T. Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection. Arch Dis Child 1992; 67: 1484–1485
  • Asano Y, Yoshikawa T, Suga S, Yazaki T, Kondo K, Yamanishi K. Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection. Lancet 1990; 335: 862–863
  • Atwood W J, Berger J R, Kaderman R, Tornatore C S, Major E O. Human immunodeficiency virus type 1 infection of the brain. Clin Microbiol Rev 1993; 6: 339–366
  • Aubin J-T, Collandre H, Candotti J. D, Ingrand D, Rouzioux C, Burgard M, Richard S, Huraux J-M, Agut H. Several groups among human herpesvirus 6 strains can be distinguished by southern blotting and polymerase chain reaction. J Clin Microbiol 1991; 29: 367–372
  • Balachandran N, Amelse R E, Zhou W W, Chang C K. Identification of proteins specific for human herpesvirus 6-infected human T cells. J Virol 1989; 63: 2835–2840
  • Blanche S, Tardieu M, Duliege A-M, Rouzioux C, LeDeist F, Fukunaga K, Caniglia M, Jacomet C, Messiah A, Griscelli C. Longitudinal study of 94 symptomatic infants with perinatally acquired human immunodeficiency virus infection. Am J Dis Child 1990; 144: 1210–1215
  • Caserta M T, Hall C B, Schnabel K, McIntyre K, Long C, Costanzo M, Dewhurst S, Insel R, Epstein L G. Neuroinvasion and persistence of human herpesvirus-6 in children. J Infect Dis 1994; 170: 1586–1589
  • Cvetkovich T A, Lazer E, Blumberg B M, Saito Y, Eskin T A, Reichman R, Baram D A, del Cerro C, Gendelman H G, del Cerro M, Estein L G. Human immunodeficiency virus type 1 infection of neural xenografts. Proc Natl Acad Sci USA 1992; 89: 5162–5166
  • Dewhurst S, Chandran B, McIntyre K, Schnabel K, Hall C B. Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants. Virology 1992; 190: 490–493
  • Dewhurst S, McIntyre K, Schnabel K, Hall C B. Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of US infants. J Clin Microbiol 1993; 31: 416–418
  • DiLoreto D, Epstein L F, Lazer E S, Britt W J, del Cerro M. Cytomegalovirus infection of human retinal tissue: An. in vivo model. Lab Invest 1994; 71: 141–148
  • Downing R G, Sewankambo N, Serwadda D, Honess R, Crawford D, Jarrett R, Griffin B E. Isolation of human lymphotropic herpesviruses from Uganda. Lancet 1987; ii: 390
  • Drobyski W R, Knox K K, Majewski D, Carrigan D R. Fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrow-transplant recipient. N Engl J Med 1994; 330: 1356–1360
  • Ensoli B, Lusso P, Schachter F, Josephs S FR, Rappaport J, Negro F, Gallo R C, Wong-Staal F. Human herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancer. EMBOJ 1989; 8: 3019–3027
  • Epstein L G, Sharer L R, Oleske J M, Connor E M, Goudsmit J, Bagdon L, Robert-Guroff M, Koenigsberger M R. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics 1986; 78: 678–687
  • Fox J D, Briggs M, Ward P A, Tedder R S. Human herpesvirus 6 in salivary glands. Lancet 1990; 336: 590–593
  • Frankel A D, Pabo C O. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988; 55: 1189–1193
  • Fraser N W, Lawrence W C, Wroblewska Z, Gilden D H, Koprowski H. Herpes simplex type 1 DNA in human brain tissue. Proc Natl Acad Sci USA 1981; 78: 6461–6465
  • Gelbard H A, Nottet H SLM, Swindells S, Jett M, Dzenko K A, Genis P, White R, Wang L, Choi Y-B, Zhang D, Lipton S A, Tourtellotte W W, Epstein L G, Gendelman H E. Platelet-activating factor: a candidate human immunodefiency virus type 1-induced neurotoxin. J Virology 1994; 68: 4628–4635
  • Genis P, Jett M, Bernton E W, Boyle T, Gelbard H A, Dzenko K, Keane R W, Resnick L, Mizrachi Y, Volsky D J, Epstein L G, Gendelman H E. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease. J Exp Med 1992; 176: 1703–1718
  • Gopal M R, Thomson B J, Fox J, Tedder R S, Honess R W. Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositives. Lancet 1990; 335: 1598–1599
  • Hall C B, Long C E, Schnabel K C, Caserta M T, McIntyre K M, Costanzo M A, Knott A, Dewhurst S, Insel R A, Epstein L G. Human herpes virus-6 (HHV-6) infection in children: Prospective evaluation for complications and reactivation. N Engl J Med 1994; 331: 432–438
  • Horvat R T, Wood C, Balachandran N. Transactivation of human immunodeficiency virus promoter by human herpesvirus 6. J Virology 1989; 63: 970–973
  • Ishiguro N, Yamada S, Takahashi T, Takahashi Y, Togashi T, Okuno T, Yamanishi K. Meningo-encephalitis associated with HHV-6 related exanthem subitum. Acta Paediatr Scand 1990; 79: 987–989
  • Jackson D P, Lewis F A, Taylor G R, Boylston A W, Quirke P. Tissue extraction of DNA and RNA and analysis by the polymerase chain reaction. J Clin Pathol 1990; 43: 499–504
  • Johnson R T. Viral Infections of the Nervous System. Raven Press, New York 1982; 237–43
  • Josephs S F, Salahuddin S Z, Ablashi D V, Schachter F, Wong-Staal F, Gallo R C. Genomic analysis of the human B-lymphotropic virus (HBLV). Science 1986; 234: 601–603
  • Karlin S, Mocarski E S, Schachtel G A. Molecular evolution of herpesviruses: Genomic and protein sequence comparisons. J Virol 1994; 68: 1886–1902
