Report of the WPA section of pharmacopsychiatry on the relationship of antiepileptic drugs with suicidality in epilepsy

References

• 1980. Suicide and epilepsy. Br Med J 281:530.
   PubMed Web of Science ®Google Scholar
• Abraham G. 2003. Topiramate-induced suicidality. Can J Psychiatry 48:127–128.
   PubMed Web of Science ®Google Scholar
• Akiskal HS, Benazzi F, Perugi G, Rihmer Z. 2005. Agitated “unipolar” depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy. J Affect Disord 85:245–258.
   PubMed Web of Science ®Google Scholar
• Andersohn F, Schade R, Willich SN, Garbe E. 2010. Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior. Neurology 75:335–340.
   PubMed Web of Science ®Google Scholar
• Arana A, Wentworth CE, Ayuso-Mateos JL, Arellano FM. 2010. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med 363:542–551.
   PubMed Web of Science ®Google Scholar
• Bagary M. 2011. Epilepsy, antiepileptic drugs and suicidality. Curr Opin Neurol 24:177–182.
   Google Scholar
• Baghai TC, Blier P, Baldwin DS, Bauer M, Goodwin GM, Fountoulakis KN, et al. 2011. General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry. Eur Arch Psychiatry Clin Neurosci 261:207–245.
   PubMedGoogle Scholar
• Baghai TC, Blier P, Baldwin DS, Bauer M, Goodwin GM, Fountoulakis KN, et al. 2012. Executive summary of the report by the WPA section on pharmacopsychiatry on general and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders. Eur Arch Psychiatry Clin Neurosci 262:13–22.
   PubMed Web of Science ®Google Scholar
• Balazs J, Benazzi F, Rihmer Z, Rihmer A, Akiskal KK, Akiskal HS. 2006. The close link between suicide attempts and mixed (bipolar) depression: implications for suicide prevention. J Affect Disord 91:133–138.
   PubMed Web of Science ®Google Scholar
• Baldessarini RJ, Tondo L, Hennen J. 2003. Lithium treatment and suicide risk in major affective disorders: update and new findings. J Clin Psychiatry 64:44–52.
   PubMed Web of Science ®Google Scholar
• Belcastro V, Gaetano G, Italiano D, Oteri G, Caccamo D, Pisani LR, et al. 2007. Antiepileptic drugs and MTHFR polymorphisms influence hyper-homocysteinemia recurrence in epileptic patients. Epilepsia 48:1990–1994.
   PubMed Web of Science ®Google Scholar
• Bell GS, Gaitatzis A, Bell CL, Johnson AL, Sander JW. 2009a. Suicide in people with epilepsy: how great is the risk? Epilepsia 50: 1933–1942.
   PubMed Web of Science ®Google Scholar
• Bell GS, Mula M, Sander JW. 2009b. Suicidality in people taking antiepileptic drugs: What is the evidence? CNS Drugs 23:281–292.
   PubMed Web of Science ®Google Scholar
• Bell GS, Sander JW. 2009. Suicide and epilepsy. Curr Opin Neurol 22:174–178.
   PubMed Web of Science ®Google Scholar
• Berman ME, Jones GD, McCloskey MS. 2005. The effects of diazepam on human self-aggressive behavior. Psychopharmacology (Berl) 178:100–106.
   PubMed Web of Science ®Google Scholar
• Brent DA. 1986. Overrepresentation of epileptics in a consecutive series of suicide attempters seen at a children's hospital, 1978–1983. J Am Acad Child Psychiatry 25:242–246.
   PubMedGoogle Scholar
• Canevini MP, De Sarro G, Galimberti CA, Gatti G, Licchetta L, Malerba A, et al. 2010. Relationship between adverse effects of antiepileptic drugs, number of coprescribed drugs, and drug load in a large cohort of consecutive patients with drug-refractory epilepsy. Epilepsia 51:797–804.
   PubMed Web of Science ®Google Scholar
• Chouinard MJ, Nguyen DK, Clement JF, Bruneau MA. 2006. Catatonia induced by levetiracetam. Epilepsy Behav 8:303–307.
   PubMed Web of Science ®Google Scholar
• Christensen J, Vestergaard M, Mortensen PB, Sidenius P, Agerbo E. 2007. Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol 6:693–698.
   PubMed Web of Science ®Google Scholar
• Christman DS, Faubion MD. 2007. Suicide attempt following initiation of topiramate. Am J Psychiatry 164:682–683.
   PubMed Web of Science ®Google Scholar
• Cipriani A, Pretty H, Hawton K, Geddes JR. 2005. Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials. Am J Psychiatry 162:1805–1819.
