Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E β-cells

References

• Biggs WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC. (1999). Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96:7421–6.
   PubMed Web of Science ®Google Scholar
• Chaika OV, Chaika N, Volle DJ, Wilden PA, Pirrucello SJ, Lewis RE. (1997). CSF-1 receptor/insulin receptor chimera permits CSF-1-dependent differentiation of 3T3-L1 preadipocytes. J Biol Chem 272:11968–74.
   PubMed Web of Science ®Google Scholar
• Dandekar AA, Wallach BJ, Barthel A, Roth RA. (1998). Comparison of the signaling abilities of the cytoplasmic domains of the insulin receptor and the insulin receptor-related receptor in 3T3-L1 adipocytes. Endocrinology 139:3578–84.
   PubMed Web of Science ®Google Scholar
• Fatrai S, Elghazi L, Balcazar N, Cras-Méneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E. (2006). Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 55:318–25.
   PubMed Web of Science ®Google Scholar
• Guillen C, Navarro P, Robledo M, Valverde AM, Benito M. (2006). Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells. Endocrinology 147:1959–68.
   PubMed Web of Science ®Google Scholar
• Hänze J, Berthold A, Klammt J, Gallaher B, Siebler T, Kratzsch J, Elmlinger M, Kiess W. (1999). Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. Horm Metab Res 31:77–9.
   PubMed Web of Science ®Google Scholar
• Hirayama I, Tamemoto H, Yokota H, Kubo SK, Wang J, Kuwano H, Nagamachi Y, Takeuchi T, Izumi T. (1999). Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2. Diabetes 48:1237–44.
   PubMed Web of Science ®Google Scholar
• Jui HY, Accili D, Taylor SI. (1996). Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH–3T3 cells. Biochemistry 35:14326–30.
   PubMed Web of Science ®Google Scholar
• Kelly-Spratt KS, Klesse LJ, Merenmies J, Parada LF. (1999). A TrkB/insulin receptor-related receptor chimeric receptor induces PC12 cell differentiation and exhibits prolonged activation of mitogen-activated protein kinase. Cell Growth Differ 10:805–12.
   PubMedGoogle Scholar
• Kelly-Spratt KS, Klesse LJ, Parada LF. (2002). BDNF activated TrkB/IRR receptor chimera promotes survival of sympathetic neurons through Ras and PI-3 kinase signaling. J Neurosci Res 69:151–9.
   PubMed Web of Science ®Google Scholar
• Kovacina KS, Roth RA. (1995). Characterization of the endogenous insulin receptor-related receptor in neuroblastomas. J Biol Chem 270:1881–7.
   PubMed Web of Science ®Google Scholar
• Marshall CJ. (1995). Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179–85.
   PubMed Web of Science ®Google Scholar
• Meloche S, Seuwen K, Pagès G, Pouysségur J. (1992). Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 6:845–54.
   PubMed Web of Science ®Google Scholar
• Párrizas M, Saltiel AR, LeRoith D. (1997). Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways. J Biol Chem 272:154–61.
   PubMed Web of Science ®Google Scholar
• Raile K, Berthold A, Banning U, Horn F, Pfeiffer G, Kiess W. (2003). IGFs, basic FGF, and glucose modulate proliferation and apoptosis induced by IFNgamma but not by IL-1beta in rat INS-1E beta-cells. Horm Metab Res 35:407–14.
   PubMed Web of Science ®Google Scholar
• Raile K, Klammt J, Laue S, Garten A, Blüher M, Kralisch S, Klöting N, Kiess W. (2005). Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells. Diabetologia 48:1798–1809.
   PubMed Web of Science ®Google Scholar
• Reinhardt RR, Chin E, Zhang B, Roth RA, Bondy CA. (1993). Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells. Endocrinology 133:3–10.
   PubMed Web of Science ®Google Scholar
• Rentería ME, Gandhi NS, Vinuesa P, Helmerhorst E, Mancera RL. (2008). A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information. PLoS ONE 3:e3667.
   PubMedGoogle Scholar
• Soos MA, Field CE, Siddle K. (1993). Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 290:419–26.
   PubMed Web of Science ®Google Scholar
• Tanaka T, Sugimoto T, Sawada T. (1998). Prognostic discrimination among neuroblastomas according to Ha-ras/trk A gene expression: a comparison of the profiles of neuroblastomas detected clinically and those detected through mass screening. Cancer 83:1626–33.
   PubMed Web of Science ®Google Scholar
• Tartare-Deckert S, Murdaca J, Sawka-Verhelle D, Holt KH, Pessin JE, Van Obberghen E. (1996). Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) receptor: comparative study using the yeast two-hybrid system. Endocrinology 137:1019–24.
   PubMed Web of Science ®Google Scholar
• Tsuji N, Tsujimoto K, Takada N, Ozaki K, Ohta M, Itoh N. (1996). Expression of insulin receptor-related receptor in the rat brain examined by in situ hybridization and immunohistochemistry. Mol Brain Res 41:250–258.
   PubMedGoogle Scholar
• Tsujimoto K, Tsuji N, Ozaki K, Ohta M, Itoh N. (1995). Insulin receptor-related receptor messenger ribonucleic acid in the stomach is focally expressed in the enterochromaffin-like cells. Endocrinology 136:558–61.
   PubMed Web of Science ®Google Scholar
• Van Horn DJ, Myers MG Jr, Backer JM. (1994). Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor. J Biol Chem 269:29–32.
   PubMed Web of Science ®Google Scholar
• Weber A, Huesken C, Bergmann E, Kiess W, Christiansen NM, Christiansen H. (2003). Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. Clin Cancer Res 9:5683–92.
   PubMed Web of Science ®Google Scholar
• Whitmore TE, Maurer MF, Day HL, Jelmberg AC, Dasovich MM, Sundborg LM, Burkhead SK, Heipel MD, Madden KL, Kramer JM, Kuijper JL, Xu WF, Jaspers SR, Holly RD, Lok S. (1999). The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21->q23 by the use of radiation hybrid mapping. Cytogenet Cell Genet 87:93–94.
   PubMedGoogle Scholar
• Zhang B, Roth RA. (1992). The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J Biol Chem 267:18320–28.
   PubMed Web of Science ®Google Scholar