Molecular aspects of HTLV-I: Relationship to neurological diseases

References

• Adya N, Zhao L J, Huang W, Boros I, Giam C Z. Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB. Proc Natl Acad Sci USA 1994; 91: 5642–5646
   PubMedGoogle Scholar
• Akagi T, Hoshida Y, Yoshino T, Teramoto N, Kondo E, Hayashi K, Takahashi K. Infectivity of human T-lymphotropic virus type I to human nervous tissue cells in vitro. Acta Neuropathol (Berl) 1992; 84: 147–152
   Google Scholar
• Anderson M G, Dynan W S. Quantitative studies of the effect of HTLV-I Tax protein on CREB protein-DNA binding. Nucleic Acids Res 1994; 22: 3194–3201
   PubMed Web of Science ®Google Scholar
• Beraud C, Lombard-Platet G, Michal Y, Jalinot P. Binding of the HTLV-I Taxi transactivator to the inducible 21 bp enhancer is mediated by the cellular factor HEBl. EMBO J 1991; 10: 3795–3803
   PubMedGoogle Scholar
• Berneman Z N, Gartenhaus R B, Retiz M S, Jr, Blattner W A, Manns A, Hanchard B, Ikehara O, Gallo R C, Klotman M E. Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers. Proc Natl Acad Sci USA 1992; 89: 3005–3009
   PubMedGoogle Scholar
• Bhat N K, Thompson C B, Lindsten T, June C H, Fujiwara S, Koizumi S, Fisher R J, Papas T S. Reciprocal expression of human ETSl and ETS2 genes during Tcell activation: regulatory role for the protooncogene ETSl. Proc Natl Acad Sci USA 1990; 87: 3723–3727
   PubMedGoogle Scholar
• Bosselut R, Duvall J F, Gegonne A, Bailly M, Hemar A, Brady J, Ghysdael J. The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia viurs HTLV-1. EMBO J 1990; 9: 3137–3144
   PubMed Web of Science ®Google Scholar
• Caron C, Rousset R, Beraud C, Moncollin V, Egly J M, Jalinot P. Functional and biochemical interaction of the HTLV-I Taxi transactivator with TBP. EMBO J 1993; 12: 4269–4278
   PubMedGoogle Scholar
• Celander D, Haseltine W A. Tissue-specific transcription preference as a determinant of cell tropism and leukaemogenic potential of murine retroviruses. Nature 1984; 312: 159–162
   PubMedGoogle Scholar
• Chen I S, Quan S G, Golde D W. Human T-cell leukemia virus type II transforms normal human lymphocytes. Proc Natl Acad Sci USA 1983; 80: 7006–7009
   PubMed Web of Science ®Google Scholar
• Chen I S, Slamon D J, Rosenblatt J D, Shah N P, Quan S G, Wachsman W. The x gene is essential for HTLV replication. Science 1985; 229: 54–58
   PubMedGoogle Scholar
• Chen Y M, Okayama A, Lee T H, Tachibana N, Mueller N, Essex M. Sexual transmission of human T-cell leukemia virus type I associated with the presence of anti-Tax antibody. Proc Natl Acad Sci USA 1991; 88: 1182–1186
   Google Scholar
• Ciminale V, Pavlakis G N, Derse D, Cunningham C P, Felber B K. Complex splicing in die human Tcell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I. J Virol 1992; 66: 1737–1745
   PubMed Web of Science ®Google Scholar
• Clemens K, Piras G, Kashanchi F, Radonovich M F, Duvall J, Dejong J, Roeder R, Brady J N. Interaction of HTLV-I Tax1 with the basal transcription factor TFIIA. 1995, (submitted)
   Google Scholar
• Connor L M, Oxman M N, Brady J N, Marriott S J. Twenty-one base pair repeat elements influence the ability of a Gal4-Tax fusion protein to transactivate the HTLV-I long terminal repeat. Virology 1993; 195: 569–577
   PubMedGoogle Scholar
• Corboy J R, Buzy J M, Zink M C, Clements J E. Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 1992; 258: 1804–1808
   PubMed Web of Science ®Google Scholar
• Cowan E P, Alexander R K, Daniel S, Kashanchi F, Brady J N. A post-mitotic human neuronal cell line produces TNF-α and undergoes cell death in response to treatment with soluble HTLV-I tax. 1995, (Abstract)
