225
Views
4
CrossRef citations to date
0
Altmetric
Editorial Article

Some reflections on the endocrinology of the aging male

Pages 163-168 | Published online: 06 Jul 2009

References

  • Schwarz D, Mayaux M J, Spira A, Moscato M C, Jouannet P, Czyglik F, David G. Semen characteristics as a function of age in 833 fertile men. Fertil Steril 1983; 39: 530–5
  • Nieschlag E, Lammers U, Freischem C W, Langer K, Wickings E J. Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab 1982; 55: 676–81
  • Lemcke B, Behre H M, Nieschlag E. Frequency of subnormal semen profiles of normal volunteers recruited over 17 years. Int J Androl 1996; 19: 135–42
  • Martin C E. Factors affecting sexual functioning in 60–79 year old married males. Arch Sex Behaviour 1981; 10: 394
  • McKinlay J D, Feldman H A. Age related variation in sexual activity and interest in normal men. Results of the Massachusetts Male Aging Study. Sexuality across the Life Course., A S Rossi. University Chicago Press, Chicago 1994; 261–81
  • Vermeulen A, Rubens R, Verdonck L. Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 1972; 37: 730–4
  • Deslypere J P, Vermeulen A. Leydig cell function in normal men. Effect of age, life style, residence, diet and activity. J Clin Endocrinol Metab 1984; 59: 955–61
  • Vermeulen A, Kaufman J M, Giagulli V A. Influence of some biological indices on sex hormone binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 1996; 81: 1821–6
  • Kaufman J M, Vermeulen A. Declining gonadal function in elderly men. Baillière's Clin Endocrinol Metab, 997: 289–309, 11
  • Handelsman D J. Testicular dysfunction in systemic disease. Endocrinol Metab Clin 1994; 23: 839–52
  • Turner H E, Wass J AHA. Gonadal function in chronic illness. Clin Endocrinol 1997; 47: 379–403
  • Van Cauter E, Leproult L, Kupfer D J. Effects of gender and age on levels and circadian rhythmicity of plasma Cortisol. J Clin Endocrinol Metab 1996; 81: 2468–73
  • Peskind E R, Raskind M A, Wingerson D, et al. Enhanced hypothalamo–pituitary adrenocortical axis responses to physostigmine in normal aging. J Gerontol. A. Biological Science and Medical Science 1995; 50: 14–20
  • Butenandt A, Dannenbaum H. Isolierung eines neuen physiologisch unwirksamen Sterinderivates aus Mannenharn, seine Verknupfung mit Dehydro–androsteron und Androsteron. Z Physiol Chem 1934; 229: 192–5
  • Labrie F, Bélanger A, Simard J, Van L uu-The, Labrie C. DUE A and peripheral androgen and estrogen formation: intracrinology. Ann NY Acad Sci 1995; 774: 16–28
  • Thomas G, Frenoy N, Legrain S, Sebag-Lanoe R, Baulieu E E, Debuire B. Serum dehydroepi–androsteronesulfate as an individual marker. J Clin Endocrinol Metab 1994; 79: 1273–6
  • Robel P, Baulieu E E. Neurosteroids: biosynthesis and function. Trends Endocrinol Metab 1994; 5: 1–8
  • Demirgoren S, Majewska M D, Spivak E, London E D. Receptor binding and electrophysiological effects of dehydroepiandrosteronesulfate, an antagonist of the GABAA receptor. Neuroscience 1991; 45: 127–35
  • Herrington D M. Dehydroepiandrosterone and coronary atherosclerosis. Ann NY Acad Sci 1995; 774: 271–80
  • Casson P R, Andersen R N, Herod R G, Stentz F B, Straughn A B, Abraham G E, Buster J E. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol 1993; 169: 393–401
  • Peters J M, Zhou Y C, Ram P M, et al. Peroxisome proliferator activated receptor alpha required for gene induction by dehydroepiandrosterone–3P sulfate. Molec Pharmacol 1996; 50: 67–74
  • Yen S SC, Morales H J, Khorram O. Replacement of DHEA in aging men and women. Potential remedial effects. Ann NY Acad Sci 1995; 774: 128–42