   PubMed Web of Science ®Google Scholar
• Cockerell OC, Johnson AL, Sander JW, Hart YM, Goodridge DM, Shorvon SD. 1994. Mortality from epilepsy: results from a prospective population-based study. Lancet 344:918–921.
   PubMed Web of Science ®Google Scholar
• FDA. 2008. Statistical review and evaluation: antiepileptic drugs and suicidality. [online], http://www.fda.gov/ohrms/dockets/ac/08/briefing/2008-4372b1-01-FDA.pdf [Internet].
   Google Scholar
• Fountoulakis KN, Gonda X, Samara M, Siapera M, Karavelas V, Ristic DI, Iacovides A. 2012a. Antiepileptic drugs and suicidality. J Psychopharmacol 26:1401–1407.
   PubMed Web of Science ®Google Scholar
• Fountoulakis KN, Kasper S, Andreassen O, Blier P, Okasha A, Severus E, et al. 2012b. Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry. Eur Arch Psychiatry Clin Neurosci 262:1–48.
   PubMed Web of Science ®Google Scholar
• Gibbons RD, Hur K, Brown CH, Mann JJ. 2009. Relationship between antiepileptic drugs and suicide attempts in patients with bipolar disorder. Arch Gen Psychiatry 66:1354–1360.
   PubMed Web of Science ®Google Scholar
• Givon L, Porter S, Padmanabhan B, Goren J, Cohen PA. 2011. Levetiracetam, seizures, and suicidality. Harv Rev Psychiatry 19:47–55.
   PubMed Web of Science ®Google Scholar
• Hall RC, Joffe JR. 1972. Aberrant response to diazepam: a new syndrome. Am J Psychiatry 129:738–742.
   PubMed Web of Science ®Google Scholar
• Hancock JC, Bevilacqua AR. 1971. Temporal lobe dysrhythmia and impulsive or suicidal behavior: preliminary report. South Med J 64:1189–1193.
   PubMed Web of Science ®Google Scholar
• Harris EC, Barraclough B. 1997. Suicide as an outcome for mental disorders. A meta-analysis. Br J Psychiatry 170:205–228.
   PubMed Web of Science ®Google Scholar
• Hawton K, Fagg J, Marsack P. 1980. Association between epilepsy and attempted suicide. J Neurol Neurosurg Psychiatry 43:168–170.
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Berg AT, Kanner AM. 2010. An update on antiepileptic drugs and suicide: are there definitive answers yet? Epilepsy Curr 10:137–145.
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, French JA, Posner K, DiVentura B, Pollard JR, Sperling MR, et al. 2013. Suicidal ideation and behavior screening in intractable focal epilepsy eligible for drug trials. Epilepsia 54:879–887.
   PubMed Web of Science ®Google Scholar
• Hesdorffer DC, Kanner AM. 2009. The FDA alert on suicidality and antiepileptic drugs: Fire or false alarm? Epilepsia 50:978–986.
   PubMed Web of Science ®Google Scholar
• Iivanainen M, Lehtinen J. 1979. Causes of death in institutionalized epileptics. Epilepsia 20:485–91.
   PubMed Web of Science ®Google Scholar
• Ishihara L, Webb DJ, Irizarry M, Weil J. 2010. Exploring differential prescribing between anti-epileptic drugs in epilepsy patients with a history of mood disorders. Pharmacoepidemiol Drug Saf 19: 289–295.
   PubMed Web of Science ®Google Scholar
• Isometsa ET, Henriksson MM, Aro HM, Heikkinen ME, Kuoppasalmi KI, Lonnqvist JK. 1994. Suicide in major depression. Am J Psychiatry 151:530–536.
   PubMed Web of Science ®Google Scholar
• Kalinin VV. 2007. Suicidality and antiepileptic drugs: is there a link? Drug Saf 30:123–142.
   PubMed Web of Science ®Google Scholar
• Kandemir H, Yumru M, Kul M, Kandemir SB. 2008. Behavioral disinhibition, suicidal ideation, and self-mutilation related to clonazepam. J Child Adolesc Psychopharmacol 18:409.
   PubMed Web of Science ®Google Scholar
• Kanner AM. 2011. Are antiepileptic drugs used in the treatment of migraine associated with an increased risk of suicidality? Curr Pain Headache Rep 15:164–169.
   PubMed Web of Science ®Google Scholar
• Kaufman KR, Struck PJ. 2011. Activation of suicidal ideation with adjunctive rufinamide in bipolar disorder. Epilepsy Behav 20: 386–389.
   PubMed Web of Science ®Google Scholar
• Khan A, Faught E, Gilliam F, Kuzniecky R. 1999. Acute psychotic symptoms induced by topiramate. Seizure 8:235–237.
