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Original Article

Androgen therapy in the aging male: assessing the effect on heart disease

Pages 151-156 | Published online: 06 Jul 2009

References

  • American Heart Association. 1999 Heart and Stroke Statistical Update. American Heart Association, Dallas, Texas 1998, (available at http://www.americanheart.org/statistics/index.html)
  • Lopez A. D., Murray C. C. J. L. The global burden of disease: 1990–2020. Nature Med 1998; 4: 1241–3
  • Godsland I. F., Wynn V., Crook D., Miller N. E. Sex, plasma lipoproteins and atherosclerosis: prevailing assumptions and outstanding questions. Am Heart J 1987; 114: 1467–503
  • Sullivan M. L., Martinez C. M., Gennis P., Gallagher E. J. The cardiac toxicity of anabolic steroids. Progr Cardiovasc Dis 1998; 41: 1–15
  • Rockhold R. W. Cardiovascular toxicity of anabolic steroids. Ann Rev Pharmacol Toxicol 1993; 33: 497–520
  • Hamilton J. B., Mestler G. E. Mortality and survival: comparison of eunuchs with intact men in a mentally retarded population. J Gerontol 1969; 24: 395–411
  • Nieschlag E., Nieschlag S., Behre H. M. Lifespan and testosterone. Nature (London) 1993; 366: 215
  • Roberts W. C., Giraldo A. A. Bilateral oophorectomy in menstruating women and accelerated coronary atherosclerosis: an unproved connection. Am J Med 1979; 67: 363–5
  • Hulley S., Grady D., Bush T., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. J Am Med Assoc 1998; 280: 605–13
  • Stampfer M. J., Colditz C. A. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiological evidence. Prev Med 1991; 20: 47–63
  • Bucher H. C., Griffith L. E., Guyatt G. H. Systematic review on the risk and benefit of different cholesterol‐lowering interventions. Arterioscler Thromb Vase Biol 1999; 19: 187–95
  • Cardiovascular diease and steroid hormone contraception. World Health Organization, Geneva 1998, WHO Technical Report Series No. 877. Report of a WHO Scientific Group
  • Alexandersen P., Haarbo J., Christiansen C. The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis 1996; 125: 1–13
  • Phillips G. B., Jing T. Y., Resmck L. M., Barbagallo M., Laragh J. H., Sealey J. E. Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension. J Hyperlens 1993; 11: 699–702
  • Jeppersen L. L., Jorgensen H. S., Nakayama H., Raaschou H. O., Skyhoj T., Winther K. Decreased serum testosterone in men with acute ischaemic stroke. Arteriosder Thromb Vase Biol 1996; 16: 749–54
  • Phillips G. B., Pinkernell B. H., Jing T ‐Y. The association of hypotestosteronemia with coronary artery disease in men. Arteriosder Thromb 1994; 14: 701–6
  • Phillips G. B., Jing T ‐Y., Laragh J. H. Serum sex hormone levels in postmenopausal women with hypertension. J Hum Hypertens 1997; 11: 523–6
  • Phillips G. B., Pinkernell B. H., Jing T ‐Y. Relationship between serum sex hormones and coronary artery disease in postmenopausal women. Arteriosder Thromb Vase Biol 1997; 17: 695–701
  • Von Eckardstein A. Androgens, cardiovascular risk factors and atherosclerosis. Testosterone, E. Nieschlag, H. M. Behre. Springer, Berlin 1998; 229–58
  • Alexandersen P., Haarbo J., Byrjalsen I., Lawaetz H., Christiansen C. Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol‐fed rabbits. Circ Res 1999; 84: 813–19
  • Hamm L. Testosterone propionate in the treatment of angina pectoralis. J Clin Endocrinol 1942; 2: 325–8
  • Lesser M. A. The treatment of angina pectoralis with testosterone propionate: further observations. N Engl J Med 1943; 228: 185–8
  • Jaffe M. D. Effect of testosterone cypionate on postexercise ST segment depression. Br Heart J 1977; 39: 1217–22
  • Webb C. M., Adamson D. L., de Zeigler D., Collins P. Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. J Am Coll Cardiol 1999; 83: 437–9
  • Webb C. M., McNeill J. G., Hayward C. S., de Ziegler D., Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 1999; 100: 1690–6
  • Yuc P., Hatterjee K., Beale C., Poole‐Wilson P. A., Collins P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995; 91: 1154–60
  • Ferenchick G. S., Adelman S. Myocardial infarction associated with anabolic steroid use, in a previously healthy 37 year old weight lifter. Am Heart J 1992; 124: 507–8
  • Adams M. R., Williams J. K., Kaplan J. R. Effects of androgens on coronary artery atherosclerosis and atherosclerosis‐related impairment of vascular responsiveness. Arteriosder Thromb Vase Biol 1995; 15: 562–70
  • Obasanjo I. O., Clarkson T. B., Weaver D. S. Effects of the anabolic steroid nandrolone decanoate on plasma lipids and coronary arteries of female cynomolgous macaques. Metabolism 1996; 45: 463–8
  • McCredie R. J., McCrohon J. A., Turner L., Griffiths K. A., Handelsman D. J., Celermajer D. S. Vascular reactivity is impaired in genetic females taking high‐dose androgens. J Am Coll Cardiol 1998; 32: 1331–5
  • van Kesteren P. J., Kooistra T., Lansink M., van Kamp G. J., Asscheman H., Gooren L. J., et al. The effects of sex steroids on plasma levels of marker proteins of endothelial cell functioning. Thromb Haemost 1998; 79: 1029–33
  • Adams M. R., Celermajer D. S. Detection of pre‐symptomatic atherosclerosis: a current perspective. Clin Sci 1999; 97: 615–24
  • Asscheman H., Gooren L. S. G., Megens J. A. J., Nauta J., Kloosterboer H. J., Eikelboom F. Serum testosterone level is the major determinant of the male‐female difference in serum levels of high‐density lipoprotein (HDL) cholesterol and HDL2 cholesterol. Metabolism 1994; 43: 935–9
  • Bagatell C. J., Knopp R. H., Vale W. W., River J. E., Bremner W. J. Physiological testosterone levels in normal men suppress high‐density lipoprotein levels. Ann Intern Med 1992; 116: 967–73
  • Barrett‐Connor E. L. Testosterone and risk factors for cardiovascular disease in men. Diabetes & Metabolisme (Paris) 1995; 21: 156–61
  • McCrohon J. A., Jessup W., Handelsman D. J., Celermajer D. S. Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule‐1. Circulation 1999; 99: 2317–22
  • Ferenchick G., Schwartz D., Ball M., Schwartz K. Androgenic‐anabolic steroid abuse and platelet aggregation: a pilot study in weight lifters. Am J Med Sci 1992; 303: 78–82
  • Ayashi A. A. L., Mathur R., Halushka P. V. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 1995; 91: 2742–7
  • Ferenchick G. S., Hirowaka S., Mammen E. F., Schwartz K. A. Anabolic‐androgenic steroid abuse in weight lifters: evidence for activation of the hemostatic system. Am J Hematol 1995; 49: 282–8
  • Sarrel P. M. Cardiovascular aspects of androgens in women. Sent Reprod Endocrinol 1998; 16: 121–8

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