   Google Scholar
• Daenke S, Nightingale S, Cruickshank J K, Bangham C R. Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates. J Virol 1990; 64: 1278–1282
   PubMedGoogle Scholar
• Dhib-Jalbut S, Hoffman P M, Yamabe T, Sun D, Xia J, Eisenberg H, Bergey G, Ruscetti F W. Extracellular human T-cell lymphotropic virus type I Tax protein induces cytokine production in adult human microglial cells. Ann Neurol 1994; 36: 787–790
   Google Scholar
• Elovaaia I, Koenig S, Brewah A Y, Woods R M, Lehky T, Jacobson S. High human T cell lymphotropic virus type 1 (HTLV-l)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease. J Exp Med 1993; 177: 1567–1573
   Google Scholar
• Ensoli B, Barillari G, Salahuddin S Z, Gallo R C, WongStaal F. Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature 1990; 345: 84–86
   PubMed Web of Science ®Google Scholar
• Ensoli B, Gendelman R, Markham P, Fiorelli V, Colombini S, Raffeld M, Cafaro A, Chang H K, Brady J N, Gallo R C. Synergy between basic fibroblast growth factor and HIV-l Tat protein in induction of Kaposi's sarcoma. Nature 1994; 371: 674–680
   PubMed Web of Science ®Google Scholar
• Fanauchi M, Saida T, Saida M, Makajima M, Matsuda S, Nishiguchi E, Nishitani H. Cytopathic effects of HTLV-I infection in human neural cell lines. HTLV-I in the Nervous System, G C Roman, J-C Vernant, M Osame. Alan R. Liss, Inc., New York 1989; 333–336
   Google Scholar
• Felber B K, Paskalis H, Kleinman-Ewing C, Wong-Staal F, Pavlakis G N. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 1985; 229: 675–679
   PubMed Web of Science ®Google Scholar
• Franchini G, Wong-Staal F, Gallo R C. Human Tcell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia. Proc Natl Acad Sci USA 1984; 81: 6207–6211
   PubMed Web of Science ®Google Scholar
• Franchini G, Mulloy J C, Koralnik I J, Lo Monico A, Sparkowski J J, Andresson T, Goldstein D J, Schlegel R. The human T-cell leukemia/lymphotropic virus type I pi21 protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase. J Virol 1993; 67: 7701–7704
   PubMed Web of Science ®Google Scholar
• Franklin A A, Kubik M F, Uittenbogaard M N, Brauweiler A, Utaisincharoen P, Matthews M A, Dynan W S, Hoeffler J P, Nyborg J K. Transactivation by the human Tcell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB). J Biol Chem 1993; 268: 21225–21231
   PubMed Web of Science ®Google Scholar
• Furukawa K, Shiku H. Alternatively spliced mRNA of the pX region of human T lymphotropic virus type I proviral genome. FEBS Lett 1991; 295: 141–145
   Google Scholar
• Gallo R C, Kalyanaraman V S, Sarngadharan M G, Sliski A, Vonderheid E C, Maeda M, Nakao Y, Yamada K, Ito Y, Gutensohn N, Murphy S, Bunn P A, Jr, Catovsky D, Greaves M F, Blayney D W, Blattner W, Jarrett W F, zur Hausen H, Seligmann M, Brouet J C, Haynes B F, Jegasothy B V, Jaffe E, Cossman J, Broder S, Fisher R I, Golde D W, Robert-Guroff M. Association of the human type C retrovirus with a subset of adult T-cell cancers. Cancer Res 1983; 43: 3892–3899
   PubMed Web of Science ®Google Scholar
• Gazzolo L, Due Dodon M. Direct activation of resting T lymphocytes by human T-lymphotropic virus type I. Nature 1987; 326: 714–717
   PubMedGoogle Scholar
• Gegonne A, Bosselut R, Bailly R A, Ghysdael J. Synergistic activation of the HTLVl LTR Ets-responsive region by transcription factors Etsl and Spl. EMBO J 1993; 12: 1169–1178
   PubMed Web of Science ®Google Scholar
