Neurological soft signs and prepulse inhibition of the startle reflex in psychosis: A pilot study

References

• Aggernaes B, Glenthoj BY, Ebdrup BH, Rasmussen H, Lublin H, Oranje B. 2010. Sensorimotor gating and habituation in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months’ treatment with quetiapine. Int J Neuropsychopharmacol 13:1383–1395.
   PubMed Web of Science ®Google Scholar
• Amaddeo F, Tansella M. 2009. Information systems for mental health. Epidemiol Psichiatr Soc 18:1–4.
   PubMed Web of Science ®Google Scholar
• Arango C, Bartko JJ, Gold JM, Buchanan RW. 1999. Prediction of neuropsychological performance by neurological signs in schizophrenia. Am J Psychiatry 156:1349–1357.
   PubMed Web of Science ®Google Scholar
• Bachmann S, Bottmer C, Schröder J. 2005. Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry 162:2337–2343.
   PubMed Web of Science ®Google Scholar
• Boks MP, Selten JP, Leask S, Van den Bosch RJ. 2006. The 2-year stability of neurological soft signs after a first episode of non-affective psychosis. Eur Psychiatry 21:288–290.
   PubMed Web of Science ®Google Scholar
• Bonora LI, Conti L, Piccinelli L, Tansella M, Cassano GB, Lecrubier Y. 1995. Mini International Neuropsychiatric Interview (Mini), Italian version, Le scale di valutazione in Psichiatria. In: Conti L, editor. Digest Neuropsichiatria Milano: Utet.
   Google Scholar
• Braff DL, Grillon C, Geyer MA. 1992. Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206–215.
   PubMed Web of Science ®Google Scholar
• Braff DL, Swerdlow NR, Geyer MA. 1999. Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. Am J Psychiatry 156:596–602.
   PubMed Web of Science ®Google Scholar
• Buchanan RW, Heinrichs DW. 1989. The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res. 27:335–350.
   PubMed Web of Science ®Google Scholar
• Cadenhead KS. 2011. Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable population. Psychiatry Res 188:208–216.
   PubMed Web of Science ®Google Scholar
• Chan RC, Xu T, Heinrichs RW, Yu Y, Wang Y. 2010. Neurological soft signs in schizophrenia: a meta-analysis. Schizophr Bull 36:1089–104.
   PubMed Web of Science ®Google Scholar
• Chen EY, Hui CL, Chan RC, Dunn EL, Miao MY, Yeung WS, et al. 2005. A 3-year prospective study of neurological soft signs in first-episode schizophrenia. Schizophr Res 75:45–54.
   PubMed Web of Science ®Google Scholar
• Cuesta MJ, Peralta V, Zarzuela A, Calvo R, García M, Serrano F. 2002. Neurological soft-signs in psychosis: threshold criteria for discriminating normal controls and for predicting cognitive impairment. Schizophr Res 58:263–271.
   PubMed Web of Science ®Google Scholar
• Csomor PA, Stadler RR, Feldon J, Yee BK, Geyer MA, Vollenweider FX. 2008. Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels. Neuropsychopharmacology 33:497–512.
   PubMed Web of Science ®Google Scholar
• Dazzan P, Lloyd T, Morgan KD, Zanelli J, Morgan C, Orr K, et al. 2008. Neurological abnormalities and cognitive ability in first-episode psychosis. Br J Psychiatry 193:197–202.
   PubMed Web of Science ®Google Scholar
• Dazzan P, Morgan KD, Orr KG, Hutchinson G, Chitnis X, Suckling J, et al. 2004. The structural brain correlates of neurological soft signs in AESOP first-episode psychoses study. Brain 127:143–153.
   PubMed Web of Science ®Google Scholar
• Dazzan P, Murray RM. 2002. Neurological soft signs in first-episode psychosis: a systematic review. Br J Psychiatry 43:50–57.
   Google Scholar
• Duncan EJ, Bollini AM, Lewison B, Keyes M, Jovanovic T, Gaytan O, et al. 2006. Medication status affects the relationship of symptoms to prepulse inhibition of acoustic startle in schizophrenia. Psychiatry Res 145:137–145.
   PubMed Web of Science ®Google Scholar
• Evans LH, Gray NS, Snowden RJ. 2005. Prepulse inhibition of startle and its moderation by schizotypy and smoking. Psychophysiology 42:223–231.
   PubMed Web of Science ®Google Scholar
• Geyer MA, Swerdlow NR, Mansbach RS, Braff DL. 1990. Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull 25:485–498.
