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Original Article

Chemokine receptors in the human brain and their relationship to HIV infection

, , , &
Pages 301-311 | Received 11 Dec 1997, Accepted 17 Feb 1998, Published online: 05 Aug 2009

Reference

  • Ahuja S. K., Murphy P. M. Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri. Biol Chem 1993; 268: 20691–20694
  • Alkhatib G., Combadiere C., Broder C. C., Feng Y., Kennedy P.E., Murphy P. M., Berger E. A. CC CKRs: a RANTES, MIP-1-alpha, MIP-1-beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272: 1955–1958
  • Asensio V. C., Campbell I. L. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. Virol 1997; 71: 7832–7840
  • Baggiolini M., Dewald B., Moser B. Human chemokines: an update. Ann Rev Immunol 1997; 15: 675–705
  • Berson J. F., Long D., Dorariz B. J., Rucker J., Jirik F. R., Doms R. W. A 7-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human-immunodeficiency-virus type 1. Virol 1996; 70: 6288–6295
  • Birkenbach M., Josefsen K., Yalamenchili R., Lenoir G., Kieff E. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. Virol 1993; 67: 2209–2220
  • Biti R., French R. F., Young J., Bennetts B., Stewart G., Liang T. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nature Medicine 1997; 3: 252–253
  • Bleul C. C., Farzan M., Choe H., Parolin C., Clarklewis I., Sodroski J., Springer T. A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996; 382: 829–833
  • Calvo C-F, Yoshimura T., Gelman M., Mallat M. Production of monocyte cherriotactic protein-1 by rat brain macrophages. Europ J Neurosci 1996; 8: 1725–1734
  • Carr M. W., Roth S. J., Luther E., Rose S. S., Springer T. A. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA 1994; 91: 3652–3656
  • Charo I. F., Myers S. J., Herman A., Franci C., Connolly A. J., Coughlin S. R. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci USA 1994; 91: 2752–2756
  • Choe H., Farzan M., Sun Y., Sullivan N., Rollins B., Ponath P. D., Wu L., Mackay C. R., Larosa G., Newman W., Gerard N., Gerard C., Sodroski J. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996; 85: 1135–1148
  • Chung C. W., Cooke R. M., Proudfoot A. E., Wells T. N. The three-dimensional solution structure of RANTES. Biochemistry 1995; 34: 9307–9314
  • Clore G. M., Gronenborn A. M. Three dimensional structures of alpha and beta chemokines. FASEB J 1995; 9: 57–62
  • Combadiere C., Ahuja S. K., Murphy P. M. Cloning, chromosomal localization, and RNA expression of a human β chemokine receptor-like gene. DNA Cell Biol 1995; 14: 673–680
  • Daugherty B. L., Siciliano S. J., De Martino J. A., Malkowitz L., Sirotina A., Springer M. S. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. Exp Med 1996; 183: 2349–2354
  • Davis C. B., Dikic I., Unutmaz D., Hill C. M., Arthos J., Siani M. A., Thompson D. A., Schlessinger J., Littman D. R. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med 1997; 186: 1793–1798
  • Deng H. K., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Dimarzio P., Marmon S., Sutton R. E., Hill C. M., Davis C. B., Peiper S. C., Schall T. J., Littman D. R., Landau N. R. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996; 381: 661–666
  • Doranz B. J., Rucker J., J Y.I., Smyth R. J., Samson M., Peiper S. C., Parmentier M., Collman R. G., Doms R. W. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3 and CKR2B as fusion cofactors. Cell 1996; 85: 1149–1158
  • Dragic T., Litwin V., Allaway G. P., Martin S. R., Huang Y., Nagashima K. A., Cayanan C., Maddon P. J., Koup R. A., Moore J. P., Paxton W. A. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381: 667–673
  • Endres M. J., Clapham P. R., Marsh M., Ahuja M., Davis Turner J., Mcknight A., Thomas J. F., Stoebenau-Haggarty B., Choe S., Vance P. J., Wells T.N.C, Power C. A., Sutterwala S. S., Doms R. W., Landau N. R. et al. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 1996; 87: 745–756
  • Farber J. M. HuMig: a new human member of the chemokine family of cytokines. Biochem Biophys Res Commun 1993; 192: 223–230
  • Federsppiel B., Melhado I. G., Duncan A.M.V, Delaney A., Schappert K., Clark-Lewis I, Jirik F. R. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-trans-membrane segment (7-TMS) receptor isolated from human spleen. Genomics 1993; 16: 707–712