• Gessain A, Barin F, Vernant J C, Gout O, Mauis L, Calender A, de The G. Antibodies to human Tlymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; 2: 407–410
   PubMed Web of Science ®Google Scholar
• Gessain A, Saal F, Morozov V, Lasneret J, Vilette D, Gout O, Emanoil-Ravier R, Sigaux F, de The G, Peries J. Characterization of HTLV-I isolates and T lymphoid cell lines derived from French West Indian patients with tropical spastic paraparesis. Int J Cancer 1989; 43: 327–333
   Google Scholar
• Giam C Z, Xu Y L. HTLV-I tax gene product activates transcription via pre-existing cellular factors and cAMP responsive element. J Biol Chem 1989; 264: 15236–15241
   PubMed Web of Science ®Google Scholar
• Gitlin S D, Bosselut R, Gegonne A, Ghysdael J, Brady J N. Sequence-specific interaction of the Etsl protein with the long terminal repeat of the human T-lymphotropic virus type I. J Virol 1991a; 65: 5513–5523
   PubMedGoogle Scholar
• Gitlin S D, Lindholm P F, Marriott S J, Brady J N. Transdominant human T-cell lymphotropic virus type I TAXI mutant that fails to localize to the nucleus. J Virol 1991b; 65: 2612–2621
   Google Scholar
• Gitlin S D, Dittmer J, Reid R L, Brady J N. The molecular biology of human T-cell lymphotropic viruses. Frontiers in Molecular Biology, B Cullen. Oxford University Press (IRL Books), Oxford, UK 1993a; 159
   Google Scholar
• Gitlin S D, Dittmer J, Shin R C, Brady J N. Transcriptional activation of the human T-lymphotropic virus type I long terminal repeat by functional interaction of Taxi and Etsl. J Virol 1993b; 67: 7307–7316
   PubMedGoogle Scholar
• Gonzalez-Dunia D, Chirinian-Syan S, Brahic M, Ozden S. Functional analysis of two long terminal repeats from the HTLV-I retrovirus. Gene 1992a; 116: 151–158
   Google Scholar
• Gonzalez-Dunia D, Grimber G, Briand P, Brahic M, Ozden S. Tissue expression pattern directed in transgenic mice by the LTR of an HTLV-I provirus isolated' from a case of tropical spastic paraparesis. Virology 1992b; 187: 705–710
   Google Scholar
• Gonzalez-Dunia D, Komurian-Pradel F, Chirinian-Syan S, de The G, Brahic M, Ozden S. Comparative analysis of HTLV-I promoter activities reveals no disease-linked pattern of expression. AIDS Res Hum Retroviruses 1993; 9: 337–341
   Google Scholar
• Grassmann R, Dengler C, Muller-Fleckenstein I, Fleckenstein B, McGuire K, Dokhelar M C, Sodroski J G, Haseltine W A. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc Natl Acad Sci USA 1989; 86: 3351–3355
   PubMed Web of Science ®Google Scholar
• Green J E, Begley C G, Wagner D K, Waldmann T A, Jay G. trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human Tlymphotropic virus type 1 tax gene. Mol Cell Biol 1989; 9: 4731–4737
   PubMed Web of Science ®Google Scholar
• Green J E. trans activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene. Mol Cell Biol 1991; 11: 4635–4641
   PubMed Web of Science ®Google Scholar
• Hai T W, Liu F, Coukos W J, Green M R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears. Genes Dev Apr, 1990; 4(4)682
   Google Scholar
• Genes Dev 1989; 3: 2083–2090
   PubMed Web of Science ®Google Scholar
• Hara H, Morita M, Iwaki T, Hatae T, Itoyama Y, Kitamoto T, Akizuki S, Goto I, Watanabe T. Detection of human T lymphotrophic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor V beta CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Exp Med 1994; 180: 831–839
   Google Scholar
• Hayami M, Tsujimoto H, Komuro A, Hinuma Y, Fujiwara K. Transmission of adult T-cell leukemia virus from lymphoid cells to non-lymphoid cells associated with cell membrane fusion. Gann 1984; 75: 99–102
