2
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Lactate Dehydrogenase-Elevating Virus Variants: Cosegregation of Neuropathogenicity and Impaired Capability for High Viremic Persistent Infection

, , , &
Pages 560-568 | Received 06 Mar 1998, Accepted 11 May 1998, Published online: 05 Aug 2009

References

  • Anderson G. W., Even C., Rowland RRR, Palmer G. A., Harty J. T., Plagemann P. GW. C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age. J Neurovirol 1995a; 1: 244–252
  • Anderson G. W., Palmer G. A., Rowland R.R.R., Even C., Plagemann P. GW. Infection of central nervous system cells by ecotropic murine leukemia virus in C58 and AKR mice and in uteio infected CE/J mice predisposes mice to paralytic infection by lactate dehydrogenase-elevating virus. J Virol 1995b; 69: 308–319
  • Anderson G. W., Palmer G. A., Rowland RRR, Even C., Plagemann P.G.W. Lactate dehydrogenase-ele-vating virus entry into central nervous system, and replication in anterior horn neurons. J Gen Virol 1995c; 76: 581–592
  • Brinton-Darnell M., Plagemann P.G.W. Structural and chemical-physical characteristics of lactate dehy-drogenase-elevating virus and its RNA. J Virol 1975; 16: 420–433
  • Chen Z., Plagemann P.G.W. Detection of lactate dehydrogenase-elevating virus in transplantable mouse tumors by biological assay and RT-PCR assays and its removal from the tumor cells. J Virol Meth 1997; 65: 227–236
  • Chen Z., Li K., Plagemann P.G.W. Selective antibody neutralization prevents neuropathogenic lactate dehydrogenase-elevating virus from causing paralytic disease in immunocompetent mice. J Neurovirol. 1998, Submitted.
  • Chen Z., Rowland RRR, Anderson G. W., Plagemann P.G.W. Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection. J Virol 1997; 71: 2913–2920
  • Faaberg K. S., Plagemann P.G.W. The envelope proteins of lactate dehydrogenase-elevating virus and their membrane topography. Virology 1995; 212: 512–525
  • Faaberg K. S., Even C., Palmer G. A., Plagemann P.G.W. Disulfide bonds between two envelope proteins of lactate dehydrogenase-elevating virus are essential for viral infectivity. J Virol 1995; 69: 613–617
  • Godeny E. K., Chen L., Kumar S. N., Methven S. L., Koonin E. V., Brinton M. A. Complete genomic sequence and phylogenetic analysis of the lactate dehydrogenase-elevating virus (LDV). Virology 1993; 194: 585–596
  • Lawrence C. B., Goldman D. A. Definition and identification of homology domains. CABIOS 1988; 4: 25–33
  • Lai M.M.C., Cavanagh D. The molecular biology of coronaviruses. Adv Virus Res 1997; 48: 1–100
  • Li K., Chen Z., Plagemann P.G.W. The neutralization epitope of lactate dehydrogenase-elevating virus is located on the short ectodomain of the primary envelope glycoprotein. Virology 1998; 242: 239–245
  • Martinez D., Brinton M. D., Tachovsky T. G., Phelps A. H. Identification of lactate dehydrogenase-elevating virus as etiological agent of genetically restricted, age-dependent polioencephalomyelitis of mice. Infect Jmmun 1980; 27: 979–987
  • Murphy W. H., Mazur J. J., Fulton S. A. Animal model for motor neuron disease. Clinical Neuroimmunology, WMH Behan, PO Behan, JA Aarli. Blackwell Scientific Publications, OxfordEngland 1987; 135–155
  • Murphy W. H., Nawrocki J. F., Pease L. R. Age-dependent paralytic viral infection in C58 mice: Possible implication in human neurologic disease. Prog Brain Res 1983; 59: 291–303
  • Nawrocki J. F., Pease L. R., Murphy W. H. Etiologic role of lactate dehydrogenase-elevating virus infection in an age-dependent neuropathic disease in C58 mice. Virology 1980; 103: 259–264
  • Palmer G. A., Kuo L., Chen Z., Faaberg K. S., Plagemann P.G.W. Sequence of genome of lactate dehydrogenase-elevating virus. Heterogeneity between strains P and C. Virology 1995; 209: 637–642
  • Plagemann PGW. Lactate dehydrogenase-elevating virus and related viruses. Virology, 3rd edition, BN Fields, DM Knipe, PM Howley. Raven Press, New York 1996; 1105–1120
  • Plagemann P.G.W., Gregory K. F., Swim H. E., Chan K. KW. Plasma lactic dehydrogenase elevating agent of mice: Distribution in tissues and effect on lactic dehydrogenase isozyme patterns. Can. J Microbiol 1963; 9: 75–86
  • Plagemann PGW, Moennig V. Lactate dehydrogenase-elevating virus, equine arteritis virus and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses. Adv Virus Res 1992; 41: 99–192
  • Plagemann P.G.W., Rowland R.R.R., Even C., Faaberg K. S. Lactate dehydrogenase-elevating virus-an ideal persistent virus?. Semin Immunopathol 1995; 17: 167–186
  • Riley V., Lilly F., Huerto E., Bardell D. Transmissible agent associated wih 26 types of experimental neoplasms. Science 1960; 132: 545–547
  • Stroop W. G., Brinton M. G. Mouse-strain-specific central nervous system lesions associated with lactate dehydrogenase-elevating virus infection. Lab Invest 1983; 49: 344–345
  • van den Broek M. T., Spöric R., Even C., Plagemann P.G.W., Hänseler E., Hengartner H., Zinkernagel R. M. Lactate dehydrogenase-elevating virus (LDV). Lifelong coexistence of virus and LDV-specific immunity. J Immunol 1997; 159: 1585–1588

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.