Toxicity and Neuronal Infection of a HSV-1 ICP34.5 Mutant in Nude Mice

References

• Adams R L, Springall D R, Levene M M, Bushell T E. The immunocytochemical detection of herpes simplex virus in cervical smears-a valuable technique for routine use. J Pathol 1984; 143: 241–247
   Google Scholar
• Brown S M, Harland J, MacLean A R, Podlech J, Clements J B. Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2. J Gen Virol 1994; 75: 2367–2377
   Google Scholar
• Chambers R, Gillespie G Y, Soroceanu L, Andreansky S, Chatterjee S, Chou J, Roizman B, Whitley R J. Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma. Proceedings of the National Academy of Sciences, USA, 1985. 92: 1411–1415
   Google Scholar
• Chou J, Chen J J, Gross M, Roizman B. Association of a Mr 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF2α and premature shutoff of protein synthesis after infection with γ34.5- mutants of herpes simplex virus 1. Proc Natl Acad Sci USA 1995; 92: 10516–10520
   Google Scholar
• Chou J, Kern E R, Whitley R J, Rouzman B. Mapping of herpes simplex virus neurovirulence to gamma 1 34.5, a gene nonessential for growth in culture. Science 1990; 252: 1262–1266
   Google Scholar
• Chou J, Roizman B. Herpes simplex virus 1 γ134.5 gene function, which blocks the host response to infections, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc Natl Acad Sci USA 1994; 91: 5247–5251
   PubMed Web of Science ®Google Scholar
• He B, Chou J, Brandimarti R, Mohr I, Gluzman Y, Roizman B. Suppression of the phenotype of γ134.5- herpes simplex virus 1: failure of activated RNA-dependant protein kinase to shut off protein synthesis is associated with a deletion in the domain of the α47 gene. J Virol 1997; 7(1)6049–6054
   Google Scholar
• Kesari S, Lee V MY, Brown S M, Trojanowski J Q, Fraser N W. Selective vulnerability of mouse CNS neurons to latent infection with a neuroattenuated herpes simplex virus-1. The Journal of Neuroscience 1996; 16: 5644–5663
   PubMedGoogle Scholar
• Kesari S, Randazzo B P, Valyi-Nagy T, Huang Q S, Brown S M, MacLean A R, Lee V MY, Trojanowski J Q, Fraser N W. Therapy of experimental human brain tumors using a neuroattenuated herpes simplex virus mutant. Lab Invest 1995; 73: 636–648
   PubMed Web of Science ®Google Scholar
• Lasner T M, Kesari S, Brown S M, Lee V MY, Fraser N W, Trojanowski J Q. Therapy of a murine model of pediatric brain tumors using a herpes simplex virus type-1 ICP34.5 mutant and demonstration of viral replication within the CNS. J Neuropath Exp Neurol 1996; 55: 1259–1269
   PubMedGoogle Scholar
• MacLean A R, Ul-Fareed M, Robertson L, Harland J, Brown S M. Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence. J Gen Virol 1991; 72: 631–639
   PubMed Web of Science ®Google Scholar
• Markert J M, Malick A, Coen D M, Martuza R L. Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery 1993; 32: 597–603
   PubMed Web of Science ®Google Scholar
• Markovitz N S, Baunoch D, Roizman B. The range and distribution of murine central nervous system cells infected with the γ134.5- mutant of herpes simplex virus 1. J Virol 1997; 71: 5560–5569
   PubMedGoogle Scholar
• McGeoch D J, Dalrymple M A, Davison A J, Dolan A, Frame M C, McNab D, Perry L J, Scott J E, Taylor P. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 1988; 69: 1531–1574
   PubMed Web of Science ®Google Scholar
• Mohr I, Gluzman Y. A herpes virus genetic element which affects translation in the absence of the viral GADD 34 function. EMBO J 1996; 15: 4759–4766
   PubMed Web of Science ®Google Scholar
• Mineta T, Rabkin S D, Yazaki T, Hunter W D, Martuza R L. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nature Med 1995; 1: 938–943
   PubMed Web of Science ®Google Scholar
• Perng G C, Chokephaibulkit K, Thompson R L, Sawtell N M, Slanina S M, Ghiasi H, Nesburn A B, Wechsler S L. The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. J Virol 1996; 70: 282–291
   PubMed Web of Science ®Google Scholar
• Pignatti P F, Cassai E, Meneguzzi G, Chenciner N, Milanesi G. Herpes simplex virus DNA isolation from infected cells with a novel procedure. Virology 1979; 93: 260–264
   PubMed Web of Science ®Google Scholar
• Tal-Singer R, Lasner T M, Podrzucki W, Skokotas A, Leary J J, Berger S L, Fraser N W. Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol 1997; 71: 5268–5276
   Google Scholar
• Thompson R L, Stevens J G. Biological characterization of a herpes simplex virus intertypic recombinant which is completely and specifically non-neurovirulent. Virology 1983; 131: 171–179
   PubMed Web of Science ®Google Scholar
• Valyi-Nagy T, Deshmane S L, Raengsakulrach B, Nicosia M, Gesser R M, Wysocka M, Dillner A, Fraser N W. Herpes simplex virus type 1 mutant strain in 1814 establishes a unique, slowly progressing infection in SCID mice. J Virol 1992; 66: 7336–7345
   PubMed Web of Science ®Google Scholar
• Valyi-Nagy T, Gesser R M, Raengsakulrach B, Deshmane S L, Randazzo B P, Dillner A J, Fraser N W. A thymidine kinase-negative HSV-1 strain establishes a persistent infection in SCID mice that features uncontrolled peripheral replication but only marginal nervous system involvement. Virology 1994; 199: 484–490
   PubMed Web of Science ®Google Scholar