   Google Scholar
• Hirayama M, Miyadai T, Yokochi T, Sato K, Kubota M, Iida M, Fujiki N. Infection of human Tlymphotropic virus type I to astrocytes in vitro with induction of the class II major histocompatibility complex. Neurosci Lett 1988; 92: 34–39
   Google Scholar
• Iwasaki Y, Tsukamoto T, Terunuma H, Osame M. Mechanisms of neural tissue damage in human retrovirus infections: Cytopathic activity in CSF of patients with HTLV-I-associated myelopathy. HTLV-I and the Nervous System, G C Roman, J-C Vernant, M Osame. Alan R Liss, Inc., New York 1989; 325–332
   Google Scholar
• Jacobson S, Shida H, McFarlin D E, Fauci A S, Koenig S. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 1990; 348: 245–248
   PubMed Web of Science ®Google Scholar
• Janssen R S, Kaplan J E, Khabbaz R F, Hammond R, Lechtenberg R, Lairmore M, Chiasson M A, Punsalang A, Roberts B, McKendall R R. HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States. Neurology 1991; 41: 1355–1357
   Google Scholar
• Jeang K-T, Brady J, Radonovich M, Duvall J, Khoury G. p40x trans-activation of the HTLV-I LTR promoter. Mechanisms of control of gene expression, B Cullen, L P Cage, M AQ Siddiqui, A M Skalka, H Weissbach. Alan R Liss, Inc., New York 1988a; 181
   Google Scholar
• Jeang K-T, Boros I, Brady J, Radonovich M, Khoury G. Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence. J Virol 1988b; 62: 4499–4509
   PubMed Web of Science ®Google Scholar
• Jeang K-T, Chiu R, Santos E, Kim S J. Induction of the HTLV-I LTR by Jun occurs through the Taxresponsive 21 bp elements. Virology 1991; 181: 218–227
   PubMedGoogle Scholar
• Kashanchi F, Duvall J F, Lindholm P F, Radonovich M F, Brady J N. Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression. J Virol 1993; 67: 2894–2902
   PubMedGoogle Scholar
• Kashanchi F, Duvall J F, Dittmer J, Mireskandari A, Reid R L, Gitlin S D, Brady J N. Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression. J Virol 1994; 68: 561–565
   PubMedGoogle Scholar
• Kira J, Koyanagi Y, Yamada T, Itoyama Y, Tateishi J, Akizuki S, Kishikawa M, Baba E, Nakamura M, Suzuki J. Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy [see comments]. Ann Neurol 1994; 36: 149–156
   Google Scholar
• Kiyokawa T, Kawaguchi T, Seiki M, Yoshida M. Association of the pX gene product of human T-cell leukemia virus type-I with nucleus. Virology 1985a; 147: 462–465
   PubMedGoogle Scholar
• Kiyokawa T, Seiki M, Iwashita S, Imagawa K, Shimizu F, Yoshida M. p27x-m and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 1985b; 82: 8359–8363
   PubMed Web of Science ®Google Scholar
• Komurian F, Pelloquin F, de The G. In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies. J Virol 1991; 65: 3770–3778
   Google Scholar
• Koralnik I J, Lemp J F, Jr, Gallo R C, Franchini G. In vitro infection of human macrophages by human T-cell leukemia/lymphotropic virus type I (HTLV-I). AIDS Res Hum Retroviruses 1992; 8: 1845–1849
   PubMed Web of Science ®Google Scholar
• Koralnik I J, Fullen J, Franchini G. The pl2l, pl3II, and p30II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments. J Virol 1993; 67: 2360–2366
   PubMed Web of Science ®Google Scholar
• Koyanagi Y, Itoyama Y, Nakamura N, Takamatsu K, Kira J, Iwamasa T, Goto I, Yamamoto N. In vivo infection of human T-cell leukemia virus type I in non-T cells. Virology 1993; 196: 25–33
   PubMed Web of Science ®Google Scholar
• Kriwacki R W, Schultz S C, Steitz T A, Caradonna J P. Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Spl. Proc Natl Acad Sci USA 1992; 89: 9759–9763
