A mechanism for selective induction of 2′-5′ oligoadenylate synthetase, anti-viral state, but not MHC Class I genes by interferon-beta in neurons

References

• Bandyopadhyay S K, Leonard G T, Jr, Bandyopadhyay T, Stark G R, Sen G C. Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3. J Biol Chem 1995; 270: 19624–19629
   PubMedGoogle Scholar
• Benech P, Mory Y, Revel M, Chebeth J. Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase based on cDNAs and gene sequences. EMBO 1985; 4: 2249–2256
   PubMed Web of Science ®Google Scholar
• Benech P, Vigneron M, Peretz D, Revel M, Chebath J. Interferon-responsive regulatory elements in the promoter of the human 2′, 5′-oligo(A) synthetase gene. Mol Cell Biol 1987; 7: 4498–4504
   PubMedGoogle Scholar
• Bluyssen H A R, Durbin J E, Levy D E. ISGF37, p48, a specificity switch for interferon activated transcription factors. Cytokine and Growth Factor Reviews 1997; 7: 11–17
   Google Scholar
• Chang C H, Hammer J, Loh J E, Fodor W L, Flavell R A. The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1). Immunogenetics 1992; 35: 378–384
   PubMedGoogle Scholar
• Chomczynski P, Sacci N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156–159
   PubMed Web of Science ®Google Scholar
• Coccia E M, Romeo G, Nissim A, Marziali G, Albertini R, Affabris E, Battistini A, Fiorucci G, Orsatti R, Rossi G B, Chebath J. A hill-length murine 2–5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virol 1990; 179: 228–233
   PubMedGoogle Scholar
• Coccia E M, Marziali G, Stellacci E, Perrotti E, Ilari R, Orsatti R. Cells resistant to interferon-beta respond to interferon-gamma via the Stat1-IRF-1 pathway. Virol 1995; 211: 113–122
   PubMed Web of Science ®Google Scholar
• Cohen B, Peretz D, Vaiman K, Benech P, Chebath J. Enhancer-like interferon responsive sequences of the human and murine (2′- 5′) oligoadenylate synthetase gene promoters. EMBO J 1988; 7: 1411–1419
   PubMedGoogle Scholar
• Decker T, Kovarik P, Meinke A. GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression. J Interferon and Cytokine Res 1997; 17: 121–134
   PubMed Web of Science ®Google Scholar
• Drew P D, Lonergan M, Goldstein M E, Lampson L A, Ozato K, McFarlin D E. Regulation of MHC class I and β2-microglobulin gene expression in human neuronal cells. J Immunol 1993; 150: 3300–3310
   PubMedGoogle Scholar
• Drew P D, Franzoso G, Becker K G, Bours V, Carlson L M, Siebenlist U, Ozato K. NFκB and interferon regulatory factor 1 physically interact and synergistically induce major histocompatability class I gene expression. J Interferon and Cytokine Res 1995a; 15: 1037–1045
   PubMed Web of Science ®Google Scholar
• Drew P D, Franzoso G, Carlson L M, Biddison W E, Siebenlist U, Ozato K. Interferon regulatory factor-2 physically interacts with NF-kapp a B in vitro and inhibits NF-kapp a B induction of major histo-caompatability class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells. J Neuroimmunol 1995b; 63: 157–162
   PubMedGoogle Scholar
• Durbin J E, Hackenmiller R, Simon M C, Levy D E. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996; 84: 443–450
   PubMed Web of Science ®Google Scholar
• Fan C -M, Maniatis T. Two different virus-inducible elements are required for human β-interferon gene regulation. EMBO J 1989; 8: 101–110
   PubMedGoogle Scholar
• Fiette L, Aubert C, Muller U, Huang S, Aguet M, Brahic M, Bureau J -F. Theiler's virus infection of 129Sv mice that lack the interferon α/β or interferon γ receptors. J Exp Med 1995; 181: 2069–2076
   PubMed Web of Science ®Google Scholar
• Fried M, Crothers D M. Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res 1981; 9: 6505–6525
   PubMed Web of Science ®Google Scholar
