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Original Article

Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant

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Pages 269-280 | Received 02 Feb 1998, Accepted 13 Feb 1998, Published online: 05 Aug 2009

Reference

  • Anderson M. G., Hauer D., Sharma D. P., Joag S. V., Narayan O., Zink M. C., Clements J. E. Analysis of envelope changes acquired by SIVmac239 during neuroadapta-tion in rhesus macaques. Virology 1993; 195: 616–626
  • Bartz S. R., Rogel M. E., Emerman M. Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. Virol 1996; 70: 2324–2331
  • Binninger D., Ennen J., Bonn D., Norley S. G., Kurth R. Mutational analysis of the simian immunodeficiency virus SIVmac nef. GeneJ Virol 1991; 65: 5237–5243
  • Budka H. Neuropathology of human immunodeficiency virus infection. Brain Pathol 1991; 1: 163–175
  • Budka H., Wiley C. A., Kleihues P. HIV-associated disease of the nervous system: Review of nomenclature and proposal for neuropathology-based terminology. Brain Pathol 1991; 1: 143–152
  • Chackerian B., Haigwood N. L., Overbaugh J. Characterization of a CD4-expressing macaque cell line that can detect virus after a single replication cycle and can be infected by diverse simian immunodeficiency virus isolates. Virology 1995; 213: 386–394
  • Chakrabarti L., Hurtrel M., Maire M-A, Vazeux R., Dormont D., Montagnier L., Hurtrel B. Early viral replication in the brain of SIV-infected rhesus monkeys. Am J Pathol 1991; 139: 1273–1280
  • Daniel M. D., Letvin N. L., King N. W., Kannagi M., Sehgai P. K., Hunt R. D., Kanki P. J., Essex M., Desrosiers R. C. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 1985; 228: 1201–1204
  • Daniel M. D., Lewin N. L., Sehgai P. K., Hunsmann G., Schmidt D. K., King N. W., Desrosiers R. C. Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. Gen Virol 1987; 68: 3183–3189
  • Desrosiers R. The simian immunodeficiency viruses. Ann Rev Immunol 1990; 8: 557
  • Desrosiers R. C., Hansen-Moosa A., Mori K., Bouvier D. P., King N. W., Daniel M.I.D, Ringler D. J. Macrophage tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS. Am J Pathol 1991; 139: 29–35
  • Edinger A. L., Mankowski J. L., Doranz B. J., Margulies B. J., Lee B., Rucker J., Sharron M., Hoffman T. L., Berson J. F., Zink M. C., Hirsch V. M., Clements J. E., Doms R. W. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proc Natl Acad Sci USA 1997; 94: 14742–14747
  • Edmonson P., Murphey-Corb M., Martin L. N., Delahunty C., Heeney J., Kornfeld H., Donahue P. R., Learn G. H., Hood L., Mullins J. I. Evolution of a simian immunodeficiency virus pathogen. Virol 1998; 72: 405–414
  • Flaherty M. T., Hauer D. A., Mankowski J. L., Zink M. C., Clements J. E. Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virus. Virol 1997; 71: 5790–5798
  • Fox H. S., Gold L. H., Henriksen S. J., Bloom F. E. Simian immunodeficiency virus: A model for neu-roAIDS. Neurobiol of Disease 1997; 4: 265–274
  • Gabuzda D. H., Ho D. D., De La Monte S. M., Hirsch M. S., Rota T. R., Sobel R. A. Immunohistochernical identification of HTLV III antigen in brains of patients with AIDS. Ann Neurol 1986; 20: 289–295
  • Glass J. D., Wesselingh S. L., Seines O. A., Mcarthur J. C. Clinical-neuropathological correlation in HlV-asso-ciated dementia. Neurology 1993; 43: 2230–2237
  • Goldstein G. W., Lorris Betz A. Recent advances in understanding brain capillary function. Neurol 1983; 14: 389–395
  • Hirsch V. M., Edmonson P., Murphey-Corb M., Arbielle B., Johnson P. R., Mullins J. I. SIV adaptation to human cells. Nature 1989; 341: 572–574, (Letter)
  • Hirsch V., Adger-Johnson D., Campbell B., Goldstein S., Brown C., Elkins W. R., Montefiori D. C. A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SrVsmE543–3. Virol 1997; 71: 1608–1620
  • Joo F. 1985; 1–25
  • Kestler H.W. I.I.I, Ringler D. J., Mori K., Panicali D. L., Sehgai P. K., Daniel M. D., Desrosiers R. C. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991; 65: 651–662
  • Kimata J. T., Overbaugh J. The cytopathicity of a simian immunodeficiency virus mne variant is determined by mutations in gag and env. Virol 1997; 71: 7629–7639