   PubMed Web of Science ®Google Scholar
• Larkin J, Sinnott J T, Weiss J, Holt D A. Human Tcell lymphotropic virus-type I. Infect Control Hosp Epidemiol 1990; 11: 314–318
   Google Scholar
• Lehky T J, Fox C H, Koenig S, Levin M C, Flerlage N, Izumo S, Sato E, Raine C S, Osame M, Jacobson S. Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization [see comments]. Ann Neurol 1995; 37: 167–175
   PubMed Web of Science ®Google Scholar
• Lehky T J, Jacobson S. Induction of HLA class II in HTLV-I infected neuronal cell lines. J Neuro Virol 1995; 1: 157–164
   Google Scholar
• Libermann T A, Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 1990; 10: 2327–2334
   PubMed Web of Science ®Google Scholar
• Lindholm P F, Marriott S J, Gitlin S D, Bohan C A, Brady J N. Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein. New Biol 1990; 2: 1034–1043
   PubMedGoogle Scholar
• Lindholm P F, Reid R L, Brady J N. Extracellular Taxi protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells. J Virol 1992; 66: 1294–1302
   PubMed Web of Science ®Google Scholar
• Lindholm P F, Kashanchi F, Brady J N. Transcriptional regulation in the human retrovirus HTLV-I. Seminars in Virology, M Peterlin. WB Saunders, London, UK 1993; 53
   Google Scholar
• Low K G, Chu H M, Schwartz P M, Daniels G M, Melner M H, Comb M J. Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element. Mol Cell Biol 1994; 14: 4958–4974
   PubMedGoogle Scholar
• Manns A, Blattner W A. The epidemiology of the human T-cell lymphotrophic virus type I and type II: etiologic role in human disease. Transfusion 1991; 31: 67–75
   PubMed Web of Science ®Google Scholar
• Marriott S J, Boros I, Duvall J F, Brady J N. Indirect binding of human T-cell leukemia virus type I taxi to a responsive element in the viral long terminal repeat. Mol Cell Biol 1989; 9: 4152–4160
   PubMedGoogle Scholar
• Marriott S J, Lindholm P F, Brown K M, Gitlin S D, Duvall J F, Radonovich M F, Brady J N. A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAXI with a responsive element in die viral long terminal repeat. Mol Cell Biol 1990; 10: 4192–4201
   PubMedGoogle Scholar
• Marriott S J, Lindholm P F, Reid R L, Brady J N. Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes. New Biol 1991; 3: 678–686
   PubMedGoogle Scholar
• Marriott S J, Trinh D, Brady J N. Activation of interleukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis. Oncogene 1992; 7: 1749–1755
   PubMed Web of Science ®Google Scholar
• Merl S, Kloster B, Moore J, Hubbell C, Tomar R, Davey F, Kalinowski D, Planas A, Ehrlich G, Clark D. Efficient transformation of previously activated and dividing T lymphocytes by human T cell leukemialymphoma virus. Blood 1984; 64: 967–974
   PubMed Web of Science ®Google Scholar
• Miyamoto K, Nishikawa H, Miyata T, Otsuki S, Tomita N, Suzuki C, Ishii A, Hiraki Y, Sugihara T, Kitajima K. Transformation of human leukocytes by co-cultivation with HTLV-1-assoicated myelopathy patients' leukocytes. Jpn J Cancer Res 1987; 78: 883–888
   Google Scholar
• Miyatake S, Seiki M, Yoshida M, Arai K. T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol Cell Biol 1988; 8: 5581–5587
   PubMed Web of Science ®Google Scholar
• Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y. Type C virus particles in a cord T-cell line derived by cocultivating normal human cord leukocytes and human leukaemic T cells. Nature 1981; 294: 770–771
   PubMed Web of Science ®Google Scholar
• Molgaard C A, Eisenman P A, Ryden L A, Golbeck A L. Neuroepidemiology of human Tlymphotrophic virus type-I-associated tropical spastic para-paresis. Neuroepidemiology 1989; 8: 109–123
