Murine models of airway fungal exposure and allergic sensitization

References

• Eduard W. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 139. Fungal Spores. Report; 2006. Arbete Och Halsa.
   Google Scholar
• Green BJ, Tovey ER, Sercombe JK, . Airborne fungal fragments and allergenicity. Med Mycol 2006; 44 (Suppl. 1): S245–255.
   Google Scholar
• Lacey J, Crook B. Fungal and actinomycete spores as pollutants of the workplace and occupational allergens. Ann Occup Hyg 1988; 32: 515–533.
   PubMed Web of Science ®Google Scholar
• Crameri R, Weichel M, Flückiger S, Glaser AG, Rhyner C. Fungal allergies: a yet unsolved problem. Chem Immunol Allergy 2006; 91: 121–133.
   PubMedGoogle Scholar
• Kurup VP, Shen HD, Banerjee B. Respiratory fungal allergy. Microb Infect 2000; 2: 1101–1110.
   PubMed Web of Science ®Google Scholar
• Portnoy JM, Barnes CS, Kennedy K. Importance of mold allergy in asthma. Curr Allergy Asthma Rep 2008; 8: 71–78.
   PubMed Web of Science ®Google Scholar
• Hogaboam CM, Carpenter KJ, Schuh JM, Buckland KF. Aspergillus and asthma – any link? Med Mycol 2005; 43 (Suppl. 1): S197–202.
   Google Scholar
• Andersson M, Downs S, Mitakakis T, Leuppi J, Marks G. Natural exposure to Alternaria spores induces allergic rhinitis symptoms in sensitized children. Pediatr Allergy Immunol 2003; 14: 100–105.
   PubMed Web of Science ®Google Scholar
• Black PN, Udy AA, Brodie SM. Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy 2000; 55: 501–504.
   PubMed Web of Science ®Google Scholar
• Downs SH, Mitakakis TZ, Marks GB, . Clinical importance of Alternaria exposure in children. Am J Respir Crit Care Med 2001; 164: 455–459.
   PubMed Web of Science ®Google Scholar
• Licorish K, Novey HS, Kozak P, Fairshter RD, Wilson AF. Role of Alternaria and Penicillium spores in the pathogenesis of asthma. J Allergy Clin Immunol 1985; 76: 819–825.
   PubMed Web of Science ®Google Scholar
• O’Hollaren MT, Yunginger JW, Offord KP, . Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. New Engl J Med 1991; 324: 359–363.
   PubMed Web of Science ®Google Scholar
• Green BJ, Sercombe JK, Tovey ER. Fungal fragments and undocumented conidia function as new aeroallergen sources. J Allergy Clin Immunol 2005; 115: 1043–1048.
   PubMed Web of Science ®Google Scholar
• Gòrny RL, Reponen T, Willeke K, . Fungal fragments as indoor air biocontaminants. Appl Environ Microbiol 2002; 68: 3522–3531.
   PubMed Web of Science ®Google Scholar
• Halstensen AS, Nordby KC, Wouters IM, Eduard W. Determinants of microbial exposure in grain farming. Ann Occup Hyg 2007; 51: 581–592.
   PubMed Web of Science ®Google Scholar
• Madsen AM, Wilkins K, Poulsen OM. Micro-particles from fungi. Johanning E. Bioaerosols, Fungi, Bacteria, Mycotoxins and Human Health: Patho-Physiology, Clinical Effects, Eexpo-sure Assessment, Prevention and Control in Indoor Environments and Work. Albany, New York: Fungal Research Group, Inc.; 2005: 276–291.
   Google Scholar
• Pady SM, Kramer CL. Kansas Aeromycology VI: Hyphal fragments. Mycologia 1960; 52: 681–687.
   Web of Science ®Google Scholar
• Romani L. Immunity to fungal infections. Nat Rev Immunol 2004; 4: 1–23.
   PubMed Web of Science ®Google Scholar
• Kauffman HF. Innate immune responses to environmental allergens. Clin Rev Allergy Immunol 2006; 30: 129–140.
   PubMedGoogle Scholar
• Martin TR, Frevert CW. Innate immunity in the lungs. Proc Am Thorac Soc 2005; 2: 403–411.
   PubMedGoogle Scholar
• Kurup VP. Interaction of Aspergillus fumigatus spores and pulmonary alveolar macrophages of rabbits. Immunobiology 1984; 166: 53–61.