  • Kodama T., Wooley D. P., Naidu Y. M., Kestler H. W., Daniel M. D., Desrosiers R. C. Significance of premature stop codons in env of simian immunodeficiency virus. Virol 1989; 63: 4709–4714
  • Koenig S., Gendleman H. E., Orenstein J. M., Del Canto M. C., Pezeshkpour G. M., Yungbiuth M., Jenotta F., Akasmit A., Martin M. A., Fauci A. S. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986; 233: 1089–1093
  • Lackner A., Smith M., Munn R., Martfeld D., Gardner M., Marx P., Dandekar S. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991; 139: 609
  • Lane T. E., Buchmeier M. J., Watry D. D., Jakubowski D. B., Fox H. S. Serial passage of microglia SIV results in selection of homogeneous env quasispecies in the brain. Virology 1995; 212: 458–465
  • Lane T. E., Buchmeier M. J., Watry D. D., Fox H. S. Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced disease. Molecular Medicine 1996; 2: 27–37
  • Lazarini F., Seilhean D., Rosenblum O., Suarez S., Conquy L., Uchihara T., Sazdovitch V., Mokhtari K., Maisonobe T., Bousin F., Katlarna C., Bricaire F., Duyckaerts C., Hauw J-J. Human immunodeficiency virus type 1 DNA and RNA load in brains of demented and nondemented patients with acquired immunodeficiency syndrome. Neurovirol 1997; 3: 299–303
  • Letvin N. L., Daniel M. D., Sehgal P. K., Desrosiers R. C., Hunt R. D., Waldron L. M., Mackey J. J., Schmidt D. K., Chalifoux L. V., King N. W. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STL-V-III. Science 1985; 230: 71–73
  • Mankowski J. L., Flaherty M. T., Spelman J. P., Hauer D. A., Didier P. J., Martin Amedee A., Murphey-Corb M., Kirstein L. M., Munoz A., Clements J. E., Zink M. C. Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neuroviru-lence. Virol 1997; 71: 6055–6060
  • Mankowski J. L., Spelman J. P., Ressetar H.G.H. G., Strandberg J. D., Laterra J., Carter D. L., Clements J. E., Zink M. C. Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro. Virol 1994; 68: 8202–8208
  • Mcarthur J. C., Hoover D.R. et al. Dementia in AIDS patients: incidence and risk factors. Neurology 1993; 43: 2245–2252
  • Moses A. V., Nelson J. A. HIV Infection of human brain capillary endothelial cells-implications for AIDS dementia. Adv in Neuroimmunol 1994; 4: 239–247
  • Moses A. V., Nelson J. A. An organ model for HIV infection of the blood-brain barrier. Technical Advances in AIDS research in the human nervous system. 20Plenum Press, New York 1995; 205–221
  • Moses A. V., Bloom F. E., Pauza C. D., Nelson J. A. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/ galactosylceramide-independent mechanism. Proc Natl Acad Sci 1993; 90: 10474–10478
  • Moses A. V., Stenglein S., Nelson J. A. HIV infection of the brain microvasculature and its contribution to the AIDS dementia complex. J Neuro AIDS 1996a; 1: 85–96
  • Moses A. V., Stenglein S. G., Strussenberg J. G., Wehrly K., Chesebro B., Nelson J. A. Sequences regulating tropism of human immunodeficiency virus type 1 for brain capillary endothelial cells map to a unique region on the viral genome. J Virol 1996b; 70: 3401–3406
  • Moses A. V., Williams S., Heneveld M. L., Strussenberg J., Rarick M., Loveless M., Bagby G., Nelson J. A. HIV infection of bone marrow endothelium reduces induction of stromal hematopoetic growth factors. Blood 1996c; 87: 919–925
  • Murray E. A., Rausch D. M., Lendvay J., Sharer L. R., Eiden L. E. Cognitive and motor impairment associated with SIV infection in rhesus monkeys. Science 1992; 255: 1246–1249
  • Naidu Y. M., Kestler H.W. I.I.I, Li Y., Butler C. V., Silva D. P., Schmidt D. K., Troup C. D., Sehgal P. K., Sonigo P., Daniel M. D., Desrosiers R. C. Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type2: persistent infection of rhesus monkeys with molecularly cloned SIVmac. Virol 1988; 62: 4691–4696
  • Navia B. A., Jordan B. D., Price R. W. The AIDS dementia complex: I. Clinical features. Ann Neurol 1986a; 19: 517–524
  • Navia B. A., Cho E-S, Petito C. K., Price R. W. The AIDS dementia complex: II. Neuropathology. Ann Neurol 1986b; 19: 525–535