   Google Scholar
• Mulloy J C, Boeri E, Gallo R C, Leonard W J, Franchini G. Association of the HTLV-I pl21 protein with immature forms of the IL-2Rβ and gammac chains: implications for leukemogenesis. 1995, (Abstract)
   Google Scholar
• Nagashima K, Yoshida M, Seiki M. A single species of pX mRNA of human T-cell leukemia virus type I encodes trans-activator p40x and two other phosphoproteins. J Virol 1986; 60: 394–399
   PubMed Web of Science ®Google Scholar
• Nakamura M, Ohtani K, Hinuma Y, Sugamura K. Functional mapping of the activity of the R region in the human T-cell leukemia virus type I long terminal repeat to increase gene expression. Virus Genes 1989; 2: 147–155
   Google Scholar
• Niewiesk S, Daenke S, Parker C E, Taylor G, Weber J, Nightingale S, Bangham C RM. The trans-activator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers Than patients with tropical spastic paraparesis. J Virol 1994; 68: 6778
   Google Scholar
• Nimer S. Tax responsiveness of the GM-CSF promoter is mediated by mitogen-inducible sequences other than kappa B. New Biol 1991; 3: 997–1004
   PubMedGoogle Scholar
• Nimer S D, Gasson J C, Hu K, Smalberg I, Williams J L, Chen I S, Rosenblatt J D. Activation of the GMCSF promoter by HTLV-I and -II tax proteins. Oncogene 1989; 4: 671–676
   PubMed Web of Science ®Google Scholar
• Nishida J, Yoshida M, Arai K, Yokota T. Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene: coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation. Int Immunol 1991; 3: 245–254
   PubMedGoogle Scholar
• Nishiura Y, Nakamura T, Takino H, Ichinose K, Nagasato K, Ohishi K, Tsujihata M, Nagataki S. Production of granulocyte-macrophage colony stimulating factor by human T-lymphotropic virus type I-infected human glioma cells. J Neurol Sci 1994; 121: 208–214
   Google Scholar
• Nyborg J K, Matthews M A, Yucel J, Walls L, Golde W T, Dynan W S, Wachsman W. Interaction of host cell proteins with the human T-cell leukemia virus type I transcriptional control region. II. A comprehensive map of protein-binding sites facilitates construction of a simple chimeric promoter responsive to the viral tax2 gene product. J Biol Chem 1990; 265: 8237–8242
   PubMedGoogle Scholar
• Nyborg J K, Dynan W S. Interaction of cellular proteins with the human T-cell leukemia virus type I transcriptional control region. Purification of cellular proteins that bind the 21-base pair repeat elements. J Biol Chem 1990; 265: 8230–8236
   PubMedGoogle Scholar
• Ohtani K, Nakamura M, Saito S, Noda T, Ito Y, Sugamura K, Hinuma Y. Identification of two distinct elements in the long terminal repeat of HTLVI responsible for maximum gene expression. EMBO J 1987; 6: 389–395
   PubMedGoogle Scholar
• Paine E, Garcia J, Philpott T C, Shaw G, Ratner L. Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients [published erratum appears. Virology May, 1992; 188(1)414
   Google Scholar
• Virology 1991; 182: 111–123
   Google Scholar
• Paul N L, Lenardo M J, Novak K D, Sarr T, Tang W L, Ruddle N H. Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B. J Virol 1990; 64: 5412–5419
   PubMed Web of Science ®Google Scholar
• Poiesz P B, Ruscetti F W, Gazdar A F, Bunn P A, Minna J D, Gallo R C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980; 77: 7415–7419
   PubMed Web of Science ®Google Scholar
• Popovic M, Sarin P S, Robert-Gurroff M, Kalyanaraman V S, Mann D, Minowada J, Gallo R C. Isolation and transmission of human retrovirus (human t-cell leukemia virus). Science 1983; 219: 856–859
