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Research Article

Hypotensive activity of auraptene, a monoterpene coumarin from Citrus spp.

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Pages 545-549 | Received 12 Apr 2012, Accepted 18 Oct 2012, Published online: 01 Feb 2013

References

  • Ari Y-N, Altan VM, Altinkurt O, Ozturk Y. (2006). Pharmacological effects of rutin. Phytother Res 5:19–23
  • Askari M, Sahebkar A, Iranshahi M. (2009). Synthesis and purification of 7-prenyloxycoumarins and herniarin as bioactive natural coumarins. Iran J Basic Med Sci 12:63–9
  • Curini M, Cravotto G, Epifano F, Giannone G. (2006). Chemistry and biological activity of natural and synthetic prenyloxycoumarins. Curr Med Chem 13:199–222
  • Curini M, Epifano F, Messina F, Genovese S. (2012). Antibacterial properties of auraptene and oxyprenylated naturally occurring benzoic and cinnamic acids. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 11:74–6
  • Davies MJ. (1991). Hypertension and atherosclerotic (ischaemic) heart disease. J Hum Hypertens 5:23–9
  • Díaz-Juárez JA, Tenorio-López FA, Zarco-Olvera G, et al. (2009). Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo. Phytother Res 23:948–54
  • El Bardai S, Wibo M, Hamaide MC, et al. (2003). Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. Br J Pharmacol 140:1211–16
  • Epifano F, Genovese S, Curini M. (2008). Auraptene: Phytochemical and pharmacological properties. In: Matsumoto T, ed. Phytochemistry Research Progressed. New York: Nova Science Publishers Inc., 145–62
  • Fusi F, Saponara S, Pessina F, et al. (2003). Effects of quercetin and rutin on vascular preparations. Eur J Nutr 42:10–17
  • Gaziano JM. (1999). Antioxidant vitamins and cardiovascular disease. Proc Assoc Am Physicians 111:2–9
  • Genovese S, Epifano F. (2011). Auraptene: A natural biologically active compound with multiple targets. Curr Drug Targets 12:381–6
  • Guerrero MF, Puebla P, Carrón R, et al. (2004). Vasorelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus. J Ethnopharmacol 94:185–9
  • Guo YI, Bruno RS. (2011). Vasoprotective activities of quercetin. Agro Food Industry Hi-Tech 22:16–19
  • Jang YJ, Ryu HJ, Choi YO, et al. (2004). Effects of an intracellular Ca2+ chelator on insulin resistance and hypertension in high-fat-fed rats and spontaneously hypertensive rats. Metabolism 53:269–72
  • Kakiuchi N, Senaratne LR, Huang SL, et al. (1991). Effects of constituents of Beli (Aegle marmelos) on spontaneous beating and calcium-paradox of myocardial cells. Planta Med 57:43–6
  • Kawaguchi S, Sunagawa Y, Murakami A, et al. (2011). Auraptene, a Citrus flavonoid, prevents the deterioration of systolic function after myocardial infarction in rat. J Cardiac Fail 17:S154
  • Kelly GS. (2011). Quercetin. Altern Med Rev 16:172–94
  • Kivipelto M, Laakso MP, Tuomilehto J, et al. (2002). Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: Potential for pharmacological intervention. CNS Drugs 16:435–44
  • Kohno H, Suzuki R, Curini M, et al. (2006). Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int J Cancer 118:2936–42
  • Kuroyanagi K, Kang MS, Goto T, et al. (2008). Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. Biochem Biophys Res Commun 366:219–25
  • Kwon YI, Vattem DA, Shetty K. (2006). Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac J Clin Nutr 15:107–18
  • Lindner E, Dohadwalla AN, Bhattacharya BK. (1978). Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskoli: Forskolin. Arzneimittelforschung 28:284–9
  • Makin A, Lip GYH, Silverman S, Beevers DG. (2001). Peripheral vascular disease and hypertension: A forgotten association?. J Hum Hypertens 15:447–54
  • Melis MS, Sainati AR. (1991). Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 33:257–62
  • Mulero J, Bernabé J, Cerdá B, et al. (2012). Variations on cardiovascular risk factors in metabolic syndrome after consume of a Citrus-based juice. Clin Nutr 31:372–7
