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Original Article

Phenotypic and functional characterization of CD8+ T lymphocytes from the central nervous system of rats with coronavirus JHM induced demyelinating encephalomyelitis

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Pages 340-348 | Received 09 May 1995, Accepted 03 Aug 1995, Published online: 10 Jul 2009

References

  • Dal Canto, Rabinowitz. Experimental models of virus-induced demyelination of the central nervous system. Ann Neurol 1982; 11: 109–127
  • Dörries, Watanabe, Wege, ter Meulen. Murine coronavirus induced encephalomyelitides in rats: analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid. J Neuroimm unol 1986; 12: 131–142
  • Dörries, Watanabe, Wege, ter Meulen. Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM. J Neuroimmunol 1987; 14: 305–316
  • Dörries, Schwender, Imrich, Harms. Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis. Immunology 1991; 74: 539–545
  • Dörries, Schwender, Imrich, Hein, Czub, Bartz. Characterization of the inflammatory T-lymphocyte response in coronavirus-induced demyelinating encephalomyelitides of rats (abstr). Abstr IXth Intern Cong Virol 1993 1993; W55–4: 88
  • Fleming, Wang, Trousdale, Hinton, Stohlman. Immunopathogenesis of demyelination induced by MHV-4. Coronaviruses and their diseases, DK Cavanagh, Brown. Plenum Press, New York 1990; 276: 565–572, Adv Exp Med Biol
  • Hudson, Streilein. Functional cytotoxic T cells are associated with focal lesions in the brains of SJL mice with experimental herpes simplex encephalitis. J Immunol 1994; 152: 5540–5547
  • Imrich, Schwender, Hein, Dörries. Cervical lymphoid tissue but not the central nervous system supports proliferation of virus-specific T lymphocytes during coronavirus-induced encephalitis in rats. J Neuroimmunol 1994; 53: 73–81
  • Knobler, Tunison, Lampert, Oldstone BA. Selected mutants of mouse hepatitis virus type 4 (JHM strain) induce different CNS diseases. Am J Pathol 1982; 109: 157–168
  • Lampert, Sims, Kniazeff. Mechanism of demyelination in JHM virus encephalomyelitis. Acta Neuropath (Berl) 1973; 24: 76–85
  • Lindsley, Thiemann, Rodriguez. Cytotoxic T cells isolated from the central nervous system of mice infected with Theiler's virus. J Virol 1991; 65: 6612–6620
  • Liu, Blanden, Müllbacher. Identification of cytolytic lymphocytes in West Nile virus-infected murine central nervous system. J Gen Virol 1989; 70: 565–573
  • Nagashima, Wege, Meyermann, ter Meulen. Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis. Acta Neuropathol (Berl) 1978; 44: 63–70
  • Nagashima, Wege, Meyermann, ter Meulen. Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats. Acta Neuropathol (Berl) 1979; 45: 205–213
  • Pearce, Hobbs, McGraw, Buchmeier. Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo. J Virol 1994; 68: 5483–5495
  • Planz, Bilzer, Sobbe, Stitz. Lysis of major histocompatibility complex class I-bearing cells in Borna disease virus-induced degenerative encephalopathy. J Exp Med 1993; 178: 163–174
  • Ramsay, Ruby, Ramshaw. A case for cytokines as effector molecules in the resolution of virus infection. Immunol Today 1993; 14: 155–157
  • Rodriguez, Sriram. Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody. J Immunol 1988; 140: 2950–2955
  • Schijns ECJ, Van der Neut, Haagmans, Bar, Schellekens, Horzinek. Tumour necrosis factor-α, interferon-γ and interferon-β exert antiviral activity in nervous tissue cells. J Gen Virol 1991; 72: 809–815
  • Schmied, Breitschopf, Gold, Zischler, Rothe, Wekerle, Lassmann. Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am J Pathol 1993; 143: 446–452
  • Schmitt, Zimmermann. Enhanced hybridoma production by electrofusion in strongly hypo-osmolar solutions. Biochim Biophys Acta 1989; 983: 42–50
  • Schwender, Imrich, Dörries. The pathogenic role of virus-specific antibody-secreting cells in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis. Immunology 1991; 74: 533–538
  • Schwender, Hein, Imrich, Dörries. On the role of different lymphocyte subpopulations in the course of coronavirus MHV IV (JHM)-induced encephalitis in Lewis rats. Coronaviruses: molecular biology and virus-host interactions. Adv Exp Med Biol, Laude, Vautherot. Plenum Press, New York 1993; 342: 425–430
  • Shulman, Wilde, Köhler. A better cell line for making hybridomas secreting specific antibodies. Nature 1978; 276: 269–270
  • Sorensen, Dugre, Percy, Dales. In vivo and in vivo models of demyelinating disease: endogenous factors influencing demyelinating disease caused by mouse hepatitis virus in rats and mice. Infect Immun 1982; 37: 1248–1260
  • Stohlman, Kyuwa, Polo, Brady, Lai MC, Bergmann. Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain. J Virol 1993; 67: 7050–7059
  • Tishon, Eddleston, de la Torre, Oldstone BA. Cytotoxic T lymphocytes cleanse viral gene products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus. Virology 1993; 197: 463–467
  • Watanabe, Wege, ter Meulen. Adoptive transfer of EAR-like lesions by BMP stimulated lymphocytes from rats with coronavirus-induced demyelinating encephalomyelitis. Nature 1983; 305: 150–153
  • Watanabe, Wege, ter Meulen. Comparative analysis of coronavirus JHM-induced demyelinating encephalomyelitis in Lewis and Brown Norway rats. Lab Invest 1987; 57: 375–384
  • Wege, Müller, ter Meulen. Genomic RNA of the murine coronavirus JHM. J Gen Virol 1978; 41: 217–227
  • Wege, Siddel, ter Meulen. The biology and pathogenesis of coronaviruses. Curr Topics Microbiol Immunol, Cooper. Springer-Verlag, Berlin 1982; 99: 165–200
  • Wege, Watanabe, Koga, ter Meulen. Coronavirus JHM-induced demyelinating encephalomyelitis in rats: influence of immunity on the course of disease. Immunology of Nervous System Infections. Prog Brain Res, Behan, ter Meulen, Clifford Rose. Elsevier Science Publishers BV, Amsterdam 1983; 59: 221–231
  • Weiner. Pathogenesis of demyelination induced by a mouse hepatitis virus (JHM virus). Arch Neurol 1973; 28: 298–303
  • Williamson SP, Stohlman. Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells. J Virol 1990; 64: 4589–4592
  • Yamaguchi, Goto, Kyuwa, Hayami, Toyoda. Protection of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones. J Neuroimmunol 1991; 32
  • Zimmermann. Electrical breakdown, electropermeabilization and electrofusion. Rev Physiol Biochem Pharmacol 1986; 105: 175–256
  • Zinkernagel, Doherty. Cytotoxic thymusderived lymphocytes in cerebrospinal fluid of mice with lymphocytic choriomeningitis. J Exp Med 1973; 138: 1266–1269

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