   PubMed Web of Science ®Google Scholar
• Radonovich M, Jeang K T. Activation of the human T-cell leukemia virus type I long terminal repeat by 12-0-tetradecanoylphorbol-13-acetate and by tax (p40x) occurs through similar but functionally distinct target sequences. J Virol 1989; 63: 2987–2994
   PubMedGoogle Scholar
• Renjifo B, Borrero I, Essex M. Tax mutation associated with tropical spastic paraparesis/human Tcell leukemia virus type I-associated myelopathy [published erratum appears. J Virol Jun, 1995; 69(6)3964
   Google Scholar
• J Virol 1995; 69: 2611–2616
   Google Scholar
• Rosen C A, Haseltine W A, Lenz J, Ruprecht R, Cloyd M W. Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. J Virol 1985; 55: 862–866
   PubMedGoogle Scholar
• Rudkin B B, Lazarovici P, Levi B Z, Abe Y, Fujita K, Guroff G. Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation. EMBO J 1989; 8: 3319–3325
   PubMedGoogle Scholar
• Sawada M, Suzumura A, Yoshida M, Marunouchi T. Human T-cell leukemia vims type I trans activator induces class I major histocompatibility complex antigen expression in glial cells. J Virol 1990; 64: 4002–4006
   PubMed Web of Science ®Google Scholar
• Sawada M, Suzumura A, Kondo N, Marunouchi T. Induction of cytokines in glial cells by trans activator of human T-cell lymphotropic virus type I. FEBS Lett 1992; 313: 47–50
   PubMed Web of Science ®Google Scholar
• Seigel L J, Nash W G, Poiesz B J, Moore J L, O'Brien S J. Dynamic and nonspecific dispersal of human T-cell leukemia/lymphoma virus type-I integration in cultured lymphoma cells. Virology 1986; 154: 67–75
   PubMed Web of Science ®Google Scholar
• Seiki M, Eddy R, Shows T B, Yoshida M. Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells. Nature 1984; 309: 640–642
   PubMed Web of Science ®Google Scholar
• Seiki M, Inoue J, Hidaka M, Yoshida M. Two cisacting elements responsible for post-transcriptional trans-regulation of gene expression of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 1988; 85: 7124–7128
   PubMedGoogle Scholar
• Semmes O J, Jeang K T. Mutational analysis of human T-cell leukemia virus type I Tax: regions necesary for function determined with 47 mutant proteins. J Virol 1992; 66: 7183–7192
   PubMedGoogle Scholar
• Shimotohno K, Golde D W, Miwa M, Sugimura T, Chen I S. Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II. Proc Natl Acad Sci USA 1984; 81: 1079–1083
   PubMed Web of Science ®Google Scholar
• Siekevitz M, Feinberg M B, Holbrook N, Wong-Staal F, Greene W C. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene produce of human T-cell leukemia virus, type I. Proc Natl Acad Sci USA 1987; 84: 5389–5393
   PubMed Web of Science ®Google Scholar
• Slamon D J, Press M F, Souza L M, Murdock D C, Cline M J, Golde D W, Gasson J C, Chen I S. Studies of the putative transforming protein of the type I human Tcell leukemia virus. Science 1985; 228: 1427–1430
   PubMedGoogle Scholar
• Suzuki T, Fujisawa J I, Toita M, Yoshida M. The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1. Proc Natl Acad Sci USA 1993; 90: 610–614
   PubMed Web of Science ®Google Scholar
• Tan T H, Horikoshi M, Roeder R G. Purification and characterization of multiple nuclear factors that bind to the TAX-inducible enhancer within the human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol 1989; 9: 1733–1745
   PubMedGoogle Scholar
• Tendler C L, Greenberg S J, Blattner W A, Manns A, Murphy E, Fleisher T, Hanchard B, Morgan O, Burton J D, Nelson D L. Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc Natl Acad Sci USA 1990; 87: 5218–5222