   PubMed Web of Science ®Google Scholar
• Hohl TM, Van Epps HL, Rivera A, . Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathogens 2005; 1: e30.
   PubMed Web of Science ®Google Scholar
• Pylkkänen L, Gullstén H, Majuri M-L, . Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages. Toxicology 2004; 200: 255–263.
   PubMed Web of Science ®Google Scholar
• Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2: 725–731.
   PubMed Web of Science ®Google Scholar
• Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006; 6: 476–483.
   PubMed Web of Science ®Google Scholar
• Sporri R, Reis e Sousa C. inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol 2005; 6: 163–170.
   PubMed Web of Science ®Google Scholar
• Bozza S, Gaziano R, Spreca A, . Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol 2002; 168: 1362–1371.
   PubMed Web of Science ®Google Scholar
• Ober C, Thompson EE. Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol 2005; 17: 670–678.
   PubMedGoogle Scholar
• von Mutius E. Allergies, infections and the hygiene hypothesis – the epidemiological evidence. Immunobiology 2007; 212: 433–439.
   PubMed Web of Science ®Google Scholar
• Noverr MC, Huffnagle GB. The ‘microflora hypothesis’ of allergic diseases. Clin Exp Allergy 2005; 35: 1511–1520.
   PubMed Web of Science ®Google Scholar
• Capilla J, Clemons KV, Stevens DA. Animal models: an important tool in mycology. Med Mycol 2007; 45: 657–684.
   PubMed Web of Science ®Google Scholar
• Kurup VP, Grunig G. Animal models of allergic bronchopulmonary aspergillosis. Mycopathologia 2002; 153: 165–177.
   PubMed Web of Science ®Google Scholar
• Schwab CJ, Straus DC. The roles of Penicillium and Aspergillus in sick building syndrome. Adv Appl Microbiol 2004; 55: 215–238.
   PubMed Web of Science ®Google Scholar
• Pestka JJ, Yike I, Dearborn DG, Ward MDW, Harkema JR. Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. Toxicol Sci 2008; 104: 4–26.
   PubMed Web of Science ®Google Scholar
• Bakker-Woudenberg IA. Experimental models of pulmonary infection. J Microbiol Methods 2003; 54: 295–313.
   PubMedGoogle Scholar
• Rao GV, Tinkle S, Weissman DN, . Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx. J Toxicol Environ Health A 2003; 66: 1441–1452.
   PubMed Web of Science ®Google Scholar
• Viana ME, Coates NH, Gavett SH, . An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model. Toxicol Sci 2002; 70: 98–109.
   PubMed Web of Science ®Google Scholar
• Waldorf AR, Levitz SM, Diamond RD. In vivo bronchoalveolar macrophage defense against Rhizopus oryzae and Aspergillus fumigatus. J Infect Dis 1984; 150: 752–760.
   PubMed Web of Science ®Google Scholar
• Olenchock SA, Mentnech MS, Mull JC, . Complement, polymorphonuclear leukocytes and platelets in acute experimental respiratory reactions to Aspergillus. Comp Immunol Microbiol Infect Dis 1979; 2: 113–124.
   PubMed Web of Science ®Google Scholar
• Schaffner A, Douglas H, Braude A. Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. J Clin Invest 1982; 69: 617–631.
   PubMed Web of Science ®Google Scholar
• Thurston JR, Cysewski SJ, Richard JL. Exposure of rabbits to spores of Aspergillus fumigatus or Penicillium sp: survival of fungi and microscopic changes in the respiratory and gastrointestinal tracts. Am J Vet Res 1979; 40: 1443–1449.
   PubMed Web of Science ®Google Scholar
• Hohl TM, Feldmesser M. Aspergillus fumigatus: principles of pathogenesis and host defense. Eukaryot Cell 2007; 6: 1953–1963.
   PubMed Web of Science ®Google Scholar
• Latgé JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999; 12: 310–350.
   PubMed Web of Science ®Google Scholar
• Grunig G, Kurup VP. Animal models of allergic bronchopulmonary aspergillosis. Front Biosci 2003; 8: e157–171.
   Google Scholar
• Yang Z, Jaeckisch SM, Mitchell CG. Enhanced binding of Aspergillus fumigatus spores to A549 epithelial cells and extracellular matrix proteins by a component from the spore surface and inhibition by rat lung lavage fluid. Thorax 2000; 55: 579–584.
