Neurotoxicity of CSF from HIV-infected humans

References

• Adamson D C, Wildemann B, Sasaki M, Glass J D, MacArthur J C, Christov V I, Dawson T M, Dawson V L. Immunologic NO synthetase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 1996; 274: 1917–1921
   PubMed Web of Science ®Google Scholar
• Bossi P, Dupin N, Coutellier A, Bricaire F, Lubetzki C, Katlama C, Calvez V. The level of human immunodeficiency virus (HIV) type 1 RNA in cerebrospinal fluid as a marker of HIV encephalitis. Clin Infect Dis 1998; 26: 1072–1073
   Google Scholar
• Brenneman D, Westbrook G, Fitgerald S, Ennis D, Elkins K, Ruff M, Pert C. Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 1988; 335: 639–642
   PubMed Web of Science ®Google Scholar
• Brew B J, Pemberton L, Cunningham P, Law M G. Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage. J Infect Dis 1997; 175: 963–966
   PubMed Web of Science ®Google Scholar
• Conrad A J, Schmid P, Syndulko K, Singer E J, Nagra R M, Russell J J, Tourtellotte W W. Quantifying HIV-1 RNA using the polymerase chain reaction on cerebrospinal fluid and serum of seropositive individuals with and without neurologic abnormalities. J Acquir Immune Defic Syndr Hum Retrovir 1995; 10: 425–435
   Google Scholar
• Dawson V, Dawson T, Uhl G, Synder S. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci USA 1993; 90: 3256–3259
   PubMed Web of Science ®Google Scholar
• Dreyer K, Kaiser P, Offerman J, Lipton S. HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990; 248: 364–367
   PubMed Web of Science ®Google Scholar
• Ellis R J, Hsia K, Spector S A, Nelson J A, Heaton R K, Wallace M R, Abramson I, Atkinson J H, Grant I, McCutchan J A. Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. HIV Neurobehavioral Research Center Group. Ann Neurol 1997; 42: 679–688
   PubMed Web of Science ®Google Scholar
• Elovaara I, Poutianien E, Raininko R, Valanne L, Virta A, Valle S, Lahdevirta J, Iivanainen M. Mild brain atrophy in early HIV infection: the lack of association with cognitive deficits and HIV-specific intrathecal immune response. J Neurol Sci 1990; 99: 121–136
   PubMed Web of Science ®Google Scholar
• Ensoli B, Buonaguro L, Barillari G, Fiorelli V, Gendelman R, Morgan R A, Wingfield P, Gallo R C. Release, uptake and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 1993; 67: 277–287
   PubMed Web of Science ®Google Scholar
• Epstein L, Gendelman H, Lipton S. Human immunodeficiency virus-1 neuropathogenesis. AIDS and the Nervous System, J R Berger, R M Levy. Lippincott-Raven, Philadelphia 1997; 59–75
   Google Scholar
• Everall I, Luthert P, Lantos P. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991; 337: 1119–1121
   PubMed Web of Science ®Google Scholar
• Gelbard H A, Nottet H S, Swindells S, Jett M, Dzenko K A, Genis P, White R, Wang L, Choi Y B, Zhang D, Lipton S A, Tourtellotte W W, Epstein L G, Gendelman H E. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 1994a; 68: 4628–4635
   PubMed Web of Science ®Google Scholar
• Gelbard H A, Dzenko K, Diloreto D, Delcerro C, Epstein L G. Neurotoxic effects of tumor necrosis factor in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev Neurosci 1994b; 15: 418–422
   Google Scholar
• Giulian D, Yu J, Li X, Tom D, Li J, Wendt E, Lin S-N, Schwarcz R, Noonan C. Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain. J Neurosci 1996; 16: 3139–3153
   PubMed Web of Science ®Google Scholar
• Glass J D, Fedor H, Wesselingh S L, McArthur J C. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995; 38: 755–762
   PubMed Web of Science ®Google Scholar
• Gray F, Haug H, Chimelli L, Geny C, Gaston A, Scaravilli F, Budka H. Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy. Acta Neuropathol (Berl) 1991; 82: 229–233
   PubMed Web of Science ®Google Scholar
• Grimaldi L M, Martino G V, Franciotta D M, Brustia R, Castagna A, Pristera R, Lazzarin A. Elevated alpha-tumor necrosis factor levels in spinal fluid from HIV-1 infected patients with central nervous system involvement. Ann Neurol 1991; 29: 21–25
   PubMed Web of Science ®Google Scholar
• Heyes M P, Brew B, Martin A, Markey S P, Price R W, Bhalla R B, Salazar A. Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome. Adv Exp Med Biol 1991a; 294: 687–690
   PubMedGoogle Scholar
• Heyes M P, Brew B J, Martin A, Price R W, Salazar A M, Sidtis J J, Yergey J A, Mouradian M M, Sadler A E, Kelip J, Rubinow D, Markey S P. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 1991b; 29: 202–209
   PubMed Web of Science ®Google Scholar
• Holliday J, Parsons K, Curry J, Lee S Y, Gruol D L. Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture. Brain Res 1995; 673: 141–148
   Google Scholar
• Ketzler S, Weis S, Haug H, Budka H. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol 1990; 80: 92–94