  • Petito C. K., Cash K. S. Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem biain. Ann Neurol 1992; 32: 658–666
  • Power C., Kong P-A, Crawford T. O., Wesselingh S., Glass J. D., Mcarthur J. C., Trapp B. D. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann Neurol 1993; 34: 339–350
  • Prospero-Garcia O, Gold L. H., Fox H. S., Polis I., Koob G. F., Bloom F. E., Henriksen S. J. Microglia-passaged simian immunodeficiency virus induces neurophysio-logical abnormalities in monkeys. Proc Natl Acad Sci USA 1996; 93: 14158–14163
  • Rhodes R. Evidence of serum-protein leakage across the blood-brain barrier in the acquired immunodeficiency syndrome. Neuropathol Exp Neurol 1991; 50: 171–183
  • Saito Y., Sharer L.R. et al. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 1994; 44: 474–481
  • Sharer L. R. Pathology of HIV-1 infection of the central nervous system. A review. Neuropathol Exp Neurol 1992; 51: 3–11
  • Sharer L., Michaels J., Murphey-Corb M., Hu F-S, Kuebler D., Martin L., Baskin G. Serial Ppathogenesis study of SIV brain infection. J Med Primatol 1991; 20: 211
  • Sharma D. P., Anderson M., Zink M. C., Adams R. J., Donnen-Berg A. D., Clements J. E., Narayan O. Pathogenesis of acute infection in rhesus macaques with a lymphocyte-tropic strain of simian immunodeficiency virus. J Inf Dis 1992a; 166: 738–746
  • Sharma D. P., Zink M. C., Anderson M., Adams R., Clements J. E., Joag S. V., Narayan O. Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques. J Virol 1992b; 66: 3550–3556
  • Simon M., Chalifoux L., Ringler D. Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution. AIDS Res Hum Retroviruses 1992; 8: 327
  • Singer E. J., Syndulko K., Fahy-Chandon B., Schmid P., Conrad A., Tourellotte W. W. Intrathecal IgG synthesis and albumin leakage are increased in subjects with HIV-1 neurological disease. J AIDS 1994; 7: 265–271
  • Smith M., Sutjipto S., Lackner A. Intrathecal synthesis of IgG in simian immunodeficiency virus. AIDS Res Hum Retroviruses 1994; 10: 81–89
  • Spencer D. C., Price R. W. Human immunodeficiency virus and the central nervous system. Annu Rev Microbiol 1992; 46: 655–693
  • Stephens E. B., Lui Z. Q., Zhu G. W., Adany I., Joag S. V., Foresman L., Berman N. J., Narayan O. Lymphocyte-tropic simian immunodeficiency virus causes persistent infection in the brains of rhesus monkeys. Virology 1995; 213: 600–614
  • Takahashi K., Wesselingh S. L., Griffin D. E., Mcarthur J. C., Johnson R. T., Glass J. D. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996; 39: 705–711
  • Tornatore C., Chandra R., Berger J. R., Major E. O. HIV-1 infection of subcortical astrocytes in the paediatric AIDS. Neurology 1994; 44: 481–487
  • Turner R., Beckstead J. H., Warnke R. A., Wood G. S. Endothelial cells' phenotypic diversity. In situ demonstration of immunologic and enzymatic heterogeneity that correlates with specific morphologic Subtypes. Am J Clin Pathol 1987; 87: 569–575
  • Vazeux' R., Brousse N., Jarry A et al. AIDS subacute encephalitis: identification of HIV-infected cells. Am f Pathol 1987; 126: 403–410
  • Von Herrath M., Oldstone M.B.A, Fox H. S. Simian immunodeficiency virus (SlV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques. Immunol 1995; 154: 5582–5589
  • Ward J. M., O'Leary T. J., Baskin G. B., Beveniste R., Harris C. A., Nora P. L., Rhodes R. H. Immunohistochemical localization of human and immunodeficiency viral antigens in fixed tissue sections. Am J Pathol 1987; 127: 199–205
  • Watry D., Lane T. E., Streb M., Fox H. S. Transfer of neuropathogenic simian immunodeficiency virus with naturally infected microglia. Am J Pathol 1995; 146: 914–923
  • Wiley C. A., Schrier R. D., Nelson J. A., Lampert P. W., Oldstone M.B.A. Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients. Proc Natl Acad Sci USA 1986; 83: 7089–7093
  • Zhu G. W., Lui Z. Q., Joag S. V., Pinson D. M., Adany I., Narayan O., Mcclure H. M., Stephens E. B. Pathogenesis of lymphocyte-tropic and macrophage-tropic SrVmacinfection in the brain. J Neurovirol 1995; 1: 78–91

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