  • Murakami A, Kuki W, Takahashi Y, et al. (1997). Auraptene, a Citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes. Jap J Cancer Res 88:443–52
  • Murakami A, Nakamura Y, Tanaka T, et al. (2000). Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21:1843–50
  • Nagao K, Yamano N, Shirouchi B, et al. (2010). Effects of Citrus auraptene (7-geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo. J Agric Food Chem 58:9028–32
  • Oboh G, Ademosun A. (2011a). Phenolic extracts from grapefruit peels (Citrus paradisi) inhibit key enzymes linked with type 2 diabetes and hypertension. J Food Biochem 35:1703–9
  • Oboh G, Ademosun AO. (2011b). Phenolic-rich extracts from orange peels (C. sinensis) inhibit key enzymes linked to non-insulin dependent diabetes mellitus (NIDDM) and hypertension. Riv Ital Sostanze Grasse 88:16–23
  • Ogawa K, Kawasaki A, Yoshida T, et al. (2000). Evaluation of auraptene content in citrus fruits and their products. J Agric Food Chem 48:1763–9
  • Ogunniyi A, Talabi O. (2001). Cerebrovascular complications of hypertension. Niger J Med 10:158–61
  • Ohashi K, Bohgaki T, Matsubara T, Shibuya H. (2000). Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae). Chem Pharm Bull 48:433–5
  • Perez YY, Jimenez-Ferrer E, Alonso D, et al. (2010). Citrus limetta leaves extract antagonizes the hypertensive effect of angiotensin II. J Ethnopharmacol 128:611–14
  • Prince M, Li Y, Childers A, et al. (2009). Comparison of Citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. Toxicol Lett 185:180–6
  • Roza JM, Xian-Liu Z, Guthrie N. (2007). Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Altern Ther Health Med 13:44–8
  • Russo M, Spagnuolo C, Tedesco I, et al. (2012). The flavonoid quercetin in disease prevention and therapy: Facts and fancies. Biochem Pharmacol 83:6–15
  • Sahebkar A. (2011). Citrus auraptene: A potential multifunctional therapeutic agent for nonalcoholic fatty liver disease. Ann Hepatol 10:575–7
  • Shehin SE, Sowers JR, Zemel MB. (1989). Impaired vacular smooth muscle 45Ca efflux and hypertension in Zucker obese rats. J Vasc Med Biol 1:278–82
  • Soltani F, Mosaffa F, Iranshahi M, et al. (2010). Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stress. Phytother Res 24:85–9
  • Talha J, Priyanka M, Akanksha A. (2011). Hypertension and herbal plants. Int Res J Pharm 2:26–30
  • Tanaka T, Kawabata K, Kakumoto M, et al. (1998). Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: The inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes. Cancer Res 58:2550–6
  • Tirapelli CR, Ambrosio SR, de Oliveira AM, Tostes RC. (2010). Anti-hypertensive action of naturally occurring diterpenes: A therapeutic promise for the treatment of hypertension. Fitoterapia 81:690–702
  • Touyz RM, Schiffrin EL. (1994). Insulin-induced Ca2+ transport is altered in vascular smooth muscle cells of spontaneously hypertensive rats. Hypertension 23:931–5
  • Tribble DL. (1999). AHA Science Advisory. Antioxidant consumption and risk of coronary heart disease: Emphasison vitamin C, vitamin E, and beta-carotene: A statement for healthcare professionals from the American Heart Association. Circulation 99:591–5
  • Vikrant S, Tiwari SC. (2001). Essential hypertension – pathogenesis and pathophysiology. J Indian Acad Clin Med 2:140–61
  • Xu YC, Leung SWS, Yeung DKY, et al. (2007). Structure–activity relationships of flavonoids for vascular relaxation in porcine coronary artery. Phytochemistry 68:1179–88
  • Yamada T, Hayasaka S, Shibata Y, et al. (2011). Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: The Jichi medical school cohort study. J Epidemiol 21:169–75
  • Yamada Y, Okamoto M, Kikuzaki H, Nakatani N. (1997). Spasmolytic activity of aurapten analogs. Biosci Biotechnol Biochem 61:740–2
  • Zhang C, Kuroyangi M, Tan BK. (1998). Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetized rat and isolated right atria. Pharmacol Res 38:413–17

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