Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 122, 2016 - Issue 2
506
Views
55
CrossRef citations to date
0
Altmetric
Original Article

Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model

, , , , , & show all
Pages 75-87 | Received 23 Dec 2015, Accepted 25 Jan 2016, Published online: 26 Feb 2016

References

  • Al-Muammar MN, Khan F. (2012). Obesity: The preventive role of the pomegranate (Punica granatum). Nutrition, 28:595–604
  • Alarcon-Aguilara F, Roman-Ramos R, Perez-Gutierrez S, et al. (1998). Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol, 61:101–10
  • Arch J, Hislop D, Wang S, Speakman J. (2006). Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals. Int J Obes, 30:1322–31
  • Arnous A, Makris DP, Kefalas P. (2001). Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines. J Agric Food Chem, 49:5736–42
  • Bagri P, Ali M, Aeri V, et al. (2009). Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol, 47:50–4
  • Bailey CJ, Day C. (1989). Traditional plant medicines as treatments for diabetes. Diabetes Care, 12:553–64
  • Basciano H, Federico L, Adeli, K. (2005). Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab, 2:5
  • Braca A, De Tommasi N, Di Bari L, et al. (2001). Antioxidant principles from bauhinia t arapotensis. J Nat Prod, 64:892–5
  • Cani PD, Bibiloni R, Knauf C, et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes, 57:1470–81
  • Cerdá B, Cerón JJ, Tomás-Barberán FA, Espín JC. (2003). Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J Agric Food Chem, 51:3493–501
  • Feinstein R, Kanety H, Papa M, et al. (1993). Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem, 268:26055–8
  • Flaishon L, Topilski I, Shoseyov D, et al. (2002). Cutting edge: Anti-inflammatory properties of low levels of IFN-γ. Immunology, 168:3707–11
  • Francis GA, Annicotte JS, Auwerx J. (2003). PPAR agonists in the treatment of atherosclerosis. Curr Opin Pharmacol, 3:186–91
  • Guariguata L, Whiting D, Hambleton I, et al. (2014). Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract, 103:137–49
  • Harvey EJ, Ramji DP. (2005). Interferon-γ and atherosclerosis: Pro-or anti-atherogenic? Cardiovasc Res, 67:11–20
  • Hontecillas R, O'Shea M, Einerhand A, et al. (2009). Activation of PPAR γ and α by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. J Am Coll Nutr, 28:184–95
  • Hotamisligil GS, Shargill NS, Spiegelman BM. (1993). Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science, 259:87–91
  • Huang TH, Peng G, Kota BP, et al. (2005). Anti-diabetic action of Punica granatum flower extract: Activation of PPAR-γ and identification of an active component. Toxicol Appl Pharmacol, 207:160–9
  • Hulman S, Falkner B. (1994). The effect of excess dietary sucrose on growth, blood pressure, and metabolism in developing Sprague-Dawley rats. Pediatr Res, 36:95–100
  • Jafri M, Aslam M, Javed K, Singh S. (2000). Effect of Punica granatum Linn. (flowers) on blood glucose level in normal and alloxan-induced diabetic rats. J Ethnopharmacol, 70:309–14
  • Kaur G, Jabbar Z, Athar M, Alam MS. (2006). Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem Toxicol, 44:984–93
  • Kelly LJ, Vicario PP, Thompson GM, et al. (1998). Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology, 139:4920–7
  • Lee CH, Olson P, Evans RM. (2003). Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology, 144:2201–7
  • Lehrke M, Lazar MA. (2005). The many faces of PPARγ. Cell, 123:993–9
  • Li Y, Qi Y, Huang TH, et al. (2008). Pomegranate flower: A unique traditional antidiabetic medicine with dual PPAR-α/-γ activator properties. Diabetes Obes Metab, 10:10–7
  • Matthews DR, Hosker JP, Rudenski AS, et al. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28:412–19
  • McFarlin BK, Strohacker KA, Kueht ML. (2009). Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice. Br J Nutr, 102:54–9
  • Mekni M, Flamini G, Garrab M, et al. (2013). Aroma volatile components, fatty acids and antibacterial activity of four Tunisian Punica granatum L. flower cultivars. Ind Crops Prod, 48:111–17
  • Melo I, Carvalho E, Mancini-Filhom J. (2014). Pomegranate seed oil (Punica granatum L.): A source of punicic acid (conjugated α-linolenic acid). J Hum Nutr Food Sci, 2:1024–35
  • Mühl H, Pfeilschifter J. (2003). Anti-inflammatory properties of pro-inflammatory interferon-γ. Int Immunopharmacol, 3:1247–55
  • Nekooeian AA, Eftekhari MH, Adibi S, Rajaeifard A. (2014). Effects of pomegranate seed oil on insulin release in rats with type 2 diabetes. Iran J Med Sci, 39:130–5
  • Nemer K. (2009). The role of punicic acid (c9t11c13-CLNA) in lipid and energy metabolism of mice. A senior honors research thesis. Ohio (OH): The Ohio State University at Columbus
  • Neyrinck AM, Van Hée VF, Bindels LB. (2013). Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: Potential implication of the gut microbiota. Br J Nutr, 109:802–9
  • Roberts CK, Liang K, Barnard RJ, et al. (2004). HMG-CoA reductase, cholesterol 7α-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X. Kidney Int, 66:1503–11
  • Shoelson SE, Herrero L, Naaz A. (2007). Obesity, inflammation, and insulin resistance. Gastroenterology, 132:2169–80
  • Singh R, Chidambara Murthy K, Jayaprakasha G. (2002). Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem, 50(1):81–6
  • Stocker CJ, Wargent E, O'Dowd J, et al. (2007). Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers. Am J Physiol Regul Integr Comp Physiol, 292:R1810–18
  • Stumvoll M, Häring H. (2002). The peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism. Diabetes, 51:2341–7
  • Vroegrijk IO, van Diepen JA, Van den Berg S, et al. (2011). Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. Food Chem Toxicol, 49:1426–30
  • Xu KZY, Zhu C, Kim MS, et al. (2009). Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. J Ethnopharmacol, 123:280–7
  • Yang ZH, Miyahara H, Takeo J, Katayama M. (2012). Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice. Diabetol Metab Syndr, 4:32–41
  • Zhang H, Potter BJ, Cao JM, Zhang C. (2011). Interferon-gamma induced adipose tissue inflammation is linked to endothelial dysfunction in type 2 diabetic mice. Basic Res Cardiol, 106:1135–45
  • Zhang L, Yang X, Zhang Y, et al. (2011). In vitro antioxidant properties of different parts of pomegranate flowers. Food Bioprod Process, 89:234–40
  • Zhao W, Li J, He X, et al. (2014). In vitro steatosis hepatic cell model to compare the lipid-lowering effects of pomegranate peel polyphenols with several other plant polyphenols as well as its related cholesterol efflux mechanisms. Toxicol Rep, 1:945–54

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.