ENOS polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Chinese Han population

References

• Congdon N, O’Colmain B, Klaver CC, et al. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004;122:477–485.
   PubMed Web of Science ®Google Scholar
• Ambati J, Ambati BK, Yoo SH, et al. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 2003;48:257–293.
   PubMed Web of Science ®Google Scholar
• Schneider U, Gelisken F, Inhoffen W. Natural course of occult choroidal neovascularization in age-related macular degeneration: Development of classic lesions in fluorescein angiography. Acta Ophthalmol Scand 2005;83:141–147.
   PubMedGoogle Scholar
• Liu Y, Wen F, Huang S, et al. Subtype lesions of neovascular age-related macular degeneration in Chinese patients. Graefes Arch Clin Exp Ophthalmol 2007;245:1441–1445.
   PubMed Web of Science ®Google Scholar
• Maruko I, Iida T, Saito M, et al. Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol 2007;144:15–22.
   PubMed Web of Science ®Google Scholar
• Ciardella AP, Donsoff IM, Huang SJ, et al. Polypoidal choroidal vasculopathy. Surv Ophthalmol 2004;49:25–37.
   PubMed Web of Science ®Google Scholar
• Kikuchi M, Nakamura M, Ishikawa K, et al. Elevated C-reactive protein levels in patients with polypoidal choroidal vasculopathy and patients with neovascular age-related macular degeneration. Ophthalmology 2007;114:1722–1727.
   PubMed Web of Science ®Google Scholar
• Yamashiro K, Mori K, Nakata I, et al. Association of elastin gene polymorphism to age-related macular degeneration and polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci 2011;52:8780–8784.
   PubMed Web of Science ®Google Scholar
• Liu K, Chen LJ, Tam PO, et al. Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology 2013;120:837–843.
   PubMed Web of Science ®Google Scholar
• Hong YJ, Miura M, Makita S, et al. Noninvasive investigation of deep vascular pathologies of exudative macular diseases by high-penetration optical coherence angiography. Invest Ophthalmol Vis Sci 2013;54:3621–3631.
   PubMed Web of Science ®Google Scholar
• Matsumiya W, Honda S, Kusuhara S, et al. Effectiveness of intravitreal ranibizumab in exudative age-related macular degeneration (AMD): Comparison between typical neovascular AMD and polypoidal choroidal vasculopathy over a 1 year follow-up. BMC Ophthalmol 2013;13:10.
   PubMed Web of Science ®Google Scholar
• Yuzawa M, Mori R, Kawamura A. The origins of polypoidal choroidal vasculopathy. Br J Ophthalmol 2005;89:602–607.
   PubMed Web of Science ®Google Scholar
• Imamura Y, Engelbert M, Iida T, et al. Polypoidal choroidal vasculopathy: A review. Surv Ophthalmol 2010;55:501–515.
   PubMed Web of Science ®Google Scholar
• Quyyumi AA, Dakak N, Andrews NP, et al. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 1995;92:320–326.
   PubMed Web of Science ®Google Scholar
• Laspas P, Goloborodko E, Sniatecki JJ, et al. Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice. Exp Eye Res 2014;127:1–8.
   PubMed Web of Science ®Google Scholar
• Pan L, Hu JL, Wang WJ, et al. Molecular mechanisms of (R,R)ZX-5 on NO synthesis and its anti-angiogenic effect. Int J Mol Sci 2012;13:2717–2726.
   PubMed Web of Science ®Google Scholar
• Kaur C, Sivakumar V, Foulds WS, et al. Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia. Invest Ophthalmol Vis Sci 2009;50:5364–5374.
   PubMed Web of Science ®Google Scholar
• Bhutto IA, Baba T, Merges C, et al. Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD). Exp Eye Res 2010;90:155–167.
   PubMed Web of Science ®Google Scholar
• Piatti PM, Marone E, Mantero M, et al. Effect of normalization of fasting glucose by intensified insulin therapy and influence of eNOS polymorphisms on the incidence of restenosis after peripheral angioplasty in patients with type 2 diabetes: A randomized, open-label clinical trial. Acta Diabetol 2013;50:373–382.
   PubMed Web of Science ®Google Scholar
• Awata T, Neda T, Iizuka H, et al. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Diabetes Care 2004;27:2184–2190.
   PubMed Web of Science ®Google Scholar
• Bazzaz JT, Amoli MM, Pravica V, et al. eNOS gene polymorphism association with retinopathy in type 1 diabetes. Ophthalmic Genet 2010;31:103–107.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wen F, Zuo C, et al. Association of genetic variation on chromosome 9p21 with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2011;52:8063–8067.
   PubMed Web of Science ®Google Scholar
• Japanese Study Group of Polypoidal Choroidal Vasculopathy. [Criteria for diagnosis of polypoidal choroidal vasculopathy]. Nihon Ganka Gakkai Zasshi 2005;109:417–427.
   Google Scholar
• The International HapMap Project. Nature 2003;426:789–796.
   Google Scholar
• Barrett JC, Fry B, Maller J, et al. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263–265.
   PubMed Web of Science ®Google Scholar
• Purcell S, Neale B, Todd-Brown K, et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559–575.
   PubMed Web of Science ®Google Scholar
• Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 1990;9:811–818.
   PubMed Web of Science ®Google Scholar
• Faul F, Erdfelder E, Lang AG, et al. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007;39:175–191.
   PubMed Web of Science ®Google Scholar
• Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109–142.
   PubMed Web of Science ®Google Scholar
• Sanders KM, Ward SM. Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 1992;262:G379–392.
   PubMed Web of Science ®Google Scholar
• Xu HM, Wei J, Pan L, et al. The mechanism of (R,R) ZX-5 on increasing NO release. Int J Mol Sci 2010;11:3323–3333.
   PubMed Web of Science ®Google Scholar
• Awadalla MS, Thapa SS, Hewitt AW, et al. Association of eNOS polymorphisms with primary angle-closure glaucoma. Invest Ophthalmol Vis Sci 2013;54:2108–2114.
   PubMed Web of Science ®Google Scholar
• Magalhaes da Silva T, Rocha AV, Lacchini R, et al. Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. Gene 2012;502:142–146.
   PubMed Web of Science ®Google Scholar
• Liao Q, Wang DH, Sun HJ. Association of genetic polymorphisms of eNOS with glaucoma. Mol Vis 2011;17:153–158.
   PubMed Web of Science ®Google Scholar
• Ayub H, Khan MI, Micheal S, et al. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts. Mol Vis 2010;16:18–25.
   PubMed Web of Science ®Google Scholar
• Shi H, Zhu R, Hu N, et al. Association of eNOS polymorphisms with anterior chamber depth in Han Chinese: Jiangsu eye study. J Ophthalmol 2014;2014:164104.
   PubMed Web of Science ®Google Scholar
• Suganthalakshmi B, Anand R, Kim R, et al. Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol Vis 2006;12:336–341.
   PubMed Web of Science ®Google Scholar
• Uthra S, Raman R, Mukesh BN, et al. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Ophthalmic Genet 2007;28:77–81.
   PubMed Web of Science ®Google Scholar
• Synowiec E, Sliwinski T, Danisz K, et al. Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD. Front Biosci (Landmark Ed) 2013;18:80–90.
   PubMed Web of Science ®Google Scholar
• Haas P, Aggermann T, Steindl K, et al. Genetic cardiovascular risk factors and age-related macular degeneration. Acta Ophthalmol 2011;89:335–338.
   PubMed Web of Science ®Google Scholar