   PubMed Web of Science ®Google Scholar
• Klenerman P, Sander JW, Shorvon SD. 1993. Mortality in patients with epilepsy: a study of patients in long term residential care. J Neurol Neurosurg Psychiatry 56:149–152.
   PubMed Web of Science ®Google Scholar
• Kwon OY, Park SP. 2013. Frequency of affective symptoms and their psychosocial impact in Korean people with epilepsy: a survey at two tertiary care hospitals. Epilepsy Behav 26:51–56.
   PubMed Web of Science ®Google Scholar
• Leon AC, Demirtas H, Li C, Hedeker D. 2012a. Two propensity score-based strategies for a three-decade observational study: investigating psychotropic medications and suicide risk. Stat Med 31:3255–3260.
   PubMed Web of Science ®Google Scholar
• Leon AC, Solomon DA, Li C, Fiedorowicz JG, Coryell WH, Endicott J, Keller MB. 2012b. Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study. Am J Psychiatry 169:285–291.
   PubMed Web of Science ®Google Scholar
• Lip GY, Brodie MJ. 1992. Sudden death in epilepsy: an avoidable outcome? J R Soc Med 85:609–611.
   PubMed Web of Science ®Google Scholar
• Machado RA, Espinosa AG, Melendrez D, Gonzalez YR, Garcia VF, Rodriguez YQ. 2011. Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy. Seizure 20:280–284.
   PubMed Web of Science ®Google Scholar
• Mago R, Huege S, Ahuja N, Kunkel EJ. 2006. Zonisamide-induced suicidal ideation. Psychosomatics 47:68–69.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG. 2010. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336–341.
   PubMed Web of Science ®Google Scholar
• Moller HJ, Baldwin DS, Goodwin G, Kasper S, Okasha A, Stein DJ, et al. 2008. Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement. Eur Arch Psychiatry Clin Neurosci 258:3–23.
   Web of Science ®Google Scholar
• Mula M, Kanner AM, Schmitz B, Schachter S. 2013. Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on Neuropsychobiology. Epilepsia 54:199–203.
   PubMed Web of Science ®Google Scholar
• Mula M, Sander JW. 2007. Suicidal ideation in epilepsy and levetiracetam therapy. Epilepsy Behav 11:130–132.
   PubMed Web of Science ®Google Scholar
• Mula M, Sander JW. 2013. Suicide risk in people with epilepsy taking antiepileptic drugs. Bipolar Disord 15:622–627.
   PubMed Web of Science ®Google Scholar
• Nilsson L, Ahlbom A, Farahmand BY, Asberg M, Tomson T. 2002. Risk factors for suicide in epilepsy: a case control study. Epilepsia 43:644–651.
   PubMed Web of Science ®Google Scholar
• Nilsson L, Tomson T, Farahmand BY, Diwan V, Persson PG. 1997. Cause-specific mortality in epilepsy: a cohort study of more than 9,000 patients once hospitalized for epilepsy. Epilepsia 38: 1062–1068.
   PubMed Web of Science ®Google Scholar
• Olesen JB, Hansen PR, Erdal J, Abildstrom SZ, Weeke P, Fosbol EL, et al. 2010. Antiepileptic drugs and risk of suicide: a nationwide study. Pharmacoepidemiol Drug Saf 19:518–524.
   PubMed Web of Science ®Google Scholar
• Patorno E, Bohn RL, Wahl PM, Avorn J, Patrick AR, Liu J, Schneeweiss S. 2010. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA 303:1401–1409.
   PubMed Web of Science ®Google Scholar
• Pereira A, Gitlin MJ, Gross RA, Posner K, Dworkin RH. 2013. Suicidality associated with antiepileptic drugs: implications for the treatment of neuropathic pain and fibromyalgia. Pain 154: 345–349.
   PubMed Web of Science ®Google Scholar
• Perlis RH. 2011. Hard outcomes: clinical trials to reduce suicide. Am J Psychiatry 168:1009–1011.
   PubMed Web of Science ®Google Scholar
• Pompili M, Baldessarini RJ. 2010. Epilepsy: risk of suicidal behavior with antiepileptic drugs. Nat Rev Neurol 6:651–653.
   PubMed Web of Science ®Google Scholar
• Pompili M, Girardi P, Tatarelli G, Angeletti G, Tatarelli R. 2006. Suicide after surgical treatment in patients with epilepsy: a meta-analytic investigation. Psychol Rep 98:323–338.
   PubMed Web of Science ®Google Scholar
• Pompili M, Tatarelli R, Girardi P, Tondo L, Baldessarini RJ. 2010. Suicide risk during anticonvulsant treatment. Pharmacoepidemiol Drug Saf 19:525–528.