   PubMed Web of Science ®Google Scholar
• Tomee JF, Kauffman HF. Putative virulence factors of Aspergillus fumigatus. Clin Exp Allergy 2000; 30: 476–484.
   Google Scholar
• Cusumano V, Costa GB, Seminara S. Effect of aflatoxins on rat peritoneal macrophages. Appl Environ Microbiol 1990; 56: 3482–3484.
   PubMed Web of Science ®Google Scholar
• Mullbacher A, Waring P, Eichner RD. Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro. J Gen Microbiol 1985; 131: 1251–1258.
   PubMedGoogle Scholar
• Robertson MD, Seaton A, Milne LJ, Raeburn JA. Suppression of host defences by Aspergillus fumigatus. Thorax 1987; 42: 19–25.
   PubMed Web of Science ®Google Scholar
• Green BJ, Mitakakis TZ, Tovey ER. Allergen detection from 11 fungal species before and after germination. J Allergy Clin Immunol 2003; 111: 285–289.
   PubMed Web of Science ®Google Scholar
• Sporik RB, Arruda LK, Woodfolk J, Chapman MD, Platts-Mills TA. Environmental exposure to Aspergillus fumigatus allergen (Asp f I). Clin Exp Allergy 1993; 23: 326–331.
   PubMed Web of Science ®Google Scholar
• Olenchock SA, Green FH, Mentnech MS, Mull JC, Sorenson WG. In vivo pulmonary response to Aspergillus terreus spores. Comp Immunol Microbiol Infect Dis 1983; 6: 67–80.
   PubMed Web of Science ®Google Scholar
• Korpi A, Kasanen JP, Raunio P, Pasanen AL. Acute effects of Aspergillus versicolor aerosols on murine airways. Indoor air 2003; 13: 260–266.
   PubMedGoogle Scholar
• Jussila J, Komulainen H, Kosma V-M, . Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs. Inhal Toxicol 2002; 14: 1261–1277.
   PubMed Web of Science ®Google Scholar
• Jussila J, Komulainen H, Kosma V-M, Pelkonen J, Hirvonen M-R. inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs. Environ Toxicol Pharmacol 2002; 12: 137–145.
   PubMed Web of Science ®Google Scholar
• Korpi A, Kasanen JP, Raunio P, . Effects of aerosols from nontoxic Stachybotrys chartarum on murine airways. Inhal Toxicol 2002; 14: 521–540.
   PubMed Web of Science ®Google Scholar
• Menache MG, Miller FJ, Raabe OG. Particle inhalability curves for humans and small laboratory animals. Ann Occup Hyg 1995; 39: 317–328.
   PubMed Web of Science ®Google Scholar
• Nikulin M, Reijula K, Jarvis BB, Veijalainen P, Hintikka EL. Effects of intranasal exposure to spores of Stachybotrys atra in mice. Fundam Appl Toxicol 1997; 35: 182–188.
   PubMedGoogle Scholar
• Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Brain JD. Strain differences influence murine pulmonary responses to Stachybotrys chartarum. Am J Respir Cell Mol Biol 2006; 35: 415–423.
   PubMedGoogle Scholar
• Pichavant M, Goya S, Hamelmann E, Gelfand EW, Umetsu DT. Animal models of airway sensitization. InColigan JE, . Current Protocols in Immunology, Wiley and Sons New York, NY 2007; Ch. 15: Unit 15 18.
   Google Scholar
• Fresno M, Kopf M, Rivas L. Cytokines and infectious diseases. Immunol Today 1997; 18: 56–58.
   PubMedGoogle Scholar
• Okano M, Nishizaki K, Abe M, . Strain-dependent induction of allergic rhinitis without adjuvant in mice. Allergy 1999; 54: 593–601.
   PubMedGoogle Scholar
• Corry DB, Grunig G, Hadeiba H, . Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med 1998; 4: 344–355.
   PubMed Web of Science ®Google Scholar
• Kurup VP, Mauze S, Choi H, Seymour BW, Coffman RL. A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE. J Immunol 1992; 148: 3783–3788.
   PubMed Web of Science ®Google Scholar
• Kurup VP, Guo J, Murali PS, Choi H, Fink JN. Immunopathologic responses to Aspergillus antigen in interleukin-4 knockout mice. J Lab Clin Med 1997; 130: 567–575.