   PubMed Web of Science ®Google Scholar
• Giakoumaki SG, Bitsios P, Frangou S. 2006. The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing. Brain Res 1078:168–170.
   PubMed Web of Science ®Google Scholar
• Goff DC, Evins AE. 1998. Negative symptoms in schizophrenia: neurobiological models and treatment response. Harv Rev Psychiatry 6:59–77.
   PubMed Web of Science ®Google Scholar
• Goghari VM, Sponheim SR, MacDonald AW III. 2010. The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question. Neurosci Biobehav Rev 34:468–486.
   PubMed Web of Science ®Google Scholar
• Hammer TB, Oranje B, Skimminge A, Aggernæs B, Ebdrup BH, Glenthøj B, Baaré W. 2013. Structural brain correlates of sensorimotor gating in antipsychotic-naive men with first-episode schizophrenia. J Psychiatry Neurosci 38:34–42.
   PubMed Web of Science ®Google Scholar
• Hasenkamp W, Norrholm SD, Green A, Lewison B, Boshoven W, Keyes M, Duncan E. 2008. Differences in startle reflex and prepulse inhibition in European-Americans and African-Americans. Psychophysiology 45:876–882.
   PubMed Web of Science ®Google Scholar
• Hong LE, Wonodi I, Lewis J, Thaker GK. 2008. Nicotine effect on prepulse inhibition and prepulse facilitation in schizophrenia patients. Neuropsychopharmacology 33:2167–2174.
   PubMed Web of Science ®Google Scholar
• Kay SR, Fiszbein A, Opler LA, 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276.
   PubMed Web of Science ®Google Scholar
• Koch M, Schnitzler HU 1997. The acoustic startle response in rats–circuits mediating evocation, inhibition and potentiation. Behavioural Brain Res 89:35–49.
   PubMed Web of Science ®Google Scholar
• Kumari V, Gray JA. 1999. Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex. Psychopharmacology 141:11–15.
   PubMed Web of Science ®Google Scholar
• Kumari V, Soni W, Sharma T 1999. Normalization of information processing deficits in schizophrenia with clozapine. Am J Psychiatry 156:1046–1051.
   PubMed Web of Science ®Google Scholar
• Kumari V, Antonova E, Zachariah E, Galea A, Aasen I, Ettinger U, et al. 2005. Structural brain correlates of prepulse inhibition of the acoustic startle response in healthy humans. Neuroimage 26:1052–1058.
   PubMed Web of Science ®Google Scholar
• Kumari V, Fannon D, Sumich AL, Sharma T. 2007a. Startle gating in antipsychotic-naïve first episode schizophrenia patients: one ear is better than two. Psychiatry Res 151:21–28.
   PubMed Web of Science ®Google Scholar
• Kumari V, Antonova E, Geyer MA, Fytche D, Williams SC, Sharma T. 2007b. A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics. Int J Neuropsychopharmacol 10:463–477.
   PubMed Web of Science ®Google Scholar
• Kumari V, Fannon D, Geyer MA, Premkumar P, Antonova E, Simmons A, Kuipers E. 2008. Cortical grey matter volume and sensorimotor gating in schizophrenia. Cortex 44:1206–1214.
   PubMed Web of Science ®Google Scholar
• Kumari V. 2011. Sex differences and hormonal influences in human sensorimotor gating: implications for schizophrenia. Curr Top Behav Neurosci 8:141–154.
   PubMedGoogle Scholar
• Maxwell ME. 1992. Family Interview for Genetic Studies (FIGS): Manual For FIGS, Clinical Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health. Bethesda, MD.
   Google Scholar
• Mayoral M, Bombín I, Zabala A, Robles O, Moreno D, Parellada M, et al. 2008. Neurological soft signs in adolescents with first episode psychosis: two-year follow up. Psychiatry Res 161:344–348.
   PubMed Web of Science ®Google Scholar
• Ludewig K, Geyer MA, Vollenweider FX. 2003. Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia. Biol Psychiatry 54:121–128.
   PubMed Web of Science ®Google Scholar
• Mackeprang T, Kristiansen KT, Glenthoj BY. 2002. Effects of antipsychotics on prepulse inhibition of the startle response in drug-naive schizophrenic patients. Biol Psychiatry 52:863–873.
   PubMed Web of Science ®Google Scholar
• Meincke U, Mörth D, Voss T, Thelen B, Geyer MA, Gouzoulis-Mayfrank E. 2004. Prepulse inhibition of the acoustically evoked startle reflex in patients with an acute schizophrenic psychosis–a longitudinal study. Eur Arch Psychiatry Clin Neurosci 254:415–421.
