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Short Communications

Ursolic acid enhances mouse liver regeneration after partial hepatectomy

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Pages 523-528 | Received 28 Dec 2010, Accepted 02 Aug 2011, Published online: 02 Dec 2011

References

  • Achiwa Y, Hasegawa K, Komiya T, Udagawa Y. (2005). Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells. Oncol Rep, 13, 51–57.
  • Andiran F, Ayhan A, Tanyel FC, Abbasoglu O, Sayek I. (2000). Regenerative capacities of normal and cirrhotic livers following 70% hepatectomy in rats and the effect of alpha-tocopherol on cirrhotic regeneration. J Surg Res, 89, 184–188.
  • Ankoma-Sey V. (1999). Hepatic regeneration-revisiting the myth of Prometheus. News Physiol Sci, 14, 149–155.
  • Aparecida Resende F, de Andrade Barcala CA, da Silva Faria MC, Kato FH, Cunha WR, Tavares DC. (2006). Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in Balb/c mice. Life Sci, 79, 1268–1273.
  • Chamuleau RA, Bosman DK. (1988). Liver regeneration. Hepatogastroenterology, 35, 309–312.
  • Cho IJ, Sung DK, Kang KW, Kim SG. (2009). Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation. Arch Pharm Res, 32, 625–635.
  • Clavien PA. (2008). Liver regeneration: a spotlight on the novel role of platelets and serotonin. Swiss Med Wkly, 138, 361–370.
  • Clavien PA, Petrowsky H, DeOliveira ML, Graf R. (2007). Strategies for safer liver surgery and partial liver transplantation. N Engl J Med, 356, 1545–1559.
  • Court FG, Wemyss-Holden SA, Dennison AR, Maddern GJ. (2002). The mystery of liver regeneration. Br J Surg, 89, 1089–1095.
  • Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, Taub R. (1996). Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science, 274, 1379–1383.
  • Francavilla A, Panella C, Polimeno L, Giangaspero A, Mazzaferro V, Pan CE, Van Thiel DH, Starzl TE. (1990). Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections. Hepatology, 12, 1134–1138.
  • Furuta K, Kakita A, Takahashi T, Tomiya T, Fujiwara K. (2000). Experimental study on liver regeneration after simultaneous partial hepatectomy and pancreatectomy. Hepatol Res, 17, 223–236.
  • Gayathri R, Priya DK, Gunassekaran GR, Sakthisekaran D. (2009). Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. Asian Pac J Cancer Prev, 10, 933–938.
  • Greenbaum LE, Li W, Cressman DE, Peng Y, Ciliberto G, Poli V, Taub R. (1998). CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest, 102, 996–1007.
  • Harmand PO, Duval R, Delage C, Simon A. (2005). Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. Int J Cancer, 114, 1–11.
  • Iatropoulos MJ, Williams GM. (1996). Proliferation markers. Exp Toxicol Pathol, 48, 175–181.
  • Ishii T, Sato M, Sudo K, Suzuki M, Nakai H, Hishida T, Niwa T, Umezu K, Yuasa S. (1995). Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J Biochem, 117, 1105–1112.
  • Ishiki Y, Ohnishi H, Muto Y, Matsumoto K, Nakamura T. (1992). Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo. Hepatology, 16, 1227–1235.
  • Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA. (2009). The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Mol Cell Biol, 29, 3867–3880.
  • Kaibori M, Kwon AH, Nakagawa M, Wei T, Uetsuji S, Kamiyama Y, Okumura T, Kitamura N. (1997). Stimulation of liver regeneration and function after partial hepatectomy in cirrhotic rats by continuous infusion of recombinant human hepatocyte growth factor. J Hepatol, 27, 381–390.
  • Kato A, Bamba H, Shinohara M, Yamauchi A, Ota S, Kawamoto C, Yoshida Y. (2005). Relationship between expression of cyclin D1 and impaired liver regeneration observed in fibrotic or cirrhotic rats. J Gastroenterol Hepatol, 20, 1198–1205.
  • Lauthier F, Taillet L, Trouillas P, Delage C, Simon A. (2000). Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. Anticancer Drugs, 11, 737–745.
  • Li F, Jiang Y, Zheng Q, Yang X, Wang S. (2011). TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF. Biochem Biophys Res Commun, 404, 79–85.
  • Lin CN, Chung MI, Gan KH. (1988). Novel antihepatotoxic principles of Solanum incanum. Planta Med, 54, 222.
  • Liu J. (1995). Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol, 49, 57–68.
  • Liu J, Liu Y, Mao Q, Klaassen CD. (1994). The effects of 10 triterpenoid compounds on experimental liver injury in mice. Fundam Appl Toxicol, 22, 34–40.
  • Ma XH, Zhao YC, Yin L, Xu RL, Han DW, Wang MS. (1986). [Studies on the preventive and therapeutic effects of ursolic acid (UA) on acute hepatic injury in rats]. Yao Xue Xue Bao, 21, 332–335.
  • Markiewski MM, DeAngelis RA, Lambris JD. (2006). Liver inflammation and regeneration: two distinct biological phenomena or parallel pathophysiologic processes? Mol Immunol, 43, 45–56.
  • Matsumoto K, Nakamura T. (1992). Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog, 3, 27–54.
  • Michalopoulos GK. (2007). Liver regeneration. J Cell Physiol, 213, 286–300.
  • Michalopoulos GK, DeFrances MC. (1997). Liver regeneration. Science, 276, 60–66.
  • Nakano K, Chijiiwa K, Tanaka M. (2001). Lower activity of CCAAT/enhancer-binding protein and expression of cyclin E, but not cyclin D1, activating protein-1 and p21(WAF1), after partial hepatectomy in obstructive jaundice. Biochem Biophys Res Commun, 280, 640–645.
  • Nolte T, Kaufmann W, Schorsch F, Soames T, Weber E. (2005). Standardized assessment of cell proliferation: the approach of the RITA-CEPA working group. Exp Toxicol Pathol, 57, 91–103.
  • Ovesná Z, Vachálková A, Horváthová K, Tóthová D. (2004). Pentacyclic triterpenoic acids: new chemoprotective compounds. Minireview. Neoplasma, 51, 327–333.
  • Price KR, Johnson IT, Fenwick GR. (1987). The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr, 26, 27–135.
  • Saraswat B, Visen PK, Agarwal DP. (2000). Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes. Phytother Res, 14, 163–166.
  • Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R, Brenner DA. (2003). c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology, 37, 824–832.
  • Tsim NC, Frampton AE, Habib NA, Jiao LR. (2010). Surgical treatment for liver cancer. World J Gastroenterol, 16, 927–933.
  • Wang GL, Timchenko NA. (2005). Dephosphorylated C/EBPalpha accelerates cell proliferation through sequestering retinoblastoma protein. Mol Cell Biol, 25, 1325–1338.
  • Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ, Timchenko NA. (2001). C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell, 8, 817–828.
  • Yan SL, Huang CY, Wu ST, Yin MC. (2010). Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. Toxicol in Vitro, 24, 842–848.
  • Zhang T, He YM, Wang JS, Shen J, Xing YY, Xi T. (2011). Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPß expression by ERK pathway activation. Anticancer Drugs, 22, 158–165.

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