   PubMedGoogle Scholar
• Kurup VP, Murali PS, Guo J, . Anti-interleukin (IL)-4 and -IL-5 antibodies downregulate IgE and eosinophilia in mice exposed to Aspergillus antigens. Allergy 1997; 52: 1215–1221.
   PubMedGoogle Scholar
• Mehlhop PD, van de Rijn M, Goldberg AB, . Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci USA 1997; 94: 1344–1349.
   PubMed Web of Science ®Google Scholar
• Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J Immunol 2002; 169: 5926–5933.
   PubMed Web of Science ®Google Scholar
• Drouin SM, Corry DB, Kildsgaard J, Wetsel RA. Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. J Immunol 2001; 167: 4141–4145.
   PubMed Web of Science ®Google Scholar
• Hogaboam CM, Blease K, Mehrad B, . Chronic airway hyperre-activity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am J Pathol 2000; 156: 723–732.
   PubMed Web of Science ®Google Scholar
• Blease K, Mehrad B, Standiford TJ, . Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease. J Immunol 2000; 165: 1564–1572.
   PubMed Web of Science ®Google Scholar
• Blease K, Mehrad B, Standiford TJ, . Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. J Immunol 2000; 165: 2603–2611.
   PubMed Web of Science ®Google Scholar
• Schuh JM, Blease K, Hogaboam CM. CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice. J Immunol 2002; 168: 1447–1456.
   PubMed Web of Science ®Google Scholar
• Schuh JM, Power CA, Proudfoot AE, . Airway hyperresponsiveness, but not airway remodeling, is attenuated during chronic pulmonary allergic responses to Aspergillus in CCR4-/- mice. Faseb J 2002; 16: 1313–1315.
   PubMed Web of Science ®Google Scholar
• Schuh JM, Blease K, Hogaboam CM. The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice. Faseb J 2002; 16: 228–230.
   PubMedGoogle Scholar
• Buckland KF, O’Connor EC, Coleman EM, . Remission of chronic fungal asthma in the absence of CCR8. J Allergy Clin Immunol 2007; 119: 997–1004.
   PubMedGoogle Scholar
• Schuh JM, Blease K, Kunkel SL, Hogaboam CM. Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus. Am J Physiol 2002; 283: L198–204.
   Google Scholar
• Havaux X, Zeine A, Dits A, Denis O. A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds. Clin Exp Allergy 2005; 139: 179–188.
   Google Scholar
• Cooley JD, Wong WC, Jumper CA, . An animal model for allergic penicilliosis induced by the intranasal instillation of viable Penicillium chrysogenum conidia. Thorax 2000; 55: 489–496.
   PubMed Web of Science ®Google Scholar
• Denis O, van den Brûle S, Heymans J, . Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling. Immunology 2007; 122: 268–278.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Iijima K, Radhakrishnan S, . Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity. J Immunol 2009; 182: 2502–2510.
   PubMed Web of Science ®Google Scholar
• Kurup VP. Aspergillus antigens: which are important? Med Mycol 2005; 43 (Suppl. 1): S189–196.
   Google Scholar
• Schwab CJ, Cooley JD, Brasel T, . Characterization of exposure to low levels of viable Penicillium chrysogenum conidia and allergic sensitization induced by a protease allergen extract from viable P. chrysogenum conidia in mice. Int Arch Allergy Immunol 2003; 130: 200–208.
   PubMed Web of Science ®Google Scholar
• Comoy EE, Pestel J, Duez C, . The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma. J Immunol 1998; 160: 2456–2462.
   PubMed Web of Science ®Google Scholar
• Stewart GA, Holt PG. Immunogenicity and tolerogenicity of a major house dust mite allergen, Der p I from Dermatophagoides pteronyssinus, in mice and rats. Int Arch Allergy Appl Immunol 1987; 83: 44–51.
   PubMedGoogle Scholar
• Kauffman HF, Tomee JF, van de Riet MA, Timmerman AJ, Borger P. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol 2000; 105: 1185–1193.
   PubMed Web of Science ®Google Scholar
• Kheradmand F, Kiss A, Xu J, . A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J immunol 2002; 169: 5904–5911.
   PubMed Web of Science ®Google Scholar
• Ebeling C, Lam T, Gordon JR, Hollenberg MD, Vliagoftis H. Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway. J Immunol 2007; 179: 2910–2917.
