Need for tailored strategies to diagnose venous thrombo-embolism in older primary care patients. Extension of a keynote presentation at the 2012 Wonca Europe conference

REFERENCES

• White RH. The epidemiology of venous thromboembolism. 2003;107(23 Suppl 1):14–8.
   Google Scholar
• Goodacre S, Sutton AJ, Sampson FC. Meta-analysis: The value of clinical assessment in the diagnosis of deep venous thrombosis. Ann Intern Med. 2005;143:129–39.
   PubMed Web of Science ®Google Scholar
• Büller HR, Ten Cate-Hoek AJ, Hoes AW, Joore MA, Moons KG, Oudega R, et al. Safely ruling out deep venous thrombosis in primary care. Ann Intern Med. 2009;150:229–35.
   PubMed Web of Science ®Google Scholar
• Oudega R, van Weert H, Stoffers HEJH, Sival PPE, Schure RI, Delemarre J, et al. NHG standaard diep veneuze trombose. Huisarts Wet. 2008;51:24–37.
   Google Scholar
• Siccama RN, Janssen KJ, Verheijden NA, Oudega R, Bax L, van Delden JJ, et al. Systematic review: Diagnostic accuracy of clinical decision rules for venous thromboembolism in elderly. Ageing Res Rev. 2011;10:304–13.
   PubMed Web of Science ®Google Scholar
• Wells PS, Owen C, Doucette S, Fergusson D, Tran H. Does this patient have deep vein thrombosis? JAMA 2006;295:199–207.
   PubMed Web of Science ®Google Scholar
• Geersing GJ, Erkens PM, Lucassen WA, Büller HR, Cate HT, Hoes AW, et al. Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: Prospective cohort study. Br Med J. 2012;345:e6564.
   PubMed Web of Science ®Google Scholar
• Oudega R, Moons KG, Hoes AW. Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing. Thromb Haemost. 2005;94:200–5.
   PubMed Web of Science ®Google Scholar
• Moons KG, Altman DG, Vergouwe Y, Royston P. Prognosis and prognostic research: application and impact of prognostic models in clinical practice. Br Med J. 2009;338:b606.
   PubMedGoogle Scholar
• Reilly BM, Evans AT. Translating clinical research into clinical practice: Impact of using prediction rules to make decisions. Ann Intern Med. 2006;144:201–9.
   PubMed Web of Science ®Google Scholar
• Stein PD, Hull RD, Patel KC, Olson RE, Ghali WA, Brant R, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: A systematic review. Ann Intern Med. 2004;20;140:589–602.
   Google Scholar
• Silverstein MD, Heit JA, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ, III. Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study. Arch Intern Med. 1998;158:585–93.
   PubMed Web of Science ®Google Scholar
• Harper PL, Theakston E, Ahmed J, Ockelford P. D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly. Intern Med J. 2007;37:607–13.
   PubMed Web of Science ®Google Scholar
• Altman DG, Vergouwe Y, Royston P, Moons KG. Prognosis and prognostic research: validating a prognostic model. Br Med J. 2009;338:b605.
   PubMed Web of Science ®Google Scholar
• Oudega R, Moons KG, Hoes AW. Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing. Thromb Haemost. 2005;94:200–5.
   PubMed Web of Science ®Google Scholar
• Gill TM, Gahbauer EA, Han L, Allore HG. The relationship between intervening hospitalizations and transitions between frailty states. J Gerontol A Biol Sci Med Sci. 2011;66:1238–43.
   PubMed Web of Science ®Google Scholar
• Schouten HJ, van GS, Koek HL, Geersing GJ, Oudega R, Moons KG, et al. Non-diagnosis decisions and non-treatment decisions in elderly patients With cardiovascular diseases, do they differ? A systematic review. J Am Med Dir Assoc. 2012;13:682–7.
   PubMed Web of Science ®Google Scholar
• Bauer G. The introduction of heparin therapy in cases of early thrombosis. Circulation 1959;19:108–9.
   PubMed Web of Science ®Google Scholar
• Barritt DW, Jordan SC. Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial. Lancet 1960;1: 1309–12.
   PubMed Web of Science ®Google Scholar
• Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro heart survey. Chest 2010;138:1093–100.
   PubMed Web of Science ®Google Scholar
• Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest 2008;133:454S–545S.
   PubMed Web of Science ®Google Scholar
• Kachroo S, Boyd D, Bookhart BK, LaMori J, Schein JR, Rosenberg DJ, et al. Quality of life and economic costs associated with postthrombotic syndrome. Am J Health Syst Pharm. 2012;69:567–72.
   PubMed Web of Science ®Google Scholar
• Prasad V, Rho J, Cifu A. The diagnosis and treatment of pulmonary embolism: A metaphor for medicine in the evidence-based medicine era. Arch Intern Med. 2012;172:955–8.
   PubMedGoogle Scholar
• Linkins L, O’Donnell M, Julian JA, Kearon C. Intracranial and fatal bleeding according to indication for long-term oral anticoagulant therapy. J Thromb Haemost. 2010;8:2201–7.
   PubMed Web of Science ®Google Scholar
• Linkins LA, Choi PT, Douketis JD. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: A meta-analysis. Ann Intern Med. 2003;139:893–900.
   PubMed Web of Science ®Google Scholar
• Nieto JA, Solano R, Ruiz-Ribo MD, Ruiz-Gimenez N, Prandoni P, Kearon C, et al. Fatal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: Findings from the RIETE registry. J Thromb Haemost. 2010;8:1216–22.
   PubMed Web of Science ®Google Scholar
• Douma RA, Le GG, Sohne M, Righini M, Kamphuisen PW, Perrier A, et al. Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: A retrospective analysis of three large cohorts. Br Med J. 2010;340:c1475.
   PubMed Web of Science ®Google Scholar
• Schouten HJ, Koek HL, Oudega R, Geersing GJ, Janssen KJ, van Delden JJ, et al. Validation of two age dependent D-dimer cut-off values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: Retrospective, cross sectional, diagnostic analysis. Br Med J 2012 Jun 6;344:ee2985.
   PubMedGoogle Scholar