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Original Article

Replication activity of JC virus large T antigen phosphorylation and zinc finger domain mutants

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Pages 78-86 | Received 21 Nov 1995, Published online: 10 Jul 2009

References

  • Arthur A K, Hass A, Fanning E. Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids. J Virol 1988; 62: 1999–2006
  • Arthur R R, Shah K V. Occurrence and significance of papovaviruses BK and JC in the urine. Prog Med Virol 1989; 36: 42–61
  • Berg J M. Potential metal binding domains in nucleic acid binding proteins. Science 1986; 232: 485–487
  • Berger J, Concha M. Progressive multifocal leukoencephalopathy: the evolution of a disease once considered rare. JNV 1995; 1: 5–18
  • Bollag B, Chuke W F, Frisque R J. Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation. J. Virol 1989; 63: 863–872
  • Borowiec J A, Dean F B, Bullock P A, Hurwitz J. Binding and unwinding — how T antigen engages the SV40 origin of DNA replication. Cell 1990; 60: 181–184
  • Cegielska A, Virshup D M. Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase-I. Mol Cell Biol 1993; 13: 1202–1211
  • Cegielska A, Shaffer S, Derua R, Goris J, Virshup D M. Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. Mol Cell Biol 1994; 14: 4616–4623
  • Chuke W F, Walker D L, Peitzman L B, Frisque R J. Construction and characterization of hybrid polyomavirus genomes. J. Virol 1986; 60: 960–971
  • DePamphilis M L, Bradley M K. Replication of SV40 and polyoma virus chromosomes. The Polyomaviruses., N P Salzman. Plenum Press, New York 1986; Vol 1: 99–246, The Papovaviridae
  • Fanning E. Simian virus-40 large T-antigen — The puzzle, the pieces, and the emerging picture. J. Virol 1992; 66: 1289–1293
  • Fanning E, Knippers R. Structure and function of simian virus 40 large tumor antigen. Annu Rev Biochem 1992; 61: 55–85
  • Feigenbaum L, Khalili K, Major E, Khoury G. Regulation of the host range of human papovavirus JCV. Proc Natl Acad Sci USA 1987; 84: 3695–3698
  • Frankel A, Pabo C. Fingering too many proteins. Cell 1988; 53: 675
  • Frisque R J, White F A. The molecular biology of JC virus, causative agent of progressive multifocal leukoencephalopathy. Molecular Neurovirology, R P Roos. Humana Press, Totowa, NJ 1992; 25–158
  • Frisque R J, Bream G L, Cannella M T. Human polyomavirus JC virus genome. J. Virol 1984; 51: 458–469
  • Haggerty S, Walker D L, Frisque R J. JC virus-simian virus 40 genomes containing heterologous regulatory signals and chimeric early regions: identification of regions restricting transformation by JC virus. J. Virol 1989; 63: 2180–2190
  • Hirt B. Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol 1967; 26: 365–369
  • Höss A, Moarefi I F, Fanning E, Arthur A K. The finger domain of simian virus 40 large T antigen controls DNA-binding specificity. J. Virol 1990; 64: 6291–6296
  • Kadonaga J T, Carner K R, Masiarz F R, Tjian R. Isolation of a cDNA encoding transcription factor Spl and functional analysis of the DNA binding domain. Cell 1987; 51: 1079–1090
  • Kunkel T A. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 1985; 82: 488–492
  • Loeber G, Parsons R, Tegtmeyer P. The zinc finger region of simian virus 40 large T antigen. J. Virol 1989; 63: 94–100
  • Loeber G, Stenger J E, Ray S, Parsons R E, Anderson M E, Tegtmeyer P. The zinc finger region of simian virus-40 large T-antigen is needed for hexamer assembly and origin melting. J. Virol 1991; 65: 3167–3174
  • Lynch K J, Frisque R J. Identification of critical elements within the JC virus DNA replication origin. J. Virol 1990; 64: 5812–5822
  • Lynch K J, Frisque R J. Factors contributing to the restricted DNA replicating activity of JC virus. Virology 1991; 180: 306–317
  • Lynch K J, Haggerty S, Frisque R J. DNA replication of chimeric JC virus-simian virus 40 genomes. Virology 1994; 204: 819–822
