The effects of qindan-capsule-containing serum on the TGF-β1/ERK signaling pathway, matrix metalloproteinase synthesis and cell function in adventitial fibroblasts

References

• Ahmed MS, Oie E, Vinge LE, et al. (2004). Connective tissue growth factor – a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats. J Mol Cell Cardiol 36:393–404
   PubMed Web of Science ®Google Scholar
• Asano K, Shikama Y, Shoji N, et al. (2010). Tiotropium bromide inhibits TGF-beta-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro. Int J Chron Obstruct Pulmon Dis 5:277–86
   PubMedGoogle Scholar
• Bradham DM, Igarashi A, Potter RL, Grotendorst GR. (1991). Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 114:1285–94
   PubMed Web of Science ®Google Scholar
• Cai XJ, Chen L, Li L, et al. (2009). Adiponectin inhibits lipopolysaccharide-induced adventitial fibroblast migration and transition to myofibroblasts via AdipoR1-AMPK-iNOS pathway. Mol Endocrinol 24:218–28
   PubMedGoogle Scholar
• Chen MM, Lam A, Abraham JA, et al. (2000). CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis. J Mol Cell Cardiol 32:1805–19
   PubMed Web of Science ®Google Scholar
• Esparza J, Kruse M, Lee J, et al. (2004). MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity. FASEB J 18:1682–91
   PubMed Web of Science ®Google Scholar
• Fan WH, Karnovsky MJ. (2002). Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. J Biol Chem 277:9800–5
   PubMed Web of Science ®Google Scholar
• Galis ZS, Khatri JJ. (2002). Matrix metalloproteinases in vascular remodeling and atherogenesis: The good, the bad, and the ugly. Circ Res 90:251–62
   PubMed Web of Science ®Google Scholar
• Gao X, Li J, Huang H, Li X. (2008). Connective tissue growth factor stimulates renal cortical myofibroblast-like cell proliferation and matrix protein production. Wound Repair Regen 16:408–15
   PubMed Web of Science ®Google Scholar
• Geng F, Song K, Xing JZ, et al. (2011). Thio-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer. Nanotechnology 22:285101 (8 pp.)
   Web of Science ®Google Scholar
• Grotendorst GR. (1997). Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8:171–9
   PubMedGoogle Scholar
• Grotendorst GR, Duncan MR. (2005). Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J 19:729–38
   PubMed Web of Science ®Google Scholar
• Hayashida T, Decaestecker M, Schnaper HW. (2003). Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB J 17:1576–8
   PubMed Web of Science ®Google Scholar
• Johnson C, Galis ZS. (2004). Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization. Arterioscler Thromb Vasc Biol 24:54–60
   PubMed Web of Science ®Google Scholar
• Kalluri R, Neilson EG. (2003). Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776–84
   PubMed Web of Science ®Google Scholar
• Kuzuya M Iguchi A. (2003). Role of matrix metalloproteinases in vascular remodeling. J Atheroscler Thromb 10:275–82
   PubMedGoogle Scholar
• Kyriakis JM, Avruch J. (2001). Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807–69
   PubMed Web of Science ®Google Scholar
• Leask A, Abraham DJ. (2003). The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 81:355–63
   PubMed Web of Science ®Google Scholar
• Leivonen SK, Hakkinen L, Liu D, Kahari VM. (2005). Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts. J Invest Dermatol 124:1162–9
   PubMed Web of Science ®Google Scholar
• Lessner SM, Martinson DE, Galis ZS. (2004). Compensatory vascular remodeling during atherosclerotic lesion growth depends on matrix metalloproteinase-9 activity. Arterioscler Thromb Vasc Biol 24:2123–9
   PubMed Web of Science ®Google Scholar
• Li X, Kong X, Huo Q, et al. (2011). Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci 102:1151–7
   Google Scholar
• Liu P, Zhang C, Feng JB, et al. (2008). Cross talk among Smad, MAPK, and integrin signaling pathways enhances adventitial fibroblast functions activated by transforming growth factor-beta1 and inhibited by Gax. Arterioscler Thromb Vasc Biol 28:725–31
   PubMed Web of Science ®Google Scholar
• Mason RP. (2011). Optimal therapeutic strategy for treating patients with hypertension and atherosclerosis: Focus on olmesartan medoxomil. Vasc Health Risk Manag 7:405–16
   PubMedGoogle Scholar