   PubMed Web of Science ®Google Scholar
• Terunuma H, Iwasaki Y, Tsukamoto T, Konno H, Yamamoto T, Ohara Y. Neurotoxic activity in HTLV-I carrier lymphocyte culture. J Neurol Sci 1989; 92: 169–180
   Google Scholar
• Tillmann M, Krebs F C, Wessner R, Pomeroy S M, Goodenow M M, Wigdahl B. Neuroglialspecific factors and the regulation of retrovirus transcription. Adv Neuroimmunol 1994a; 4: 305–318
   Google Scholar
• Tillmann M, Wessner R, Wigdahl B. Identification of human T-cell lymphotropic virus type I 21-base-pair repeat-specific and glial cellspecific DNA-protein complexes. J Virol 1994b; 68: 4597–4608
   Google Scholar
• Tillmann M, Wigdahl B. Identification of HTLV-I 21 bp repeat-specific DNA-protein complexes. Leukemia 1994; 8(Suppl 1)S83–S87
   Google Scholar
• Tsujimoto A, Nyunoya H, Morita T, Sato T, Shimotohno K. Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol 1991; 65: 1420–1426
   PubMedGoogle Scholar
• Urba W J, Longo D L. Clinical spectrum of human retroviral-induced diseases. Cancer Res 1985; 45: 4637s–4643s
   Google Scholar
• Wagner S, Green M R. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science 1993; 262: 395–399
   PubMed Web of Science ®Google Scholar
• Wano Y, Feinberg M, Hosking J B, Bogerd H, Greene W C. Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth. Proc Natl Acad Sci USA 1988; 85: 9733–9737
   PubMed Web of Science ®Google Scholar
• Watabe K, Saida T, Kim S U. Human and simian glial cells infected by human T-lymphotropic virus type I in culture. J Neuropathol Exp Neurol 1989; 48: 610–619
   Google Scholar
• Watanabe H, Nakamura T, Nagasato K, Shirabe S, Ohishi K, Ichinose K, Nishiura Y, Chiyoda S, Tsujihata M, Nagataki S. Exaggerated messenger RNA expression of inflammatory cytokines in human Tcell lymphotropic virus type I-associated myelopathy. Arch Neurol 1995; 52: 276–280
   Google Scholar
• Wessner R, Tillmann-Bogush M, Wigdahy B. Characterization of a glial cell-specific DNA-protein complex formed with the human T cell lymphotropic virus type I (HTLV-I) enhancer. Journal of NeuroVirology 1995; 1: 62–77
   Web of Science ®Google Scholar
• Wong-Staal F, Gallo R C. The family of human Tlymphotropic leukemia viruses: HTLV-I as the cause of adult T cell leukemia and HTLV-III as the cause of acquired immunodeficiency syndrome. Blood 1985; 65: 253–263
   PubMed Web of Science ®Google Scholar
• Xu X, Brown D A, Kitajima I, Bilakovics J, Fey L W, Nerenberg M I. Transcriptional suppression of the human T-cell leukemia virus type I long terminal repeat occurs by an unconventional interaction of a CREB factor with the R region. Mol Cell Biol 1994; 14 5371–5383
   PubMedGoogle Scholar
• Yamamoto N, Okada M, Koyanagi Y, Kannagi M, Hinuma Y. Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line. Science 1982; 217: 737–739
   PubMed Web of Science ®Google Scholar
• Yin M J, Paulssen E J, Seeler J S, Gaynor R B. Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB. J Virol 1995; 69: 3420–3432
   PubMedGoogle Scholar
• Yoshimura T, Fujisawa J, Yoshida M. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J 1990; 9: 2537–2542
   PubMed Web of Science ®Google Scholar
• Zhao L J, Giam C Z. Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in die HTLV-I enchancer. Proc Natl Acad Sci USA 1991; 88: 11445–11449
   PubMed Web of Science ®Google Scholar
• Zhao L J, Giam C Z. Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc Natl Acad Sci USA 1992; 89: 7070–7074
   PubMed Web of Science ®Google Scholar