• Fu X -Y, Schindler C, Improta T, Aebersold R, Darness J E, Jr. The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 1992; 89: 7840–7843
   PubMed Web of Science ®Google Scholar
• Garner M, Rezvin A. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: app lications to components of the E. coli lactose operon regulatory system. Nucleic Acids Res 1981; 9: 3047–3060
   PubMed Web of Science ®Google Scholar
• Ghosh S K, Kusari J, Bandyopadhyay S K, Samanta H, Kumar R, Sen G C. Cloning, sequencing, and expression of two murine 2′- 5′-oligoadenylate synthetases. Structure-function relationships. J Biol Chem 1991; 266: 15293–15299
   PubMed Web of Science ®Google Scholar
• Gorman C, Moffat L, Howard B. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 1982; 2: 1044–1051
   PubMed Web of Science ®Google Scholar
• Gribaudo G, Lembo D, Cavallo G, Landolfo S, Lengyel P. Interferon action: binding of viral RNA to the 40-kilodalton 2′-5′-oligoadenylate synthetase in inter-feron-treated HeLa cells infected with encephalomyocarditis virus. J Virol 1991; 65: 1748–1757
   PubMedGoogle Scholar
• Harada H, Fukita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 1989; 58: 729–739
   PubMed Web of Science ®Google Scholar
• Harada H, Willison K, Sakakibara J, Miayamoto M, Taniguchi T. Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell 1990; 63: 303–312
   PubMed Web of Science ®Google Scholar
• Harada H, Takahashi E, Itoh S, Harada K, Hori T A, Taniguchi T. Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. Mol Cell Biol 1994; 14: 1500–1509
   PubMed Web of Science ®Google Scholar
• Hobart M, Ramassar V, Goes N, Urmson J, Halloran P H. IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo. J Immunol 1997; 158: 4260–4269
   PubMed Web of Science ®Google Scholar
• Horvath C M, Darnell J E, Jr. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionallv active Stat1 protein. J Virol 1996; 70: 647–650
   PubMed Web of Science ®Google Scholar
• Hovanessian A G. Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2′, 5′-oligoadenylate synthetases. J Interferon Res 1991; 11: 199–205
   PubMedGoogle Scholar
• Ichii Y, Fukunaga R, Shiojiri S, Sokawa Y. Mouse 2–5A synthetase cDNA: nucleotide sequence and comparison to human 2–5A synthetase. Nucleic Acids Res 1986; 14: 10117
   Google Scholar
• Ihle J N. STATS: Signal transducers and activators of transcription. Cell 1996; 84: 331–334
   PubMed Web of Science ®Google Scholar
• Israel A, Le Bail O, Hatat D, Piette J, Kieran M, Logeat F, Wallach D, Fellous M, Kourilsky P. TNF stimulates expression of mouse MHC class I genes by inducing an NF kapp a B-like enhancer binding activity which displaces constitutive factors. EMBO J 1989; 8: 3793–3800
   PubMedGoogle Scholar
• Joly E, Mucke L, Oldstone M B A. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 1991; 253: 1283–1285
   PubMedGoogle Scholar
• Joly E, Oldstone M B. Neuronal cells are deficient in loading peptides onto MHC class I molecules. Neuron 1992; 8: 1185–1190
   PubMedGoogle Scholar
• Khabar K S A, Al-Zoghaibi F, Dzimiri M, Taha M, Al-Tuwaijri A, Al-Ahda N. MTS interferon assay: A simplified cellular dehydrogenase assay for interferon activity using a water-soluble tetrazolium salt. J Interferon and Cytokine Res 1996; 16: 31–33
   Google Scholar
• Korber B, Mermod N, Hood L, Stroynowski I. Regulation of gene expression by interferons: control of H-2 promoter responses. Science 1988; 239: 1301–1306
   Google Scholar
• Kumar A, Yang Y -L, Flati V, Der S, Kadereit S, Deb A, Haque J, Reis L, Weissman C, Williams B R G. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRG-1 and NF.-KB. EMBO J 1997; 16: 406–416
   PubMed Web of Science ®Google Scholar