• Massague J, Wotton D. (2000). Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19:1745–54
   PubMed Web of Science ®Google Scholar
• Matsuura I, Wang G, He D, Liu F. (2005). Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 44:12546–53
   PubMed Web of Science ®Google Scholar
• McGrath JC, Deighan C, Briones AM, et al. (2005). New aspects of vascular remodelling: The involvement of all vascular cell types. Exp Physiol 90:469–75
   PubMed Web of Science ®Google Scholar
• Nishida T, Kawaki H, Baxter RM, et al. (2007). CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal 1:45–58
   PubMed Web of Science ®Google Scholar
• Overall CM, Wrana JL, Sodek J. (1989). Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 264:1860–9
   PubMed Web of Science ®Google Scholar
• Perbal B. (2004). CCN proteins: Multifunctional signalling regulators. Lancet 363:62–4
   PubMed Web of Science ®Google Scholar
• Ren M, Wang B, Zhang J. (2009). Study on quality standard of Qindan Capsule. Chin J Integrative Med Cardio-/Cerebrovascular Dis 7:597–8
   Google Scholar
• Ren M, Wang B, Zhang J, et al. (2011). Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming growth factor beta1. Mol Med Report 4:561–7
   PubMed Web of Science ®Google Scholar
• Ren M, Zhang J, Wang B, et al. (2010). Qindan-capsule inhibits proliferation of adventitial fibroblasts and collagen synthesis. J Ethnopharmacol 129:53–8
   PubMed Web of Science ®Google Scholar
• Ruperez M, Lorenzo O, Blanco-Colio LM, et al. (2003). Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis. Circulation 108:1499–505
   PubMed Web of Science ®Google Scholar
• Sartore S, Chiavegato A, Faggin E, et al. (2001). Contribution of adventitial fibroblasts to neointima formation and vascular remodeling: From innocent bystander to active participant. Circ Res 89:1111–21
   PubMed Web of Science ®Google Scholar
• Schulze-Bauer CA, Regitnig P, Holzapfel GA. (2002). Mechanics of the human femoral adventitia including the high-pressure response. Am J Physiol Heart Circ Physiol 282:lH2427–40
   Web of Science ®Google Scholar
• Scott J. (2002). The pathogenesis of atherosclerosis and new opportunities for treatment and prevention. J Neural Transm Suppl 63:1–17
   Google Scholar
• Shi-Wen X, Leask A, Abraham D. (2008). Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 19:133–44
   PubMed Web of Science ®Google Scholar
• Shi Y, O'Brien Jr JE, Fard A, Zalewski A. (1996). Transforming growth factor-beta 1 expression and myofibroblast formation during arterial repair. Arterioscler Thromb Vasc Biol 16:1298–305
   PubMed Web of Science ®Google Scholar
• Standridge JB. (2005). Hypertension and atherosclerosis: Clinical implications from the ALLHAT trial. Curr Atheroscler Rep 7:132–9
   PubMedGoogle Scholar
• Tian Y, Yuan C, Ma D, et al. (2011). IL-21 and IL-12 inhibit differentiation of Treg and TH17 cells and enhance cytotoxicity of peripheral blood mononuclear cells in patients with cervical cancer. Int J Gynecol Cancer 21:1672–8
   PubMed Web of Science ®Google Scholar
• Wang B, Zhang JD, Feng JB, et al. (2007). Effect of traditional Chinese medicine Qin-Dan-Jiang-Ya-Tang on remodeled vascular phenotype and osteopontin in spontaneous hypertensive rats. J Ethnopharmacol 110:176–82
   PubMed Web of Science ®Google Scholar
• Wang B, Zhang JD, Wang SH. (2006). Effects of qindan capsule on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin- II in spontaneous hypertensive rats. Chin J Integr Med 12:287–91
   PubMedGoogle Scholar
• Werb Z. (1997). ECM and cell surface proteolysis: Regulating cellular ecology. Cell 91:439–42
   PubMed Web of Science ®Google Scholar
• Wetzker R, Bohmer FD. (2003). Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol 4:651–7
   PubMedGoogle Scholar
• Yang M, Huang H, Li J, et al. (2004). Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation. FASEB J 18:1920–1
   PubMed Web of Science ®Google Scholar
• Yang M, Huang H, Li J, et al. (2007). Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts. Wound Repair Regen 15:817–24
   PubMed Web of Science ®Google Scholar
• Yuan C, Jiao L, Yang L, et al. (2008). The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen. Proteomics 8:2230–43
   PubMed Web of Science ®Google Scholar