  • McVey D, Brizuela L, Mohr I, Marshak D R, Gluzman Y, Beach D. Phosphorylation of large tumor antigen by cdc2 stimulates SV40 DNA replication. Nature 1989; 341: 503–507
  • McVey D, Ray S, Gluzman Y, Berger L, Wildeman A G, Marshak D R, Tegtmeyer P. cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J. Virol 1993; 67: 5206–5215
  • Miller J, McLachlan A D, Klug A. Repetitive zinc binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 1985; 4: 1609–1614
  • Moarefi I F, Small D, Gilbert I, Hopfher M, Randall S K, Schneider C, Russo A AR, Ramsperger U, Arthur A K, Stahl H, Kelly T J, Fanning E. Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T-antigen specifically blocks SV40 origin DNA unwinding. J. Virol 1993; 67: 4992–5002
  • Myers C, Frisque R J, Arthur R R. Direct isolation and characterization of JC virus from urine samples of renal and bone marrow transplant patients. J. Virol 1989; 63: 4445–4449
  • Padgett B L, Rogers C M, Walker D L. JC virus, a human polyoma virus associated with progressive multifocal leukoencephalopathy: additional biological characteristics and antigenic relationships. Infect Immun 1977a; 15: 656–662
  • Padgett B L, Walker D L, Zu Rhein G M, Varakis J N. Differential neurooncogenicity of strains of JC virus, a human polyoma virus, in newborn Syrian hamsters. Cancer Res 1977b; 37: 718–720
  • Pipas J M. Common and unique features of T-antigens encoded by the polyomavirus group. J. Virol 1992; 66: 3979–3985
  • Prives C. The replication functions of SV40 T antigen are regulated by phosphorylation. Cell 1990; 61: 735–738
  • Rose P, Schaffhausen B. Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger. J. Virol 1995; 69: 2842–2849
  • Sanger F, Nicklen S, Coulson A R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977; 74: 5463–5467
  • Scheidtmann K, Harding M, Echle B, Walter G. DNA binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state. J. Virol 1984; 50: 1–12
  • Scheidtmann K H, Buck M, Schneider J, Kalderon D, Fanning E, Smith A E. Biochemical characterization of phosphorylation site mutants of simian virus 40 large T-antigen: evidence for interaction between amino- and carboxy-terminal domains. J. Virol 1991; 65: 1479–1490
  • Schneider J, Fanning E. Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for site I or II and affect SV40 DNA replication activity. J. Virol 1988; 62: 1598–1605
  • Sompayrac L M, Danna K J. Efficient infection of monkey cells with DNA of simian virus 40. Proc Natl Acad Sci USA 1981; 78: 7575–7578
  • Southern E M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol Biol 1975; 98: 503–517
  • Stillman B. Smart machines at the replication fork. Cell 1994; 78: 725–728
  • Swenson J J, Frisque R J. Biochemical characterization and lpcalization of JC virus large T antigen phosphorylation domains. Virology 1995; 212: 295–308
  • Tavis J E, Frisque R J. Altered DNA binding and replication activities of JC virus T-antigen mutants. Virology 1991; 183: 239–250
  • Tavis J E, Trowbridge P W, Frisque R J. Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability. Virology 1994; 199: 384–392
  • Tooze J. Molecular biology of tumor viruses, part 2: DNA tumor viruses, (ed). Cold Spring Harbor Laboratory. 1981, Cold Spring Harbor, NY
  • Trowbridge P W, Frisque R J. Analysis of G418-selected Rat2 cells containing prototype, variant, mutant, and chimeric JC-virus and SV40 genomes. Virology 1993; 196: 458–474
  • Van Roy F, Fransen L, Fiers W. Improved localization of phosphorylation sites in simian virus 40 large T antigen. J. Virol 1983; 45: 315–331
  • Virshup D, Cegielska A, Russo A, Kelly T, Shaffer S. The initiation of SV40 DNA replication is controlled by a phosphorylation-dephosphorylation cycle. Advances Prot Phos 1993; 7: 271–293
  • Walker D L, Frisque R J. The biology and molecular biology of JC virus. The Papovaviridae, The Polyomaviruses, P J Vinken, G W Bruyn, H L Klawans. Plenum Publishing Corp, New York 1986; Vol I: 327–377

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