• Kumar R, Choubey D, Lengyel P, Sen G C. Studies on the role of the 2′-5′-oligoadenylate synthetase-RNase L pathway in beta interferon-medaited inhibiton of encephalomyocarditis virus replication. J Virol 1988; 62: 3175–3181
   PubMedGoogle Scholar
• Landolfo S, Gribaudo G, Angeretti A, Gariglio M. Mechanisms of viral inhibition by interferons. Pharmac Ther 1995; 65: 415–442
   PubMed Web of Science ®Google Scholar
• Lee K A, Bindereif A, Green M R. A small-scale procedure for preparation of nuclear extracts that supp ort efficient transcription and pre-mRNA splicing. Gene Anal Tech 1988; 5: 22–31
   PubMedGoogle Scholar
• Lenardo M J, Fan C -M, Maniatis T, Baltimore D. The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 1989; 57: 287–294
   PubMed Web of Science ®Google Scholar
• Levine B, Hardwick J M, Trapp B D, Crawford T O, Bollinger R C, Griffin D E. Antibody-mediated clearance of alphavirus infection from neurons. Science 1991; 254: 856–860
   PubMed Web of Science ®Google Scholar
• Levine B, Goldman J E, Jiang H H, Griffin D E, Hardwick J M. BCL-2 protects mice against fatal alpha-virus encephalitis. Proc Natl Acad Sci USA 1996; 93: 4810–4815
   PubMedGoogle Scholar
• Levy D E, Kessler D S, Pine R, Reich N, Darnell J E, Jr. Interferon-induced nuclear factors that bind a shared promoter element correlate with psoitive and negative transcriptional control. Genes & Development 1988; 2: 383–393
   PubMed Web of Science ®Google Scholar
• Lew D J, Decker T, Strehlow I, Darnell J E. Overlapp ing elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol Cell Biol 1991; 11: 182–191
   PubMed Web of Science ®Google Scholar
• Massa P T, Hirschfeld S, Levi B -Z, Quigley L A, Ozato K, McFarlin D E. Expression of major histocompatibility complex (MHC) class I genes in astrocytes correlates with the presence of nuclear factors that bind to constitutive and inducible enhancers. J Neoroimmunol 1992; 41: 35–42
   PubMedGoogle Scholar
• Massa P T, Ozato K, McFarlin D E. Cell type-specific regulation of major histocompatibility complex (MHC) class I gene expression in astrocytes, oligodendrocytes, and neurons. Glia 1993; 8: 201–207
   PubMedGoogle Scholar
• Massa P T, Wu H. Interferon regulatory factor element and interferon regulatory factor 1 in the induction of major histocompatibility complex class I genes in neural cells. J Interferon and Cytokine Res 1995; 15: 799–810
   Google Scholar
• McCutchan J H, Pagano J G. Enhancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylamino-ethyl-dextran. J Natl Cancer Inst 1968; 41: 351–356
   PubMed Web of Science ®Google Scholar
• Meier E, Schousboe A. Differences between GABA receptor binding to membranes from cerebellum during postnatal development and from cultured cerebellar granule cells. Dev Neurosci 1982; 5: 546–553
   Google Scholar
• Miyazaki J -I, App ella E, Ozato K. Negative regulation of the major histocompatibility class I gene in undifferentiated embryonal carcinoma cells. Proc Natl Acad Sci USA 1986; 83: 9537–9541
   PubMedGoogle Scholar
• Mokhtarian F, Wesselingh S L, Choi S, Maeda A, Griffin D E, Sobel R A. Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis. J Neuroimmunol 1996; 66: 11–22
   Google Scholar
• Mucke L, Oldstone M B. The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). J Neuroimmunol 1992; 36: 193–198
   Google Scholar
• Oldstone M B A, Blount P, Southern P J, Lampert P W. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature 1986; 321: 239–243
   PubMed Web of Science ®Google Scholar
• Oldstone M B A. How viruses escape from cytotoxic T lymphocytes - molecular parameters and players. Virol 1997; 234: 179–185
   PubMed Web of Science ®Google Scholar
