88
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Identification of a metallopeptidase with TOP-like activity in Paracoccidioides brasiliensis, with increased expression in a virulent strain

, , , , , , , , & show all
Pages 81-90 | Received 31 Oct 2010, Accepted 20 May 2011, Published online: 05 Jul 2011

References

  • Brummer E, Castaneda E, Restrepo A. Paracoccidioidomycosis: an update. Clin MicrobiolVer 1993; 6: 89–117.
  • Restrepo A, McEwen JG, Castaneda E. The habitat of Paracoccidioides brasiliensis: how far from solving the riddle? Med Mycol 2001; 39: 233–241.
  • Franco M, Peracoli MT, Soares A, . Host-parasite relationship in paracoccidioidomycosis. Curr Top Med Mycol 1993; 5: 115–149.
  • Hernández O, Almeida AJ, Gonzalez A, . A 32-Kilodalton hydrolase plays an important role in Paracoccidioides brasiliensis adherence to host cells and influences pathogenicity. Infect Immun 2010; 78: 5280–5286.
  • Silva Neto BR, Silva JF, Mendes-Giannini MJ, . The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin. BMC Microbiol 2009; 9: 272–284.
  • Donofrio FC, Calil AC, Miranda ET, . Enolase from Paracoccidioides brasiliensis: isolation and identification as a fibronectin-binding protein. J Med Microbiol 2009; 58: 706–713.
  • Parente JA, Salem-Izacc SM, Santana JM, . A secreted serine protease of Paracoccidioides brasiliensis and its interactions with fungal proteins. BMC Microbiol 2010; 10: 292–302.
  • Tacco BA, Parente JA, Barbosa MS, . Characterization of a secreted aspartyl protease of the fungal pathogen Paracoccidioides brasiliensis. Med Mycol 2009; 47: 845–854.
  • Carmona AK, Puccia R, Oliveira MCF, . Characterization of an exocellular serine-thiol proteinase activity in Paracoccidioides brasiliensis. Biochem J 1995; 309: 209–214.
  • Parente JA, Costa M, Pereira M, Soares CM. Transcriptome overview of Paracoccidioides brasiliensis proteases. Genet Mol Res 2005; 4: 358–371.
  • Lasdun A, Orlowski M. Inhibition of endopeptidase 24.15 slows the in vivo degradation of luteinizing hormone-releasing hormone. J Pharmacol Exp Ther 1989; 251: 439–447.
  • Molineaux CJ, Ayala JM. An inhibitor of endopeptidase 24.15 blocks the degradation of intraventricularly administered dynorphins. J Neurochem 1990; 55: 611–618.
  • Schriefer JA, Molineaux CJ. Modulatory effect of endopeptidase inhibitors on bradykinin-induced contraction of rat uterus. J Pharmacol Exp Ther 1993; 266: 700–706.
  • Isaya G, Sakati WR, Rollins RA, . Mammalian mitochondrial intermediate peptidase: structure/function analysis of a new homologue from Schizophyllum commune and relationship to thimet oligopeptidases. Genomics 1995; 28: 450–461.
  • Marcondes MF, Torquato RJ, Assis DM, . Mitochondrial intermediate peptidase: expression in Escherichia coli and improvement of its enzymatic activity detection with FRET substrates. Biochem Biophys Res Commun 2009; 391: 123–128.
  • Hrycyna CA, Clarke S. Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Biochemistry 1993; 32: 11293–11301.
  • Buchler M, Tisljar U, Wolf DH. Proteinase yscD (oligopeptidase yscD) – Structure, function and relationship of the yeast enzyme with mammalian thimet oligopeptidase (metalloendopeptidase, EP 24.15). Eur J Biochem 1994; 219: 627–639.
  • Ibrahim-Granet O, D'Enfert C. The Aspergillus fumigatus mepB gene encodes an 82kDa intracellular metalloproteinase structurally related to mammalian thimet oligopeptidase. Microbiology 1997; 143: 2247–2253.
  • Conlin CA, Miller CG. Cloning and nucleotide sequence of OpdA, the gene encoding opligopeptidase A in Salmonella typhimurium. J Bacteriol 1992; 174: 1631–1640.
  • Monteiro AC, Schmitz V, Svensjo E, . Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 2006; 177:6325–6335.
  • Scharfstein J, Schmitz V, Svensjo E, Granato A, Monteiro AC. Kininogens coordinate adaptive immunity through the proteolytic release of bradykinin, an endogenous danger signal driving dendritic cell maturation. Scand J Immunol 2007; 66: 128–136.
  • Taborda CP, Juliano MA, Puccia R, Franco M, Travassos LR. Mapping of the T-cell epitope in the major 43-kDa glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB/c mice. Infect Immun 1998; 66: 786–793.
