877
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Flavonoids from Inula britannica reduces oxidative stress through inhibiting expression and phosphorylation of p47phox in VSMCs

, , , , , , & show all
Pages 815-820 | Received 19 Oct 2010, Accepted 18 Dec 2010, Published online: 18 Apr 2011

References

  • Chan EC, Datla SR, Dilley R, Hickey H, Drummond GR, Dusting GJ. (2007). Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits. Cardiovasc Res, 75, 710–718.
  • Dhalla NS, Temsah RM, Netticadan T. (2000). Role of oxidative stress in cardiovascular diseases. J Hypertens, 18, 655–673.
  • Duarte J, Pérez-Palencia R, Vargas F, Ocete MA, Pérez-Vizcaino F, Zarzuelo A, Tamargo J. (2001). Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol, 133, 117–124.
  • Geng HM, Zhang DQ, Zha JP, Qi JL. (2007). Simultaneous HPLC determination of five flavonoids in Flos inulae. Chromatographia, 66, 271–275.
  • Griendling KK, FitzGerald GA. (2003). Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation, 108, 2034–2040.
  • Griendling KK, Harrison DG. (1999). Dual role of reactive oxygen species in vascular growth. Circ Res, 85, 562–563.
  • Griendling KK, Sorescu D, Ushio-Fukai M. (2000). NAD(P)H oxidase: Role in cardiovascular biology and disease. Circ Res, 86, 494–501.
  • Han M, Wen JK, Zheng B, Cheng Y, Zhang C. (2006). Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells. Am J Physiol, Cell Physiol, 291, C50–C58.
  • Heckenkamp J, Gawenda M, Brunkwall J. (2002). Vascular restenosis. Basic science and clinical implications. J Cardiovasc Surg (Torino), 43, 349–357.
  • Hollman PC, Katan MB. (1999). Dietary flavonoids: Intake, health effects and bioavailability. Food Chem Toxicol, 37, 937–942.
  • Jiang F, Drummond GR, Dusting GJ. (2004). Suppression of oxidative stress in the endothelium and vascular wall. Endothelium, 11, 79–88.
  • Jiang GJ, Han M, Zheng B, Wen JK. (2006). Hyperplasia suppressor gene associates with smooth muscle alpha-actin and is involved in the redifferentiation of vascular smooth muscle cells. Heart Vessels, 21, 315–320.
  • Lyle AN, Griendling KK. (2006). Modulation of vascular smooth muscle signaling by reactive oxygen species. Physiology (Bethesda), 21, 269–280.
  • Middleton E Jr, Kandaswami C, Theoharides TC. (2000). The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev, 52, 673–751.
  • Min LJ, Mogi M, Iwanami J, Li JM, Sakata A, Fujita T, Tsukuda K, Iwai M, Horiuchi M. (2007). Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence. Cardiovasc Res, 76, 506–516.
  • Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. (2001). Flavonoids: A review of probable mechanisms of action and potential applications. Am J Clin Nutr, 74, 418–425.
  • Sánchez M, Galisteo M, Vera R, Villar IC, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. (2006). Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens, 24, 75–84.
  • Sanchez M, Lodi F, Vera R, Villar IC, Cogolludo A, Jimenez R, Moreno L, Romero M, Tamargo J, Perez-Vizcaino F, Duarte J. (2007). Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. J Nutr, 137, 910–915.
  • Spitz DR, Oberley LW. (1989). An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem, 179, 8–18.
  • Srivastava S, Chandrasekar B, Bhatnagar A, Prabhu SD. (2002). Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: Role of aldose reductase. Am J Physiol Heart Circ Physiol, 283, H2612–H2619.
  • Taniyama Y, Griendling KK. (2003). Reactive oxygen species in the vasculature: Molecular and cellular mechanisms. Hypertension, 42, 1075–1081.
  • Touyz RM, Yao G, Schiffrin EL. (2003). c-Src induces phosphorylation and translocation of p47phox: Role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol, 23, 981–987.
  • Zhang HB, Wen JK, Wang YY, Zheng B, Han M. (2009). Flavonoids from Inula britannica L. inhibit injury-induced neointimal formation by suppressing oxidative-stress generation. J Ethnopharmacol, 126, 176–183.
  • Zheng B, Han M, Bernier M, Zhang XH, Meng F, Miao SB, He M, Zhao XM, Wen JK. (2009). Kruppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. J Biol Chem, 284, 22773–22785.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.