   PubMed Web of Science ®Google Scholar
• Lane J H, Sasseville V G, Smith M O, Vogel P, Pauley D R, Heyes M P, Lackner A A. Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation. J NeuroVirol 1996; 2: 423–432
   PubMed Web of Science ®Google Scholar
• Lendhardt T, Super M, Wiley C. Neuropathological changes in an asymptomatic HIV seropositive man. Ann Neurol 1988; 23: 209–210
   Google Scholar
• Lipton S, Sucher N, Kaiser P, Dreyer E. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991; 7: 111–118
   PubMed Web of Science ®Google Scholar
• Lipton S. Requirement of macrophages in neuronal injury induced by HIV envelope protein gp120. NeuroReport 1992a; 3: 913–915
   PubMed Web of Science ®Google Scholar
• Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor?. TINS 1992b; 15: 75–80
   PubMed Web of Science ®Google Scholar
• Magnuson D, Knudsen B, Geiger J, Brownstone R, Nath A. Human immunodeficiency virus type 1 Tat activates non-M-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995; 37: 373–380
   PubMed Web of Science ®Google Scholar
• McArthur J C, McClernon D R, Cronin M F, Nance-Sproson T E, Saah A J, St Clair M, Lanier E R. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol 1997; 42: 689–698
   PubMed Web of Science ®Google Scholar
• McPhee D A, Greenway A L, Holloway G, Smith K, Deacon N, Pemberton L, Brew B J. Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex. J Neurovirol 1998; 4: 291–300
   Web of Science ®Google Scholar
• Meeker R B, English R, Tompkins M. Enhanced excitotoxicity in primary feline neural cultures exposed to feline immunodeficiency virus (FIV). J NeuroAIDS 1996; 1: 1–27
   Google Scholar
• Meeker R B, Thiede B A, Hall C, English R, Tompkins M. Cortical cell loss in asymptomatic cats experimentally infected with feline immunodeficiency virus. AIDS Res Hum Retrovir 1997; 13: 1131–1140
   Google Scholar
• Mitchell T W, Rojko J L, Hartke J R, Mihajlov A R, Kasameyer G A, Gasper P W, Whalen L R. FeLV envelope protein (gp 70) variable region 5 causes alterations in calcium homeostasis and toxicity of neurons. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 14: 307–320
   Google Scholar
• Nath A, Padua R A, Geiger J D. HIV-1 coat protein gp120-induced increases in levels of intrasynaptosomal calcium. Brain Res 1995; 678: 200–206
   PubMed Web of Science ®Google Scholar
• Nath A, Geiger J D. Neurobiological aspects of human immunodeficiency virus infection: neurotoxic mechanisms. Prog Neurobiol 1998; 54: 19–33
   PubMed Web of Science ®Google Scholar
• New D R, Ma M, Epstein L G, Nath A, Gelbard H A. Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. J Neurovirol 1997; 3: 168–173
   PubMed Web of Science ®Google Scholar
• Nuovo G J, Alfieri M L. AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines. Mol Med 1996; 2: 358–366
   PubMed Web of Science ®Google Scholar
• Price R W, Sidtis J J. Evaluation of the AIDS Dementia Complex in clinical trials. J AIDS 1990; 3(S2)S51–S60
   Google Scholar
• Ranki A, Nyberg M, Ovod V, Haltia M, Elovaara I, Raininko R, Haapasalo H, Krohn K. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 1995; 9: 1001–1008
   PubMed Web of Science ®Google Scholar
• Robertson K, Fiscus S, Kapoor C, Robertson W, Schneider G, Shepard R, Howe L, Suva S, Hall C. CSF, plasma viral load and HIV associated dementia. J Neurovirol 1998; 4: 90–94
   Web of Science ®Google Scholar
• Sopper S, Demuth M, Stahl-Hennig C, Hunsmann G, Plesker R, Coulibaly C, Czub S, Ceska M, Koutsilieri E, Riederer P, Brinkmann R, Katz M, ter Meulen V. The effect of simian immunodeficiency virus infection in vitro and in vivo on the cytokine production of isolated microglia and peripheral macrophages from rhesus monkey. Virology 1996; 220: 320–329
   Google Scholar
• Tymianski M, Charlton M P, Carlen P L, Tator C H. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci 1993; 13: 2085–2104
   PubMed Web of Science ®Google Scholar
• Weis S, Haug H, Budka H. Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study. Acta Neuropathol (Berl) 1993; 85: 185–189
   Google Scholar
• Wesselingh S L, Takahashi K, Glass J D, McArthur J C, Griffin J W, Griffin D E. Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry. J Neuroimmunol 1997; 74: 1–8
   PubMed Web of Science ®Google Scholar
• Westmoreland S V, Kolson D, Gonzalez-Scarano F. Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. J Neurovirol 1996; 2: 118–126
   PubMed Web of Science ®Google Scholar
• Wiley C, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R. Neocortical damage during HIV infection. Ann Neurol 1991; 29: 651–657
   PubMed Web of Science ®Google Scholar
• Yeung M C, Pulliam L, Lau A S. The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-alpha. AIDS 1995; 9: 137–143
   PubMed Web of Science ®Google Scholar