   PubMed Web of Science ®Google Scholar
• Minassian A, Feifel D, Perry W. 2007. The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients. Schizophrenia Res 89:225–231.
   PubMed Web of Science ®Google Scholar
• Mohr F, Hubmann W, Albus M, Franz U, Hecht S, Scherer J, et al. 2003. Neurological soft signs and neuropsychological performance in patients with first episode schizophrenia. Psychiatry Res 121:21–30.
   PubMed Web of Science ®Google Scholar
• Mueser KT, Nishith P, Tracy JI, DeGirolamo J, Molinaro M. 1995. Expectations and motives for substance use in schizophrenia. Schizophr Bull. 21:367–378.
   PubMed Web of Science ®Google Scholar
• Negash A, Kebede D, Alem A, Melaku Z, Deyessa N, Shibire T, et al. 2004. Neurological soft signs in bipolar I disorder patients. J Affect Disord 80:221–230.
   PubMed Web of Science ®Google Scholar
• Nelson HE. 1991. National Adult Reading Test, 2nd edition. Windsor, UK: NFER-Nelson.
   Google Scholar
• Reichenberg A. 2010. The assessment of neuropsychological functioning in schizophrenia. Dialogues Clin Neurosci 12:383–392.
   PubMedGoogle Scholar
• Sanders RD, Keshavan MS, Schooler NR. 1994. Neurological examination abnormalities in neuroleptic-naive patients with first-break schizophrenia: preliminary results. Am J Psychiatry 151:1231–1233.
   PubMed Web of Science ®Google Scholar
• Sartori G, Colombo L, Vallar G, Rusconi ML, Pinarello A. 1997. T.I.B.: Test di Intelligenza Breve per la valutazione del quoziente intellettivo attuale e pre-morboso. La Professione di Psicologo. 1:II–XXIV.
   Google Scholar
• Smieskova R, Fusar-Poli P, Allen P, Bendfeldt K, Stieglitz RD, Drewe J, et al. 2010. Neuroimaging predictors of transition to psychosis–a systematic review and meta-analysis. Neurosci Biobehav Rev 34:1207–1222.
   PubMed Web of Science ®Google Scholar
• Spitzer RL, Williams JBW, Gibbon M, First MB. 1993. SCID Intervista strutturata per il DSMIII-R (Italian version by Fava M, Guaraldi GP, Mazzi F, Rigatelli M.) Organizzazioni Speciali, Firenze.
   Google Scholar
• Swerdlow NR, Geyer MA, Braff DL. 2001. Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology 156:194–215.
   PubMed Web of Science ®Google Scholar
• Swerdlow NR, Talledo JA, Braff DL. 2005. Startle modulation in Caucasian-Americans and Asian-Americans: a prelude to genetic/endophenotypic studies across the ’Pacific Rim’. Psychiatr Genet 15:61–65.
   PubMed Web of Science ®Google Scholar
• Thaker G. 2008. Psychosis endophenotypes in schizophrenia and bipolar disorder. Schizophr Bull 34:720–721.
   PubMed Web of Science ®Google Scholar
• Tosato S, Dazzan P. 2005. The psychopathology of schizophrenia and the presence of neurological soft signs: a review. Curr Opin Psychiatry 18:285–288.
   PubMed Web of Science ®Google Scholar
• Venkatasubramanian G, Jayakumar PN, Gangadhar BN, Keshavan MS. 2008. Neuroanatomical correlates of neurological soft signs in antipsychotic-naive schizophrenia. Psychiatry Res 164:215–222.
   PubMed Web of Science ®Google Scholar
• Venkatasubramanian G, Latha V, Gangadhar BN, Janakiramaiah N, Subbakrishna DK, Jayakumar PN, Keshavan MS. 2003. Neurological soft signs in never-treated schizophrenia. Acta Psychiatr Scand 108:144–146.
   PubMed Web of Science ®Google Scholar
• Whitty P, Clarke M, McTigue O, Browne S, Gervin M, Kamali M, et al. 2006. Diagnostic specificity and predictors of neurological soft signs in schizophrenia, bipolar disorder and other psychoses over the first 4 years of illness. Schizophr Res 86:110–117.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 1992. Schedules for Clinical Assessment in Neuropsychiatry (Version 1.0). Geneva, CH: WHO.
   Google Scholar