   PubMed Web of Science ®Google Scholar
• Procopio M. 2010. New users of the anticonvulsants gabapentin, lamotrigine, oxcarbazepine or tiagabine are at increased risk of suicidal acts compared with new users of topiramate. Evid Based Ment Health 13:102.
   PubMedGoogle Scholar
• Prudhomme C. 1941. Epilepsy and suicide. J Nerv Ment Dis 94: 722–727.
   Google Scholar
• Pugh MJ, Copeland LA, Zeber JE, Wang CP, Amuan ME, Mortensen EM, et al. 2012. Antiepileptic drug monotherapy exposure and suicide-related behavior in older veterans. J Am Geriatr Soc 60:2042–2047.
   PubMed Web of Science ®Google Scholar
• Pugh MJ, Hesdorffer D, Wang CP, Amuan ME, Tabares JV, Finley EP, et al. 2013. Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior. Neurology 81:1900–1906.
   PubMed Web of Science ®Google Scholar
• Reinares M, Rosa AR, Franco C, Goikolea JM, Fountoulakis K, Siamouli M, et al. 2013. A systematic review on the role of anticonvulsants in the treatment of acute bipolar depression. Int J Neuropsychopharmacol 16:485–496.
   PubMed Web of Science ®Google Scholar
• Rihmer Z. 2007. Suicide risk in mood disorders. Curr Opin Psychiatry 20:17–22.
   PubMed Web of Science ®Google Scholar
• Rihmer Z, Akiskal H. 2006. Do antidepressants t(h)reat(en) depressives? Toward a clinically judicious formulation of the antidepressant-suicidality FDA advisory in light of declining national suicide statistics from many countries . J Affect Disord 94:3–13.
   PubMed Web of Science ®Google Scholar
• Rosa AR, Fountoulakis K, Siamouli M, Gonda X, Vieta E. 2011. Is anticonvulsant treatment of mania a class effect? Data from randomized clinical trials . CNS Neurosci Ther 17:167–177.
   PubMed Web of Science ®Google Scholar
• Rudzinski LA, Meador KJ. 2011. Epilepsy: five new things. Neurology 76:S20–25.
   PubMed Web of Science ®Google Scholar
• Ryan HF, Merrill FB, Scott GE, Krebs R, Thompson BL. 1968. Increase in suicidal thoughts and tendencies. Association with diazepam therapy. JAMA 203:1137–1139.
   PubMed Web of Science ®Google Scholar
• Schmitz EB, Robertson MM, Trimble MR. 1999. Depression and schizophrenia in epilepsy: social and biological risk factors. Epilepsy Res 35:59–68.
   PubMed Web of Science ®Google Scholar
• Shneker BF, Cios JS, Elliott JO. 2009. Suicidality, depression screening, and antiepileptic drugs: reaction to the FDA alert. Neurology 72:987–991.
   PubMed Web of Science ®Google Scholar
• Sperling MR, Feldman H, Kinman J, Liporace JD, O’Connor MJ. 1999. Seizure control and mortality in epilepsy. Ann Neurol 46:45–50.
   PubMed Web of Science ®Google Scholar
• Striano P, Zara F, Minetti C. 2010. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med 363:1873–1874; author reply 1874.
   PubMedGoogle Scholar
• Tandon R, Belmaker RH, Gattaz WF, Lopez-Ibor JJ Jr, Okasha A, Singh B, et al. 2008. World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia. Schizophr Res 100:20–38.
   PubMed Web of Science ®Google Scholar
• VanCott AC, Cramer JA, Copeland LA, Zeber JE, Steinman MA, Dersh JJ, et al. 2010. Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system. BMC Med 8:4.
   PubMed Web of Science ®Google Scholar
• Wen X, Meador KJ, Loring DW, Eisenschenk S, Segal R, Hartzema AG. 2011. Is antiepileptic drug use related to depression and suicidal ideation among patients with epilepsy? Epilepsy Behav 19:494–500.
   Web of Science ®Google Scholar
• White SJ, McLean AE, Howland C. 1979. Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy. Lancet 2:458–461.
   Google Scholar
• Zebley BD, Ferrando SJ. 2010. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med 363:1873; author reply 1874.
   PubMedGoogle Scholar
• Zielinski JJ. 1974. Epilepsy and mortality rate and cause of death. Epilepsia 15:191–201.
   PubMed Web of Science ®Google Scholar
• Ziemba KS, O’Carroll CB, Drazkowski JF, Wingerchuk DM, Hoffman-Snyder C, Wellik KE, Demaerschalk BM. 2010. Do antiepileptic drugs increase the risk of suicidality in adult patients with epilepsy?: A critically appraised topic. Neurologist 16:325–328.
   PubMed Web of Science ®Google Scholar