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Research Article

HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics

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Pages 21-30 | Received 03 Feb 2013, Accepted 12 May 2013, Published online: 18 Sep 2013

References

  • Asuming WA, Beauchamp PS, Descalzo JT, et al. (2005). Essential oil composition of four Lomatium Raf. species and their chemotaxonomy. Biochem Syst Ecol 33:17–26
  • Bohrmann H, Stahl E, Mitsmhashi H. (1967). Constituents of umbelliferous plants. XIII Chromatographic studies on the constituents of Cnidium officinale. Chem Pharm Bull 15:1606–8
  • Cao YX, Zhang W, He JY, et al. (2006). Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release. Vasc Pharmacol 45:171–6
  • Chao WW, Kuo YH, Lin BF. (2007). Construction of promoters based immunity screening system and its application on the study of traditional Chinese medicine herbs. Taiwanese J Agric Chem Food Sci 45:193–205
  • Chao WW, Kuo YH, Hsieh SL, et al. (2009a). Inhibitory effects of ethyl acetate extract of Andrographis paniculata on NF-κB trans-activation activity and LPS-induced acute inflammation in mice. Evid Based Compl Alt Med 18:206–15
  • Chao WW, Kuo YH, Li WC, et al. (2009b). The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. J Ethnopharmacol 122:68–75
  • Chao WW, Hong YH, Chen ML, et al. (2010). Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-κB trans-activation activity and LPS-induced inflammation. J Ethnopharmacol 129:244–9
  • Chao ZZ, Chao RB. (2004). Determination of ligustilide content in Chuanxiong by HPLC. West Chin J Pharm Sci 19:197–8
  • Chen LL, Wang YH, Qi J, et al. (2011). Identification and determination of absorbed components of Danggui-Shaoyao-San in rat plasma. Chin J Nat Med 9:0363–8
  • Chen QC, Lee JP, Jin WY, et al. (2007). Cytotoxic constituents from Angelica sinensis radix. Arch Pharm Res 30:565–9
  • Chen QH, Li P, Li B, et al. (2010). A GC-MS-SIM simultaneous determination of ligustilide and butylidenephthalide from Ligusticum chuanxiong using SFE. Chromatographia 72:963–7
  • Cheng LL, Chen XN, Wang Y, et al. (2011). Z-Ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice. Fitoterapia 82:1128–32
  • Cho SK, Abd El-Aty AM, Choi JH, et al. (2007). Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction. J Pharm Biomed Anal 44:1154–8
  • Chung JW, Choi RJ, Seo EK, et al. (2012). Antiinflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways. Arch Pharm Res 35:723–32
  • Cui F, Feng L, Hu J. (2006). Factors affecting stability of Z-ligustilide in the volatile oil of Radix Angelicae sinensis and Ligusticum chuanxiong and its stability prediction. Drug Dev Ind Pharm 32:747–55
  • Davies B, Morris T. (1993). Physiological parameters in laboratory animals and humans. Pharm Res 10:1009–95
  • Deng CH, Ji J, Wang XC, et al. (2005). Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of ligustilides in Ligusticum chuanxiong and Angelica sinensis. J Sep Sci 28:1237–43
  • Dietz BM, Liu D, Hagos GK, et al. (2008). Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD (P) H: Quinine oxidoreductase 1 by alkylating Keap1. Chem Res Toxicol 21:1939–48
  • Du JR, Bai B, Kuang X, et al. (2006). Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus. J Ethnopharmacol 108:54–8
  • Du JR, Yu Y, Ke Y, et al. (2007). Ligustilide attenuates pain behavior induced by acetic acid or formalin. J Ethnopharmacol 112:211–14
  • Fang HJ, Lu RM, Liu GS, et al. (1979). Studies on the components of essential oils. II. Comparison of the major constituents of the essential oil from two species of Danggui Angelica sinensis (Oliv.) Diels and Levisticum officinale Koch. Yao Xue Xue Bao 14:617–23
  • FDA. (2001). U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), Guidance for Industry, Bioanalytical Method Validation
  • Feng ZB, Lu YP, Wu XM, et al. (2012). Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. J Ethnopharmacol 144:313–21
  • Gibaldi M, Perrier D. (1982). Non-Compartmental Analysis Based on Statistical Moment Theory. Pharmacokinetics, 2nd ed. New York: Marcel Dekker, 409–17
  • Gijbels MJM, Scheffer JJC, Svendsen AB. (1982). Phthalides in the essential oil from roots of Levisticum officinale. Planta Med 44:207–11
  • Granero GE, Amidon GL. (2008). Possibility of enterohepatic recycling of ketoprofen in dogs. Int J Pharm 349:166–71