  • Calich VL, da Costa TA, Felonato M, . Innate immunity to Paracoccidioides brasiliensis infection. Mycopathologia 2008; 165: 223–236.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–254.
  • Hirata I, Cezari MHC, Nakaie CR, . Internally quenched fluorogenic protease substrates: solid-phase synthesis and fluorescent spectroscopy of peptides containing ortho-aminobenzoil-dinitrophenyl groups as donor-acceptor pairs. Lett Peptide Sci 1994; 1: 299–308.
  • Paschoalin T, Carmona AK, Rodrigues EG, . Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth. Mol Cancer 2007; 6: 44–58.
  • Shrimpton CN, Abbenante G, Lew RA, Smith AI. Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15. Biochem J 2000; 345: 351–356.
  • Camargo Z, Unterkircher C, Campoy SP, Travassos LR. Production of Paracoccidioides brasiliensis exoantigens for immunodiffusion tests. J Clin Microbiol 1988; 26: 2147–2151
  • Vandesompele J, De Preter K, Pattyn F, . Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 2002; 3: 34.1–34.11.
  • Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002; 30: e36.
  • Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. J Biol Chem 2004; 279: 20480–20489.
  • Camargo ACM, Gomes MD, Reichl AP, . Structural features that make oligopeptidases susceptible substrates for hydrolysis by recombinant thimet oligopeptidase. Biochem J 1997; 324: 517–522.
  • Paschoalin T, Carmona AK, Oliveira V, Juliano L, Travassos LR. Characterization of thimet- and neurolysin-like activities in Escherichia coli M3A peptidases and description of a specific substrate. Arch Biochem Biophys 2005; 441: 25–34.
  • Oliveira V, Campos M, Hemerly JP, . Selective neurotensin-derived internally quenched fluorogenic substrates for neurolysin (EC 3.4.24.16): comparison with thimet oligopeptidase (EC 3.4.24.15) and neprilysin (EC 3.4.24.11). Anal Biochem 2001; 292: 257–265.
  • Medeiros MA, Franca MS, Boileau G, Juliano L, Carvalho KM. Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases. Braz J Med Biol Res 1997; 30: 1157–1162.
  • Rawlings ND, Barrett AJ, Bateman A. MEROPS: the peptidase database. Nucleic Acids Res 2010; 38: D227–D233.
  • Dauch P, Vincent JP, Checler F. Specific inhibition of endopeptidase 24.16 by dipeptides. Eur J Biochem 1991; 202: 269–276.
  • Machado MF, Rioli V, Dalio FM, . The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and Gly608 of neurolysin in substrate hydrolysis and inhibitor binding. Biochem J 2007; 404: 279–288
  • Rodier MH, el Moudni B, Kauffmann-Lacroix C, Daniault G, Jacquemin JL. A Candida albicans metallopeptidase degrades constitutive proteins of extracellular matrix. FEMS Microbiol Lett 1999; 177: 205–210.
  • Soares GC, Silva BA, Santos MH, . Metallopeptidases produced by group B Streptococcus: influence of proteolytic inhibitors on growth and on interaction with human cell lineages. Int J Mol Med 2008; 22: 119–125.
  • Elias CG, Pereira FM, Silva BA, . Leishmanolysin (gp63 metallopeptidase)-like activity extracellularly released by Herpetomonas samuelpessoai. Parasitology 2006; 132: 37–47.
  • Klimpel KR, Arora N, Leppla SH. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol 1994; 13: 1093–1100.
  • Karhawi SA, Colombo AL, Salomão R. Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission. Med Mycol 2002; 38: 225–229.
  • Benard G, Romano CC, Cacere CR, . Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. Cytokine 2001; 13: 248–252.
  • Oliveira SJ, Mamoni RL, Musatti CC, Papaiordanou PM, Blotta MH. Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis. Comparison with infected and non-infected controls. Microbes Infect 2002; 4: 139–144.
  • Mello LM, Vergara MLS, Rodrigues JV. Patients with active infection with Paracoccidioides brasiliensis immune response characterized by high interleukin 4 and interleukin 5 production. Hum Immunol 2002; 63: 149–154.
  • Stoika RS, Lutsik MD, Barska ML, Tsyrulnyk AA, Kashchak NI. In vitro studies of activation of phagocytic cells by bioactive peptides. J Physiol Pharmacol 2002; 53: 675–688.
  • Schulze-Topphoff U, Prat A, Bader M, Zipp F, Aktas O. Roles of the kallikrein/kinin system in the adaptive immune system. Int Immunopharmacol 2008; 8: 155–160.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.