  • Feng Y., Broder C. C., Kennedy P. E., Berger E. A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G-protein-coupled receptor. Science 1996; 211: 872–877
  • Gao J. L., Kuhns B. D., Tiffany H. L., Mcdermott D., Li X., Francke U., Murphy P. M. Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. Exp Med 1993; 177: 1421–1427
  • Gao J. L., Murphy P. M. Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor. Biol Chem 1994; 269: 28539–28542
  • Gayle R.B.D, Sleath P. R., Srinivason S., Birks C. W., Weerawama K. S., Cerretti D. P., Kozlosky C. J., Nelson N., Vanden Bos T., Beckmann M. P. Importance of the amino terminus of the interleukin-8 receptor in ligand interactions. J Biol Chem 1993; 268: 7283–7289
  • Ghirinkar R. S., Lee Y. L., He T. R., Eng L. F. Chemokine expression in rat stab wound brain injury. Neurosci Res 1996; 46: 727–733
  • Glabinski A. R., Balasingam M., Tani M., Kunkel S. L., Strieter R. M., Yong V. M., Ransohoff R. M. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. Immunol 1996; 156: 4363–4368
  • Glabinski A. R., Tani M., Tuohy V. K., Tuthill R., Ransohoff R. M. Central nervous system chemokine mRNA accumulation follows initial leukocyte entry at the onset of acute murine experimental autoimmune encephalomyelitis. Brain Behav Immun 1995; 9: 315–330
  • Harrison J. K., Barber C. M., Lynch K. R. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Neurosci Lett 1994; 169: 85–89
  • He J., Chen Y., Farzan M., Choe H., Ohagen A., Gartner S., Busciglio J., Yang X., Hofmann W., Newman W., Mackay C. R., Sodroski J., Gabuzda D. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 1997; 385: 645–649
  • Heesen M., Berman M. A., Benson J. D., Gerard E. Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor. J Immunol 1996a; 157: 5455–5460
  • Heesen M., Berman M. A., Hopken U. E., Gerard N. P., Dorf M. E. Alternate splicing of mouse fusin CXC chemokine receptor-4 - Stromal cell-derived factor-1 alpha is a ligand for both CXC chemokine receptor-4 isoforms. J Immunol 1996b; 158: 3561–3564
  • Hesselgesser J., Halks-Miller M., Delvecchio V., Peiper S. C., Hoxie J., Kolson D. L., Taub D., Horuk R. CD4-independent association between HIV-1 gpl20 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 1997; 7: 112–121
  • Holmes W. E., Lee J., Kuang W. J., Rice G. C., Wood W. I. Structure and functional expression of a human interleukin-8 receptor. Science 1991; 253: 1278–1280
  • Horuk R., Martin A., Hesselcesser J., Hadley T., Lu Z., Wang Z., Peiper S. C. The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. Leukoc Biol 1996; 59: 29–38
  • Horuk R., Martin A. W., Wang Z., Schweitzer L., Gerassi-Mides A., Guo H., Lu Z., Hesselgesser J., Perez H. D., Kim J., Parker J., Hadley T.J., Peiper S. C. Expression of chemokine receptors by subsets of neurons in the central nervous system. Immunol 1997; 158: 2882–2890
  • Ishizuka K., Igata-Yi R., Kimura T., Hieshima K., Kukita T., Kin Y., Misumi Y., Yamamoto M., Nomiyama H., Miura R., Takamatsu J., Katsuragi S., Miyakawa T. Expression and distribution of CC chemokine macrophage inflammatory protein-1 alpha/LD78 in the human brain. Neuroreport 1997; 8: 1215–1218
  • Jose P. J., Griffiths-Johnson D. A., Collins P. D., Walsh D. T., Moqbel R., Totty N. F., Truong O., Hsuan J. J., Williams T. J. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 1994; 179: 881–887
  • Lane T. E., Asenio V. C., Yu N., Paoletti A. D., Campbell I. L., Buchmeier M. J. Dynamic regulation of α and β chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. J Immunol 1998; 160: 970–978
  • Lapham C. K., Ouyang J., Chandrasekhar B., Nguyen N. Y., Dimitrov D. S., Golding H. Evidence for cell-surface association between fusin and the CD4-GP120 complex in human cell-lines. Science 1996; 274: 602–605
  • Larosa G. J., Thomas K. M., Kaufmann M. E., Mark R., White M., Taylor L., G G., Witt D., Navarro J. Aminoterminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity. Biol Chem 1992; 267: 25402–25406
  • Lavi E., Strizki J. M., Ulrich A. M., Zhang W., Fu L., Wang Q., O'Connor M., Hoxie J. A., GonzÁLez-Scarano F. CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types including microglia and neurons. Am J Pathol 1997; 151: 1035–1042
  • Levy J. A. HIV pathogenesis and long-term survival. AIDS 1993; 7: 1401–1410