  • Guo JM, Duan JA, Shang EX, et al. (2009). Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma chuanxiong. Fitoterapia 80:168–72
  • Guo JM, Shang EX, Duan JA, et al. (2011). Determination of ligustilide in the brains of freely moving rats using microdialysis coupled with ultra performance liquid chromatography/mass spectrometry. Fitoterapia 82:441–5
  • Hu CY, Ding XL. (2006). Two methods for determining ligustilide content of Angelica oil. J Chin Cereal Oil Assoc 21:152–5
  • Hu LH, Chen XG, Kong L, et al. (2005a). Improved performance of comprehensive two-dimensional HPLC separation of traditional Chinese medicines by using a silica monolithic column and normalization of peak heights. J Chromatogr A 1092:191–8
  • Hu J, Feng LL, Liu Y, et al. (2005b). Study on the determination and extraction of ligustilide in Radix Angelicae sinensis and Rhizoma chuanxiong. J Shenyang Pharm Univ 22:67–70
  • Ji SG, Chai YF, Wu YT, et al. (1999). Determination of ferulic acid in Angelica sinensis and Chuanxiong by capillary zone electrophoresis. Biomed Chromatogr 13:333–4
  • Kanamori H, Sakamoto I. (1992). Evaluation of Angelicae radix. Purification method and stability of ligustilide. Hiroshima-ken Eisei Kenkyusho Kenkyu Hokoku, 39:23–6
  • Kan WLT, Cho CH, Rudd JA, et al. (2008). Study of the antiproliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. J Ethnopharmacol 120:36–43
  • Kim MR, Abd EI-Aty AM, Choi JH, et al. (2006a). Identification of volatile components in Angelica species using supercritical-CO2 fluid extraction and solid phase microextraction coupled to gas chromatography-mass spectrometry. Biomed Chromatogr 20:1267–73
  • Kim MR, Abd EI-Aty AM, Kim IS, et al. (2006b). Determination of volatile flavor components in danggui cultivars by solvent free injection and hydrodistillation followed by gas chromatographic-mass spectrometric analysis. J Chromatogr A 1116:259–64
  • Kuang X, Yao Y, Du JR, et al. (2006). Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice. Brain Res 102:145–53
  • Kuang X, Du JR, Chen YS, et al. (2009). Protective effect of Z-ligustilide against amyloid β-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains. Pharmacol Biochem Behav 92:635–41
  • Kuang X, Du JR, Liu YX, et al. (2008). Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacol Biochem Behav 88:213–21
  • Kwon YS, Kobayashi A, Kajiyama S, et al. (1997). Antimicrobial constituents of Angelica dahurica roots. Phytochemistry 44:887–9
  • Lao SC, Li SP, Kan KKW, et al. (2004). Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Anal Chim Acta 526:131–7
  • Li CY, Qi LW, Li P. (2011). Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC-TOF/MS. J Pharm Biomed Anal 55:146–60
  • Li CY, Qi LW, Li P, et al. (2009). Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 23:1977–88
  • Li G, Ma C, Li X, et al. (2000). Studies on the stability of ligustilide and the analysis of its isomerized products by GC-MS. Chin Tradit Herb Drug 31:405–7
  • Li GS, Ma CJ, Lim ZF. (2001). Extraction of essential oil from Angelica sinensis by supercritical-CO2 fluid in comparison with that by steam distillation. Chin Tradit Herb Drug 32:581–3
  • Li H, Wang YT. (2003). Influencing factor of the stability of ligustilide and means of stabilization. J Jiangxi Coll Tradit Chin Med 15:56–59
  • Li P, Li SP, Lao SC, et al. (2006a). Optimization of pressurized liquid extraction for Z-ligustilide, Z-butylidenephthalide and ferulic acid in Angelica sinensis. J Pharm Biomed Anal 40:1073–9
  • Li XR, Liang YZ, Guo FQ. (2006b). Analysis of volatile oil in Rhizoma Ligustici Chuanxiong--Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. Acta Pharmacol Sin 27:491–8
  • Lin LZ, He XG, Lian LZ, et al. (1998). Liquid chromatographic-electro-spray mass spectrometric study of the phthalides of Angelica sinensis and chemical changes of Z-ligustilide. J Chromatogr A 810:71–79
  • Liu EH, Qi LW, Peng YB, et al. (2009). Rapid separation and identification of 54 major constituents in Buyang Huanwu decoction by ultra-fast HPLC system coupled with DAD-TOF/MS. Biomed Chromatogr 23:828–42
  • Lu GH, Chan K, Chan CL, et al. (2004). Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry. J Chromatogr A 1046:101–7
  • Lu GH, Chan K, Leung K, et al. (2005a). Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensis. J Chromatogr A 1068:209–19
  • Lu GH, Chan K, Liang YZ, et al. (2005b). Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs. J Chromatogr A 1073:383–92