  • Knox K K, Carrigan D R. Disseminated active HHV-6 infections in patients with AIDS. Lancet 1994; 343: 577–578
  • Kondo K, Kondo T, Okuno T, Takahashi M, Yamanishi K. Latent human herpesvirus 6 infection of human monocytes/macrophages. J Gen Virol 1991; 72: 1401–1408
  • Kondo K, Nagafuji H, Hata A, Tomomori C, Yamanishi K. Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. J Infect Dis 1993; 167: 1197–1200
  • Levy J A, Ferro F, Greenspan D, Lennette E T. Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet 1990a; 335: 1047–1050
  • Levy J A, Ferro F, Lennette E T, Oshiro L, Poulin L. Characterization of a new strain of HHV-6 (HHV-6 SF) recovered from the saliva of an HIV-infected individual. Virology 1990b; 178: 113–121
  • Lusso P, Ensoli B, Markham P D, Ablashi D V, Salahuddin S Z, Tschachler E, Wong-Staal F, Gall R C. Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6. Nature 1989; 337: 370–373
  • Möller K L. Exanthema subitum and febrile convulsions. Acta Pediatr 1956; 45: 534–540
  • Nicoll J AR, Maitland N J, Love S. Autopsy neuropathological findings in ‘burnt out’ herpes simplex encephalitis and use of the polymerase chain reaction to detect viral DNA. Neuropathol Appl Neurobiol 1991; 17: 375–382
  • Nuovo G J, Gallery F, MacConnell P, Braun A. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-α RNA in the central nervous system. Am J Pathol 1994; 144: 659–666
  • Okuno T, Higashi K, Shiraki K, Yamanishi K, Takahashi M, Kokado Y, Ishibashi M, Takahara S, Sonoda T, Tanaka K, Baba K, Yabuuchi H, Kurata T. Human herpesvirus 6 infection in renal transplantation. Transplantation 1990; 49: 519–522
  • Okuno T, Takahashi K, Balachandra K, Shiraki K, Yamanishi K, Takahashi M, Baba K. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol 1989; 27: 651–653
  • Pellett P E, Sànchez-Martìnez D, Dominguez G, Black J B, Anton E, Greenamoyer C, Dambaugh T R. A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: Identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope. Virology 1993; 195: 521–531
  • Pruksananonda P, Hall C B, Insel R A, McIntyre K, Pellett P E, Long C E, Schnabel K C, Pincus P H, Stamey F R, Dambaugh T R, Stewart J A. Primary human herpesvirus 6 infection in young children. N Eng J Med 1992; 326: 1445–1450
  • Rossi P, et al. Report of a consensus workshop. Maternal factors involved in mother-to-child transmission of HIV-1, Siena, Italy, January 17–18, 1992. J Acquir Immun`e Defic Syndr 1992; 5: 1019–1029
  • Saito Y, Sharer L R, Epstein L G, Michaels J, Mintz M, Louder M, Golding K, Cvetkovich T A, Blumberg B M. Overexpression of nef, as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 1994; 44: 474–481
  • Salahuddin S Z, Ablashi D V, Markham P D, Josephs S F, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, Gallo R C. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986; 234: 596–600
  • Saxinger C, Polesky H, Eby N, Grufferman S, Murphy R, Tegtmeir G, Parekh V, Memon S, Hung C. Antibody reactivity with HBLV (HHV-6) in US populations. J Virol Methods 1988; 21: 199–208
  • Schirmer E C, Wyatt L S, Yamanishi K, Rodriguez W J, Frenkel N. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci USA 1991; 88: 5922–5926
  • Scott G B, Hutto C, Makuch R W, Mastrucci M T, O'Connor T, Mitchell C D, Trapido E J, Parks W P. Survival in children with perinatally acquired human immunodeficiency virus type 1 infection. N Engl J Med 1989; 321: 1791–1796
  • Seibl R, Höltke H-J, Rüger R, Meindl A, Zachau H G, Raßhofer R, Roggendorf M, Wolf H, Arnold N, Wienberg J, Kessler C. Non-radioactive labeling and detection of nucleic acids: III. Applications of the digoxigenin system. Biol Chem Hoppe-Seyler 1990; 371: 939–951
  • Sharer L R, Epstein L G, Cho E-S, Joshi V V, Meyenhofer M F, Rankin L F, Petito C K. Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain. Hum Pathol 1986; 17: 271–284
  • Sharer L R. Pathology of HIV-1 infection of the central nervous system, a review. J Neuropathol Exp Neurol 1992; 51: 3–11
  • Shaw G M, Harper M E, Hahn B H, Epstein L G, Gajdusek D C, Price R W, Navia B A, Petito C K, O'Hara C J, Groopman J E, Cho E-S, Oleske J M, Wong-Staal F, Gallo R C. HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science 1985; 227: 177–182
  • Tedder R S, Briggs M, Cameron C H, Honess R, Robertson D, Whittle H. A novel lymphotropic herpesvirus. Lancet 1987; ii: 390–392
  • Tornatore C, Chandra R, Berger J R, Major E O. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 1994; 44: 481–487
  • Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988; i: 1065–1067
  • Yoshikawa T, Nakashima T, Suga S, Asano Y, Yazaki T, Kimura H, Morishima T, Kondo K, Yamanishi K. Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningo-encephalitis. Pediatrics 1992; 89: 888–890

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