   PubMedGoogle Scholar
• Lamhamedi-Cherradi S-E, Martin RE, Ito T, . Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J Immunol 2008; 180: 6000–6009.
   Google Scholar
• Robinson BW, Venaille TJ, Mendis AH, McAleer R. Allergens as proteases: an Aspergillus fumigatus proteinase directly induces human epithelial cell detachment. J Allergy Clin Immunol 1990; 86: 726–731.
   PubMed Web of Science ®Google Scholar
• Borger P, Koëter GH, Timmerman JA, . Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms. J Infect Dis 1999; 180: 1267–1274.
   PubMed Web of Science ®Google Scholar
• Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008; 9: 310–318.
   PubMed Web of Science ®Google Scholar
• Mambula SS, Sau K, Henneke P, Golenbock DT, Levitz SM. Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J Biol Chem 2002; 277: 39320–39326.
   PubMed Web of Science ®Google Scholar
• Meier A, Kirschning CJ, Nikolaus T, . Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol 2003; 5: 561–570.
   PubMed Web of Science ®Google Scholar
• Netea MG, Warris A, Van der Meer JW, . Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis 2003; 188: 320–326.
   PubMed Web of Science ®Google Scholar
• Brown GD, Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 2001; 413: 36–37.
   PubMed Web of Science ®Google Scholar
• Taylor PR, Brown GD, Reid DM, . The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol 2002; 169: 3876–3882.
   PubMed Web of Science ®Google Scholar
• Gersuk GM, Underhill DM, Zhu L, Marr KA. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J immunol 2006; 176: 3717–3724.
   PubMed Web of Science ®Google Scholar
• Saijo S, Fujikado N, Furuta T, . Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol 2007; 8: 39–46.
   PubMed Web of Science ®Google Scholar
• Taylor PR, Tsoni SV, Willment JA, . Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 2007; 8: 31–38.
   PubMed Web of Science ®Google Scholar
• Rivera A, Ro G, Van Epps HL, . Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity 2006; 25: 665–675.
   PubMed Web of Science ®Google Scholar
• Romani L. Cell mediated immunity to fungi: a reassessment. Med Mycol 2008; 46: 515–529.
   PubMed Web of Science ®Google Scholar
• Romani L, Fallarino F, De Luca A, . Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 2008; 451: 211–215.
   PubMed Web of Science ®Google Scholar
• Hellings PW, Kasran A, Liu Z, . Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol 2003; 28: 42–50.
   PubMed Web of Science ®Google Scholar
• Nakae S, Komiyama Y, Nambu A, . Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002; 17: 375–387.
   PubMed Web of Science ®Google Scholar
• Ebbens FA, Fokkens WJ. The mold conundrum in chronic rhinosinusitis: where do we stand today? Curr Allergy Asthma Rep 2008; 8: 93–101.
   PubMedGoogle Scholar
• Strachan DP. Hay fever, hygiene, and household size. BMJ (Clinical research ed 1989; 299: 1259–1260.
   PubMed Web of Science ®Google Scholar
• Riedler J, Braun-Fahrlander C, Eder W, . Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001; 358: 1129–1133.
   PubMed Web of Science ®Google Scholar
• Macpherson AJ, Harris NL. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 2004; 4: 478–485.
   PubMed Web of Science ®Google Scholar
• Noverr MC, Noggle RM, Toews GB, Huffnagle GB. Role of antibiotics and fungal microbiota in driving pulmonary allergic responses. Infect Immun 2004; 72: 4996–5003.
   PubMed Web of Science ®Google Scholar
• Noverr MC, Falkowski NR, McDonald RA, McKenzie AN, Huffnagle GB. Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13. Infect Immun 2005; 73: 30–38.
   PubMed Web of Science ®Google Scholar
• Montagnoli C, Fallarino F, Gaziano R, . Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 2006; 176: 1712–1723.
   PubMed Web of Science ®Google Scholar
• Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004; 4: 762–774.
   PubMed Web of Science ®Google Scholar
• Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol 2007; 7: 875–888.
   PubMed Web of Science ®Google Scholar
• Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003; 3: 331–341.
   PubMed Web of Science ®Google Scholar
• Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 2005; 174: 3237–3246.
   PubMed Web of Science ®Google Scholar
• Wilson MS, Taylor MD, Balic A, . Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med 2005; 202: 1199–1212.
   PubMed Web of Science ®Google Scholar