  • Lu Q, Qiu TQ, Yang H. (2006). Ligustilide inhibits vascular smooth muscle cells proliferation. EurJ Pharmacol 542:136–40
  • Lu JL, Zhao J, Duan JA, et al. (2009). Quality evaluation of Angelica sinensis by simultaneous determination of ten compounds using LC-PDA. Chromatographia 70:455–65
  • Lv Y, Lou ZH, Chen SH, et al. (2011). Pharmacokinetics and tissue distribution of 2,3,5,4-tetrahydroxystilbene-2-O-β-d-glucoside from traditional Chinese medicine Polygonum multi florum following oral administration to rats. J Ethnopharmacol 137:449–456
  • Ma ZJ, Bai LH. (2013). Antiinflammatory effects of Z-Ligustilide nanoemulsion. Inflammation 36:294–99
  • Mei QB, Tao JY, Cui B. (1991). Advances in the pharmacological studies of radix Angelica sinensis (Oliv) Diels (Chinese danggui). Chin Med J 104:776–81
  • Naito T, Katsuhara T, Niitsu K, et al. (1992). Two phthalides from Ligusticum chuangxiong. Phytochemistry 31:639–42
  • Qi HY, Han YF, Rong JH. (2012). Potential roles of PI3K/Akt and Nrf2eKeap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation. Neuropharmacology 62:1659–70
  • Qi LW, Wen XD, Cao J, et al. (2008). Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 22:2493–509
  • Schinkovitz A, Pro SM, Main M, et al. (2008). Dynamic nature of the ligustilide complex. J Nat Prod 71:1604–11
  • Shao M, Qu K, Liu K, et al. (2011). Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits. Planta Med 77:809–16
  • Shi LF, Zheng XM, Cai Z, et al. (1995). Comparison of influence of essential oil from Ligusticum chuanxiong Hort on microcirculation in rabbit conjunctiva bulbar before and after decomposition of ligustilide. J Chin Pharmacol Toxicol 9:157–8
  • Shi YF, He LC, Wang SC. (2006). Determination of ligustilide in rat blood and tissues by capillary gas chromatography/mass spectrometry. Biomed Chromatogr 20:993–8
  • Sun XH, Niu LJ, Li XQ, et al. (2009). Characterization of metabolic profile of mosapride citrate in rat identification of two new metabolites: Mosapride N-oxide and morpho linering-opened mosapride by UPLC-ESI-MS/MS. J Pharm Biomed Anal 50:27–34
  • Su YW, Chiou WF, Chao SH, et al. (2011). Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways. Int Immunopharmacol 11:1166–72
  • Takashi Y. (1982). Quantitative determination of ligustilide and butylidenephthalide in touki (Angelica radix) and senkyu (Cnidii rhizome) by high-performance liquid chromatography. Hokkaidoritsu Eisei Kenkyusyoho 32:12–16
  • Tang J, Zhang Y, Hartman TG, et al. (1990). Free and glycosidically bond volatile compounds in fresh celery (Apium graveolens L.). J Agri Food Chem 38:1937–40
  • Tsai NM, Chen YL, Lee CC, et al. (2006). The natural compound n-butylidenephthaliude derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. J Neurochem 99:1251–62
  • Wang J, Du JR, Wang Y, et al. (2010). Zligustilide attenuates lipopolysaccharide induced proinflammatory response via inhibiting NF-κB pathway in primary rat microglia. Acta Pharmacol Sin 31:791–7
  • Wu XM, Qian ZM, Zhu L, et al. (2011). Neuroprotective effect of ligustilide against ischaemia--reperfusion injury via up-regulation of erythropoietin and down regulation of RTP801. Brit J Pharmacol 164:332–43
  • Yan R, Ko NL, Li SL, et al. (2008). Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma chuanxiong in the rat. Drug Metab Dispos 36:400–8
  • Yeh JC, Garrard IJ, Cho CWC, et al. (2012). Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. J Chromatogr A 1236:132–8
  • Yi T, Leung KSY, Lu GH, et al. (2007). Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry. Planta Med 73:392–8
  • Yu Y, Du JR, Wang CY, et al. (2008). Protection against hydrogen peroxide induced injury by Z-ligustilide in PC12. Exp Brain Res 184:307–12
  • Zhang L, Du JR, Wang J, et al. (2009). Z-Ligustilide extracted from radix Angelica sinensis decreased platelet aggregation induced by adp ex vivo and arterio-venous shunt thrombosis in vivo in rats. Yakugaku Zasshi 129:855–9
  • Zhou C, Li X. (2001). Studies on the stability of ligustilide with solvent effect. Acta Pharmacol Sin 36:793–5
  • Zschocke S, Liu JH, Stuppner H, et al. (1998). Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography-mass spectrometry. Phytochem Anal 9:283–90
  • Zuo AH, Wang L, Xiao HB, et al. (2011). Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma chuanxiong decoction by HPLC-ESI-MS/MS. J Pharm Biomed Anal 56:1046–56

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