4
Views
2
CrossRef citations to date
0
Altmetric
Original Article

The regulation of quinolinic acid in human immunodeficiency virus-infected monocytes

, , , , &
Pages 111-117 | Received 13 Dec 1995, Accepted 23 Feb 1996, Published online: 10 Jul 2009

References

  • Brenneman D E, Westbrook G L, Fitzgerald S P, Ennist D L, Elkins K L, Ruff M R, Pert C B. Neuronal cell killing by the envelope protein of HTV and its prevention by vasoactive intestinal peptide. Nature 1988; 335: 639–642
  • Bukrinsky M I, Nottet H SLM, Schmidtmayerova H, Dubrovsky L, Mullins M E, Lipton S A, Gendelman H E. Regulation of nitric oxide synthase in HTV-1-infected monocytes: implications for HTV-associated neurological disease. J. Exp Med 1995; 185: 735–845
  • Dreyer E B, Kaiser P K, Offerman J T, Lipton S A. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990; 248: 364–367
  • Foster A C, Vezzani A, French E D, Schwarcz. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related metabolite quinolinic acid. Neurosic Lett 1984; 48: 273–278
  • Gelbard H A, Nottet H SLM, Swindells S, Jett M, Dzenko K A, Genis P, White R, Wang L, Choi Y-B, Zhang D, Lipton S A, Tourtellotte W W, Epstein L G, Gendelman H E. Platelet-activating factor: A candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 1994; 68: 4628–4635
  • Gendelman H E, Orenstein J M, Martin M A, Ferrua C, Mitra R, Phipps T, Wahl L A, Lane H C, Fauci A S, Burke D S, Skillman D R, Meltzer M S. Efficient isolation and propagation of human immunodeficiency virus on recombinant colonystimulating factor 1-treated monocytes. J Exp Med 1988; 167: 1428–1441
  • Gendelman H E, Friedman R M, Joe S, Baca L M, Turpin J A, Dveksler G, Meltzer M S, Dieffenbach C. A selective defect of interferon a production in human immunodeficiency virus-infected monocytes. J Exp Med 1990; 172: 1433–1442
  • Genis P, Jett M, Bernton E W, Boyle T, Gelbard H A, Dzenko K, Keane R W, Resnick L, Mizrachi Y, Volsky D J, Epstein L G, Gendelman H E. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HN)-infected macrophageastroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 1992; 176: 1703–1718
  • Giulian D, Vaca K, Noonan C A. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 1991; 250: 1593–1596
  • Glass J D, Fedor H, Wesselingh S L, McArthur J C. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995; 38: 755–762
  • Heyes M P, Markey S P. Quantification of quinolinic acid rat brain, whole blood and plasma by gas chromatrography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations. Anal Biochem 1988; 174: 349–359
  • Heyes M P, Brew B J, Martin A, Price R W, Salazar A M, Sidtis J J, Yergey J A, Mouradian M M, Sadler A Fi, Keilp J, Rubinow D, Markey S P. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 1991; 29: 202–209
  • Heyes M P, Saito K, Markey S P. Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid. Biochem J 1992; 283: 633–635
  • Heyes M P, Saito K, Mayor E O, Milstien S, Markey S P, Vickers J H. A mechanism of quinolinic acid formation by brain inflammatory neurological disease: attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain 1993; 116: 1425–1450
  • Kim J P, Choi D W. Quinolinate neurotoxicity in cortical cell culture. Neurosci 1987; 25: 423–432
  • Koenig S, Gendelman H E, Orenstein J M, Dal Canto D C, Pezeshkpour G M, Yungbluth M, Janotta F, Aksamit A, Martin M A, Fauci A S. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986; 233: 1089–1093
  • Kure K, Lyman W D, Weidenheim K M, Dickson D W. Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Am J Pathol 1990; 136: 1085–1092
  • Lipton S A, Gendelman H E. Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 1995; 332: 934–940
  • Moses A V, Bloom E E, Pauza C D, Nelson J A. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4 galactosylceramide-independent mechanism. Proc Nu 1993; 1 Acad Sci USA 90: 10474–10478, t
  • Nottet H SLM, Jett M, Flanagan C R, Zhai Q-H, Peridsky Y, Rizzino A, Bernton E W, Genis P, Baldwin T, Schwartz J, LaBenz C, Gendelman H E. A regulatory role for astrocytes in HIV-1 encephalitis: an overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-a by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J Immunol 1995; 154: 3567–3581
  • Nottet H SLM, Gendelman H E. Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitivelmotor complex. Immunol Today 1995; 16: 441–448
  • Nottet H SLM, Persidsky Y, Sasseville V G, Nukuna A N, Bock P, Zhai Q-H, Sharer L R, McComb R D, Swindells S, Soderland C, Gendelman H E. Mechanisms for the transendothelial migration of HIV-1 infected monocytes in brain. J Immunol 1996; 156: 1284–1295
  • Okuno E, Kohler C, Schwarcz R. Rat 3- hydroxyanthralic acid oxygenase: purification from the liver and immunocytochemical localization in the brain. J Neurochem 1987; 49: 771–780
  • Okuno E, Nakmura M, Schwarcz R. Two kynurenine aminotransferases in human brain. Brain Res 1991; 542: 307–312
  • Pulliam L, West D, Haigwood N, Swanson R A. HIV-1 envelope gp120 alters astrocytes in human brain cultures. AIDS Res Hum Retroviruses 1993; 9: 439–444
  • Pulliam L, Herndier B G, Tang N M, McGrath M S. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 1991; 87: 503–512
  • Schwarcz R, Whetsell W O, Mangano R EM. Quinolinic acid: an endogenous metabolite can produce axon sparing lesions in rat brain. Science 1983; 219: 316–318
  • Sei S, Saito K, Stewart S K, Crowley J S, Brouwers P, Kleiner D E, Katz D A, Pizzo P A, Heyes M P. Increased human immunodeficiency virus (HIV) type 1 DNA content and quinolinic acid concentration in brain tissues hom patients with HIV encephalopathy. J Infect Dis 1995; 172: 638–647
  • Tardieu M, Hery C, Peudenier S, Boesflug O, Montagnier L. Human immunodeficiency virus type-1 infected monocytic cells can destroy human neural cells after cell-to-cell adhesion. Ann Neurol 1992; 32: 11–17
  • Wesselingh S L, Power C, Glass J D, McArthur J C, Farber J M, Griffi J W, Griffin D E. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993; 33: 576–582
  • Wiley C A, Achim C. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 1994; 36: 673–676

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.