  • Liao F., Rabin R. L., Yannelli J. R., Koniaris L. G., Vanguri P., Farber J. M. Human Mig chemokine: biochemical and functional characterization. Exp Med 1995; 182: 1301–1314
  • Liu R., Paxton W. A., Choe S., Ceradini D., Martin S. R., Horuk R., Macdonald M. E., Stuhlmann H., Koup R. A., Landau N. R. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996; 86: 367–377
  • Lodi P. J., Garrett D. S., Kuszewski J., Tsang M. L., Weatherbee J. A., Leonard W. J., Gronenborn A. M., Clore G. M. High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR. Science 1994; 263: 1762–1767
  • Loetscher M., Geiser T., O'Reilly T., Zwahlen R., Baggiolini M., Moser B. Cloining of a human seven-transmembrane domain receptor LESTR, that is highly expressed in leukocytes. J Biol Chem 1994a; 269: 232–237
  • Loetscher P., Seitz M., Clark-Lewis I., Baggiolini M., Moser B. Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes. FASEB J 1994b; 1055–1060
  • Loetscher M., Gerber B., Loetscher P., Jones S. A., Piali L., Clark-Lewis I., Baggiolini M., Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. Exp Med 1996; 184: 963–969
  • Luster A. D., Ravetch J. V. Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). Exp Med 1987; 166: 1084–1097
  • Matsumoto M., Hidaka K., Akiho H., Tada S., Okada M., Yamaguchi T. Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmem-brane receptor, APJ, in human brain. Neurosci Lett 1996; 219: 119–122
  • Muller-Ladner U., Jones J. L., Wetsel R. A., Gay S., Raine C. S., Barnum S. R. Enhanced expression of chemotactic receptors in multiple sclerosis lesions. Neurol Sci 1996; 144: 135–141
  • Murphy P. M., Tiffany H. L. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science 1991; 253: 1280–1283
  • Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., Yoshida N., Kikutani H., Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996; 382: 635–638
  • Neote K., Digregorio D., Mak J. Y., Horuk R., Schall T. J. Molecular cloning, functional expression and signaling characteristics of a C-C chemokine receptor. Cell 1993; 72: 415–425
  • Nuovo G. J., Alfieri M. L. AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines. Molec Med 1996; 2: 358–366
  • O'Brien T. R., Winkler C., Dean M., Nelson J.A.E, Carrington M., Michael N. L., White G. C. HIV-1 infection in a man homozygous for CCR5 Delta 32. Lancet 1997; 349: 1219–1219
  • Oberlin E., Amara A., Bacheleile F., Bessia C., Virelizier J. L., Arenzanaseisdedos F., Schwartz O., Heard J. M., Clarkle-Wis I., Legler D. F., Loetscher M., Baggiolini M., Moser B. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 1996; 382: 833–835
  • Pan Y., Lloyd C., Zhou H., Dolich S., Deeds J., Gonzalo J. A., Vath J., Gosselin M., Ma Y. Y., Dussault B., Woolf E., Alperin G., Culpepper J., Gutierrez-Ramos J. C., Gearing D. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 1997; 389
  • Paxton W. A., Martin S. R., Tse D., O'Brien T. R., Skurnick J., Van Devanter N. L., Padian N., Braun J. F., Kotler D. P., Wolinsky S. M., Koup S. A. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Medicine 1996; 2: 412–417
  • Pleskoff O., Treboute C., Brelot A., Heveker N., Seman M., Alizon M. Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry. Science 1997; 276: 1874–1878
  • Ponath P. D., Qin S., Post T. W., Wang J., Wu L., Gerard N. P., Newman W., Gerard C., Mackay C. R. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. Exp Med 1996; 183: 2437–2448
  • Power C. A., Mever A., Nemeth K., Bacon K. B., Hoogewerf A. J., Proudfoot A. E., Wells T. N. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. Biol Chem 1995; 270: 19495–19500
  • Price R. N., Brew B., Sidtis J., Rosenblum U., Schneck A. C., Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementiacomplex. Science 1988; 939: 586–592
  • Rimland J., Xin W., Sweetnam P., Saijoh K., Nestler E. J., Duman R. S. Sequence and expression of a neuropeptide Y receptor cDNA. Molec Pharm 1991; 40: 869–875
  • Roth S. J., Carr M. W., Springer T. A. C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. Eur J Immunol 1995; 25: 3482–3288
  • Rucker J., Samson M., Dorariz B. J., Libert F., Berson J. F., Yi Y. J., Smyth R. J., Collman R. G., Broder C. C., Vassaxt G., Doms R. W., Parmentier M. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 1996; 87: 437–446