  • Labrie F, Diamond P, Cusan L, Gomez J L, Belanger A, Candas B. Effect of 12 months dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997; 82: 3492–505
  • Rudman D. Growth hormone, body composition and age. J Am Geriatr Soc 1992; 33: 800–7
  • Vermeulen A. Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin C levels. J Clin Endocrinol Metab 1987; 64: 884–8
  • Janssen J AMJL, Stolk R P, Pols H AP, Grobbee D E, de Jong F H, Lamberts S WJ. Serum free IGF–1, total IGF–1, IGFBP–1 and IGFBP–3 levels in an elderly population: relation to age and steroid levels. Clin Endocrinol 1998; 48: 471–8
  • Martin F C, Yeo A L, Sonksen P H. Growth hormone secretion in the elderly: aging and the somatopause. Bailliere's Clin Endocrinol Metab, Endocrinology of Aging 1997; 11: 223–50
  • Corpas E, Harman S M, Pineyro M A, Roberson R, Blackman M R. Growth hormone (GH)–releasing hormone (1–29), twice daily reverses the decreased GH and insulin–like growth hormone factor–1 levels in old men. J Clin Endocrinol Metab 1992; 75: 530–8
  • Rudman D, Mattson D E. Serum insulin–like growth factor–1 in healthy elderly men in relation to physical activity J Am. Geriatr Soc 1994; 42: 71–6
  • Binnerts A, Swart G R, Wilson J HP, et al. The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis as well as on body composition. Clin Endocrinol 1992; 37: 79–81
  • Marcus R. Skeletal effects of growth hormone and IGF–1 in adults. Hormone Res 1997; 48: 60–4
  • Rudman D, Feller A G, Nagraj H S, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323: 1–6
  • Papadakis M A, Grady D, Black D, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 1996; 124: 708–16
  • Lamberts S WJ, van den Beld A W, van der Lely A. The endocrinology of aging. Science 1997; 278: 419–24
  • Saenger P. Oral growth hormone secretagogues: better than Alice in Wonderland's growth elixir (Editorial). J Clin Endocrinol Metab 1996; 81: 2773–5
  • Rosen C J, Conover C. Growth hormone/insulinlike growth factor–1 axis in aging: a summary of a National Institutes of Aging–sponsored symposium. J Clin Endocrinol Metab 1997; 82: 3919–22
  • Meneilly G S, Tessier D. Diabetes in the elderly. Diabetic Med 1995; 12: 949–60
  • Haffner S M. Androgens in relation to cardiovascular disease and insulin resistance in aging men. Androgens and the Aging Male., B Oddens, A Vermeulen. Parthenon Publishing, CarnforthUK 1996; 68–83
  • Mariotti S, Franceschi C, Cossarizza A, Pinchera A. The aging thyroid. Endocr Rev 1995; 16: 686–715
  • Rubinstein H A, Butler V PJ, Werner S C. Progressive decrease in serum triiodothyronine concentrations with human aging: radioimmunoassay following extraction of serum. J Clin Endocrinol Metab 1973; 37: 247–53
  • Mariotti S, Sansoni P, Barbesino G, et al. Thyroid and other organ specific autoantibodies in healthy centenarians. Lancet 1992; 339: 1506–8
  • Nicoloff J F, LoPresti J S. Non thyroidal illnesses. Wemer and Ingbar's The Thyroid – A Fundamental and Clinical Text., L E Braverman, P D Utiger. Lippincott–Raven, Philadelphia 1996; 286–96
  • Stockigt J R. Guidelines for diagnosis and monitoring of thyroid disease: non thyroidal illness. Clin Chem 1996; 42: 188–92
  • Van der Pump M PJ, Tunbridge W MG, French J M, et al. The incidence of thyroid disorders in the community: a twenty year follow–up of the Whickham Survey. Clin Endocrinol 1995; 43: 55–68
  • Wiersinga W M. Subclinical hypothyroidism and hyperthyroidism. I. Prevalence and clinical relevance. Netherlands J Med 1995; 46: 197–204

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.