• Rail G F, Mucke L, Oldstone M B A. Consequences of cytotoxic T lymphocyte interactions with major histocompatibility complex class I-expressing neurons in vivo. J Exp. Med 1995; 182: 1201–1212
   Google Scholar
• Reed L J, Muench M. A simple method for estimating fifty percent endpoints. Amer J Hyg 1983; 27: 493–497
   Google Scholar
• Reich N C, Darnell J E, Jr. Differential binding of interferon-induced factors to an oligoncuelotide that mediates transcriptional activation. Nucleic Acids Res 1989; 17: 3415–3424
   PubMedGoogle Scholar
• Rutherford M N, Hannigan G E, Williams B R. Interferon-induced binding of nuclear factors to promoter elements of the 2–5A synthetase gene. EMBO J 1988; 7: 751–759
   PubMed Web of Science ®Google Scholar
• Rutherford M N, Kumar A, Nissim A, Chebath J, Williams B R. The murine 2–5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res 1991; 19: 1917–1924
   PubMedGoogle Scholar
• Rutherford M N, Kumar A, Coulombe B, Skup D, Carver D H, Williams B R G. Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection. J Interferon and Cytokine Res 1996; 16: 507–510
   PubMedGoogle Scholar
• Saunders M E, Gewert D R, Tugwell M E, McMahon M, Williams B R F. Human 2–5A synthetase: characterization of a novel cDNA and corresponding gene structure. EMBO J 1985; 4: 1761–1768
   PubMed Web of Science ®Google Scholar
• Schijns V E, Van der Neut R, Haagmans B L, Bar D R, Schellekens H, Horzinek M C. Tumor necrosis factor-alpha, interferon-gamma and interferon-beta exert antiviral activity in nervous tissue cells. J Gen Virol 1991; 72: 809–815
   Google Scholar
• Sedgwick J D, Domes R. The immune system response to viral infection of the CNS. Sem Neurosci 1991; 3: 93–100
   Google Scholar
• Segars J H, Nagata T, Bours V, Medin J A, Franzoso G, Blanco J C, Drew P D, Becker K G, An J, Tang T, Stephany D A, Neel B, Siebenlist U, Ozato K. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-κB (p50-p65) and retinoic acid receptor-beta-retinoid X receptor beta heterodimers. Mol Cell Biol 1993; 13: 6157–6169
   PubMed Web of Science ®Google Scholar
• Sen G C, Ransohoff R M. Interferon-induced antiviral actions and their regulation. Adv Virus Res 1993; 42: 57–102
   PubMed Web of Science ®Google Scholar
• Sriram S, Topham D J, Huang S K, Rodriguez M. Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies. J Virol 1989; 63: 4242–4248
   Google Scholar
• Steinhoff U, Muller U, Schertler A, Hengartner H, Aguet M, Zinkernagel R M. Antiviral protection by vesicular stomatitus virus-specific antibodies in alpha/beta interferon receptor-deficient mice. J Virol 1995; 69: 2153–2158
   PubMed Web of Science ®Google Scholar
• Tanaka N, Kawakami T, Taniguchi T. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol Cell Biol 1993; 13: 4531–4538
   PubMed Web of Science ®Google Scholar
• Tucker P C, Griffin D E, Choi S, Bui N, Wesselingh S. Inhibition of nitric oxide synthesis increases mortality in sindbis virus encephalitis. J Virol 1996; 70: 3972–3977
   Google Scholar
• Veals S A, Maria Santa T, Levy D E. Two domains of ISGF3γ that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity. Mol Cell Biol 1993; 13: 196–206
   PubMed Web of Science ®Google Scholar
• Ward L A, Massa P T. Neuron-specific regulation of major histocompatibility complex class I, interferon-β, and anti-viral state genes. J Neuroimmunol 1995; 58: 145–155
   Google Scholar
• Williams B R G, Golgher R R, Brown R E, Gilbert C S, Kerr I M. Natural occurrence of 2–5A in interferon-treated EMC virus-infected L cells. Nature 1979; 282: 582–586
   PubMed Web of Science ®Google Scholar
• Yamamoto H, Lamphier M S, Fujita T, Taniguchi T, Harada H. The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domain. Oncogene 1994; 9: 1423–2428
   PubMedGoogle Scholar