  • Samson M., Labbe O., Mollereau C., Vassart G., Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 1996a; 35: 3362–3367
  • Samson M., Libert F., Doranz B. J., Rucker J., Liesnard C., Farber C. M., Saragosti S., Lapoumeroulie C., Cognaux J., Forceilie C., Muyldermans G., Verhofstede C., Burton-Boy G., Georges M., Imai T. et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996b; 382: 722–725
  • Sasseville V. G., Smith M. M., Mackay C. R., Pauley D. R., Mansfield K. G., Ringler D. J., Lackner A. A. Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am J Pathol 1996; 149: 1459–1467
  • Schmidtmayerova H., Nottet H.S.L.M., Nuovo G., Raabe T., Flanagan C. R., Dubrovsky L., Gendelman H. E., Cerami A., Bukrinsky M., Sherry B. Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: Implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996; 93: 700–704
  • Smith M. W., Dean M., Carrington M., Winkler C., Huttley G. A., Lomb D. A., Goedert J. J., O'Brien T. R., Jacobson L. P., Kaslow R., Buchbinder S., Vittinghoff E., Vlahov D., Hoots K., Hilgartner M. W. et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Science 1997; 277: 959–965
  • Sprenger H., Rosier A., Tonn P., Braune H. J., Huffmann G., Gemsa D. Chemokines in the cerebrospinal fluid of patients with meningitis. Clin Immunol Immutiopathol 1996; 80: 155–161
  • Takahashi K., Wesselmgh S. L., Griffin D. E., Mcarthur J. C., Johnson R. T., Glass J. D. Localization of HIV- 1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann Neurol 1996; 39: 705–711
  • Tanabe S., Heesen M., Berman M. A., Fischer M. B., Yoshizawa I., Luo Y., Dorf M. E. Murine astrocytes express a functional chemokine receptor. J Neurosci 1997a; 17: 6522–6528
  • Tanabe S., Heesen M., Yoshizawa I., Berman M. A., Luo Y., Bleul C. C., Springer T. A., Okuda K., Gerard N., Dorf M. E. Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J Immunol 1997b; 159: 905–911
  • Taub D. D., Lloyd A. R., Conlon K., Wang J. M., Ortaldo J. R., Harada A., Matsushima K., Kelvin D. J., Oppenheim J. J. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. Exp Med 1993; 177: 1809–1814
  • Taub D. D., Sayers T. J., Carter C. R., Ortaldo J. R. Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis. Immunol 1995; 155: 3877–3888
  • Theodorou I., Meyer L., Magierowska M., Katlama C., Rouzioux C. HIV-1 infection in an individual homozygous for CCR5 Delta 32. Lancet 1997; 349: 1219–1220
  • Trkola A., Dragic T., Arthos J., Binley J. M., Olson W. C., Allaway G. P., Cheng-Mayer C., Robinson J., Maddon P. J., Moore J. P. CD-I-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 1996; 384: 184–187
  • Uguccioni M., Loetscher P., Forssmann U., Dewald B., Li H., Lima S. H., Li Y., Kreider B., Garotta G., Thelen M., Baggiolini M. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Exp Med 1996; 183: 2379–2384
  • Van Damme J., Proost P., Lenaerts J. P., Opdenakker G. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. Exp Med 1992; 176: 59–65
  • Vanguri P. Interferon-gamma-inducible genes in primary glial cells of the central nervous system: comparisons of astrocytes with microglia and Lewis with brown Norway rats. J. Neuroimmunol 1995; 56: 35–43
  • Watkins B. A., Dorn H. H., Kelly W. B., Armstrong R. C., Potts B. J., Michaels F., Kufta C. V., Dubois-Dalcq M. Specific tropism of HIV-1 for Microglial cells in primary human brain cultures. Science 1990; 249: 549–53
  • Winkler C., Modi W., Smith M. W., Nelson G. W., Wu X. Y., Carrington M., Dean M., Honjo T., Tashiro K., Yabe D., Buchbinder S., Vittinghoff E., Goedert J. J., O'Brien T. R., Jacobson L. P. et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene. variant 1998; 279: 389–393
  • Wong M-L, Xin W. W., Duman R. S. Rat LCR1: cloning and cellular distribution of a putative chemokine receptor in brain. Molec Psychiat 1996; 1: 133–140
  • Wu L., Gerard N. P., Wyatt R., Choe H., Parolin C., Ruffing N., Borsetti A., Cardoso A. A., Des Jardin E., Newman W., Gerard C., Sodroski J. CD4-induced interaction of primary HIV-1 gpl20 glycoproteins with the chemokine receptor CCR-5. Nature 1996; 384: 179–183
  • Xia M., Qin S., Mcnamara M., Mackay C, Hyman B. T. Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease. Am. J. Pathol 1997; 150: 1267–1274

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